Claims:1. A synergistic fungicidal suspension concentrate composition comprising combination of azoxystrobin and difenoconazole consisting by mass percentage,
1 to 20% (w/w) of azoxystrobin as first active ingredient,
1 to 15% (w/w) of difenoconazole as second active ingredient,
1 to 15% (w/w) of wetting agent / dispersing agent, and
0.1 to 70% of other additives / auxiliaries.
2. The composition as claimed in claim 1, comprising combination of azoxystrobin and difenoconazole consisting by mass percentage,
1 to 20% (w/w) of azoxystrobin as first active ingredient,
1 to 15% (w/w) of difenoconazole as second active ingredient,
2 to 3% (w/w) of wetting agent,
2 to 3% (w/w) of dispersing agent,
5 to 10% (w/w) of antifreezing agent,
0.1 to 0.2% (w/w) of biocide,
0.5 to 1% (w/w) of defoamer,
5 to 10% (w/w) of viscosity modifier and balance is water.
3. The composition as claimed in claim 1 and claim 2, wherein said composition comprising combination of azoxystrobin and difenoconazole in the weight ratio of 1: 5 to 5: 1 of first active ingredient to the second active ingredient.
4. The composition as claimed in claim 1 and claim 2, wherein the said wetting agent is selected from polyoxyethylene alkyl ether (Atlox-4894), polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox-4913), fatty alcohol ethoxylate (Tersperse 4894), di alkyl naphthalene sulphonate sodium salt (Supragil WP), ethoxylated TSP-phosphate ester (Agrilan 1015), polymeric emulsifier (Atlas G-5002L), polycondensation product of naphthalene sulfonic acid, which is alkyl naphthalene sulphonate sodium salt, polyalkyl naphthalene sulphonate, salts of alkylphenol condensates, salts of sulphonated lignins, salts of poly acid resin copolymers, salts of polyphenol formaldehyde resins, salts of polyarylether sulphates such as tristyrylphenolethoxylate sulphate salts, alkoxylated alkylphenols and alcohols as well as block copolymers of ethyleneoxide and propylene oxide and mixtures thereof.
5. The composition as claimed in claim 1 and claim 2, wherein the said dispersing agent is selected from polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox-4913), EO-PO Polymeric dispersant (Tersperse 2288), polyoxy alkylene glycol butyl ether (ethylan NS 500 LQ), polymeric dispersant (Atlox Metasperse 500L), sodium salt of naphthalene sulfonate condensate (Morwet D-425), sodium ligno sulphonates, sodium naphthalene sulphonates formaldehyde condensates; tristyrylphenol ethoxylate phosphate esters, alkyl sulfonates, alkenyl sylfonates, mixture of alkyl sulfonates and alkenyl sylfonates, methyl oleyltaurates and poly vinyl alcohols or mixtures thereof.
6. The composition as claimed in claim 1 and claim 2, wherein the said antifreezing agent is selected from ethylene glycol, propylene glycol, other glycols, glycerin, or urea.
7. The composition as claimed in claim 1, wherein the said biocide is selected from Proxel GXl, Nipacide® BIT 20 which is a formaldehyde-free, in-can biocide based on benzisothiazolinone (BIT).
8. The composition as claimed in claim 1 and claim 2, wherein the said defoamer is selected from absorbed Polydimethyl siloxane, stearates; silicones (Sag-1572, SILFOAM®, SILFAR®, PULPSIL® and WACKER® AK) and ethoxylates.
9. The composition as claimed in claim 1 and claim 2, wherein the said viscosity modifier is selected from xanthan gum, Rhodopol gel (2%), PVOH, cellulose and its derivatives, clay hydrated silicates, magnesium aluminum silicates or a mixture thereof.
10. A process for the preparation of synergistic fungicidal suspension concentrate composition of azoxystrobin and difenoconazole comprising the steps of:
a) aqueous slurry preparation,
b) wet milling of slurry, and
c) gelling of wet milled slurry.
, Description:The present invention relates to synergistic fungicidal composition comprising methoxy acrylate fungicide and triazole fungicide and other agrochemical auxiliaries.

The present invention specifically relates to synergistic fungicidal composition comprising combination of azoxystrobin and difenoconazole and other agrochemical auxiliaries.

The present invention more specifically relates to synergistic fungicidal composition comprising azoxystrobin and difenoconazole, a wetting agent, dispersing agent, antifreezing agent, viscosity modifying agent, deformer, and other agrochemical auxiliaries.
The present invention more specifically relates to synergistic fungicidal composition comprising azoxystrobin and difenoconazole, at a weight in the ratio of 1:5 to 5:1 of first active ingredient to the second active ingredient, more preferably in the ratio of 1:3 to 3:1, a wetting agent, dispersing agent, antifreezing agent, viscosity modifying agent, deformer, and other agrochemical auxiliaries.
The present invention also relates to synergistic fungicidal suspension concentrate composition comprising combination of azoxystrobin and difenoconazole is prepared by aqueous slurry process, followed by milling the slurry and gelling of the milled slurry.

BACKGROUND OF THE INVENTION

Fungicides are biocidal chemical compounds or biological organisms used to kill parasitic fungi or their spores. Fungi can cause serious damage in agriculture, resulting in critical losses of yield, quality, and profit. Fungicides are used both in agriculture and to fight fungal infections in animals. Although pesticides remain indispensable in agriculture, a great potential still exists to improve their efficiency and thus reduce their input into the environmental and food chain. Depending on the field of application, and the mode of application, and depending on physical, chemical, and biological parameters, the active substances are employed as active substance formulation in the form of a mixture with customary carriers, adjuvants and additives.

Azoxystrobin is a methoxy acrylate fungicide and is a plant protection fungicide with protectant, curative, eradicant, translaminar and systemic properties commonly used in agriculture.

Azoxystrobin chemically known as, Methyl(E)-2-(2-((6-(2-cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylate and has the following structure:

Azoxystrobin is disclosed in US 5,395,837. The pure product is white crystal.

Difenoconazole is a colorless solid, a triazole fungicide with protective, therapeutic, and systemic activities. It is widely used in crops such as fruit trees and vegetables to effectively prevent black spot disease, black pox disease, white rot, spotted leaf disease, powdery mildew, brown spot disease, rust, stripe rust, and scab.

Difenoconazole chemically known as, 1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole and has the following structure:

Difenoconazole is described as a fungicidal active substance in GB patent application 2,098,607.

Though, conventionally each of these active ingredients are used individually, and combination product with other products is approved, however, the combination of the present invention is not found. In view of the advantageous properties of the synergistic properties, there is increased interest in the use of Active ingredients in combination to give synergistic results.

We surprisingly found that a combination of azoxystrobin and difenoconazole, characterized by different modes of action, exhibits a considerable synergistic effect, allowing a higher fungicidal activity to be obtained than that envisaged on the basis of the activities of individual azoxystrobin and difenoconazole.

The fungicide aqueous suspension concentrate is under the effect of auxiliary agent (wetting dispersing agent, thickener, structure regulator and defoamer etc.), and former medicine water insoluble or that be insoluble in water is distributed in the water, forms uniform and stable dispersion.

The fungicidal mixtures according to the invention have very advantageous properties for protecting plants against disease infestation, particularly in the control and prevention of disease infestation on seed and soil.

SUMMARY OF THE INVENTION

Accordingly, the present invention provides synergistic fungicidal composition comprising methoxy acrylate fungicide and triazole fungicide and other agrochemical auxiliaries.

In another embodiment, the present invention provides synergistic fungicidal composition comprising azoxystrobin and difenoconazole and other agrochemical auxiliaries.

In another embodiment, the present invention provides synergistic fungicidal composition comprising azoxystrobin and difenoconazole, a wetting agent, dispersing agent, antifreezing agent, viscosity modifying agent, deformer, and other agrochemical auxiliaries.

In another embodiment, the present invention specifically provides synergistic fungicidal composition comprising combination of azoxystrobin and difenoconazole, at a weight in the ratio of 1:5 to 5:1 of first active ingredient to the second active ingredient, more preferably in the ratio of 1:3 to 3:1, a wetting agent, dispersing agent, antifreezing agent, viscosity modifying agent, deformer, and other agrochemical auxiliaries.

In yet another embodiment, the present invention also provides synergistic fungicidal suspension concentrate composition comprising combination of azoxystrobin and difenoconazole is prepared by aqueous slurry process, followed by milling the slurry and gelling of the milled slurry.

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to synergistic fungicidal composition comprising methoxy acrylate fungicide and triazole fungicide and other agrochemical auxiliaries.

In preferred embodiment, the present invention relates to synergistic fungicidal composition comprising azoxystrobin and difenoconazole and other agrochemical auxiliaries.

In preferred embodiment the synergistic fungicidal suspension concentrate comprising from
1 to 20% (w/w) of azoxystrobin as first active ingredient,
1 to 15% (w/w) of difenoconazole as second active ingredient,
1 to 15% (w/w) of wetting agent / dispersing agent, and optionally
0.1 to 70% of other additives / auxiliaries.

In preferred embodiment the synergistic fungicidal suspension concentrate comprising from
1 to 20% (w/w) of azoxystrobin as first active ingredient,
1 to 15% (w/w) of difenoconazole as second active ingredient,
2 to 3% (w/w) of wetting agent,
2 to 3% (w/w) of dispersing agent,
5 to 10% (w/w) of antifreezing agent,
0.1 to 0.2% (w/w) of biocide,
0.5 to 1% (w/w) of defoamer,
5 to 10% (w/w) of viscosity modifier and balance is water.

In preferred embodiment the synergistic fungicidal suspension concentrate composition, the weight ratio of azoxystrobin and difenoconazole in the composition independently is in the range of from 5:1 to 1:5, preferably 3:1 to 1:3. However, variables of the ratios of each of the active ingredients can be used and the selection of the amount is dependent upon many factors including, for example, type of formulations, the crop, disease sought to be controlled and environmental conditions. The selection of the proper quantity of active agent to be applied, however, is within the expertise of one skilled in the art.

The term "comprising", which is synonymous with "including", "containing", or "characterized by" here is defined as being inclusive or open-ended, and does not exclude additional, unrecited elements or method steps, unless the context clearly requires otherwise.

The wetting agent is a compound that facilitates rapid wetting of the powder when added to the water. The wetting agent employed in the formulation composition is selected from the group consisting of non-ionic surfactants, anionic surfactant and a mixture of anionic and non-ionic surfactant and polymeric surfactant. The wetting agent as used herein is selected from and not limited to a blend of anionic and nonionic surfactants (Atlox 5406B), polyoxyethylene alkyl ether (Atlox-4894), polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox-4913), fatty alcohol ethoxylate (Tersperse 4894), di alkyl naphthalene sulphonate sodium salt (Supragil WP), ethoxylated TSP-phosphate ester (Agrilan 1015), polymeric emulsifier (Atlas G-5002L), polycondensation product of naphthalene sulfonic acid, which is alkyl Naphthalene sulphonate sodium salt, Polyalkyl Naphthalene sulphonate; Aqarius BP14332 Yellow IH, salts of alkylphenol condensates, salts of sulphonated lignins, salts of poly acid resin copolymers, salts of polyphenol formaldehyde resins, salts of polyarylether sulphates such as tristyrylphenolethoxylate sulphate salts, alkoxylated alkylphenols and alcohols as well as block copolymers of ethyleneoxide and propylene oxide.

The wetting agent used in the proposed composition in a range of about 1 to 5%, more preferably 2 to 3% of the total weight of the composition. The wetting agent may also be used as a dispersing agent.

The dispersing agent is a compound which ensures that the particles remain suspended in water. The dispersing agent can be ionic or non-ionic or a mixture of such surface-active agents or graft co-polymer dispersant.

The dispersing agents as used herein is selected from sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenol ethoxylate phosphate esters; aliphatic alcohol ethoxylates; alkyl ethoxylates (Geronol SCR); EO-PO Polymeric dispersant (Tersperse 2288); polyoxy alkylene glycol butyl ether (ethylan NS 500 LQ), polymeric dispersant (Atlox Metasperse 500L) and graft copolymers, polycarboxylates, alkyl naphthalene sulfonates (such as Morwet IP, Morwet EFW, Morwet 3028), sodium salt of naphthalene sulfonate condensate (Morwet D-425), phenol sulphonic acid condensates, alkyl sulfonates, alkenyl sylfonates, mixture of alkyl sulfonates and alkenyl sylfonates (Lissapol D), alkyl suflosuccinates (Geropon), L-Wet, methyl oleyltaurates and poly vinyl alcohols. Preferred dispersing agents are polymethyl methacrylate-polyethylene glycol graft copolymer (Atlox-4913), polycarboxylates, alkyl naphthalene sulfonates, phenol sulphonic acid condensates, lignosulphonates, methyl oleyltaurates and poly vinyl alcohols, STEPSPERSE DF-600 is a blend of nonionic surfactant and sodium lignosulfonate, BREAK-THRU® DA 646 is a non-ionic dispersant based on a specialty polyether, BREAK-THRU® DA 647, a modified polyether, is a non-ionic dispersant, BREAK-THRU® DA 655 is a polyether phosphate, BREAK-THRU® DA 675 is a non-ionic, aqueous based organically modified polymer, Atlox Metasperse™ 550S Modified styrene acrylic polymer.

The dispersing agent is present in the proposed composition in a range of about 1 to 5%, more preferably 2 to 3% of the total weight of the composition.

The antifreezing agent as used herein is selected from ethylene glycol, propylene glycol, other glycols, glycerin, or urea.

The antifreezing agent used in the proposed composition in a range of about 1 to 10%, more preferably 5 to 10% of the total weight of the composition.

The biocide as used herein is selected from Proxel GXl, Nipacide® BIT 20 which is a formaldehyde-free, in-can biocide based on benzisothiazolinone (BIT).

The biocide in the proposed composition in a range of about 0.1 to 2%, more preferably 0.1 to 0.2% of the total weight of the composition.

The defoamer as used herein is selected from absorbed Polydimethyl siloxane, stearates; silicones (Sag-1572, SILFOAM®, SILFAR®, PULPSIL® and WACKER® AK) and ethoxylates. The viscosity modifying agent as used herein include all substances which can normally be used for this purpose in agrochemical compositions. For example, xanthan gum, PVOH, cellulose and its derivatives, clay hydrated silicates, magnesium aluminum silicates or a mixture thereof.

The defoamer used in the proposed composition in a range of about 0.1 to 2%, more preferably 0.5 to 1% of the total weight of the composition.

The viscosity modifying agent as used herein include all substances which can normally be used for this purpose in agrochemical compositions. For example, xanthan gum, Rhodopol gel (2%), PVOH, cellulose and its derivatives, clay hydrated silicates, magnesium aluminum silicates or a mixture thereof. The fungicidal composition may further comprise one or more solid adherents. Such adherents are known in the art and available commercially. They include organic adhesives, including tackifiers, such as celluloses of substituted celluloses, natural and synthetic polymers in the form of powders, granules, or lattices, and inorganic adhesives such as gypsum, silica, or cement.

The viscosity modifier used in the proposed composition in a range of about 1 to 15%, more preferably 5 to 10% of the total weight of the composition.

The adjuvants as used herein is selected from silicon (Wacker L0 99), propriety blend of amino acids (Active 3.0 1X) and polyoxyethylene (12) sorbitan monolaurate (Tween 23).

The adjuvant used in the proposed composition in a range of about 1 to 10%, more preferably 3 to 7% of the total weight of the composition.

The inert fillers as used in the present invention are includes but are not limited to water, natural minerals such as calcite, talc, china clay series, and montmorillonite or attapulgite clays including various forms of Bentonite, Kaolin; lactose, starches, calcium carbonate, calcium sulphate, calcium phosphate, sodium tripoly phosphate (STPP), woodflours, activated carbon, sugars, diatomaceous earth, cereal flours, fine-grain inorganic solids, and the like. Clays and inorganic solids which may be used include calcium bentonite, perlite, mica, vermiculite, silicas, quartz powder, montmorillonite and mixtures thereof. Sugars which may be useful include dextrin and maltodextrin. Cereal flours include wheat flour, oat flour and barley flour and a mixture thereof.

Preferred inert fillers are water, lactose anhydrous and china clay. Highly disperse silica or highly disperse absorptive polymers may also be used to improve physical properties.

Formulation includes water soluble concentrate (SL), an emulsifiable concentrate (EC), an emulsion (EW), a microemulsion (ME), a suspension concentrates (SC), an oil-based suspension concentrates (OD), a flowable suspension (FS), a water-dispersible granule (WG), water-soluble granule (SG), a water-dispersible powder (WP), a water soluble powder (SP), a granule (GR), an encapsulated granule (CG), a fine granule (FG), a macrogranule (GG), an aqueous suspoemulsion (SE), capsule suspension (CS) and a microgranule (MG). Preferably, the synergistic fungicidal composition can be formulated as suspension concentrates (SC), water-dispersible powder (WP) or water-dispersible granule (WG). Most preferably, the synergistic fungicidal composition can be formulated as suspension concentrates (SC).

A synergistic fungicidal composition comprising azoxystrobin and difenoconazole surprisingly and substantially enhances the fungicidal effectiveness of difenoconazole, and vice versa. "Plant" as used herein, refers to all plant and plant populations such as desired and undesired wild plants or crop plants. "Plant parts" as used herein, refers to all parts and organs of plants, such as shoot, leaves, needles, stalks, stems, fruit bodies, fruits, seeds, roots, tubers and rhizomes. Harvested materials, and vegetative and generative propagation materials, for example, cutting, tubers, meristem tissue, rhizomes, offsets, seeds, single and multiple plant cells and any other plant tissues, are also included. The synergistic fungicidal composition according to the present invention is suitable for plants of the crops: cereals (wheat, barley, rye, oats, corn, rice, sorghum, triticale and related 15 crops); fruit, such as pomes, stone fruit and soft fruit, such as apples, pears, plums, peaches, almonds, cherries, and berries, for example grape, strawberries, raspberries and blackberries; leguminous plants (beans, lentils, peas, soybeans); oil plants (rape, mustard, sunflowers); cucurbitaceae (marrows, cucumbers, melons); citrus fruit, such as oranges, lemons, grapefruit and mandarins; and vegetables (spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, paprika, chili).

Preferably, the composition of the present invention is applied on cereals, fibre plants, leguminous plants and vegetables. More preferably, the composition is applied on cereals and vegetables. Each composition of the present invention can be used in the agricultural sector and related fields of use for preventing and/or treating fungal infestations example, but not limited to: Cercospora spp., Colletotrichum spp., Dreschlera spp., Erysiphe spp., Exserohilum spp., Microsphaera spp., Phaeoisariopsis spp., Phakopsora spp., Phakospsora spp., Puccinia spp., Septoria spp., Cercospora kikuchii, Cercospora sp., Colletotrichum gossypii, Dreschlera triticirepentis, Erysiphe diffusa, Exserohilum turcicum, Microsphaera diffusa, Phaeoisariopsis griseola, Phakopsora pachyrhizi, Phakospsora pachyrizhizi, Puccinia recondite, Septoria glycines and Septoria tritici. The synergistic fungicidal composition according to this invention is effective in preventing and/or treating fungal infestations caused by, particularly Cercospora spp., Colletotrichum spp., Dreschlera spp., Erysiphe spp., Exserohilum spp., Microsphaera spp., Phaeoisariopsis spp., Phakopsora spp., Phakospsora spp., Puccinia spp., and Septoria spp, in plants and plant parts, particularly plants and their plant parts of cereals, fibre plants, leguminous plants and vegetables.

Although the invention has been described above with reference to the disclosed embodiments, those skilled in the art will readily appreciate that the specific embodiments detailed are only illustrative of the invention. Various modifications can be made without departing from the spirit of the invention. Accordingly, the invention is limited only by the claims.

In a preferred embodiment of the present invention also provides synergistic fungicidal suspension concentrate composition of combination of azoxystrobin and difenoconazole comprising the steps of:
a) aqueous slurry preparation,
b) wet milling of slurry, and
c) gelling of wet milled slurry

The present invention is further illustrated by the following examples which are provided merely to be exemplary of the inventions and is not intended to limit the scope of the invention. Certain modifications and equivalents will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.

The fungicidal mixtures according to the invention have very advantageous properties for protecting plants against disease infestation, particularly in the control and prevention of disease infestation on seed and soil.

These properties are for example the synergistically enhanced action of mixtures of azoxystrobin and difenoconazole, resulting in lower disease infestation, lower rates of application, a longer duration of action and altogether higher crop yields. Another property improved by the instant mixtures is summarized as plant vigor. Under the term plant vigor there are understood various sorts of improvements of plants which are not connected to the control of pests. For example such advantageous properties that may be mentioned are improved crop characteristics including: emergence, crop yields, protein content, more developed root system, tillering increase, increase in plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf color, less fertilizer needed, less seeds needed, more productive tillers, earlier flowering, early grain maturity, less plant verse (lodging), increased shoot growth, increased plant stand and early germination; or any other advantages familiar to a person skilled in the art. Such enhancements were not to be expected from the activity of the individual components.
EXAMPLES

Example-1: Composition of azoxystrobin 18.5 % and difenoconazole 11.4 % (SC):
S. No. Ingredients/Raw Materials Composition (% w/w) Role
1. Azoxystrobin Technical @98 % (b) 18.5 % 18.87 Active ingredient
2. Difenoconazole Technical @94% (b) 11.4 % 12.12 Active ingredient
3. Atlox 4894 2.0 Wetting agent
4. Atlox 4913 2.0 Dispersing agent
5. Propylene glycol 10 Antifreezing agent
6. Proxel GXL 0.1 Biocide
7. Sag 1572 0.5 Defoamer
8. 2% Rhodopol gel 10 Viscosity Modifier
9. Distilled water 44.41 Filler
Total 100

The composition of the present invention is prepared by a process which comprises: Step-1: Preparation of aqueous slurry
Propylene glycol is taken in vessel No. 1 (pre mixer) and add Atlox 4894 and Atlox 4913 to this mixer. After 15 mins add Proxel GXL followed by Sag 1572. Then after 15 mins add DM water under stirring. The mixture was stirred for 15 mins and add azoxystrobin technical and followed by difenoconazole technical. Stir the mixture for 30 mins until homogenization (the mixture should be thoroughly homogenized).
Step-2: Wet milling of slurry
The wet slurry was passed from vessel No. 1 through Dyno-Mill at a temperature below 30 oC and collect material in vessel No.2 (Post-Mixer). Maintaining continuous stirring in both the vessels to avoid the sedimentation.
The Particle size distribution (PSD) of the sample was checked. The PSD of the material should be in between d90 < 15µ. If the d90 is higher than > 15µ then grind the mixture till the PSD value complies the specification.
Step 3: Gelling of wet milled slurry
The required quantity of Agrhopol 23W gel added to the wet slurry in vessel No.2 and the mixture was stirred until it forms lumps-free smooth homogeneous gel-suspension. The sample was checked for complete analysis and packed in a Bottle.

Example-2: Composition of azoxystrobin 18.5 % and difenoconazole 11.4 % (SC):
S. No. Ingredients/Raw Materials Composition
(% w/w) Role
1. Azoxystrobin technical @98 % (b) 18.5 % 18.87 Active Ingredient
2. Difenoconazole technical @94% (b) 11.4 % 12.12 Active Ingredient
3. Tersperse 4894 2.0 Wetting agent
4. Tersperse 2288 2.0 Dispersing agent
5. Wacker L0 99 1.0 Adjuvant
6. Propylene glycol 10 Antifreezing agent
7. Proxel GXl 0.1 Biocide
8. Sag 1572 1.0 Defoamer
9. 2% Rhodopol gel 10 Viscosity Modifier
10. Distilled water 42.91 Filler
Total 100

Example-3: Composition of azoxystrobin 18.5 % and difenoconazole 11.4 % (SC):
S. No. Ingredients/Raw Materials Composition (% w/w) Role
1. Azoxystrobin technical @98 % (b) 18.5 % 18.87 Active Ingredient
2. Difenoconazole technical @94% (b) 11.4 % 12.12 Active Ingredient
3. Supragil WP 1.5 Wetting agent
4. Morwet D-425 2.0 Dispersing agent
5. Active 3.0 1X 3.0 Adjuvant
6. Propylene glycol 10 Antifreezing agent
7. Proxel GXl 0.1 Biocide
8. Sag 1572 0.5 Defoamer
9. 2% Rhodopol gel 10 Viscosity Modifier
10. Distilled water 41.91 Filler
Total 100

Example-4: Composition of azoxystrobin 18.5 % and difenoconazole 11.4 % (SC):
S. No. Ingredients/Raw Materials Composition (% w/w) Role
1. Azoxystrobin technical @98 % (b) 18.5 % 18.87 Active Ingredient
2. Difenoconazole technical @94% (b) 11.4 % 12.12 Active Ingredient
3. Agrilan 1015 1.5 Wetting agent
4. Ethylane NS 500 LQ 2.0 Dispersing agent
5. Wacker L0 99 3.0 Adjuvant
6. Propylene glycol 10 Antifreezing agent
7. Proxel GXl 0.1 Biocide
8. Sag 1572 0.5 Defoamer
9. 2% Rhodopol gel 10 Viscosity Modifier
10. Distilled water 41.91 Filler
Total 100

Example-5: Composition of azoxystrobin 18.5 % and difenoconazole 11.4 % (SC):
S. No. Ingredients/Raw Materials Composition (% w/w) Role
1. Azoxystrobin technical @98 % (b) 18.5 % 18.87 Active Ingredient
2. Difenoconazole technical @94% (b) 11.4 % 12.12 Active Ingredient
3. Atlas G-5002L 1.5 Wetting agent
4. Atlox Metasperse 500L 2.0 Dispersing agent
5. Tween 23 7.0 Adjuvant
6. Propylene glycol 10 Antifreezing agent
7. Proxel GXl 0.1 Biocide
8. Sag 1572 0.5 Defoamer
9. 2% Rhodopol gel 10 Viscosity Modifier
10. Distilled water 37.91 Filler
Total 100