The present invention relates to a new crystalline and pure polymorphic form of strontium ranelate monohydrate of formula-II and process for the preparation thereof. The new crystalline polymorph is characterized by X-ray powder diffraction pattern (XRD) and water content of 3.0 to 4.5% measured by thermogravimet...

The present invention discloses a new and an improved process for preparation of Ibandronate sodium monohydrate. According to the process pentylamine is reacted with ethylacrylate to give N-pentyl-β-alanine ethyl ester (XXIV), which on methylation provided N-methyl-N-pentyl-p-alanineethylester (XXV). The reresulting...

The present invention relates to an improved process for preparation of pure strontium ranelate hydrates (Ia-c) by using the intermediates, amino dimethyl ester (II) and tetramethyl ester (III), which are prepared by novel methods. Ia- Strontium ranelate octahydrate: n=8 Ib- Strontium ranelate tetrahydrate: n=4 ...

The present invention relates to a process for preparation of stable anhydrous form of Risedronate Monosodium Salt, by reacting 3-pyridyl-1 -hydroxyethylidene-l,l-biphosphonic acid Monosodium salt Hemipentahydrate in water with glycol, which comprises reacting -pyridyl-1-hydroxyethylidene-1,1-biphosphonic acid Monos...

The present invention discloses a new and an improved process for preparation of Ibandronate sodium monohydrate. According to the process pentylamine is reacted with ethylacrylate to give N-pentyl-β-alanine ethyl ester (XXIV), which on methylation provided N-methyl-N-pentyl-β-alanineethylester (XXV). The reresulting...

The invention relates to the process of preparation of Risedronic acid and Risedronate sodium hemipentahydrate in the absence of organic solvents. The process comprises, reacting 3-pyridyl acetic acid with phosphorous acid and phosphorus trichloride to give Risedronic acid which is further reacted with sodium hydrox...

A novel Strontium Risedronate compound, a process for producing Strontium Risedronate and a pharmaceutical composition comp ringing the same. The present invention relates to a compound of Formula I or a pharmaceutical salts thereof. A process for producing a compound of formula I by reacting risedronic acid and...

The present invention relates to an improved process for the preparation of an antihistamine agent. The present invention particularly relates to an improved process for the preparation of Cyclizine or its salts. The present invention more particularly relates to an improved process for the preparation of Cyclizine ...