A Novel Biocompatible Sustained Release Nano Particle Pharmaceutical Formulation And Method Of Preparation Using Basella Alba And Chitosan As Matrix Formers


Updated about 1 year ago

Abstract

APPLICANT: SRI RAMACHANDRA UNIVERSITYTITLE: A NOVEL BIOCOMPATIBLE SUSTAINED-RELEASE NANO- PHARMACEUTICAL FORMULATION AND METHOD OF PREPARATION USING BASELLA ALBA AND CHITOSAN AS MATRIX FORMERSABSTRACTThe present invention relates to a novel biocompatible sustained-release nano-particle pharmaceutical formulation and method of preparation thereof. The formulation comprises of at least one therapeutic drug entrapped in a bio degradable antimicrobial activity exhibiting polymeric carrier to form a polymer nano-carrier system. The formulation is characterized in the bio degradable polymer comprising of chitosan as cationic polymer and polysaccharides extracted from Basella alba leaf mucilage as an anionic polymer in which the therapeutic drug is complexed with the polymer thereby it retains the biological activity of the drug. The present invention also discloses the process of production of novel biocompatible sustained-release nano-particle pharmaceutical formulation by the modified coacervation method using polysaccharides extracted from Basella alba leaf mucilage as anionic polymer with chitosan as cationic polymer at different concentrations of polymeric solutions as matrix formers to sustain the drug release and thus bioavailability and therapeutic efficacy of the drug can be enhanced.

Information

Application ID 4313/CHE/2015
Invention Field CHEMICAL
Date of Application 2015-08-18
Publication Number 08/2017

Applicants

Name Address Country Nationality
SRI RAMACHANDRA UNVIERSITY No 1. RAMACHANDRA NAGAR, PORUR, CHENNAI, - 600116 India India

Inventors

Name Address Country Nationality
HARIKA BALYA JUNIOR RESEARCH FELLOW DEPARTMENT OF PHARMACEUTICS, FACULTY OF PHARMACY, SRI RAMACHANDRA UNIVERSITY, PORUR, CHENNAI-600116 India India
SHANMUGANATHAN SEETHARAMAN PROFESSOR & HEAD, DEPARTMENT OF PHARMACEUTICS, FACULTY OF PHARMACY, SRI RAMACHANDRA UNIVERSITY, PORUR, CHENNAI-600116 India India
GOWTHAMARAJAN KUPPUSAMY PROFESSOR & HEAD, DEPARTMENT OF PHARMACEUTICS, JSS COLLEGE OF PHARMACY, OOTY, TAMILNADU-643001 India India
THYAGARAJAN SADRAS PANCHATCHARAM PROFESSOR OF EMINENCE &DEAN (RESEARCH), SRI RAMACHANDRA UNIVERSITY, PORUR, CHENNAI-600116. India India

Specification

Documents

Name Date
Power of Attorney [18-08-2015(online)].pdf 2015-08-18
Form 5 [18-08-2015(online)].pdf 2015-08-18
Form 20 [18-08-2015(online)].pdf 2015-08-18
4313-CHE-2015-CORRESPONDENCE-F1-PA-130116.pdf 2016-06-20
Form 3 [18-08-2015(online)].pdf 2015-08-18
Description(Complete) [18-08-2015(online)].pdf 2015-08-18
4313-CHE-2015 POWER OF ATTORNRY 1312016.pdf 2016-06-20
4313-CHE-2015-FORM 18 [14-06-2019(online)].pdf 2019-06-14
Drawing [18-08-2015(online)].pdf 2015-08-18
4313-CHE-2015-OTHERS [03-09-2020(online)].pdf 2020-09-03
4313-CHE-2015 FORM-1 1312016.pdf 2016-06-20
4313-CHE-2015-FER.pdf 2020-03-17
4313-CHE-2015-FER_SER_REPLY [03-09-2020(online)].pdf 2020-09-03
4313-CHE-2015-CLAIMS [03-09-2020(online)].pdf 2020-09-03
4313-CHE-2015-Correspondence to notify the Controller [06-01-2021(online)].pdf 2021-01-06
4313-CHE-2015-Written submissions and relevant documents [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-Retyped Pages under Rule 14(1) [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-Annexure [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-2. Marked Copy under Rule 14(2) [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-US(14)-HearingNotice-(HearingDate-21-01-2021).pdf 2021-10-17
4313-CHE-2015-Proof of Right [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-PatentCertificate26-07-2022.pdf 2022-07-26
4313-CHE-2015-NBA Approval Submission [23-07-2022(online)].pdf 2022-07-23
4313-CHE-2015-IntimationOfGrant26-07-2022.pdf 2022-07-26
4313-CHE-2015-OTHERS [21-10-2022(online)].pdf 2022-10-21
4313-CHE-2015-EDUCATIONAL INSTITUTION(S) [21-10-2022(online)].pdf 2022-10-21
Power of Attorney [18-08-2015(online)].pdf 2015-08-18
Form 5 [18-08-2015(online)].pdf 2015-08-18
Form 20 [18-08-2015(online)].pdf 2015-08-18
4313-CHE-2015-CORRESPONDENCE-F1-PA-130116.pdf 2016-06-20
Description(Complete) [18-08-2015(online)].pdf 2015-08-18
Drawing [18-08-2015(online)].pdf 2015-08-18
4313-CHE-2015 POWER OF ATTORNRY 1312016.pdf 2016-06-20
Form 3 [18-08-2015(online)].pdf 2015-08-18
4313-CHE-2015-Written submissions and relevant documents [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-FER.pdf 2020-03-17
4313-CHE-2015 FORM-1 1312016.pdf 2016-06-20
4313-CHE-2015-FORM 18 [14-06-2019(online)].pdf 2019-06-14
4313-CHE-2015-CLAIMS [03-09-2020(online)].pdf 2020-09-03
4313-CHE-2015-FER_SER_REPLY [03-09-2020(online)].pdf 2020-09-03
4313-CHE-2015-OTHERS [03-09-2020(online)].pdf 2020-09-03
4313-CHE-2015-Correspondence to notify the Controller [06-01-2021(online)].pdf 2021-01-06
4313-CHE-2015-Retyped Pages under Rule 14(1) [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-Annexure [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-2. Marked Copy under Rule 14(2) [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-PatentCertificate26-07-2022.pdf 2022-07-26
4313-CHE-2015-US(14)-HearingNotice-(HearingDate-21-01-2021).pdf 2021-10-17
4313-CHE-2015-Proof of Right [21-01-2021(online)].pdf 2021-01-21
4313-CHE-2015-OTHERS [21-10-2022(online)].pdf 2022-10-21
4313-CHE-2015-IntimationOfGrant26-07-2022.pdf 2022-07-26
4313-CHE-2015-NBA Approval Submission [23-07-2022(online)].pdf 2022-07-23
4313-CHE-2015-EDUCATIONAL INSTITUTION(S) [21-10-2022(online)].pdf 2022-10-21

Orders

Applicant Section Controller Decision Date URL