DESC:FORM 2

THE PATENTS ACT, 1970
(SECTION 39 OF 1970)
&
The Patents Rules, 2003

COMPLETE SPECIFICATION
(Section 10 and Rule 13)

SYNERGISTIC FUNGICIDAL COMBINATIONS, COMPOSITIONS, PROCESS FOR PREPARING AND USE THEREOF

We, COROMANDEL INTERNATIONAL LIMITED,
an Indian company incorporated under Companies Act of 1956, having its principal place of business at Coromandel House, Sardar Patel Road, Secunderabad – 500 003, Telangana, India.

The following specification particularly describes the invention and the manner in which it is to be performed:
FIELD OF THE INVENTION
The present invention relates to synergistic fungicidal wettable powder composition comprising polymeric dithiocarbamate fungicide complex with zinc salt and urea derivative.

The present invention also relates to synergistic fungicidal wettable powder composition comprising polymeric dithiocarbamate fungicide complex with zinc salt, urea derivative and other agrochemical auxiliaries.

The present invention also relates to synergistic fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil.

The present invention specifically relates to synergistic fungicidal wettable powder composition comprising combination of Propineb, Cymoxanil and other agrochemical auxiliaries.

The present invention more specifically relates to fungicidal wettable powder composition comprising combination of Propineb, Cymoxanil, wetting agents, dispersing agents and other agrochemical auxiliaries.

The present invention more specifically relates to fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil, at a weight ratio of 15 : 1 to 1 : 15, wetting agents, dispersing agents and other agrochemical auxiliaries.

The present invention also relates to a process for the preparation of fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil, wherein said process comprises simple blending and milling.

BACKGROUND OF THE INVENTION
Fungicides are biocidal chemical compounds or biological organisms used to kill parasitic fungi or their spores. Fungi can cause serious damage in agriculture, resulting in critical losses of yield, quality, and profit. Fungicides are used both in agriculture and to fight fungal infections in animals. It is clear that, although pesticides remain indispensable in agriculture, a great potential still exists to improve their efficiency and thus reduce their input into the environmental and food chain. Depending on the field of application, the mode of application, and depending on physical, chemical and biological parameters, the active substances are employed as active substance formulation in the form of a mixture with customary carriers, adjuvants and additives.

Propineb is a dithiocarbamate fungicide and chemically polymeric zinc 1,2-propylenebis(dithiocarbamate). Propylene 1,2-bis(dithiocarbamic acid) is a member of the class or dithiocarbamic acids resulting from the formal addition of a molecule of carbon disulfide to each of the nitrogens of propylenediamine. It derives from a propylenediamine. It is a conjugate acid of a propylene 1,2-bis(dithiocarbamate).

The molecular formula of Propineb is (C5H8N2S4Zn)x and the structural formula is:

Propineb, a contact fungicide with broad spectrum activity against various diseases of rice, chilli, grapes, potato and other vegetables and fruits. Due to the release of zinc, the application of Propineb results in greening effect on the crop and subsequent improvement in quality of produce. Propineb interferes at different locations in the metabolism of the fungi; on several points of the respiration chain, in the metabolism of carbohydrates and proteins, in the cell membranes. This multi-site mode of action of Propineb prevents development of resistance in the fungi.

Propineb is available in the following formulations: wettable powder (WP, wettable granules (WG) and dustable powders (DP) when formulated as the sole active ingredient, in wettable powders when co-formulated with copper Oxychloride, Cymoxanil, Dimethmorph, Iprodione, Iprovalicarb, Oxadixyl, Tebuconazole or Triadimefon and wettable granules when co-formulated with Iprovalicarb. Propineb is applied as a WG or WP formulation mainly as a spray. It is also used in combination with Oxadixyl, Copper Oxychloride, Triadimefon or Cymoxanil. In two trials in Portugal (Walz-Tylla, 1998) red grape vines (Amostrinha and Piriquita) were sprayed five times at intervals of 14 days with a wettable powder formulation containing 58% Propineb and 4.8% Cymoxanil.

Cymoxanil is a synthetic acetamide compound first developed in 1977. It acts as a curative fungicide for potatoes. Cymoxanil is applied as a foliar spray and acts as a local systemic fungicide. The compound penetrates the leaves rapidly, making it rainfast. As it is local acting however, it is not the most persistant of fungicides and is usually applied in combination with a protective translocatable systemic fungicide, such as Mancozeb. Cymoxanil acts by preventing sporulation. Diseases that are treatable with Cymoxanil are most members of the Peronosporales order: Phytophthora, Plasmopara, and Peronospora - blights and mildews.

Its post-infection activity stops the development of the fungus during the incubation. Local systemic action: it is able to penetrate the crop leaf and improves the effectiveness of companion fungicides, especially during periods of intensive disease pressure. Alone, it has a very short period of activity: two days at most. Therefore it is used in two or three-way mixtures with protectants and/or systemic fungicides. It inhibits different metabolic processes and promotes the natural defenses of the plant.

Cymoxanil is chemically known as 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea or 2-cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide and has the following structure:

US 3,957,847 A claims 2-cyano-2-hydroxyiminoacetamides which generically covers Cymoxanil.

GB 935 981 discloses Propineb generically and its uses.

CN 104430441 A discloses water dispersible granules containing Propineb and Cymoxanil comprise the following components in percentage by mass: 5-70% of Propineb, 5-70% of Cymoxanil, 0.001-0.01% of oxyenadenine, 0.001-0.01% of enadenine, 1-5% of a wetting agent, 2-15% of a dispersant, 1-20% of a disintegrating agent, 0-5% of an adhesive, 0-3% of a defoamer and the balance of a carrier.

Cymoxanil and Propineb combination is used commercially by many companies like Propineb + Cymoxanil 76 WP of DVA Colombia/Sino Agro-Chemical Industry Ltd. Further, Propineb and Cymoxanil individually are also used in combination with many other active Ingredients.

Though, conventionally each of these active ingredients are used individually, in combination with other products, however, the specific composition of the present invention is not found. In view of the advantageous properties of the synergestic properties, there is increased interest in the use of active ingredients in combination to give synergistic results.

We surprisingly found that wettable powder compositions comprising combination of Propineb and Cymoxanil characterized by different modes of action, exhibits a considerable synergistic effect, allowing a higher fungicidal activity to be obtained than that envisaged on the basis of the activities of individual Propineb and Cymoxanil.

OBJECTIVE OF INVENTION
The main objective of the present invention is to provide synergistic fungicidal wettable powder composition comprising polymeric dithiocarbamate fungicide complex with zinc salt and triazole fungicide.

Another objective of the present invention is to provide synergistic fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil.

Another objective of the present invention is to provide fungicidal wettable powder composition comprising combination of Propineb, Cymoxanil and other agrochemical auxiliaries.

Another objective of the present invention is to provide fungicidal wettable powder composition comprising combination of Propineb, Cymoxanil, wetting agents, dispersing agents and other agrochemical auxiliaries.

Yet another objective of the present invention is to provide fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil at a weight ratio of 15 : 1 to 1 : 15, wetting agents, dispersing agents and other agrochemical auxiliaries.

Still yet another objective of the present invention is to provide a process for the preparation of fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil, wherein said process comprises simple blending and milling.

SUMMARY OF INVENTION
Accordingly, the present invention provides a synergistic fungicidal wettable powder composition comprising polymeric dithiocarbamate fungicide complex with zinc salt and urea derivative.

In one embodiment, the present invention provides a synergistic fungicidal wettable powder composition comprising polymeric dithiocarbamate fungicide complex with zinc salt and urea derivative and other agrochemical auxiliaries.

In one embodiment, the present invention provides a synergistic fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising combination of Propineb, Cymoxanil and other agrochemical auxiliaries.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising combination of Propineb, Cymoxanil, wetting agents, dispersing agents and other agrochemical auxiliaries.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil, at a weight ratio of 15 : 1 to 1 : 15, wetting agents, dispersing agents and other agrochemical auxiliaries.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of wetting agents,
1% to 15% (w/w) of dispersing agents, and
0.1% to 30% (w/w) of other additives / auxiliaries.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of wetting agents,
1% to 15% (w/w) of dispersing agents,
0.1% to 5% (w/w) of defoamers, and
1% to 25% (w/w) of fillers.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of sodium salt of dibutyl naphthalene sulphonate,
1% to 10% (w/w) of sodium salt of naphthalene sulfonate condensate,
1% to 10% (w/w) of sodium lignosulfonate, and
0.1% to 30% (w/w) of other additives / auxiliaries.

In another embodiment, the present invention provides a fungicidal wettable powder composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of sodium salt of dibutyl naphthalene sulphonate,
1% to 10% (w/w) of sodium salt of naphthalene sulfonate condensate,
1% to 10% (w/w) of sodium lignosulfonate,
1% to 5% (w/w) of silicone defoamers,
1% to 5% (w/w) of precipitated silica and
1% to 25% (w/w) of hydrated aluminum silicate.

In another embodiment, the present invention provides a process for the preparation of fungicidal wettable powder composition comprising combination of Propineb and Cymoxanil, wherein said process comprising simple blending and milling.

In another embodiment, the present invention provides a process for the preparation of fungicidal wettable powder composition comprising steps of:
a. weighing and mixing active agents and auxiliaries,
b. milling the sample through air jet milling instrument, and
c. collecting the material and packing.

In another embodiment, the present invention provides a process for the preparation of fungicidal wettable powder composition comprising steps of:
a. weighing and mixing Propineb technical, Cymoxanil technical, sodium salt of dibutyl naphthalene sulphonate, sodium salt of naphthalene sulfonate condensate, sodium lignosulfonate, silicone defoamers, precipitated silica and hydrated aluminum silicate.
b. milling the sample through air jet milling instrument, and
c. collecting the material and packing.

In yet another embodiment the present invention also provides a method of combatting phytophogenic fungi which comprises applying to the plants Propineb and Cymoxanil in a synergistic fungicidally effective aggregate amount.

DETAILED DESCRIPTION OF THE INVENTION
The term "comprising", which is synonymous with "including", "containing", or "characterized by" here is defined as being inclusive or open-ended, and does not exclude additional, unrecited elements or method steps, unless the context clearly requires otherwise.

Propineb and Cymoxanil may be present in the composition or applied in any amounts relative to each other, to provide the enhanced or synergistic effect of the mixture. Propineb and Cymoxanil may be present in the synergistic fungicidal composition in any suitable amount, and is generally present in an amount of from 90% to 10% by weight of the composition, preferably from 80% to 25% by weight of the composition. However, variables of the ratios of each of the active ingredients can be used and the selection of the particular amount is dependent upon many factors including, for example, type of formulations, the crop, disease sought to be controlled and environmental conditions. The selection of the proper quantity of active agent to be applied, however, is within the expertise of one skilled in the art.

Formulation includes water soluble concentrate (SL), an emulstifiable concentrate (EC), an emulsion (EW), a microemulsion (ME), a suspension concentrates (SC), an oil-based dispersions (OD), a flowable suspension (FS), water soluble powder (WS), water-dispersible granule (WDG), water-soluble granule (SG), a wettable powder (WP), a water soluble powder (SP), a granule (GR), an encapsulated granule (CG), a fine granule (FG), a macrogranule (GG), an aqueous suspoemulsion (SE), capsule suspension (CS) and a microgranule (MG).

Preferably, the synergistic fungicidal composition can be formulated as water soluble powder (WS), wettable powder (WP) or water-dispersible granule (WG). Most preferably, the synergistic fungicidal composition can be formulated as wettable powder (WP).

The wetting agent is a compound that facilitates rapid wetting of the powder when added to the water. The wetting agent employed in the formulation composition is selected from the group consisting of non-ionic surfactants, anionic surfactant, a mixture of anionic and non-ionic surfactant and polymeric surfactant.

The wetting agent as used herein is selected from and not limited to a blend of anionic and nonionic surfactants (Atlox 5406B), polyoxyethylene alkyl ether (Atlox-4894), polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox 4913), alkyl naphthalene sulfonates (such as Morwet IP, Morwet EFW, Morwet 3028, Supragil WP etc), sodium salt of dibutyl naphthalene sulphonate (Jeemol BX), polycondensation product of naphthalene sulfonic acid, which is alkyl naphthalene sulphonate sodium salt, polyalkyl naphthalene sulphonate; Aqarius BP14332 Yellow IH, salts of alkylphenol condensates, salts of sulphonated lignins, salts of poly acid resin copolymers, modified styrene acrylic polymer, salts of polyphenol formaldehyde resins, salts of polyarylether sulphates such as tristyrylphenolethoxylate sulphate salts, alkoxylated alkylphenols and alcohols as well as block copolymers of ethyleneoxide and propylene oxide.

The wetting agent is present in the composition in a range of about 1% to 15%, more preferably 1% to 10% of the total weight of the composition.

The wetting agent may also be used as a dispersing agent.

The compositions of the present invention contain additional dispersing agents selected from and not limited to sodium lignosulphonates; sodium salt of naphthalene sulfonate condensate (Morwet D 425), sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenol ethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers, polycarboxylates, alkyl naphthalene sulfonates (such as Morwet IP, Morwet EFW, Morwet 3028,), phenol sulphonic acid condensates, alkyl sulfonates, alkenyl sylfonates, mixture of alkyl sulfonates and alkenyl sylfonates (Lissapol D), alkyl suflosuccinates (Geropon), L-Wet, methyl oleyltaurates and poly vinyl alcohols. Preferred dispersing agents are polycarboxylates, alkyl naphthalene sulfonates, phenol sulphonic acid condensates, lignosulphonates, methyl oleyltaurates and poly vinyl alcohols, STEPSPERSE DF-600 is a blend of nonionic surfactant and sodium lignosulfonate, BREAK-THRU® DA 646 is a non-ionic dispersant based on a specialty polyether, BREAK-THRU® DA 647, a modified polyether, is a non-ionic dispersant, BREAK-THRU® DA 655 is a polyether phosphate, BREAK-THRU® DA 675 is a non-ionic, aqueous based organically modified polymer, Atlox Metasperse™ 550S. Dispersing agents disclosed in US 6,677,399; US 6,767,865; EP 1 16 470; US 9,526,241 can be used in the present invention. Once the granule has been diluted in water, ready for spraying (with the aid of the wetting agent), a dispersant is required to maintain the particles in suspension and prevent them from agglomerating. The dispersing agent is a compound which ensures that the particles remain suspended in water. The dispersing agent can be ionic or non-ionic or a mixture of such surface active agents or graft co-polymer dispersant.

The dispersing agent is present in the composition in a range of about 1 to 15%, more preferably 1% to 10% of the total weight of the composition.

The defoamer as used herein is selected from and not limited to absorbed polydimethyl siloxane, stearates; silicones (SILFOAM®, Xiameter APW-4253, SILFAR®, PULPSIL® and WACKER® AK) and ethoxylates.

The defoamer is present in the composition in a range of about 0.1% to 5%, more preferably 0.1% to 2% of the total weight of the composition.

The inert fillers as used in the present invention are includes but are not limited to water, natural minerals such as calcite, talc, china clay series like hydrated aluminum silicate, and montmorillonite or attapulgite clays including various forms of Bentonite, Kaolin; lactose, starches, calcium carbonate, calcium sulphate, calcium phosphate, sodium tripoly phosphate (STPP), woodflours, activated carbon, sugars, diatomaceous earth, cereal flours, fine-grain inorganic solids, and the like. Clays and inorganic solids which may be used include calcium bentonite, perlite, mica, vermiculite, precipitated silica, silica, silicate salts, quartz powder, montmorillonite and mixtures thereof. Sugars which may be useful include dextrin and maltodextrin. Cereal flours include wheat flour, oat flour and barley flour and a mixture thereof.

The fillers are present in the composition in a range of about 1% to 30%, more preferably 2% to 30% of the total weight of the composition.

The compositions of the present invention can be diluted with water or water solutions of agronomic compounds before use to produce a sprayable composition which is used in treating plants or increasing plant growth. Dilution in water usually results in suspensions, emulsions, suspoemulsions or solutions of the agrochemical active ingredient at a concentration of at least 0.001 g/l.

The formulated composition may for example be applied in spray form, e.g., employing appropriate dilutions. The rates of application (use) of the composition of the present invention may vary, for example, according to type of use, soil type, season, climate, soil ecology, type of plants, but is such that Propineb and Cymoxanil in the combination in an effective amount to provide the desired action. The application rate of the composition for a given set of conditions can readily be determined by trials. The composition of the present invention may contain or be mixed with other pesticides, such as fungicides, insecticides and nematicides, growth factor and fertilizers, to enhance the activity of the association of the invention or to widen its spectrum of activity.

A particular mode of administering the composition of the present invention is the administration to the aboveground parts of plants, in particular to the leaves thereof (leaf-application). The number of applications and the administered doses are chosen in accordance with the biological and climatic conditions of life of the causative agent. The antifungal compositions though, can also be applied to the soil and get into the plants through the root system (systemic activity), in case the locus of the plants is sprayed with a liquid composition or if the components are added to the soil in a solid formulation e.g. in the form of granulate (soil application).

When using the active compound combinations according to the invention, the application rate can be varied within a relatively wide range, depending on the kind of application. For the treatment of parts of plants, the active-compound combination application rates are generally between 0.1 and 10000 g/ha, preferably between 100 and 2500 g/ha. For seed dressing, the active compound combination application rates are generally between 0.001 and 50 g per kilogram of seed, preferably between 0.01 and 20 g per kilogram of seed. For the treatment of the soil, the active-compound combination application rates are generally between 0.1 and 10000 g/ha preferably between 1 and 5000 g/ha.

The following examples describes the nature of the invention which are given only for the purpose of illustrating the present invention in more detail and are not limitative and relate to solutions, which have been particularly effective on bench scale.

EXAMPLES

Example 1: Propineb 70% + Cymoxanil 6% (WP):
S. No. Ingredients/Raw Materials Quantity (% w/w)
1. Propineb technical @ 81% (b) 70% 78
2. Cymoxanil @ 97% (b) 6% 8.0
3. Sodium salt of dibutyl naphthalene sulphonate (Jeemol BX) 3.0
4. Sodium salt of naphthalene sulfonate condensate (Morwet D 425) 5.0
5. Sodium lignosulfonate 3.0
6. Silicones (Xiameter APW-4253) 1.0
7. Precipitated Silica 2.0
8. Hydrated aluminum silicate (China clay) QS
Total 100

Manufacturing process
All the raw materials were weighed, dispensed and the mixture was mixed in a ribbon blender for 15 minutes. The mixture was passed through air jet milling instrument, Inlet pressure - 4kg/cm2 and Grinding pressure - 6kg/ cm2 for milling the sample. The milled material was collected and packed. The particle size distribution (PSD) of the milled material should be <10 µ.

Field efficacy trials for Example 1

Trial 1: Bio-efficacy against Potato late blight
The late blight is caused by the Oomycete group of fungal pathogen Phytophthora infestans. This is potentially devasting disease can infect potato foliage and tuber at any stage of crop development. The first symptoms of late blight in the field are small, light to dark green, circular to irregular-shaped water-soaked spots. These lesions usually appear first on the lower leaves. Lesions often begin to develop near the leaf tips or edges, where dew is retained the longest. During cool, moist weather, these lesions expand rapidly into large, dark brown or black lesions, often appearing greasy. The lesions are not limited by leaf veins, and as new infections occur and existing infections coalesce, entire leaves can become blighted and killed within just a few days. The lesions also may be present on petioles and stems of the plant. Maximum and minimum temperatures in the range of 16-20°C and 1-6°C were found favourable for potato blight disease. Similarly, relative humidity, rainfall, and wind speed in the range of 63-71%, 1.5-3.75 mm and 1-5.5 Km/h, respectively, were conducive for PLB disease which is helpful in disease development.

The field trial was conducted to evaluate the efficacy of Propineb and Cymoxanil WP composition against phytophthora infestans fungus in potato crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Potato crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after planting. The visual observations were recorded for % disease control from ten plants per plot. The observations were recorded before spraying, 7 DAA (days after application) and 14 DAA (days after application).

Table 1: Late blight disease control in potato:
Compositions Dose (gram active per hectare) Percent disease control – Phytophthora infestans.
07 DAA 14 DAA
Propineb 70% + Cymoxanil 6% WP (Example 1) 1330 90 85
Propineb 70% WP 1225 50 45
Cymoxanil 50% WP 105 70 60
WP - Wettable Powder and DAA - Days after application.

The trial results show excellent efficacy of Propineb 70% + Cymoxanil 6% WP product against late blight disease of potato. The solo application of two active ingredients tested here were not able to provide satisfactory control of late blight disease. The Propineb 70% + Cymoxanil 6% WP product found very promising against potato late blight in terms of efficacy as well as residual control.

Trial 2: Bio-efficacy against potato Early blight
The early blight is caused by the fungal pathogen Alternaria solani. This is potentially devasting disease. Warm, humid (24-29°C/ 75-84°F) environmental conditions are conducive to infection. Its major threat to many vegetable and fruit crops and can also affect the crop stand and yield. The first symptoms of early blight appear as small, circular, or irregular, dark brown to black spots on the older (lower) leaves. These spots enlarge up to 3/8 inch in diameter and gradually may become angular-shaped. These first lesions appear about two to three days after infection, with further sporulation on the surface of these lesions occurring three to five days later. Early blight lesions can be diagnosed in the field easily due to the dark concentric rings alternating with bands of light-tan tissue, giving them a distinctive target spot appearance. Multiple lesions on the same leaf also may coalesce, or grow together, to form one mass. As lesions coalesce, chlorosis (yellowing of plant tissue) may be visible due to clusters of infection. Elongated, brown to black lesions also may develop on stems and petioles of infected plants.

The field trial was conducted to evaluate the efficacy of propineb and cymoxanil WP product against Alternaria solani fungus in potato crop. Trial was conducted with randomized block design with net plot size of 5m x 6m. Potato crop was raised with all standard agronomic practices. Spraying was done with manual operated backpack knapsack sprayer with 500 L of water spray volume per hectare at 45 days after planting. The visual observations were recorded for % disease control from ten plants per plot. The observations were recorded at before spraying, 7 DAA (days after application) and 14 DAA (days after application).

Table 2: Early blight disease control in Potato:
Compositions Dose (gram active per hectare) Percent disease control – Alternaria solani.
07 DAA 14 DAA
Propineb 70% + Cymoxanil 6% WP 1330 85 80
Propineb 70% WP 1225 65 55
Cymoxanil 50% WP 105 50 40
WP - Wettable Powder, SC – Suspension concentrates and DAA - Days after application.

The trial results shown excellent efficacy of Propineb 70% + Cymoxanil 6% WP product against late blight disease of potato. The solo application of two active ingredients tested here were not able to provide satisfactory control of late blight disease. The combination of Propineb 70% + Cymoxanil 6% WP found very promising against potato late blight in terms of efficacy as well as residual control.

,CLAIMS:WE CLAIM

1. A fungicidal wettable powder composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of wetting agents,
1% to 15% (w/w) of dispersing agents, and
0.1% to 30% (w/w) of other additives / auxiliaries.
2. The fungicidal wettable powder composition as claimed in claim 1, wherein said composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of sodium salt of dibutyl naphthalene sulphonate,
1% to 10% (w/w) of sodium salt of naphthalene sulfonate condensate,
1% to 10% (w/w) of sodium lignosulfonate, and
0.1% to 30% (w/w) of other additives / auxiliaries.
3. The fungicidal wettable powder composition as claimed in claim 1, wherein said composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of wetting agents,
1% to 15% (w/w) of dispersing agents,
0.1% to 5% (w/w) of defoamers and
1% to 25% (w/w) of fillers.
4. The fungicidal wettable powder composition as claimed in claim 3, wherein said composition comprising:
1% to 75 % (w/w) of Propineb as first active ingredient,
1% to 20% (w/w) of Cymoxanil as second active ingredient,
1% to 15% (w/w) of sodium salt of dibutyl naphthalene sulphonate,
1% to 10% (w/w) of sodium salt of naphthalene sulfonate condensate,
1% to 10% (w/w) of sodium lignosulfonate, and
0.1% to 30% (w/w) of other additives / auxiliaries

5. The process for the preparation of fungicidal wettable powder composition as claimed in claim 1, wherein said process comprising steps of:
a. weighing and mixing active agents and auxiliaries,
b. milling the sample through air jet milling instrument, and
c. collecting the material and packing.

6. The process for the preparation of fungicidal wettable powder composition as claimed in claim 4, wherein said process comprising steps of:
a. weighing and mixing Propineb technical, Cymoxanil technical, sodium salt of dibutyl naphthalene sulphonate, sodium salt of naphthalene sulfonate condensate, sodium lignosulfonate, silicones defoamers, precipitated silica and hydrated aluminum silicate.
b. milling the sample through air jet milling instrument, and
c. collecting the material and packing.

Dated this Thirtieth (30th) day of July, 2020

__________________________________
Dr. S. Padmaja
Agent for the Applicant
IN/PA/883