DESC:FORM 2

THE PATENTS ACT 1970
(SECTION 39 OF 1970)

&

THE PATENT RULES, 2003

COMPLETE SPECIFICATION
(Section 10 and Rule 13)

NOVEL FUNGICIDAL COMBINATIONS OF THIFLUZAMIDE

We, COROMANDEL INTERNATIONAL LIMITED,
an Indian company incorporated under the Companies Act, 1956 having its
principal place of business at Coromandel House, Sardar Patel Road,
Secunderabad – 500 003, Telangana, India

The following specification particularly describes the invention and the manner in which it is to be performed.
FIELD OF THE INVENTION
The present invention relates to a novel synergistic fungicidal composition.

Particularly the present invention relates to a fungicidal composition comprising of thifluzamide, pyraclostrobin and propineb with suitable agrochemical excipients and process for the preparation thereof.

BACKGROUND OF THE INVENTION
In the field of crop protection, the use of a particular active substance for the control of specific fungi may become increasingly difficult in time, because of the adaptation of the mentioned fungi to the fungicide being used. This leads to the loss of effectiveness in the control of the pathogen, and, consequently, downfall in crop production and profitability.

A very well-known and widely used form of approaching this problem is by using a combination of different active substances presenting different mechanisms of action.

Fungicides are biocidal chemical compounds or biological organisms used to kill parasitic fungi or their spores. Fungi can cause serious damage in agriculture, resulting in critical losses of yield, quality, and profit. Fungicides are used both in agriculture and to fight fungal infections in animals. Although pesticides remain indispensable in agriculture, a great potential still exists to improve their efficiency and thus reduce their input into the environmental and food chain.

Thifluzamide is highly active against Basidiomycete fungi, Rhizoctonia solani, primarily in rice, potatoes, and turf markets. Thifluzamide was first disclosed in US5045554. Chemically Thifluzamide is known as 2',6'-dibromo-2-methyl-4'-trifluoromethoxy-4-trifluoromethyl-1,3-thiazole-5-carboxanilide, having following structure:

Pyraclostrobin is chemically, methyl N-{2-[1-(4-chlorophenyl)pyrazol-3-yloxymethyl] phenyl}(N-methoxy)carbamate and has the following structure:

Propineb is a dithiocarbamate fungicide and chemically polymeric zinc 1,2-propylenebis(dithiocarbamate). propylene 1,2-bis (dithiocarbamic acid) is a member of the class dithiocarbamic acids resulting from the formal addition of a molecule of carbon disulfide to each of the nitrogen of propylene diamine. It derives from a propylene diamine. It is a conjugate acid of a propylene 1,2-bis(dithiocarbamate) and has the following structure:

IN 390212 of GSP Crop Science private ltd, discloses fungicidal compositions of thifluzamide and metalaxyl-M with at least one additional fungicide selected from ametoctradin, chlorothalonil, fluazinam, fluopicolide, folpet, mancozeb, mandipropamid, metiram, propineb, zoxamide along with one or more inactive excipients.

IN 309298 of Willowood chemicals private limited, discloses a synergistic fungicidal combination comprising thifluzamide, difenoconazole and validamycin.

Depending on the field of application, and the mode of application, and depending on physical, chemical, and biological parameters, the active substances are employed as active substance formulation in the form of a mixture with customary carriers, adjuvants, and additives.

It is always desirable to reduce the quantity of fungicides used while ensuring effective protection of crops from diseases caused by fungal pathogens. Combinations of fungicides may provide significantly enhanced disease control against fungal pathogens than would be possible based on the activity of the individual fungicide.

It was observed that during the field trail the mixture of thifluzamide, pyraclostrobin and propineb in the ranges in accordance with the present invention leads to much better percentile control of the different fungal diseases like blast, blight, spot, rot, smut, and wilt etc. in comparison to the individual commercial formulations. It is an objective of this invention to provide a synergistic fungicidal combination which demonstrates an enhanced anti-fungal effect along with reduced cost and minimal environmental damage. Accordingly, the present invention provides a synergistic fungicidal composition comprising of thifluzamide, pyraclostrobin and propineb.

OBJECT OF THE INVENTION
One object of the present invention is to provide a novel fungicidal composition.

Another object of the present invention is to provide a synergistic fungicidal composition of thifluzamide, pyraclostrobin and propineb.

Another object of the present invention is to provide a wettable powder (WP) composition of thifluzamide, pyraclostrobin and propineb with suitable agrochemical excipients.

Yet another object of the present invention is to provide a wettable powder composition comprising thifluzamide, pyraclostrobin and propineb.

SUMMARY OF THE INVENTION
The present invention provides a novel synergistic fungicidal composition of thifluzamide, pyraclostrobin and propineb.

One aspect of the present invention provides a synergistic fungicidal composition comprising of a) thifluzamide, b) pyraclostrobin, c) propineb, with suitable agrochemical excipients.

Another aspect of the present invention provides a synergistic fungicidal composition comprising of:
a) thifluzamide in a range from 2% (w/w) to 10% (w/w),
b) pyraclostrobin in a range from 2% (w/w) to 10% (w/w),
c) propineb present in a range from 40% (w/w) to 65% (w/w), and
d) agrochemical excipients.

Another aspect of the present invention provides a wettable powder composition comprising of:
a) thifluzamide in a range from 2% (w/w) to 10% (w/w),
b) pyraclostrobin in a range from 2% (w/w) to 10% (w/w),
c) propineb present in a range from 40% (w/w) to 65% (w/w), and
d) agrochemical excipients.

In an aspect of the present invention, the suitable agrochemical excipients are selected from a wetting agent, a dispersing agent, a defoamer, an anticaking agent, a co-filler, and a filler.

In an aspect of the present invention, the wetting agent is selected from the group comprising of anionic sodium diisopropyl naphthalene sulfonate, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, and sodium methyl cocoyl taurate, present in a range from 1% to 8% (w/w).

In an aspect of the present invention, the dispersing agent is selected from the group comprising of sodium lignosulfonate, alkyl naphthalene sulfonate condensate, sodium salt of naphthalene sulfonate condensate, salt of phenol sulphonic acid condensation product, and alkyl naphthalene sulfonate present in a range from 5% to 15% (w/w).

In an aspect of the present invention, the defoamer is polydimethylsiloxane, present in a range from 0.1% to 2% (w/w).

In an aspect of the present invention, the anti-caking agent is silicon dioxide, present in an amount of 0.5% to 3% (w/w).

In an aspect of the present invention, the co-filler is selected from the group comprising lactose monohydrate, ammonium sulphate, and combination thereof, present in a range from 1% to 10% (w/w).

In an aspect of the present invention, the filler is china clay, present in Q.S.

Yet another aspect of the present invention provides a process for the preparation of a wettable powder composition comprising of thifluzamide, pyraclostrobin and propineb with one or more agrochemical excipients.

Yet another aspect of the present invention provides an improved stable and ready to use fungicidal composition, having superior bio-efficacy compared to the individual formulations.

DESCRIPTION OF THE INVENTION
The term "comprising", which is synonymous with "including", "containing", or "characterized by” here is defined as being inclusive or open-ended, and does not exclude additional, unrecited elements or method steps, unless the context clearly requires otherwise.

It is to be noted that, as used in the specification, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

As used herein, the terms "crops" and "vegetation" can include, for instance, dormant seeds, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, immature vegetation, and established vegetation.

As used herein, immature vegetation may be understood to include small vegetative plants prior to reproductive stage, and mature vegetation may be understood to include vegetative plants during and after the reproductive stage.

As used herein, the term “synergistic composition” may be understood to include effective combination of more than one agrochemical that allows the application of the said agrochemical in a much lower dosage, which results in a less dosage treatment for the crops.

The term "comprising", which is synonymous with "including", "containing", or "characterized by" here is defined as being inclusive or open-ended, and does not exclude additional, unrecited elements or method steps, unless the context clearly requires otherwise.

As used herein, the term “agrochemical excipients” may be understood to include a range of surfactants, dispersing agents, pigments, solvents, co-solvents, defoamers, and emulsions, crystallization inhibitors, viscosity modifiers, suspending agents, dyes, antioxidants, light absorbers, mixing aids, neutralizers or pH adjusting substances and buffers, corrosion inhibitors, fragrances, wetting agents, absorption enhancers, micronutrients, plasticizers, lubricants, thickeners, anti-freezing agents, sterilization agents, biocide, adjuvant among others.

The fungicidal composition of the present invention may be formulated as capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) Tablet (TB), Water dispersible granules (WG or WDG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW) among others. Preferably, the composition of the present invention is formulated as wettable powder (WP).

One embodiment of the present invention provides a novel fungicidal composition.

Another embodiment of the present invention provides a synergistic fungicidal composition comprising of a) thifluzamide, b) pyraclostrobin, c) propineb, with suitable agrochemical excipients.

Another embodiment of the present invention provides a synergistic fungicidal composition comprising of
a) thifluzamide in a range from 2% (w/w) to 10% (w/w),
b) pyraclostrobin in a range from 2% (w/w) to 10% (w/w),
c) propineb present in a range from 40% (w/w) to 65% (w/w), and
d) agrochemical excipients.

Another embodiment of the present invention provides a wettable powder composition comprising of:
a) thifluzamide in a range from 2% (w/w) to 10% (w/w),
b) pyraclostrobin in a range from 2% (w/w) to 10% (w/w),
c) propineb present in a range from 40% (w/w) to 65% (w/w), and
d) agrochemical excipients.

According to the present invention, the suitable agrochemical excipients are selected from a wetting agent, a dispersing agent, a defoamer, an anticaking agent, a co-filler, and a filler.

According to the present invention, the wetting agent is selected from the group comprising of an anionic sodium diisopropyl naphthalene sulfonate, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, and sodium methyl cocoyl taurate, present in a range from 1% to 8% (w/w).

According to the present invention, the dispersing agent is selected from the group comprising of sodium lignosulfonate, alkyl naphthalene sulfonate condensate, sodium salt of naphthalene sulfonate condensate, salt of phenol sulphonic acid condensation product, and alkyl naphthalene sulfonate present in a range from 5% to 15% (w/w).

According to the present invention, the defoamer is polydimethylsiloxane, present in a range from 0.1% to 2% (w/w).

According to the present invention, the anti-caking agent is silicon dioxide, present in an amount of 0.5% to 3% (w/w).

According to the present invention, the co-filler is selected from the group comprising lactose monohydrate, ammonium sulphate, and combination thereof, present in a range from 1% to 10% (w/w).

According to the present invention, the filler is china clay, present in Q.S.

Yet another embodiment of the present invention is to provide a process for the preparation of novel synergistic fungicidal composition comprising of thifluzamide, pyraclostrobin and propineb.

The fungicidal composition of the present invention is having curative, preventive and systemic fungicidal properties for protecting cultivated plants. As has been mentioned, said active ingredient mixtures can be used to inhibit or destroy the pathogens that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such pathogens. Active ingredient mixtures have the special advantage of being highly active against diseases in the soil that mostly occur in the early stages of plant development.

The novel compositions of thifluzamide, pyraclostrobin and propineb are effective for management of mixed infestation of fungal diseases.

The compositions according to the invention have very good fungicidal properties and can be employed for controlling phytopathogenic fungi such as Ascomycetes, Basidiomycetes, Chytridiomycetes, Deuteromycetes, Oomycetes, Plasmodiophoromycetes, Zygomycetes, and the like. Examples which may be mentioned, but not by limitation, are some pathogens of fungal diseases.

The present invention is further illustrated by the following examples which are provided merely to be exemplary of the inventions and is not intended to limit the scope of the invention. Certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.

EXAMPLES:
Example-1: The illustrative embodiments show the composition of thifluzamide + pyraclostrobin + propineb in wettable powder form in different amount as follows:

Table-1: Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP
S. No. Composition Function Charge in (%)
1. Thifluzamide Active ingredient 5.6
2. Pyraclostrobin Active ingredient 5.6
3. Propineb Active ingredient 56.0
4. Anionic sodium diisopropyl naphtalene sulfonate Wetting agent 5.0
5. Sodium lignosulfonate Dispersing agent 10.0
6. Polydimethylsiloxane Defoamer 0.5
7. China clay Filler Q.S.

Process for manufacture of composition is as follows: 5.6 gm of thifluzamide, 5.6 gm of pyraclostrobin, 56.0 gm of propineb, 5.0 gm of anionic sodium diisopropyl naphthalene sulfonate, 10.0 gm of sodium lignosulfonate, 0.5 gm of polydimethylsiloxane, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 15 microns). Collecting the milled material and post blending the material for 1 hour followed by packing the material in a suitable package.

Table-2: Thifluzamide 2.0% + Pyraclostrobin 2.0% + Propineb 60.0% WP
S. No. Composition Function Charge in (%)
1. Thifluzamide Active ingredient 2.0
2. Pyraclostrobin Active ingredient 2.0
3. Propineb Active ingredient 60.0
4. Sodium isopropyl naphthalene sulfonate Wetting agent 5.0
5. Alkyl naphthalene sulfonate condensate Dispersing agent 10.0
6. Polydimethylsiloxane Defoamer 1.5
7. Lactose monohydrate Co-Filler 5.0
8. Ammonium sulphate Co-Filler 5.0
9. China clay Filler Q.S.

Process for manufacture of composition is as follows: 2.0 gm of thifluzamide, 2.0 gm of pyraclostrobin, 60.0 gm of propineb, 5.0 gm of anionic Sodium isopropyl naphthalene sulfonate, 10.0 gm of Alkyl naphthalene sulfonate condensate, 1.5 gm of polydimethylsiloxane, 5.0 gm of lactose monohydrate, 5.0 gm of ammonium sulphate, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 15 microns). Collecting the milled material and post blending the material 5 for 1 hour followed by packing the material in a suitable package.

Table-3: Thifluzamide 10.0% + Pyraclostrobin 10.0% + Propineb 40.0% WP
S. No. Composition Function Charge in (%)
1. Thifluzamide Active ingredient 10.0
2. Pyraclostrobin Active ingredient 10.0
3. Propineb Active ingredient 40.0
4. Anionic sodium diisopropyl naphtalene sulfonate Wetting agent 8.0
5. Sodium salt of naphthalene sulfonate condensate Dispersing agent 15.0
6. Polydimethylsiloxane Defoamer 0.2
7. China clay Filler Q.S.

Process for manufacture of composition is as follows: 10.0 gm of thifluzamide, 10.0 gm of pyraclostrobin, 40.0 gm of propineb, 8.0 gm of anionic sodium diisopropyl naphthalene sulfonate, 15.0 gm of sodium salt of naphthalene sulfonate condensate, 0.2 gm of polydimethylsiloxane, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 15 microns). Collecting the milled material and post blending the material for 1 hour followed by packing the material in a suitable package.

Table-4: Thifluzamide 6.0% + Pyraclostrobin 6.0% + Propineb 50.0% WP
S. No. Composition Function Charge in (%)
1. Thifluzamide Active ingredient 6.0
2. Pyraclostrobin Active ingredient 6.0
3. Propineb Active ingredient 50.0
4. Alkyl naphtalene sulfonate Wetting agent 2.5
5. Salt of Phenol Sulphonic Acid condensation product Dispersing agent 5.0
6. Polydimethylsiloxane Defoamer 1.0
7. China clay Filler Q.S.

Process for manufacture of composition is as follows: 6.0 gm of thifluzamide, 6.0 gm of pyraclostrobin, 50.0 gm of propineb, 2.5 gm of alkyl naphthalene sulfonate, 5.0 gm of salt of phenol sulphonic acid condensation product, 1.0 gm of polydimethylsiloxane, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 15 microns). Collecting the milled material and post blending the material for 1 hour followed by packing the material in a suitable 10 package.

Table-5: Thifluzamide 3.5% + Pyraclostrobin 3.5% + Propineb 45.0% WP
S. No. Composition Function Charge in (%)
1. Thifluzamide Active ingredient 3.5
2. Pyraclostrobin Active ingredient 3.5
3. Propineb Active ingredient 45.0
4. Sodium methyl cocoyl taurate Wetting agent 5.0
5. Alkyl naphthalene sulfonate Dispersing agent 10.0
6. Polydimethylsiloxane Defoamer 0.1
7. Silicon dioxide Anti caking agent 0.5
8. China clay Filler Q.S.

Process for manufacture of composition is as follows: 3.5 gm of thifluzamide, 3.5 gm of pyraclostrobin, 45.0 gm of propineb, 5.0 gm of sodium methyl cocoyl taurate, 10.0 gm of alkyl naphthalene sulfonate, 0.1 gm of polydimethylsiloxane, 0.5 gm of silicon dioxide, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 15 microns). Collecting the milled material and post blending the material for 1 hour followed by packing the material in a suitable package.

Example 2: Efficacy study of thifluzamide 5.6% + Pyraclostrobin 5.6% + propineb 56% in wettable powder (WP) form:

SYNERGY STUDIES:
The synergistic pesticidal action of the inventive mixtures calculated by Colby’s formula as follows:

Appropriate analysis of plant response to Fungicide combination is critical in determining the type of activity observed. The most widely used model is the one Gowing* derived and Colby** modified. Gowing described a mathematical formula for calculating the predicting response values for pesticide mixtures. He suggested the expected (E) percent inhibition of growth induced by pesticide A plus pesticide B and plus pesticide C is as follows, *(Jerry Flint et al, 1988)***

(AB+AC+BC) ABC
Expected (E) = A + B + C - +
100 10000

Where,

A = observed efficacy of active ingredient A at the same concentration as used in the mixture.
B = observed efficacy of active ingredient B at the same concentration as used in the mixture.
C = observed efficacy of active ingredient C at the same concentration as used in the mixture.
When the percentage of pesticidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)

Reference:
*Gowing, D. P. 1960. Comments on tests of Fungicide mixtures. Weeds 8:379–391.
**Colby, S. R. 1967. Calculating synergistic and antagonistic responses of Fungicide combinations. Weeds 15:20–22
*** Jerry Flint et al, 1988. Analyzing Fungicide Interactions: A Statistical Treatment of Colby's Method. Weed Technology 2: 304-309

Trial 1: Bio-efficacy against rice sheath blight -
The sheath blight is caused by the fungal pathogen Rhizoctonia solani. This is potentially devasting disease can infect rice foliage at any stage of crop development. Its major threat to many crops and can also affect the crop stand and yield Rhizoctonia solani fungus is cosmopolitan, polyphagous, widely distributed in tropical, subtropical, and temperate regions and for its development required hot and humid environment. The fungus spreads in the field by growing its runner hyphae from tiller to tiller, from leaf to leaf, and from plant to plant, resulting in a circular pattern of damage. The infection spreads most quickly when susceptible varieties are grown under favorable conditions such as warm temperature (28 to 32°C), high humidity (95% or above), and dense stands with a heavily developed canopy.

The field trial was conducted to evaluate the efficacy of innovative mixtures of Pyraclostrobin, cyproconazole and Propineb against sheath blight fungus in rice crop. The trial was conducted with randomized block design with net plot size of 5m x 6m. rice crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after transplanting.

The visual observations were recorded for % disease control from ten hills per plot. The observations were recorded before spraying, 7 DAA (Days after application) and 14 DAA (Days after application).

Table 6: sheath blight disease control in rice:
Compositions Dose
(g AI/ha) Percent disease control – rice sheath blight
07 DAA 14 DAA
Thifluzamide 24% SC 70 60 50
Pyraclostrobin 20% WG 70 55 50
Propineb 70% WP 700 50 40
Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP 840 95 90
SC – Suspension concentrates, WG – Wettable granules, WP – Wettable powder, and DAA - Days after application.

The trial results show excellent efficacy of Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP combinations against sheath blight disease of rice. The solo application of three active ingredients tested here, were also not able to provide satisfactory control of sheath blight disease. The combination of Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP found very promising against rice sheath blight in terms of efficacy as well as residual control.

Table 7: Percent sheath blight disease control at 14 DAA
Compositions Dose
(g or ml/ha) % Sheath blight disease control
Expected Actual
Thifluzamide 24% SC 70 NA 50
Pyraclostrobin 20% WG 70 NA 50
Propineb 70% WP 700 NA 40
Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP 840 85 90
Ratio of O/E 1.05
SC – Suspension concentrates, WG – Wettable granules, WP – Wettable powder, and DAA - Days after application.

The results in table 7 clearly demonstrate synergy between Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP in controlling rice sheath blight disease. The large difference between the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.

Thifluzamide 5.6% + Pyraclostrobin 5.6% + Propineb 56% WP provided excellent control against rice sheath blight, dirty panicle, and false smut diseases. The combinations had shown synergistic effect on various disease control in rice. ,CLAIMS:WE CLAIM:

1. A synergistic fungicidal composition comprising of (a) thifluzamide, (b) pyraclostrobin, and (c) propineb with suitable agrochemical excipients.

2. The composition claimed in claim 1, wherein the composition comprising of:
a) thifluzamide in a range from 2% (w/w) to 10% (w/w),
b) pyraclostrobin in a range from 2% (w/w) to 10% (w/w),
c) propineb present in a range from 40% (w/w) to 65% (w/w), and
d) agrochemical excipients.

3. The composition as claimed in claim 2, wherein the agrochemical additives are selected from a wetting agent, a dispersing agent, a defoamer, an anti-caking agent, a co-filler, and a filler.

4. The composition as claimed in claim 3, wherein the wetting agent is selected from the group comprising of an anionic sodium diisopropyl naphthalene sulfonate, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, and sodium methyl cocoyl taurate, present in a range from 1% to 8% (w/w).

5. The composition as claimed in claim 3, wherein the dispersing agent is selected from the group comprising of sodium lignosulfonate, alkyl naphthalene sulfonate condensate, sodium salt of naphthalene sulfonate condensate, salt of phenol sulphonic acid condensation product, and alkyl naphthalene sulfonate present in a range from 5% to 15% (w/w).

6. The composition as claimed in claim 3, wherein the defoamer is polydimethylsiloxane, present in a range from 0.1% to 2% (w/w).

7. The composition as claimed in claim 3, wherein the anti-caking agent is silicon dioxide, present in an amount of 0.5% to 3% (w/w).
8. The composition as claimed in claim 3, wherein the co-filler is selected from the group comprising lactose monohydrate, ammonium sulphate, and combination thereof, present in a range from 1% to 10% (w/w).

9. The composition as claimed in claim 3, wherein the filler is china clay, present in Q.S.

10. The composition as claimed in claims 1 and 2, wherein the composition is formulated as a wettable powder (WP) form.

Dated this Fifteenth (15th) day of December, 2023

_____________________________
Dr. S. Padmaja
Agent for the Applicant
IN/PA/883