DESC:FORM 2

THE PATENTS ACT, 1970
(SECTION 39 OF 1970)
&
The Patents Rules, 2003

COMPLETE SPECIFICATION
(Section 10 and Rule 13)

FUNGICIDAL COMPOSITION CONTAINING PICOXYSTROBIN, COPPER OXYCHLORIDE AND HEXACONAZOLE

We, COROMANDEL INTERNATIONAL LIMITED,
an Indian company incorporated under Companies Act of 1956, having its principal place of business at Coromandel House, Sardar Patel Road, Secunderabad – 500 003, Telangana, India.

The following specification particularly describes the invention, and the manner in which it is to be performed.
FIELD OF THE INVENTION
The present invention relates to a synergistic fungicidal composition comprising of picoxystrobin, copper oxychloride and hexaconazole in effective amounts, along with suitable agrochemical additives, and a process for the preparation thereof.

BACKGROUND OF THE INVENTION
In the field of crop protection, the use of a particular active substance for the control of specific fungi may become increasingly difficult in time, because of the adaptation of the mentioned fungi to the fungicide being used. This leads to the loss of effectiveness in the control of the pathogen, and, consequently, downfall in crop production and profitability.

Fungicides are compounds, of natural or synthetic origin, which act to protect plants against damage caused by fungi. Current methods of agriculture rely heavily on the use of fungicides. In fact, some crops cannot be grown usefully without the use of fungicides. Using fungicides allows a grower to increase the yield and the quality of the crop, and consequently, increase the value of the crop. In most situations, the increase in value of the crop is worth at least three times the cost of the use of the fungicide.

A very well-known and widely used form of approaching this problem is by using a combination of different active substances presenting different mechanisms of action.

Picoxystrobin is a fungicide belonging to the strobilurin group of chemicals. It is a preventative and curative fungicide with systemic and translaminar movement, acting by inhibition of mitochondrial respiration by blocking electron transfer at the Qo centre of cytochrome Bc1. It is used for control of a range of fungal diseases, including brown rust, tan spot, powdery mildew, and net blotch in cereals, pulses, and oilseeds.

Copper oxychloride is an agricultural fungicide and bactericide used as a foliar spray. Since copper oxychloride is an organic copper compound, it manifests greater systemic toxicity than inorganic compounds. It exists in several forms with different appearances that can be prepared by different routes, but all are the same compound. Copper oxychloride finds real-world applications as a fungicide and as a blue or green colouring agent in pyrotechnics, while also being used in niche applications as a catalyst for various reactions, such as the production of vinyl chloride.

Hexaconazole is a broad-spectrum systemic triazole fungicide used for the control of many fungi particularly ascomycetes and basidiomycetes. It is used to control both seed-borne and soil-borne diseases.

Various compositions have been developed to control fungi and in practice have been used as a single or a mixed agent. Practical agricultural experience has shown that the repeated and exclusive application of an individual active compound in the control of harmful fungi leads in many cases to a rapid selection of those fungus strains which have developed natural or adapted resistance against the active compound in question.

Syngenta’s WO 2002/019821 A1 discloses aqueous pesticidal suspensions of a mixture of picoxystrobin and a fungicide selected from the group comprising hexaconazole, tebuconazole, cyproconazole, quinoxyfen, epoxiconazole, cyprodinil, azoxystrobin, chlorothalonil and fluazinam.

BASF’s WO 2005/036967 A1, discloses copper-containing formulations comprising basic amino acids and at least one further fungicidal active ingredient.

Effective control of these fungi with the active compound in question is very difficult in such cases. Active compounds having different mechanisms of action are combined to delay the generation of resistance and reduce the application amount and prevention and treatment costs. Consequently, research is being conducted to produce fungicides and combinations of fungicides that are safer, that have better performance, that require lower dosages, that are easier to use, and that cost less.

The present invention aims to provide one such combination of picoxystrobin, copper oxychloride, and hexaconazole to providing broader control spectrum at lower dosages.

OBJECT OF THE INVENTION
One object of the present invention is to provide a synergistic fungicidal composition comprising picoxystrobin, copper oxychloride, and hexaconazole.

Another object of the present invention is to provide a fungicidal composition comprising of picoxystrobin, copper oxychloride, and hexaconazole in effective amounts, along with suitable agrochemical additives.

In yet another object of the present invention is to provide a method of preparing a stable, non-phytotoxic formulation of picoxystrobin, copper oxychloride, and hexaconazole.

In yet another object of the present invention may provide combinations of fungicides that possess an enhanced efficacy over the individual fungicides used in isolation.

In yet another object of the present invention is to provide a fungicidal combination of picoxystrobin, copper oxychloride, and hexaconazole results into reduced fungal disease incidence in the crops to which it is applied, especially soyabean crop.

SUMMARY OF THE INVENTION
The present invention is to provide a synergistic fungicidal composition comprising of a) Picoxystrobin, b) copper oxychloride and c) hexaconazole.

The present invention is to provide a synergistic fungicidal composition comprising of a) Picoxystrobin, b) copper oxychloride, and c) hexaconazole along with suitable agrochemical additives.

In an aspect of the present invention is to provide a fungicidal composition comprising of:
a) Picoxystrobin is present in a range from 2% (w/w) to 6% (w/w),
b) Copper oxychloride is present in a range from 35% (w/w) to 45% (w/w),
c) Hexaconazole is present in a range from 1% (w/w) to 5% (w/w), and
d) Agrochemical additives.

According to the present invention the suitable agrochemical additives are selected from wetting agents, dispersing agents, anti-caking agents, anti-freezing agents, deformers, bactericides, emulsifiers, rheology modifiers, co-filler, and fillers.

In yet another aspect, the synergistic fungicidal composition of the present invention is formulated as Wettable powder (WP), and Suspension concentrate (SC).

In yet another aspect, the present invention is to provide a process for preparation of different types of composition; wherein, these compositions are prepared by mixing appropriate quantity of active ingredients with agrochemically acceptable excipients under certain appropriate conditions.

In yet another aspect, the present invention is to provide a fungicidal composition that results into reduced fungal disease incidence in the crops to which it is applied, especially soyabean crop.

In yet another aspect, the present invention is to provide a fungicidal composition that results into increased yield of the treated plant.

In yet another aspect, the present invention is to provide a synergistic fungicidal composition with an improved stability and ready to use fungicidal composition, having superior bio-efficacy compared to the individual formulations.

In yet another aspect, the present invention is to provide a synergistic fungicidal composition that results in an improved plant health and increases the plant longevity.

DETAILED DESCRIPTION OF THE INVENTION
The terms "comprise," "comprises," and "comprising" are to be interpreted inclusively rather than exclusively. Likewise, the terms "include," "including" and "or" should all be construed to be inclusive, unless such a construction is clearly prohibited from the context. However, the embodiments provided by the present disclosure may lack any element that is not specifically disclosed herein. Thus, a disclosure of an embodiment defined using the term "comprising" is also a disclosure of embodiments "consisting essentially of” and "consisting of” the disclosed components. Where used herein, the term "example," particularly when followed by a listing of terms, is merely exemplary and illustrative, and should not be deemed to be exclusive or comprehensive. Any embodiment disclosed herein can be combined with any other embodiment disclosed herein unless explicitly indicated otherwise.

It is to be noted that, as used in the specification, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

As used herein, the terms "crops" and "vegetation" can include, for instance, dormant seeds, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, immature vegetation, and established vegetation.

As used herein, immature vegetation may be understood to include small vegetative plants prior to reproductive stage, and mature vegetation may be understood to include vegetative plants during and after the reproductive stage.

As used herein, the terms “fungicide” may be understood as a chemical substance that is used to destroy the parasitic fungi and their spores.

As used herein, a "fungicidally effective amount" may be understood to include an amount of an active ingredient that causes a "fungicidal effect," i.e., an adversely modifying effect including, for instance, a deviation from natural growth or development, killing, regulation, desiccation, growth inhibition, growth reduction, and retardation of fungi.

As used herein, the term “synergistic composition” may be understood to include effective combination of more than one agrochemical that allows the application of the said agrochemical in a much lower dosage, which results in a less dosage treatment for the crops.

As used herein, the term plant health refers to the condition of the plant and its products.

As used herein, the term yield refers to the economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood or even flowers.

As used herein, the term “agrochemical additives” may be understood to include a range of surfactants, dispersing agents, pigments, solvents, co-solvents, defoamers, emulsions, crystallization inhibitors, viscosity modifiers, suspending agents, dyes, antioxidants, light absorbers, mixing aids, neutralizers or pH adjusting substances and buffers, corrosion inhibitors, fragrances, wetting agents, absorption enhancers, micronutrients, plasticizers, lubricants, thickeners, anti-freezing agents, sterilization agents, biocide, adjuvant among others.

The compositions of the present invention are formulated into various formulations such as Granular composition (GR), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsifiable water-in-oil (EO), Emulsifiable powder (EP), Emulsifiable for seed treatment (ES), Emulsifiable oil-in-water Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW).

The present invention provides a synergistic fungicidal composition comprising as its active ingredient’s picoxystrobin, copper oxychloride, and hexaconazole.

In an embodiment of the present invention, a synergistic fungicidal composition comprising of:
a) picoxystrobin is present in a range from 2% (w/w) to 6% (w/w),
b) copper oxychloride is present in a range from 35% (w/w) to 45% (w/w),
c) hexaconazole is present in a range from 1% (w/w) to 5% (w/w), and
d) agrochemical additives.

The agrochemically acceptable excipients of the present synergistic fungicidal composition are selected from wetting agents, dispersing agents, anti-caking agents, anti-freezing agents, deformers, bactericides, emulsifiers, rheology modifiers, co-filler, and fillers.

A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical compositions: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules.

Examples of wetting agents include but not limited to aliphatic alcohol ethoxylates, isodecyl alcohol ethoxylate, sodium alkyl naphthalene sulphonate blend, sodium dioctyl sulphosuccinate, sodium isopropyl naphthalene sulfonate, naphthalene sulfonic acid and phenol sulphonic acid sodium salt, and alkyl phenol ethoxylates, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).

A dispersant or a dispersing agent is a substance which absorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical compositions to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules.

Examples of dispersing agents include but not limited to acrylic copolymer, polyaryl phenol ethoxylated phosphate ester, sodium salt of alkyl naphthalene sulphonates, potassium salt of polycarboxylates, modified polyacrylate, naphthalene sulfonic acid condensate, kraft lignosulfonate, polyalkylene glycol fatty alkyl ether, sodium ligno sulphonates, and tristyryl phenol ethoxylate phosphate esters, either alone or mixtures thereof, present in a range from 1% to 10% (w/w).

An anti-caking agent is an additive used in the pesticide industry to avoid the formation of lumps. Examples of anti-caking agent include but not limited to silicon dioxide, precipitated silica powder, polydimethylsiloxane, silicon-based agents, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).

Defoamer is a chemical reagent developed for defoaming and foam suppression based on the principle of foaming. Examples of defoamer include but not limited to silicon emulsion, precipitated silica, fumed silica, modified phyllosilicate, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).

Examples of anti-freezing agent include but not limited to glycol, polyethylene glycols, mono ethylene glycol, glycerine, diethylene glycol, Propylene glycol, methoxy polyethylene glycols, polypropylene glycols, polybutylene glycols, glycerine, and ethylene glycol, either alone or mixtures thereof, present in a range from 1% to 10% (w/w).

Examples of bactericide include but not limited to 1,2-benzisothiazol-3(2H)-one, formaldehyde, sodium benzoate, and 5-chloro-2-methyl-4-isothiazolin-3-one, either alone or mixtures thereof, present in a range from 0.05% to 0.5% (w/w).

Examples of emulsifiers include but not limited to tristyryl phenol ethoxylate, calcium alkyl benzene sulfonate, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).

Examples of rheology modifier include but not limited to xanthan gum, and aluminium magnesium silicate, either alone or mixtures thereof, present in a range from 5% to 15% (w/w).

Examples of co-fillers include but not limited to Lactose monohydrate, Starch, and sucrose, present in a range from 5% to 10% (w/w).

Examples of filler include but not limited to distilled water, china-clay, and kaolin, either alone or mixtures thereof, present in Q.S.

In another embodiment, the synergistic fungicidal composition of the present invention is formulated as Wettable powder (WP), and Suspension concentrate (SC).

In yet another embodiment, the present invention discloses the process for preparation of different formulations such as Wettable powder (WP), and Suspension concentrate (SC); wherein these formulations/compositions prepared by mixing required quantity of active ingredients with agrochemical additives/excipients under certain appropriate conditions. The process for preparation of each composition is provided in the example section.

In yet another embodiment, the present invention provides a synergistic fungicidal composition that is useful as plant disease control agents. The present invention therefore further comprises a method for effectively controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof to be protected, or to the plant seed or seedling to be protected, an effective amount of a mixtures of the invention or a fungicidal composition containing said mixture.

In yet another embodiment, the present invention provides a synergistic fungicidal composition that provide control of diseases caused by a broad spectrum of fungal plant pathogens in the Basidiomycete, Ascomycete, Oomycete and Deuteromycete classes. They are effective in controlling a broad spectrum of plant diseases, particularly foliar pathogens of ornamental, vegetable, field, cereal, and fruit crops.

In yet another embodiment, the present invention provides a synergistic fungicidal composition to provide effective control over the diseases caused by a broad spectrum of fungal pathogens preventatively or curatively by applying an effective amount of present mixture or composition either pre-or post-infection, to the portion of the plant to be protected such as the roots, stems, foliage, fruit, seeds, tubers or bulbs, or to the media (soil or sand) in which the plants to be protected are growing, or can also be applied to the seed to protect the seed and seedling.

The composition of the present invention and method provided may be utilized to control fungi and their spores such as Phakopsora pachyrhizi, Magnaporthe oryzae, Botrytis cinerea, Puccinia spp, Fusarium graminearum, Fusarium oxysporum, Blumeria graminis, Mycosphaerella graminicola, Colletotrichum spp.Usti, lago maydis, Melampsora lini, and Rhizoctonia solani among others. in crops or other settings, including but not limited to cereal crops, market gardening, ornamental cultures, vineyards, tree nuts, vegetables, turfgrasses among others.

EXAMPLES:
The examples illustrating different embodiments of the present invention are provided herein. However, these are exemplary only and should not be regarded as limiting the elements of the present invention.

Example-1: Picoxystrobin 4 % + Copper Oxy Chloride 40 % + Hexaconazole 2.5 % WP
S. No. Composition Function % (w/w)
1. Picoxystrobin Active ingredient 4.0
2. Copper oxychloride Active ingredient 40.0
3. Hexaconazole Active ingredient 2.50
4. Isodecyl alcohol ethoxylate Wetting agent 1.0
5. Sodium lignosulphonate Dispersing agent 2.0
6. Sodium salt of alkyl naphthalene sulphonate Dispersing agent 8.0
7. Silicon dioxide Anticaking Agent 3.0
8. Lactose monohydrate Co-filler 5.0
9. China clay Filler Q.S.

Manufacturing Process:
Charged required quantity of Picoxystrobin, Copper oxychloride & Hexaconazole technical in ribbon blender. Then added 1.0 gm of Isodecyl alcohol ethoxylate, 2.0 gm of Sodium lignosulphonate, 8.0 gm of Sodium salt of alkyl naphthalene sulphonate, 3.0 gm of Silicone dioxide, 5.0 gm of Lactose monohydrate and finally added China clay in required quantity and homogenize it for 30 minutes. Pre-blended material was then ground through Jet mill/ air classifier mills. Finely ground material was blended in post blender till it became homogeneous (for approx. 1.5 hr).

Example-2: Picoxystrobin 4 % + Copper Oxy Chloride 40 % + Hexaconazole 2.5 % SC
S. No. Composition Function % (w/w)
1. Picoxystrobin Active ingredient 4.0
2. Copper oxychloride Active ingredient 40.0
3. Hexaconazole Active ingredient 2.5
4. Tristyrylphenol ethoxylate Emulsifier 2.0
5. Kraft lignosulfonate Dispersing Agent 1.0
6. Polyalkylene glycol fatty alkyl ether Dispersing Agent 3.0
7. Silicone emulsion Defoamer 3.0
8. 1,2-benzisothiazolin-3-one Bactericide 0.1
9. Propylene Glycol Anti-freezing agent 5.0
10. Xanthan Gum Rheology Modifier 9.0
11. Distilled water Filler Q.S.

Manufacturing Process:
2% gum solution was prepared by charging 2 gm of xanthan gum into require quantity of distilled water and homogenizing 12-18 hours prior to use. Charged DM water, 5.0 gm of 1,2-propylene glycol and 0.5 gm of silicone emulsion into designated vessel and mixed thoroughly. Added 2.0 gm of tristyrylphenol ethoxylate, 1.0 gm of Kraft lignosulfonate and 3.0 gm of Polyalkylene glycol fatty alkyl ether into the vessel having water and homogenize the contents for 45 – 60 minutes using high shear homogenizer. Then added 4.0 gm of Picoxystrobin technical, 40.0 gm of copper oxychloride technical and 2.5 gm of Hexaconazole technical to this premix slowly and homogenize to get uniform slurry ready for grinding. The material was subjected to grinding in Dyno mill till desired particle size was achieved. Finally added 2% xanthan gum solution to above milled slurry under stirring condition to achieve SC formulation.

Evaluation of synergistic effect of the fungicidal composition of the present invention:
A synergistic effect exists whenever the action of an active ingredient combination is greater than the sum of the actions of the individual components.

After calculating % disease control, the synergism was calculated by below formula:

The synergistic pesticidal action of the inventive mixtures calculated by Colby’s formula as follows:

Appropriate analysis of plant response to fungicide combination is critical in determining the type of activity observed. The most widely used model is the one Gowing* derived and Colby** modified. Gowing described a mathematical formula for calculating the predicting response values for pesticide mixtures. He suggested the expected (E) percent inhibition of growth induced by pesticide A plus pesticide B is as follows, *(Jerry Flint et al, 1988) ***

The synergistic action expected for a given combination of three active components can be calculated as follows:
(AB + AC + BC) ABC
Expected (E) = A + B + C - +
100 10000

Where:
“E” represents expected percentage of pesticidal control for the combination of the two or three active ingredients at defined doses (for example equal to A, B and C, respectively).
“A” is the percentage of fungicidal control observed by the compound at a defined dose.
“B” is the percentage of fungicidal control observed by the compound at a defined dose.
“C” is the percentage of fungicidal control observed by the compound at a defined dose.

The synergistic action expected for given combination of two active components can be calculated as follows:
AB
Expected (E) = A + B
100
Where:
“A” is the percentage of fungicidal control observed by the compound at a defined dose.
“B” is the percentage of fungicidal control observed by the compound at a defined dose.

When the percentage of fungicidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)

Reference:
*Gowing, D. P. 1960. Comments on tests of fungicide mixtures. Weeds 8:379–391.
**Colby, S. R. 1967. Calculating synergistic and antagonistic responses of fungicide combinations. Weeds 15:20–22
*** Jerry Flint et al, 1988. Analyzing Fungicide Interactions: A Statistical Treatment of Colby's Method. Weed Technology 2: 304-309

Field efficacy trials:
Asian soybean rust, caused by the fungus Phakopsora pachyrhizi, has been the most serious disease that affects soybean crops across the globe, causing losses of up to 80% if not controlled. It’s Infection under favourable temperature and moisture conditions takes place within 6 hours and uredinia can develop in lesions 5 to 8 days afterwards. The first urediniospores can be produced as early as 9 days after infection, and spore production can continue a uredinium for up to 3 weeks.

The field trial was conducted to evaluate the efficacy of innovative mixtures of Picoxystrobin, Copper Oxychloride and Hexaconazole against Phakopsora pachyrhizi fungus in soybean crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Soya bean was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 30-35 days after sowing.

The visual observations were recorded for % disease control from ten hills per plot. The observations were recorded at before spraying, 7 DAA (Days after application) and 14 DAA (Days after application)

Table 1 demonstrates synergy against Asian Soybean rust using the combination of Picoxystrobin 4 % + Copper Oxychloride 40 % + Hexaconazole 2.5 % WP. The field trials were carried out at various locations. The percentage disease control was calculated after 14 days of application. The target disease was Asian Soybean Rust, and the results are recorded as below:

Table-1:
Compositions Dose
(GAH) % Asian Soybean Rust control
Expected Actual
Picoxystrobin 22.5 SC 100 60
Copper Oxychloride 50% WP 1000 40
Hexaconazole 5% SC 62.5 65
Picoxystrobin 22.5 SC +
Copper Oxychloride 50% WP 100 + 1000 76 72
Ratio of O/E 0.91
Copper Oxychloride 50% WP + Hexaconazole 5% SC 1000 + 62.5 79 75
Ratio of O/E 0.94
Picoxystrobin 22.5 SC +
Hexaconazole 5% SC 100 + 62.5 86 82
Ratio of O/E 0.95
Picoxystrobin 4 % +
Copper Oxychloride 40 % +
Hexaconazole 2.5 % WP 1162.5 91.6 98
Ratio of O/E 1.06

Table 2 demonstrates synergy against Asian Soybean rust using the combination of Picoxystrobin 4 % + Copper Oxychloride 40 % + Hexaconazole 2.5 % SC. The field trials were carried out at various locations. The percentage disease control was calculated after 14 days of application. The target disease was Asian Soybean Rust, and the results are recorded as below:

Table-2:
Compositions Dose
(GAH) % Asian Soybean Rust control
Expected Actual
Picoxystrobin 22.5 SC 100 58
Copper Oxychloride 50% WP 1000 42
Hexaconazole 5% SC 62.5 64
Picoxystrobin 22.5 SC +
Copper Oxychloride 50% WP 100 + 1000 77 72
Ratio of O/E 0.93
Copper Oxychloride 50% WP + Hexaconazole 5% SC 1000 + 62.5 78.5 75
Ratio of O/E 0.95
Picoxystrobin 22.5 SC +
Hexaconazole 5% SC 100 + 62.5 87 82
Ratio of O/E 0.94
Picoxystrobin 4 % +
Copper Oxychloride 40 %
+ Hexaconazole 2.5 % SC 1162.5 91.6 95
Ratio of O/E 1.04

From the above trial results in Table 1 & 2 showed an excellent efficacy of Picoxystrobin 4 % + Copper Oxychloride 40 % + Hexaconazole 2.5 % WP/SC combinations against Asian rust of soybean in terms of efficacy as well as residual control. The solo application of three active ingredients tested here, were also not able to provide satisfactory control of Asian soybean rust disease. ,CLAIMS:WE CLAIM:
1. A synergistic fungicidal composition comprising (a) Picoxystrobin, (b) Copper oxychloride, and (c) Hexaconazole.
2. The composition as claimed in claim 1, where the fungicidal composition comprising of:
a) picoxystrobin is present in a range from 2% (w/w) to 6% (w/w),
b) copper oxychloride is present in a range from 35% (w/w) to 45% (w/w),
c) hexaconazole is present in a range from 1% (w/w) to 5% (w/w), and
d) agrochemical additives.
3. The composition as claimed in claim 2, wherein the suitable agrochemical additives are selected from wetting agents, dispersing agents, anti-foaming agents, anti-freezing agents, deformers, bactericides, emulsifiers, rheology modifiers, co-filler, and fillers.
4. The fungicidal composition as claimed in claim 1, wherein the composition is formulated as Wettable powder (WP), and Suspension concentrate (SC).
5. The composition as claimed in claim 3, wherein the wetting agent is selected from aliphatic alcohol ethoxylates, isodecyl alcohol ethoxylate, sodium alkyl naphthalene sulphonate blend, sodium dioctyl sulphosuccinate, sodium isopropyl naphthalene sulfonate, naphthalene sulfonic acid and phenol sulphonic acid sodium salt, and alkyl phenol ethoxylates, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).
6. The composition as claimed in claim 3, wherein the dispersing agent is selected from acrylic copolymer, polyaryl phenol ethoxylated phosphate ester, sodium salt of alkyl naphthalene sulphonates, potassium salt of polycarboxylates, modified polyacrylate, naphthalene sulfonic acid condensate, kraft lignosulfonate, polyalkylene glycol fatty alkyl ether, sodium ligno sulphonates, and tristyryl phenol ethoxylate phosphate esters, either alone or mixtures thereof, present in a range from 1% to 10% (w/w).
7. The composition as claimed in claim 3, wherein the anti-caking agent is selected from silicon dioxide, precipitated silica powder, polydimethylsiloxane, silicon-based agents, either alone or mixtures thereof, present in a range from 1% to 5% (w/w), wherein the filler is selected from distilled water, china-clay, and kaolin, either alone or mixtures thereof, present in Q.S, wherein co-filler is selected from Lactose monohydrate, Starch, and sucrose, present in a range from 5% to 10% (w/w).
8. The composition as claimed in claim 3, wherein the anti-freezing agent is selected from glycol, polyethylene glycols, mono ethylene glycol, glycerine, diethylene glycol, Propylene glycol, methoxy polyethylene glycols, polypropylene glycols, polybutylene glycols, glycerine, and ethylene glycol, either alone or mixtures thereof, present in a range from 1% to 10% (w/w), wherein Defoamer is selected from silicon emulsion, precipitated silica, fumed silica, modified phyllosilicate, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).
9. The composition as claimed in claim 3, wherein the emulsifier is selected from tristyryl phenol ethoxylate, calcium alkyl benzene sulfonate, either alone or mixtures thereof, present in a range from 1% to 5% (w/w).
10. The composition as claimed in claim 3, wherein the bactericide is selected from 1,2-benzisothiazol-3(2H)-one, formaldehyde, sodium benzoate, and 5-chloro-2-methyl-4-isothiazolin-3-one, either alone or mixtures thereof, present in a range from 0.05% to 0.5% (w/w), wherein rheology modifier selected from xanthan gum, and aluminium magnesium silicate, either alone or mixtures thereof, present in a range from 5% to 15% (w/w).

Dated this Seventeenth (17th) day of July, 2024
________________________________
Dr. S. Padmaja
Agent for the Applicant
IN/PA/883