DESC:PESTICIDAL COMPOSITION COMPRISING INSECTICIDE AND FUNGICIDE

FIELD OF THE INVENTION
The present invention relates generally to pesticidal compositions and to methods of using such compositions for control of a wide variety of undesired phytopathogenic micro-organisms, insect pests and mites. The present invention relates to pesticidal compositions comprising insecticide and fungicidal combinations. Particularly, the present invention relates to pesticidal compositions comprising combination of anthranilic diamide insecticide, a strobilurin fungicide and an azole fungicide with one or more suitable additives or excipients.
BACKGROUND OF THE INVENTION
Pesticides are substances or mixtures of substances that are mainly used in agriculture or in public health protection programs in order to protect plants from pests, weeds or diseases, and humans from vector-borne diseases, such as malaria, dengue fever, and schistosomiasis. Insecticides, fungicides, herbicides, rodenticides, and plant growth regulators are typical examples of pesticides.
In many economically important crops and cash crops such as rice, peppers, grapes and other agricultural crops, fungal infection and insect infestation may occur simultaneously. In order to control this farmer usually apply compositions comprising either single active or combinations of actives. Control of plant diseases and pests is an inevitable work in efficiently performing the agricultural production, and in order to achieve this purpose, synthetic pesticides have been used, resulting in making a remarkable achievement.
The mixing of insecticides with fungicides results in incompatibility of physical nature and also may alter efficacy of the active ingredients. Hence, it requires due trial and experimentation to assess the compatibility of fungicides with insecticides and their influence on crops. Many pesticides with combination of one or more actives have been used by farmers. But still there is requirement for new combinations which can provide efficacy, low-cost benefit ratio, broad spectrum protection and decreased environmental load.
With increased use of chemical compounds as insecticides, herbicides, fungicides it has been observed that crops are becoming tolerant and resistant to use of composition comprising single active. Hence, there is a need for combination of actives belonging to different classes and groups to allow for broader disease control spectrum that combines curative and preventive actives and has a lower dosage. There is a need in the art for new combinations of anthranilamide insecticidal compounds like chlorantraniliprole with different fungicides that help improve spectrum.
OBJECT OF THE INVENTION
It is an objective of the present invention to provide a pesticidal composition comprising a combination of an insecticide, a first fungicide and a second fungicide.
It is yet another objective of the present invention to provide a pesticidal comprising a combination of anthranilic diamide insecticide, a strobilurin fungicide and an azole fungicide.
It is yet another objective of the present invention to provide a pesticidal composition comprising of a combination of anthranilic diamide insecticide chlorantraniliprole, a strobilurin fungicide pyraclostrobin, and an azole fungicide tebuconazole.
It is yet another objective of the present invention to provide a pesticidal composition comprising of a combination of anthranilic diamide insecticide chlorantraniliprole, a strobilurin fungicide pyraclostrobin, and an azole fungicide cyproconazole.
It is yet another objective of the present invention to provide pesticidal compositions to control broad spectrum of phytopathogenic microorganisms and insect pests.
It is yet another objective of the present invention to provide pesticidal compositions with low toxicity to humans or other mammals.
It is yet another objective of the present invention to provide pesticidal compositions resulting in increased yield of the crop.
It is yet another objective of the present invention to provide pesticidal compositions comprising an insecticidal and fungicidal combination that causes an enhanced insecticidal and fungicidal activity.
SUMMARY OF THE INVENTION
The present invention is for a pesticidal composition comprising as its active ingredient an anthranilic diamide insecticide chlorantraniliprole, a strobilurin fungicide pyraclostrobin, and an azole fungicide tebuconazole or cyproconazole and excipients.
In an embodiment of the present invention, the pesticidal composition comprises: chlorantraniliprole present in a range from 2% to 10% (w/w); pyraclostrobin present in a range from 6% to 15% (w/w); tebuconazole present in a range from 5% to 20% (w/w); and cyproconazole present in a range from 5% to 20% (w/w).
In an embodiment of the present invention, the pesticidal composition comprises the excipients selected from the group comprising a wetting agent, a dispersing agent, an anti-freezing agent, a biocide, a viscosity modifier, a defoamer and a base.
In an embodiment of the present invention, the pesticidal composition comprises the wetting agent selected from the group comprising Amine salt of poly aryl phenyl ether phosphate, polyoxyethylenated alkylphenol, EO/PO Polymeric dispersant, Polyoxy alkylene glycol butyl ether, dialkyl naphthalene sulphonate sodium salt, alkyl naphthalene sulfonate (ANS) condensate blend, sodium ligno sulphonate, linear alcohol derivative and polyethylene glycol nonyl phenyl ether ammonium sulfate present in an amount of 1 to 2% (w/w).
In an embodiment of the present invention, the pesticidal composition comprises the dispersing agent selected from the group comprising EO/PO polymeric dispersant, Ethoxylated TSP-phosphate ester, Polyoxy alkylene glycol butyl ether, Polyoxyethylene-Polyoxypropylene Block Polymer, Polyethylene glycol, 2,4,6-tris(1-phenylethyl)phenyl ether sulfate ammonium salt, Methyl methacrylate graft copolymer, Sodium polyalkyl naphthalene sulfonate, Sodium salt of methyl naphthalene sulfonate, sodium ligno sulphonate, acrylate copolymer, phenol sulfonic acid-formaldehyde-polycondensation as sodium salt, sodium polycarboxylate, sodium methyl oleoyl taurate and sodium lauryl sulphate or combination thereof present in an amount of 1 to 5% (w/w).
In an embodiment of the present invention, the pesticidal composition comprises the anti-freezing agent selected from propylene glycol, glycerin, and monoethylene glycol, present in an amount of 10% (w/w).
In an embodiment of the present invention, the pesticidal composition comprises the biocide selected from 2-Benzisothiazol-3(2H)-one and formaldehyde, present in an amount of 0.1% (w/w).
In an embodiment of the present invention, the pesticidal composition comprises the viscosity modifiers selected from the group comprising of xanthan gum, Carboxymethyl cellulose, and polyvinyl pyrrolidine (PVP), present in an amount of 10% (w/w).
In an embodiment of the present invention, the pesticidal composition comprises base as water present in an amount of 30% to 60% (w/w).
In an embodiment of the present invention, the pesticidal composition is formulated as a suspension concentrate.
DESCRIPTION OF THE INVENTION
The following detailed description is presented to enable any person skilled in the art to make and use the invention. For purposes of explanation, specific nomenclature is set forth to provide a thorough understanding of the present application. However, it will be apparent to one skilled in the art that these specific details are not required to practice the invention. Descriptions of specific applications are provided only as representative examples. The present application is not intended to be limited to the embodiments shown but is to be accorded the widest possible scope consistent with the principles and features disclosed herein.
It is to be noted that, as used in the specification, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
Similarly, the words "comprise", "comprises", and "comprising" are to be interpreted inclusively rather than exclusively. Likewise, the terms "include", "including", and "or" should all be construed to be inclusive, unless such a construction is clearly prohibited from the context. However, the embodiments provided by the present disclosure may lack any element that is not specifically disclosed herein. Thus, a disclosure of an embodiment defined using the term "comprising" is also a disclosure of embodiments "consisting essentially of” and "consisting of” the disclosed components. Where used herein, the term "example" particularly when followed by a listing of terms, is merely exemplary and illustrative, and should not be deemed to be exclusive or comprehensive. Any embodiment disclosed herein can be combined with any other embodiment disclosed herein unless explicitly indicated otherwise.
The expression of various quantities in terms of “% w/w” or “%” means the percentage by weight, relative to the weight of the total solution or composition unless otherwise specified.
The term “active ingredient” (a.i.) or “active agent” used herein refers to that component of the composition responsible for control of fungi, insects-pests or disease.
As used herein, the term "effective amount" means the amount of the active substances in the compositions to achieve an observable effect on growth, including the effects of necrosis, death, retardation, prevention, and removal, destruction, or otherwise diminishing the occurrence and activity of the target organism. An effective amount of the compositions will also vary according to the prevailing conditions such as desired pesticidal effect and duration, weather, target species, locus, mode of application, and the like.
As used herein, the terms "crops" and "vegetation" can include, for instance, dormant seeds, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, immature vegetation, and established vegetation.
As used herein, immature vegetation may be understood to include small vegetative plants prior to reproductive stage, and mature vegetation may be understood to include vegetative plants during and after the reproductive stage.
The present invention relates to a pesticidal composition comprising a combination of an insecticide, a first fungicide and a second fungicide. Preferably, a combination of anthranilic diamide insecticide, a strobilurin fungicide and an azole fungicide. More preferably, a combination of anthranilic diamide insecticide Chlorantraniliprole, a strobilurin fungicide Pyraclostrobin and an azole fungicide Cyproconazole or Tebuconazole.
Chlorantraniliprole is an insecticide and belongs to anthranilic diamide chemical class. It was developed world-wide by DuPont and belongs to a class of selective insecticides featuring a novel mode of action to control a range of pests belonging to the order Lepidoptera (moth) and some other Coleoptera (beetle), Diptera (fly), and Isoptera (termite) species. Chlorantraniliprole is a ryanodine receptor modulator that modulates intracellular Ca+2 releases.
Chlorantraniliprole opens muscular calcium channels, in particular the ryanodine receptor, rapidly causing paralysis and ultimately death of sensitive species. The differential selectivity chlorantraniliprole has towards insect ryanodine receptors explain the outstanding profile of low mammalian toxicity. Chlorantraniliprole is active on chewing pest insects primarily by ingestion and secondarily by contact.
Chlorantraniliprole, chemically known as 3-Bromo-N- [4-chloro-2-methyl-6-(methyl carbamoyl) phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide. The structure of chlorantraniliprole is

Pyraclostrobin is a quinone outside inhibitor (QoI)-type fungicide used in agriculture. Among the QoIs, it lies within the strobilurin chemical class. Quinone outside inhibitors (QoI) are powerful fungicides, which have been reported, additionally to their fungicide activity, to increase plant capacity to activate cellular defence responses and to promote plant growth. Their wide range of activity relies on their ability to disrupt the energy cycle of the fungus by binding to the quinone outside ubiquinol oxidation center of the cytochrome bc1 complex (complex III) in the inner mitochondrial membrane.
Pyraclostrobin is used against Botrytis cinerea and Alternaria alternata. Pyraclostrobin is used to protect Fragaria, Rubus idaeus, Vaccinium corymbosum, Ribes rubrum, Ribesuva-crispa, blackberry (various Rubus spp.) and Pistachio vera.
Pyraclostrobin a carbamate ester chemically known as the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl] oxy} methyl) phenyl] methoxycarbamic acid. The structure of pyraclostrobin is

The azoles, 14-alpha demethylase inhibitors, have been the fungicide class used most widely to control fungal plant diseases for more than four decades. More than 25 different azoles have been developed for the control of plant diseases in crops and the group has a world market value share of 20-25%. Azoles have proven to provide long-lasting control of many target plant pathogens and are categorized to have moderate risk for developing fungicide resistance. Azoles target a broad spectrum of fungal pathogens in various crops. As one of the first azoles, imazalil was registered in the late 1970s as a seed treatment widely used in cereals and the protection of seed potatoes. Over time, the first azoles introduced have been replaced to a large extent by other active ingredients, such as tebuconazole, cyproconazole, difenoconazole, epoxiconazole, bromuconazole and prothioconazole. These newer azoles have been extensively used to control seed-borne, leaf and ear blight diseases.
Cyproconazole is an agricultural fungicide of the class of azoles, used on cereal crops, coffee, sugar beet, fruit trees and grapes, on sod farms and golf courses and on wood as a preservative. Cyproconazole inhibits demethylation, a particular step in the synthesis of a component of the fungal cell wall called sterol. This means it affects fungal growth, but not the fungal sporulation. Hence, it is preferably used when fungal growth is maximum, early in the infection, because in late infections fungal growth slows down and the agent is ineffective. Cyproconazole is used against powdery mildew, rust on cereals and apple scab, and applied by air or on the ground to cereal crops, coffee, sugar beet, fruit trees and grapes. It controls the following pests: Puccinia graminis, Puccinia spp., Pseudocercosporella herpotrichoides and
Septoria species. It can be used on above-ground wood to prevent it from decay from fungi.
Cyproconazole chemically known as 2-(4-Chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl) butan-2-ol. The structure of cyproconazole is

Tebuconazole is a triazole fungicide used agriculturally to treat plant pathogenic fungi. It is a systemic fungicide and delivers both curative and preventative control of diseased plants. Tebuconazole is used in a number of different popular fungicide products to control fungi, bacteria, and viruses affecting plants.
Some of the common fungal and disease problems tebuconazole is known to treat are rust fungus, sheath blight, leaf spot, and anthracnose.
Tebuconazole is a fungicide that is known as a DMI (demethylation inhibiting fungicide). This means that tebuconazole works by affecting the cell walls of fungi by suppressing spore germination and fungus growth. It also interferes with the production of ergosterol—a molecule essential to the formation of fungus. As a result, the formation of fungus is slowed and eventually stopped. Because of this unique mode of action tebuconazole is fungistatic or growth-inhibiting rather than fungicidal or fungus killing.
Tebuconazole chemically known as (RS)- 1-(4-Chlorophenyl)- 4,4-dimethyl-3-(1H, 1,2,4-triazol-1-ylmethyl) pentan-3-ol. The structure of tebuconazole is

In another embodiment of the invention, the anthranilic diamide insecticide is selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, flubendiamide and tetraniliprole.
In a preferred embodiment, the anthranilic diamide insecticide is chlorantraniliprole.
In another embodiment of the invention, the strobilurin fungicide is selected from pyraclostrobin, azoxystrobin, coumoxystrobin, enoxastrobin, flufenoxystrobin, picoxystrobin, pyraoxystrobin, mandestrobin, pyrametostrobin, triclopyricarb, kresoxim-methyl, dimoxystrobin, fenaminostrobin, metominostrobin, trifloxystrobin, famoxadone, fluoxastrobin, fenamidone, and pyribencarb.
In a preferred embodiment, the strobilurin fungicide is pyraclostrobin.
In another embodiment of the invention, an azole fungicide is selected from cyproconazole, tebuconazole, azaconazole, bitertanol, bromuconazole, difenoconazole, diniconazole, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, hexaconazole, imibenconazole, Ipconazole, metconazole, myclobutanil, penconazole, Propiconazole, simeconazole, tetraconazole, triadimefon, triadimenol, triticonazole, and prothioconazole.
In a preferred embodiment, an azole fungicide is cyproconazole or tebuconazole.
In another embodiment of the invention, the present invention provides a composition of (i) insecticide chlorantraniliprole present in a range from 2% to 10% (w/w), a strobilurin fungicide pyraclostrobin present in a range from 6% to 15% (w/w), and an azole fungicide tebuconazole present in a range from 5% to 20%(w/w), or cyproconazole present in a range from 5% to 20% (w/w).
In another embodiment of the invention, the present invention provides a method for preparing the compositions of (i) insecticide chlorantraniliprole, a strobilurin fungicide pyraclostrobin, and an azole fungicide tebuconazole, (ii) insecticide chlorantraniliprole, a strobilurin fungicide pyraclostrobin, and an azole fungicide cyproconazole.
In an embodiment, the compositions of the present invention may typically be produced by mixing the actives in the composition with an inert carrier and adding surfactants and other excipients and carriers as needed for various formulations. During application, a common excipient can be mixed with the composition.
Suitable adjuvants may be a solid or liquid and are generally a substance commonly used in formulation processing process, for example, a dispersing agent, a wetting agent, a anti-freezing agent, a biocide, a viscosity modifier, a defoamer, a base and combination thereof.
The novel pesticidal composition of the present invention may be formulated as Granular composition (GR), Capsule suspension (CS), Dispersible concentrate (DC), Dustable powder (DP), Powder for dry seed treatment (DS), Emulsifiable concentrate (EC), Emulsifiable granule (EG), Emulsion water-in-oil (EO), Emulsifiable powder (EP), Emulsion for seed treatment (ES), Emulsion oil-in-water (EW), Flowable concentrate for seed treatment (FS), Granules (GR), Micro-emulsion (ME), Oil-dispersion (OD), Oil miscible flowable concentrate (OF), Oil miscible liquid (OL), Oil dispersible powder (OP), Suspension concentrate (SC), Suspension concentrate for direct application (SD), Suspo-emulsion (SE), Water soluble granule (SG), Soluble concentrate (SL), Spreading oil (SO), Water soluble powder (SP), Water soluble tablet (ST), Ultra-low volume (ULV) suspension, Tablet (TB), Ultra-low volume (ULV) liquid, Water dispersible granules (WG), Wettable powder (WP), Water dispersible powder for slurry seed treatment (WS), Water dispersible tablet (WT), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW). Preferably, the formulation is in form of suspension concentrate (SC).
In addition, by treating the pesticidal composition of the present invention in the soil, it becomes possible to simultaneously control pests inhabiting the soil and pests inhabiting the ground. In addition, in this method, since the dosage and the number of times of application of the active ingredient are reduced and the long-lasting effect is long, it is possible to provide a comprehensive control method.
The present invention provides combinations of insecticides and fungicides that possess an enhanced efficacy over the individual active compound used in isolation.
The amount of a composition according to the invention to be applied, will depend on various factors, such as the subject of the treatment, such as, for example plants, soil or seeds; the type of treatment, such as, for example spraying, dusting or seed dressing; the purpose of the treatment, such as, for example prophylactic or therapeutic disease control; in case of disease control the type of fungi or pest to be controlled or the application time. This amount of the combinations of the present invention to be applied can be readily deduced by a skilled agronomist.
In an embodiment, the constituents of the composition of the present invention may be used for foliar application, ground or applications to plant propagation materials.
Wetting is the first stage of dispersion, in which the air surrounding the granular composition is substituted with water. Wetting of the pesticidal composition with water cannot occur if the surface tension of the liquid is very high. Hence, it is recommended to add a wetting agent to the pesticidal composition to facilitate the process of dispersion of the granules in the liquid. Accordingly, the composition of the present invention preferably contains a wetting agent suitable for use in the present invention are Amine salt of poly aryl phenyl ether phosphate, polyoxyethylenated alkylphenol, EO/PO Polymeric dispersant, Polyoxy alkylene glycol butyl ether, dialkyl naphthalene sulphonate sodium salt, alkyl naphthalene sulfonate (ANS) condensate blend, sodium ligno sulphonate, linear alcohol derivative and polyethylene glycol nonyl phenyl ether ammonium sulfate. Preferably, the wetting agent is present in a range from 1% to 2% (w/w).
It is generally observed that solid particles in a liquid undergo spontaneous aggregation to form lumps. Hence it is recommended to add a dispersant or a dispersing agent which prevents aggregation of solid particles and keeps them suspended in the fluid. One or more dispersing agents may be used in the synergistic composition of the present invention. Accordingly, the composition of the present invention preferably contains a dispersing agent suitable for use in the present invention are EO/PO polymeric dispersant, Ethoxylated TSP-phosphate ester, Polyoxy alkylene glycol butyl ether, Polyoxyethylene-Polyoxypropylene Block Polymer, Polyethylene glycol 2,4,6-tris(1-phenylethyl)phenyl ether sulfate ammonium salt, Methyl methacrylate graft copolymer, Sodium polyalkyl naphthalene sulfonate, Sodium salt of methyl naphthalene sulfonate, sodium ligno sulphonate, acrylate copolymer, phenol sulfonic acid-formaldehyde-polycondensation as sodium salt, sodium polycarboxylate, sodium methyl oleoyl taurate and sodium lauryl sulphate or combination thereof. Preferably, the dispersing agent is present in a range from 1% to 5% (w/w) in the compositions of the present invention.
Antifreezing agent is an additive which lowers the freezing point of a water-based liquid. An anti-freezing agent is used in suspension concentrate so as to prevent freezing of water. The suitable anti-freezing agent for the present invention is selected from Propylene glycol, glycerin, and monoethylene glycol. Preferably, the anti-freeze agent is present in an amount of 10% (w/w).
Biocide is a chemical agent intended to destroy, render harmless, or control potentially harmful organism. The biocide suitable for use in the present invention is selected from 2-Benzisothiazol-3(2H)-one, and formaldehyde. Preferably, the biocide is present in an amount of 0.1% (w/w).
It is essential in suspension concentrate to prevent the dispersed solid particles from sedimentation upon storage. The sedimentation may adversely affect efficacy of the composition during application. In order to maintain uniform distribution of active ingredient during shelf life, viscosity modifiers are used, like xanthan gum. Xanthan gum thickeners generate a supporting structure within the aqueous phase through controlled incompatibility with the water phase. Suitable viscosity modifiers for the purpose of the present invention are xanthan gum, Carboxymethyl cellulose, and polyvinyl pyrrolidine (PVP). Preferably, the viscosity modifier is present in an amount of 10% (w/w).
The composition of the suspension concentrate formulation, excipients, surfactant, and water, promotes the generation of foam in the presence of high shear equipment. Foam may adversely affect the efficiency of processing equipment and the bulk density of the formulation during packaging. Therefore, defoamers are incorporated into the formulation in order to eliminate foam formation during processing. Suitable defoamers for the present invention is Polydimethylsiloxane antifoam emulsion present in an amount of 0.5% (w/w).
The base is liquid media and can be water or any organic/inorganic solvent in which the solid meets the insolubility criteria, under all temperature conditions. The base suitable for the present invention is distilled water. Preferably, the base is present in a range from 30% to 60% (w/w).
It has been surprisingly found that the novel pesticidal composition of the present invention delays the appearance of the resistant strains of fungi and pests and achieves effective and economical control of undesired fungicide and pest infection. The composition achieves improved biological activity by enhancing overall control of diseases caused by fungi and pest over a shorter period of time. Additional benefits of using the pesticidal composition of the present invention includes reduced risk of occupational hazard, lower cost of application, better cost: benefit ratio to the end user, reduced fuel and labour cost, saving in applicator’s time and loss caused by mechanical damage to the crop and soil.
The composition of the present invention can also be applied in conjunction with one or more herbicides, fungicides, insecticides, nematicides, growth factor enhancers and/or one or more fertilizers. The composition when used in conjunction may comprise other actives like one or more herbicides, fungicides, insecticides, nematicides, growth factor enhancers and/or one or more fertilizers.
The composition of the present invention may be applied by one of the methods selected from atomization, spreading, dusting, spraying, diffusion, immersion, irrigation, injection, mixing, sprinkling (water immersion), foaming, dressing, coating, blasting, and fumigation.
The present invention is further illustrated by the following examples which are provided merely to be exemplary of the inventions and is not intended to limit the scope of the invention. Certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.
Examples:
Example 1: Preparation of composition of Chlorantraniliprole, Pyraclostrobin, and Tebuconazole or Cyproconazole in Suspension Concentrate form
The composition of the present invention is prepared in following steps:
Process Description:
For enablement preparation of Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC and Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC is being shown, other formulations may also be prepared by following similar steps.

Step 1: Preparation of Aqueous Slurry
? Taking 10 parts by weight of propylene glycol (anti-freezing agent), in Vessel No. 1 (pre mixer). Adding 5 parts by weight of EO/PO Polymeric dispersant (dispersing agent/wetting agent) and mixing well after 15 min adding 0.1 parts by weight of 1,2-Benzisothiazol-3(2H)-one (biocide) followed by 0.1 parts by weight of Polydimethylsiloxane antifoam emulsion (defoamer), after 15 min, adding 100 % of distilled water (base);
? Continuing the mixing for 20 minutes and then adding 3 parts by weight of chlorantraniliprole (active) over the period of 15 min after that adding 7.5 parts by weight of pyraclostrobin (active) over the period of 15 min after that adding 12.5 parts by weight of cyproconazole or tebuconazole (active) over the period of 15 min;
? Continuing the mixture for homogenization (the mixture should be thoroughly homogenized) for 30 min.
Step 2: Wet Milling of Slurry
? Passing the wet slurry from Vessel No. 1 through Dyno-Mill at temperature less than 30 °C and collecting material in Vessel No.2 (post-Mixer).
? Maintaining continuous flowrate of the Dyno mill to avoid the sedimentation.
? Submitting the sample to quality control department to check the particle size distribution (PSD). The PSD of the material should be d90 < 5 µ. If the d90 is higher than > 5 µ then grind the mixture further till the PSD value complies the specification.
? Collecting the sample to a vessel No. 2 under homogenization.
Step 3: Preparation of Gel Suspension
? Adding 10 parts by weight of Xanthan gum (viscosity modifier) in 4.0 parts by weight of Propylene glycol (anti-freezing agent) then adding 0.1 part by weight 1,2-Benzisothiazol-3(2H)-one (biocide) to this slurry into 93.95 parts by weight of distilled water (base) and stirring the mixture until it gets lumps free homogeneous mixture.
? Keeping this gel as such for 4-5 hours to get a translucent homogeneous gel.
Step 4: Gel addition
? Adding required quantity of Gel (prepared above) to the wet slurry in Vessel No. 2 and stir the mixture for ~3h for homogenization.
? Submitting the sample for quality control for complete analysis.
? Packing the material in suitable bottle.

Example 2: Compositions of the present invention
The illustrative embodiments show the composition of Chlorantraniliprole, Pyraclostrobin and Tebuconazole or Cyproconazole in suspension concentrate form in different amount as follows:

Table-1: Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 3.0
2. Pyraclostrobin Fungicide 7.5
3. Tebuconazole Fungicide 12.5
4. EO/PO Polymeric dispersant Dispersing agent/Wetting agent 5.0
5. Propylene glycol Antifreezing agent 10
6. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
7. Xanthan gum Viscosity Modifier 10
8. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
9. Distilled water Base 51.4
Total 100

Table-2: Chlorantraniliprole 2% + Pyraclostrobin 6% + Tebuconazole 10% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 2.0
2. Pyraclostrobin Fungicide 6.0
3. Tebuconazole Fungicide 10
4. Ethoxylated TSP-phosphate ester Dispersing agent 2.0
5. Polyoxy alkylene glycol butyl ether Wetting agent 2.0
6. Propylene glycol Antifreezing agent 10
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 57.4
Total 100

Table-3: Chlorantraniliprole 4% + Pyraclostrobin 10% + Tebuconazole 14% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 4.0
2. Pyraclostrobin Fungicide 10
3. Tebuconazole Fungicide 14
4. Polyethylene glycol 2,4,6-tris(1-phenylethyl)phenyl ether sulfate ammonium salt Dispersing agent 2.0
5. Amine salt of poly aryl phenyl ether phosphate Wetting agent 2.0
6. Propylene glycol Antifreezing agent 10
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 47.4
Total 100

Table-4: Chlorantraniliprole 6% + Pyraclostrobin 13% + Tebuconazole 5% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 6.0
2. Pyraclostrobin Fungicide 13
3. Tebuconazole Fungicide 5.0
4. Polyoxyethylene-Polyoxypropylene Block Polymer Dispersing agent 1.5
5. Amine salt of poly aryl phenyl ether phosphate Wetting agent 1.5
6. Propylene glycol Antifreezing agent 10
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 52.4
Total 100

Table-5: Chlorantraniliprole 10% + Pyraclostrobin 15% + Tebuconazole 20% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 10
2. Pyraclostrobin Fungicide 15
3. Tebuconazole Fungicide 20
4. Polyoxyethylenated alkyl phenol Wetting agent 1.5
5. Methyl methacrylate graft copolymer Dispersing agent 1.5
6. Propylene glycol Antifreezing agent 10.0
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 31.4
Total 100

Table-6: Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 3.0
2. Pyraclostrobin Fungicide 7.5
3. Cyproconazole Fungicide 12.5
4. EO/PO Polymeric dispersant Dispersing agent/Wetting agent 5.0
5. Propylene glycol Antifreezing agent 10
6. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
7. Xanthan gum Viscosity Modifier 10
8. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
9. Distilled water Base 51.4
Total 100

Table-7: Chlorantraniliprole 2% + Pyraclostrobin 6% + Cyproconazole 10% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 2.0
2. Pyraclostrobin Fungicide 6.0
3. Cyproconazole Fungicide 10
4. Ethoxylated TSP-phosphate ester Dispersing agent 2.0
5. Polyoxy alkylene glycol butyl ether Wetting agent 2.0
6. Propylene glycol Antifreezing agent 10
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 57.4
Total 100

Table-8: Chlorantraniliprole 4% + Pyraclostrobin 10% + Cyproconazole 14% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 4.0
2. Pyraclostrobin Fungicide 10
3. Cyproconazole Fungicide 14
4. Polyethylene glycol 2,4,6-tris(1-phenylethyl)phenyl ether sulfate ammonium salt Dispersing agent 2.0
5. Amine salt of poly aryl phenyl ether phosphate Wetting agent 2.0
6. Propylene glycol Antifreezing agent 10
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 47.4
Total 100

Table-9: Chlorantraniliprole 6% + Pyraclostrobin 13% + Cyproconazole 5% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 6.0
2. Pyraclostrobin Fungicide 13
3. Cyproconazole Fungicide 5.0
4. Polyoxyethylene-Polyoxypropylene Block Polymer Dispersing agent 1.5
5. Amine salt of poly aryl phenyl ether phosphate Wetting agent 1.5
6. Propylene glycol Antifreezing agent 10
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 52.4
Total 100

Table-10: Chlorantraniliprole 10% + Pyraclostrobin 15% + Cyproconazole 20% SC
S. No. Ingredients Function % (w/w)
1. Chlorantraniliprole Fungicide 10
2. Pyraclostrobin Fungicide 15
3. Cyproconazole Fungicide 20
4. Polyoxyethylenated alkylphenol Wetting agent 1.5
5. Methyl methacrylate graft copolymer Dispersing agent 1.5
6. Propylene glycol Antifreezing agent 10.0
7. 1,2-Benzisothiazol-3(2H)-one Biocide 0.1
8. Xanthan gum Viscosity Modifier 10
9. Polydimethylsiloxane antifoam emulsion Defoamer 0.5
10. Distilled water Base 31.4
Total 100

Example 3: Synergy study for combination of Chlorantraniliprole, Pyraclostrobin and Tebuconazole or Chlorantraniliprole, Pyraclostrobin and Cyproconazole in suspension concentrate (SC) formulation
SYNERGY STUDIES:
After calculating % disease control, the synergism was calculated by below formula:
The synergistic pesticidal action of the inventive mixtures calculated by Colby’s formula as follows:
Appropriate analysis of plant response to pesticide combination is critical in determining the type of activity observed. The most widely used model is one Gowing* derived and Colby** modified. Gowing described a mathematical formula for calculating the predicting response values for pesticide mixtures. He suggested the expected (E) percent inhibition of growth induced by pesticide A plus pesticide B and plus pesticide C is as follows, *(Jerry Flint et al, 1988) ***

Where,
A = observed efficacy of active ingredient A at the same concentration as used in the mixture.
B = observed efficacy of active ingredient B at the same concentration as used in the mixture.
C = observed efficacy of active ingredient C at the same concentration as used in the mixture.
When the percentage of pesticidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)

Reference:
*Gowing, D. P. 1960. Comments on tests of herbicide mixtures. Weeds 8:379–391.
**Colby, S. R. 1967. Calculating synergistic and antagonistic responses of herbicide combinations. Weeds 15:20–22
*** Jerry Flint et al, 1988. Analysing Herbicide Interactions: A Statistical Treatment of Colby's Method. Weed Technology 2: 304-309

Rice: Sheath blight and Stem borer
Trial 1: Bio-efficacy against rice sheath blight
The sheath blight is caused by the fungal pathogen Rhizoctonia solani. This potentially devasting disease can infect rice foliage at any stage of crop development. It is a major threat to many crops and can also affect the crop stand and yield. Rhizoctonia solani fungus is cosmopolitan, polyphagous, widely distributed in tropical, subtropical, and temperate regions and for its development it requires hot and humid environment. The fungus spreads in the field by growing its runner hyphae from tiller to tiller, from leaf to leaf, and from plant to plant, resulting in a circular pattern of damage. The infection spreads most quickly when susceptible varieties are grown under favourable conditions such as warm temperature (28 to 32°C), high humidity (95% or above), and dense stands with a heavily developed canopy.
The field trial was conducted to evaluate the efficacy of innovative mixtures of Chlorantraniliprole, Pyraclostrobin, and Tebuconazole (or) Cyproconazole against Rhizoctonia solani fungus in rice crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Rice crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after transplanting.
The visual observations were recorded for % disease control from ten hills per plot. The observations were recorded at before spraying, 7 DAA (Days after application) and 14 DAA (Days after application).

Table 11: Sheath blight disease control in rice:
Compositions Dose
(g AI/ha) Percent disease control – rice sheath blight
07 DAA 14 DAA
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230 95.5 85.7
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230 92.5 83.4
Pyraclostrobin 75 65 35
Tebuconazole 125 70 50
Cyproconazole 125 70 50
Chlorantraniliprole 30 85 75
SC – Suspension concentrates, and DAA - Days after application.

The trial results show excellent efficacy of Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% and Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% combinations against sheath blight disease of rice and these combinations are found very promising against sheath blight in terms of efficacy as well as residual control in rice crop. The solo application of three active ingredients tested here, were also not able to provide satisfactory control of sheath blight disease.

Table 12: Percent Sheath blight disease control at 14 DAA
Compositions Dose
(g or ml/ha) % Sheath blight disease control Ratio of O/E
Expected Actual
Pyraclostrobin 75 35
Tebuconazole 125 50
Cyproconazole 125 50
Chlorantraniliprole 30 60
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230
67.5
85.6
1.27
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230
66
84.5
1.28
SC – Suspension concentrates, and DAA - Days after application.

The results in table 12 clearly demonstrates synergy between Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% and Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% in controlling rice sheath blight disease. The large difference between the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.

Trial 2: Bio-efficacy against rice stem borer
The rice stem borer (Scirpophaga incertulas) is potentially devasting pest and it can destroy rice at any stage of the plant from seedling to maturity. Six species of stemborer attack rice. These are the yellow stemborer, white stemborer, striped stemborer, gold-fringed stemborer, dark-headed striped stemborer, and the pink stemborer. Among the stem borers, the pink stem borer is less important. It is polyphagous and prefers sugarcane to rice.
The field trial was conducted to evaluate the efficacy of innovative mixtures of Chlorantraniliprole, Pyraclostrobin, and Tebuconazole or Cyproconazole against Scirpophaga incertulas in rice crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Rice crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after transplanting.
The visual observations were recorded for % pest damage from ten hills per plot. The observations were recorded at before spraying, 7 DAA (Days after application) and 14 DAA (Days after application).
Table 13: % stem borer control in rice:
Compositions Dose
(g AI/ha) % Control – rice stem borer
07 DAA 14 DAA
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230 90.5 80.7
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230 88.2 79.8
Pyraclostrobin 75 10 9
Tebuconazole 125 10 9
Cyproconazole 125 15 10
Chlorantraniliprole 30 80 70
SC – Suspension concentrates, and DAA - Days after application.

The trial results show excellent efficacy of Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% and Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% combinations against stem borer of rice and these combinations are found very promising against stem borer in terms of efficacy as well as residual control in rice crop. The solo application of three active ingredients tested here, were also not able to provide satisfactory control of rice stem borer.

Table 14: Percent stem borer control at 14 DAA
Compositions Dose
(g or ml/ha) % Stem borer control Ratio of O/E
Expected Actual
Pyraclostrobin 75 35
Tebuconazole 125 35
Cyproconazole 125 50
Chlorantraniliprole 30 70
Pyraclostrobin 7.5% + Tebuconazole 12.5% + Chlorantraniliprole 3% SC 230
70
80.4
1.15
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230
70
78.7
1.12

The results in table 14 clearly demonstrates synergy between Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% and Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% in controlling rice stem borer. The large difference between the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.

SOYABEAN: Brown spot and Pod borer
Trial 1: Bio-efficacy against Soybean brown spot
The Septoria brown spot is caused by the fungus Septoria glycines. It is the most common foliar disease of soybean. Disease develops soon after planting and is usually present throughout the growing season. Symptoms are typically mild during vegetative growth stages of the crop and progress upward from lower leaves during grain fill. Infected young plants have purple lesions on the unifoliate leaves. Lesions on later leaves are small, irregularly shaped, dark brown, and are found on both leaf surfaces. Adjacent lesions can grow together and form larger, irregularly shaped blotches. Infected leaves quickly turn yellow and drop. Disease starts in the lower canopy and, if favourable conditions continue, will progress to the upper canopy. Yield losses depend on how far up the canopy the disease progresses during grain fill.
The fungus survives on infected leaf and stem residue. Warm, wet weather favours disease development. Disease usually stops developing during hot, dry weather but may become active again near maturity or when conditions are more favourable.
The field trial was conducted to evaluate the efficacy of innovative mixtures of Chlorantraniliprole, Pyraclostrobin, and Tebuconazole (or) Cyproconazole against Septoria glycines fungus in Soybean crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Soybean crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after transplanting.
The visual observations were recorded for % disease control from ten plants per plot. The observations were recorded at before spraying, 7 DAA (Days after application) and 14 DAA (Days after application).
Table 15: Brown spot disease control in Soybean:
Compositions Dose
(g AI/ha) % Control – Soybean brown spot
07 DAA 14 DAA
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230 95.4 85.7
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230 90.2 80.8
Pyraclostrobin 75 70 60
Tebuconazole 125 60 40
Cyproconazole 125 60 40
Chlorantraniliprole 30 68 52
SC – Suspension concentrates, and DAA - Days after application.

The trial results show excellent efficacy of Chlorantraniliprole 3%+ Pyraclostrobin 7.5%+ Tebuconazole 12.5% and Chlorantraniliprole 3%+ Pyraclostrobin 7.5% + Cyproconazole 12.5% combinations against brown spot disease of Soybean and these combinations found very promising against soybean brown spot in terms of efficacy as well as residual control. The solo application of three active ingredients tested here, were also not able to provide satisfactory control of brown spot disease.

Table 16: Percent soybean brown spot disease control at 07 DAA
Compositions Dose
(g or ml/ha) % Brown spot disease control Ratio of O/E
Expected Actual
Pyraclostrobin 75 60.5
Tebuconazole 125 40.4
Cyproconazole 125 40.7
Chlorantraniliprole 30 55.8
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230
76
85.7
1.13
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230
76
84.9
1.12

The results in table 16 clearly demonstrates synergy between Chlorantraniliprole 3%+ Pyraclostrobin 7.5%+ Tebuconazole 12.5% and Chlorantraniliprole 3%+ Pyraclostrobin 7.5%+ Cyproconazole 12.5% in controlling Soybean brown spot disease. The large difference between the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.

Trial 2: Bio-efficacy against Soybean pod borer
Soybean (Glycine max (L.) Merrill) is one of the most important and widely grown oil seed crops in the world. Successful production in soybean cropping systems is hampered due to the incidence of several insect pests such as Etiella zinkienella Treitschke, Tetranychus urticae Koch, Thrips tabaci Koch Lindeman, Spodoptera exigua (Hübner) and Helicoverpa armigera (Hübner). Among these pests, H. armigera represents a significant challenge to soybean production in different soybean-growing areas around the world. Helicoverpa armigera is an important pest of many crops in many parts of the world and is reported to attack more than 60 plant species belonging to more than 47 families (such as soybean, cotton, sorghum, maize, sunflower, groundnuts, cowpea, tomato, and green pepper). This noctuid pest is distributed eastwards from southern Europe and Africa through the Indian subcontinent to Southeast Asia, and thence to China, Japan, Australia, and the Pacific Islands. The pest status of this species can be derived from its four life history characteristics (polyphagy, high mobility, high fecundity, and a facultative diapause) that enable it to survive in unstable habitats and adapt to seasonal changes. Direct damage of the larvae of this noctuid pest to flowering and fruiting structures together with extensive insecticide spraying resulted in low crop yield and high costs of production.
The young larvae feed on the chlorophyll of young leaves and skeletonize it. They feed voraciously on the foliage in early stage, may defoliate the plant and later they feed on flowers and pods. Older larvae feeds on buds, flowers, and parts in a characteristic manner with head thrust into the pod and rest of the body remain outside.
The field trial was conducted to evaluate the efficacy of innovative mixtures of Chlorantraniliprole, Pyraclostrobin, and Tebuconazole (or) Cyproconazole and against Helicoverpa armigera in Soybean crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Soybean crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after transplanting.
The visual observations were recorded for % pest damage from ten hills per plot. The observations were recorded at before spraying, 7 DAA (Days after application) and 14 DAA (Days after application).

Table 17: % Pod borer control in Soybean:
Compositions Dose
(g AI/ha) % Control – Soybean pod borer
07 DAA 14 DAA
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230 90.2 80.7
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Cyproconazole 12.5% SC 230 88.8 76.6
Pyraclostrobin 75 10.8 9.5
Tebuconazole 125 10.6 9.5
Cyproconazole 125 15.5 10.2
Chlorantraniliprole 30 75 65
SC – Suspension concentrates, and DAA - Days after application.

The trial results show excellent efficacy of Chlorantraniliprole 3%+ Pyraclostrobin 7.5%+ Tebuconazole 12.5% and Chlorantraniliprole 3%+ Pyraclostrobin 7.5%+ Cyproconazole 12.5% combinations against pod borer of Soybean, and these combinations found to be very promising against Soybean brown spot in terms of efficacy as well as residual control. The solo application of three active ingredients tested here, were also not able to provide satisfactory control of Soybean pod borer.

Table 18: Percent pod borer control at 14 DAA
Compositions Dose
(g or ml/ha) % Pod borer control Ratio of O/E
Expected Actual
Pyraclostrobin 75 35.5
Tebuconazole 125 50.8
Cyproconazole 125 50.5
Chlorantraniliprole 30 65.5
Chlorantraniliprole 3% + Pyraclostrobin 7.5% + Tebuconazole 12.5% SC 230
65
80.6
1.24
Pyraclostrobin 7.5% + Cyproconazole 12.5% + Chlorantraniliprole 3% SC 230
65
81.8
1.26

The results in table 18 clearly demonstrates synergy between Chlorantraniliprole+ Pyraclostrobin + Tebuconazole and Chlorantraniliprole + Pyraclostrobin + Cyproconazole in controlling Soybean pod borer. The large difference between the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.
Combinations of Chlorantraniliprole + Pyraclostrobin + Tebuconazole and Chlorantraniliprole + Pyraclostrobin + Cyproconazole provided excellent control of brown leaf spot and soybean pod borer in soybean. Both the combinations had shown synergistic effect on insect and disease control in soybean.
The present invention provides an effective composition of Chlorantraniliprole, Pyraclostrobin and Tebuconazole or Cyproconazole which is effective in controlling a wide variety of undesired phytopathogenic microorganisms, insect pests and mites. The composition of the present invention provides longer residual control, crop health improvement and offering a single application as uniform composition instead of separate application of insecticide and fungicides. The compositions show synergistic effect and hence resulting in lower disease and pest infestation, lower rates of application, a longer duration of action and altogether higher crop yields.
Although the present invention has been described and illustrated with respect to preferred embodiments and a preferred user thereof, it is not to be so limited since modifications and changes can be made therein which are within the full scope of the invention.
,CLAIMS:We claim:
1. A pesticidal composition comprising as its active ingredient an anthranilic diamide insecticide chlorantraniliprole, a strobilurin fungicide pyraclostrobin, and an azole fungicide tebuconazole or cyproconazole and excipients.
2. The pesticidal composition as claimed in claim 1, comprising:
- chlorantraniliprole present in a range from 2% to 10% (w/w);
- pyraclostrobin present in a range from 6% to 15% (w/w);
- tebuconazole present in a range from 5% to 20% (w/w); and
- cyproconazole present in a range from 5% to 20% (w/w).
3. The pesticidal composition as claimed in claim 1, wherein the excipients are selected from the group comprising a wetting agent, a dispersing agent, an anti-freezing agent, a biocide, a viscosity modifier, a defoamer and a base.
4. The pesticidal composition as claimed in claim 3, wherein the wetting agent is selected from the group comprising Amine salt of poly aryl phenyl ether phosphate, polyoxyethylenated alkylphenol, EO/PO Polymeric dispersant, Polyoxy alkylene glycol butyl ether, dialkyl naphthalene sulphonate sodium salt, alkyl naphthalene sulfonate (ANS) condensate blend, sodium ligno sulphonate, linear alcohol derivative and polyethylene glycol nonyl phenyl ether ammonium sulfate present in an amount of 1 to 2% (w/w).
5. The pesticidal composition as claimed in claim 3, wherein the dispersing agent is selected from the group comprising EO/PO polymeric dispersant, Ethoxylated TSP-phosphate ester, Polyoxy alkylene glycol butyl ether, Polyoxyethylene-Polyoxypropylene Block Polymer, Polyethylene glycol, 2,4,6-tris(1-phenylethyl)phenyl ether sulfate ammonium salt, Methyl methacrylate graft copolymer, Sodium polyalkyl naphthalene sulfonate, Sodium salt of methyl naphthalene sulfonate, sodium ligno sulphonate, acrylate copolymer, phenol sulfonic acid-formaldehyde-polycondensation as sodium salt, sodium polycarboxylate, sodium methyl oleoyl taurate and sodium lauryl sulphate or combination thereof present in an amount of 1 to 5% (w/w).
6. The pesticidal composition as claimed in claim 3, wherein the anti-freezing agent is selected from propylene glycol, glycerin, and monoethylene glycol, present in an amount of 10% (w/w).
7. The pesticidal composition as claimed in claim 3, wherein the biocide is selected from 2-Benzisothiazol-3(2H)-one and formaldehyde, present in an amount of 0.1% (w/w).
8. The pesticidal composition as claimed in claim 3, wherein the viscosity modifier is selected from the group comprising of xanthan gum, Carboxymethyl cellulose, and polyvinyl pyrrolidine (PVP), present in an amount of 10% (w/w).
9 The pesticidal composition as claimed in claim 3, wherein the base is water present in an amount of 30% to 60% (w/w).
10. The pesticidal composition as claimed in claim 1, wherein the composition is formulated as a suspension concentrate.