FIELD OF INVENTION
The invention relates to a herbicidal composition for effective control of weeds.

BACKGROUND OF THE INVENTION:
In recent times the trend of growing resistance to all kinds of Herbicides, control of multiple weeds of different types on same host, formation of residues are great concern and utmost challenge to the scientist community as a whole. With rapid urbanization there is a constant erosion of farming land and at the same time increasing population has created a growing demand of farm products resulted increasing trend of intensive cultivations of crops which favours numerous disease attack on crop plant
.
The diversity of weeds and their potential for causing serious loss of crop yield in combination or singly has resulted in the need for broad-spectrum weeds control. There are numerous chemical compounds (Herbicides), which aid in preventing weeds of plants, however most of them have practical deficiencies, which restricts their application. The inability of any one Herbicide to control all of the potentially serious weeds on one-crop makes the use of combinations or mixtures of Herbicides a part of normal control practice. Further, continuous uses of Herbicide, which has one way mode of action, always lead the resistance development in target weed. This as one of the many sufferings of the prior art.

OBJECTIVES OF THE INVENTION
The main object is to use a combination or mixture of the herbicide which has a different mode of action on target pathogen and can prevent resistance development in harmful fungal pathogen.

The other main objective of this invention is to provide a broad spectrum herbicidal composition. Another objective of the present invention is to provide a synergistic Herbicide combination, the bio-efficacy of which is superior to the mixture of the individual formulations at reduced rate of application of individual active in combination which will prevent accumulations of residue in plant and its harvests.

Another objective of the present invention is to provide an improved, stable and ready to use herbicidal composition effective against a wide spectrum of weeds like Post-emergence, annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax, and Early post-emergence control of broad-leaved weeds in soya beans, Snap Beans.. Lupin, Pea, Lima beans etc.
Another objective of the present inventions is to prevent resistant development in weeds, more particularly in Cereals crop like Soya bean, Pea, and other crop like potato, sugar beets, peanuts vegetables, cotton, flax etc.

Yet another objective of the present invention is to provide an herbicidal composition which is non-phytotoxic and results in high yield of various economically important crops such as potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax Snap Beans, Lupin, Pea, Lima beans etc. and still further objective of the present invention is to provide an herbicidal composition in a Suspension Concentrate (SC) or Suspo-Emulsion (SE) form.

Still further objective of the present invention is to provide an herbicidal composition containing lower concentration of Di-phenyl ether derivative Herbicide as compared to the known Herbicide formulations containing individual ingredients.

Still further objective of the present invention is to provide better plant growth and yield by supplementing natural oil.

Still further objective of the present invention is to provide an herbicidal composition of Fomesafen Herbicide to overcome the problems faced by the farmers of physically mixing the individual, commercially available formulations at the field.

Still further objective of the invention to load less actives and more efficacy in a single formulation.

Still further objective is to check out the physical compatibility of the actives.

Still further objective is to check out the chemical compatibility of the actives.

Still further objective is to select the type of formulation for such a combination of actives for optimum result and process development.

Still further objective is to develop the stable recipe of the actives using natural oil.

SUMMARY OF INVENTION
One possibility for overcoming such difficulties suffered in piror art is to alternate the active compounds used, so that the development of resistance can be prevented or atleast slowed down. However, this requires the continual development of new active compounds, so as to avoid selection to the particular mechanism of action.

In contrast, it is more sensible to be able to employ combination which has proven Sufficiently effective and able to control multiple weeds for as long as possible, especially when it has shown itself to be environmentally compatible to a particularly high degree and to possess only minimal side-effects.

The present invention relates to novel crop-protecting active ingredients mixture having synergistically enhanced action, comprising atleast two active ingredients component together with a suitable carrier, wherein component I is Quizalofop-p-ethyl, a phenoxy

acid derivative compound as active ingredient is known herbicidal compound and have been found to be effective against many annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax. The activity of this compound is good; however, it is sometimes unsatisfactory a low application rates and take care of selective grassy weeds only. The preparation of this compound is likewise known.

Fom&s'afen Sediurii, a di-phenyl ether derivative eempound as active ingredient is known herbicidal compound and have been found to be effective against broad-leaved weeds in soya beans, Snap Beans, Lupin, Pea, Lima beans etc. The activity of this compound is good at higher application dose which some time led the accumulation of residue resulted harmful for human consumptions; however, at lower application dose, it is sometimes unsatisfactory to control the weeds and only take care of broad leaves weeds. Some of the herbicidal compositions containing phenoxy acid derivatives are disclosed in the prior art. Though the combinations in prior arts are effective, there is still a need to find an effective and synergistic Herbicide to control many grassy and broad leaves weeds in a wide range of field crops, with reduced rate of individual active in combination.

Efficacy of the combination formulations in present invention are depends upon the use of proper quantities of ingredients of individual active. There are practical problems in dispensing exact quantities of the individual herbicidal formulation as tank mix by the farmer in the field. Use of the higher quantities of the individual Herbicide then recommended dose can result in phyto-toxicity, accumulation of residue in plant as well as lead wastage and hence higher cost. There are also possibilities of using Herbicides with lower dose than recommended dosage, which can lead to fast resistance, insufficient weed control and crop yield loss.

Therefore, considering the importance of effective control of a wide spectrum of weeds like Post-emergence, annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax, and Early post-emergence control of broad-leaved weeds in soya beans, Snap Beans, Lupine, Pea, Lima beans etc. occurs,

usually, simultaneously need for a herbicidal composition which is stable, synergistic, broad spectrum, eco-friendly, ready to use and less expensive was felt.

DESCRIPTION OF INVENTION:
The present invention relates to herbicidal mixtures for controlling wide spectrum of weeds like Post-emergence, annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax, and Early post-emergence control of broad-leaved weeds in soya beans, Snap Beans, Lupine, Pea, Lima beans etc., which mixtures comprise, as active components,

1) The Quizalofop-p-ethyl of the formula I, and

2) Fomesafen of the formula II, in a synergistically effective amount.

The following specification describes the invention and discloses a synergistic herbicidal combination comprising Quizalofop-p-ethyl and Fomesafen Sodium which are at weight ratio of 5:4-1:5 molar ratio of first active ingredient to the second active ingredient, more preferably in the ratio of 55:18. The synergistic effect of the pesticide combination can be prepared to Suspension Concentrate (SC) and Suspo-emulsion (SE). Compared with the existing single preparation, the combination not only has obvious herbicidal effect but also has excellent synergistic effect & reduces the development of resistance, has less amount of residue and causes less contamination to the crops, so the combination is safe & environment friendly. The active compound combinations according to the invention have very good herbicidal properties and can be employed for controlling Post-emergence, annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax, and Early post-emergence control of broad-leaved weeds in soya beans, Snap Beans, Lupine, Pea, Lima beans etc., which compete with the main crops and causes the lack of nutrients for main crop in field. Thus Result in the low yield.

Moreover, the invention relates to a method for controlling wide spectrum of weeds like Post-emergence, annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax, and Early post-emergence control of broad-leaved weeds in soya beans, Snap Beans, Lupin, Pea, Lima beans etc. using mixtures of the compound I with the compound II and to the use of the compound I with the compound II for preparing such mixtures and compositions comprising these mixtures:

a) Quizalefop-p-ethyl in the range of 1 to 15% ef the total mass of the composition;

b) Fomesafen in the range of 5 to 30 % of the total mass of the composition;

c) Atleast one natural oil having mass of range from 0.5 to 20% of total mass of the compositions,

d) Atleast one wetting agent with 0.5 to 5 % of total mass of the composition,

e) Atleast one suspending agent with 0.5 to 5 % of the total mass of the composition,

f) Atleast one anti-freezing agent ranging from 5 to 15 % of the total mass of the composition,

g) Atleast one anti-bacterial agent with 0.1 to 0.5 % of the mass of the composition,
h) Atleast one of the Anti-Foaming Agent with 0.1 to 1.5% of the mass of the composition, i) Atleast one of the Rheology Modifier with 1 to 15% of the mass of the composition, and j) Optionally Filler with 20 to 50% of the mass of the composition preferably water.

In preferred embodiment of the present invention, Quizalofop-p-ethyl is preferably in the range of 2.5 to 10% of the total mass of the composition. In preferred embodiment of the present invention, Fomesafen Sodium is preferably in the range of 8 -20%of the total mass of the composition.

Typically, the wetting agent is atleast one compound selected from a group of compounds eShsisting of alcohol alkylate .fatty alcohol eth6xylates, alkyl naphthalene sulfonate, sodium lauryl sulphates, sodium dodecyl benzene sulfonate and sodium dialkylnaphthalene sulfonate, blend of Polymeric Surfactants .

Typically, the suspending agent is atleast one compound selected from a group of compounds consisting of sodium lignosulfonate, calcium lignosulfonate, sodium salt of alkyl naphthalene sulfonate condensate, Lignosulfonic acid, sodium salt sulfomethylated, sulfonated aromatic polymer, sodium salt., alcohol ethoxylates and fatty alcohol ethoxylates, blends of polymeric surfactants.

In preferred embodiment of the present invention the herbicidal composition is a Suspo-emulsion (SE). Typically, the Suspo-emulsion composition has two actives, which can be formulated as EC and SC whenformulated alone. In preferred embodiment of the present invention the herbicidal composition is in the form of suspension Concentrate (SC).

Typically, the Suspension Concentrate (SC) has a solid pesticide suspended in liquid medium. In accordance with another aspect of the present invention there is provided a process for preparing a synergistic herbicidal composition, said process comprising the following steps:

a) blending atleast one Herbicide selected from the group consisting of Quizalofop-p-ethyl and Fomesafen, with atleast one adjuvant selected from the group consisting of wetting agents, suspending agents, anti-foaming agent, anti-bacterial agent, anti-freezing agent, and water, to obtain a mixture;

b) grinding the mixture by atleast one process selected from the group consisting of pulverizing and wet milling, to obtain a grinded mixture; and
c) Adding the atleast one natural oil

d) Adding the atleast one rheology modifier to obtain the stable formulation of synergistic herbicide composition.

Typically, in step d) the grinded mixture is modified by adding atleast one rheology modifier to obtain a stable SC or SE Formulation. This can be tested for all in accordance with FAO guidelines. In accordance with the preferred embodiment of the process of the present invention, atleast one Herbicide selected from the group consisting of Quizalofop-p-ethyl and Fomesafen sodium, is blended with atleast one adjuvant selected from the group consisting of wetting agents, suspending agents, natural oil, anti-freezing agent, anti-bacterial agent, and water to get a mixture in the form of a slurry having total solid content in the range of 10 to 50 %.

Typically, in step b) the mixture is wet milled to obtain slurry having a particle size in the range of 0.1 to 2 microns. In accordance with the preferred embodiment of the process of the present invention, the wet milled slurry is blended with atleast one ingredient selected from the group consisting of rheology modifier to get the stable formulation of slurry ranges 10 to 60%.

BRIEF DESCRIPTION OF THE DRAWINGS:
Figure 1 illustrates the preparation process of the synergistic herbicidal composition of Quizalofop-p-ethyl and Fomesafen formulated using Dyno-Mill labmodel equipment.

DETAILED DESCRIPTION OF THE INVENTION:
Herbicides: I
IUPAC name: ethyl (f?S)-2-[4-(6-chloroquinoxalin-2-yloxy) phenoxy] propionate
CAS number: {76573-14-8)
Molecular Weight: 372.8 Molecular Formula. C19H17CIN2O4
Molecular Structure:

Form: Colorless crystals.
91.7-92.1 °C B£,220 °C/0.2 V.P. 8.65 x 10-4 mPa (20 °C) Kowlog P = 4.28 (23±1 °C, distilled water) Henry 1.07 * 10-3 Pa m3 mol-1 (20 °C) S.g./density 1.35 (20 °C) Solubility In water 6.3 mg/l (20 °C). In benzene 290, xylene 120, acetone 111, ethanol 9, hexane 2.6 (all in g/l, 20 °C). Stability Stable at 50 °C for 90 d. Stable in organic solvents at 40 °C for 90 d. Unstable to light (DT50 10-30 d). Stable at gH 3-7. Uses: Post-emergence, annual and perennial grass weeds in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax. Typical application rates are 1000-2000 g/ha. Used for foliar application.
Herbicides: II
IUPAC Name: 5-(2-chloro-a, a, a-trifluoro-p-tolyloxy)-A/-methylsulfonyl-2-nitrobenzamide
sodium salt
CAS Number 108731-70-0
Molecular Weight: 460.7
Molecular Formula: Ci5H9CIF3N2Na06S
Molecular Structure:

Water solubility: Soluble Form: White Crystal
Uses: Early post-emergence control of broad-leaved weeds in soya beans, Snap
Beans, Lupin, Pea, Lima beans etc.
This invention relates to an herbicidal composition containing a combination of Herbicides such as Quizalofop-p-ethyl and Fomesafen Sodium, which mutually affect each other when used together and display a biological activity greater than the sum of the activities when used alone. They target both the types of the weeds occurs in potatoes, soybeans, sugar beets, peanuts vegetables, cotton, flax Snap Beans, Lupin, Pea, Lima beans etc.

In the course of our studies of Herbicides we have found, that the combination of Quizalofop-p-ethyl and Fomesafen Sodium, results in a synergistic mixture which is remarkably more effective than the individual compounds at the considered doses.

The weight ratio of the components A and B depends on the sensitivity and resistance of the plants, the time of application, the climatic conditions and the soil conditions.

The synergistic composition of the present invention is prepared by initially mixing one of the active ingredients with a suspending agent / wetting agent / anti foam agent/anti-bacterial agent/anti freezing agent/natural oil and water in a vessel. The mixture is then homogenised, grounded in a Dyno-mill. To this milled mixture a specified quantity of rheology modifier is added to achieve the preferred stable formulation. Mixture obtained is then mixed again in vessel to yield the desired homogeneous composition. The method provides the synergistic mixture of Quizalofop-p-ethyl and Fomesafen Sodium in a Suspension Concentrate (SC) or Suspo-emulsion (SE) form.

In accordance with the present invention, the natural oil employed in the composition are selected from the vegetable oils-castor oil, mustard oil, cotton seed oil, soya bean oil, ground nut oil, sunflower oil, neem seed oil.

The natural oil is used in an amount in the range of 0.5% to 20% of the total mass of the composition, more preferably in the range of 0.5 to 15% of the total mass of the composition.

The wetting agent employed in the formulation composition is selected from the group consisting of non-ionic surfactants, anionic surfactant and a mixture of anionic and non-ionic surfactant and polymeric surfactant wherein the non-ionic surfactants are selected form the class of alcohol alkoxylate and fatty alcohol ethoxylates and the anionic surfactants are selected form the group of alkyl naphthalene sulfonate condensate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate, EO-PO polymeric and acrylate polymeric surfactant.

The wetting agent is used in an amount of 1 to 5%, more preferably 1 to 4% of the total mass of the composition.

The suspending agent is selected from the group consisting of sodium ligno sulfonate, calcium lignosulfonafe and sodium salt of alkyl naphthalene sulfonate condensate, EO-PO polymeric and acrylate polymeric surfactant.

The suspending agent is used in an amount of 1 to 12%, preferably in 1 to 10% of the total mass of the composition.

Following is the list of surfactant used as wetting and suspending agents,
Surfactant A: Sodium ligno sulphonate (Borresperse NA)
Surfactant B: Sulfonated naphthalene condensate, sodium salt (Lomar D from Cognis).
Surfactant C: Sodium alkyl naphthalene sulphonate (Morwet IP from Akzonobel)

Surfactant D: Modified Sodium Ligno sulphonate,
Surfactant E: Blend of polymeric surfactants (Huntsman),
Surfactant F: Blend of EO-PO polymericsurfactant.
Surfactant G: Sodium alkyl naphthalene sulfonate, formaldehyde condensate (Morwet
D450 from Akzonobel)
Surfactant H: Sodium lauryl sulphate
Surfactant H: Poiyc'oridensate of napHthaleilesurphoflie acid sodium salt
Surfactant I: Sodium dibutyl naphthalene sulphonate.
Surfactant J: Alkyl naphthalene sulfonate (Sellogen DFL)
Surfactant K: Sodiumalkyl naphthalene sulfonate
Surfactant L: Blend of sodium salt of fatty alcohol sulphate and sodium naphthalene
Sulphonate formaldehyde condensate (Jeemol DW)
Surfactant M: Blend of dialkyl Naphthalene Sulphonic acid and alcohol sulphate (Jeemol
WP)
Surfactant N: Alcohol ethoxylates and fatty alcohol ethoxylate (Jeemol DML)
Surfactant O: Blend of naphthalene sulfonic acid formaldehyde condensate and dioctyl
Sulfosuccinate (Jeemol CI)
Surfactant P: Sulfonated aromatic polymer, sodium salt (Morwet D 425)
Surfactant Q: Calcium Ligno sulphonate
Surfactant R: Polyalkyl naphthalene sulphonate (MNS 90) and
Surfectant S; Ligno sulfonic acid, sodium saltsU If ©methylated.
The anti-foam agent used in the present invention are selected from the group consisting of Polydimethylsiloxane powder (Dow corning 1920) and (Polydimethylsiloxane liquid) (Dow corningLDC 120A), Reliance and BASF.
The anti-bacterial agent used in the present invention are selected from benzisothiazol group (Clariant), Bromo nitro alcohol (Navdeep) etc.
The rheology modifier used in the present invention are xanthane gum suspension, precipitated silica, attagel clay mineral, Bentone clay etc.

The anti-freezing agent used in the present invention are Glycol- propylene glycol, Monoethylene glycol, Diethylene glycol etc.
The description and disclosure are made with an intention to teach the invention to the skilled persons in the art. Accordingly few embodiments and examples and illustrations have been provided. Otherwise all modifications and variations are known to skilled persons in the art is well within the scope and sport of the invention.

WE CLAIM
1. A synergistic herbicidal composition comprising of (a) Quizalofop-p-ethyl (b) Fomesafen Sodium as active ingredients.

2. The composition as claimed in claim 1, comprising of (a) Quizalofop-p-ethyl (b) Fomesafen Sodium as active ingredients in a weight ratio ranging from 5:4 to 1:5.

3. The composition as claimed in claim 1, comprising of Quizalofop-p-ethyl in the range of 1 to 15% of the total mass of the composition and preferably in the range 2.5 to 10% of the total mass of the composition.

4. The composition as claimed in claim 1, comprising of Fomesafen in the range of 5 to 30 % of the total mass of the composition and preferably in the range of 8 -20%of the total mass of the composition.

5. The composition as claimed in claim 1, is a herbicidal composition which is Suspo-emulsion (SE).
6. The composition as claimed in claim 1, including atleast one natural oil having mass of range from 0.5 to 20% of total mass of the compositions and most preferably with 0.5 to 15% of the total mass of the composition.

7. The composition as claimed in claim 1, including atleast one wetting agent with 0.5 to 5 % of total mass of the composition, preferably 1 to 5% of the total mass of the composition and most preferably with 1 to 4% of the total mass of the composition.

8. The composition as claimed in claim 1, including atleast one suspending agent with 0.5 to 5 % of the total mass of the composition, preferably in the range 1 to 12% of the total mass of the composition and most preferably in the range 1 to 10% of the total mass of the composition.

9. The composition as claimed in claim 1, including atleast one anti-freezing agent ranging from 5 to 1 § % of the total mass of the composition,

10.The composition as claimed in claim 1, including atleast one anti-bacterial agent with 0.1 to 0.5 % of the mass of the composition,

11 .The composition as claimed in claim 1, including atleast one of the Anti-Foamin Agent with 0.1 to 1.5% of the mass of the composition, 12.The composition as claimed in claim 1, including atleast one of the Rheology Modifier with 1 to 15% of the mass of the composition, and 13. The composition as claimed in claim 1, including filler with 20 to 50% of the mass of the composition preferably water.

14.The composition as claimed in claim 6, wherein the natural oil is selected from the vegetable oils-castor oil, mustard oil, cotton seed oil, soya bean oil, ground nut oil, sunflower oil, neem seed oil.

15. The composition as claimed in claim 7, wherein the wetting agent is atleast one compound selected from a group of compounds consisting of alcohol alkylate, fatty alcohol ethoxylates, alkyl naphthalene sulfonate, sodium lauryl sulphates, sodium dodecyl benzene sulfonate and sodium dialkylnaphthalene sulfonate, blend of Polymeric Surfactants characterised in that the wetting agent is selected from the group consisting of non-ionic surfactants, anionic surfactant and a mixture of anionic and non-ionic surfactant and polymeric surfactant wherein the non-ionic surfactants are selected form the class of alcohol alkoxylate and fatty alcohol ethoxylates and anionic surfactants are selected form the group of alkyl naphthalene sulfonate condensate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate, EO-PO polymeric and acrylate polymeric surfactant.

16. The composition as claimed in claim 8, wherein the suspending agent is atleast one compound selected from a group of compounds consisting of sodium lignosulfonate, calcium lignosulfonate, sodium salt of alkyl naphthalene sulfonate condensate, Lignosulfonic acid, sodium salt sulfomethylated, sulfonated aromatic polymer, sodium salt, alcohol ethoxylates and fatty alcohol ethoxylates, blends of polymeric surfactants.

17.The composition as claimed in claim 9, wherein the anti-freezing agent is selected from Glycol-propylene glycol, Monoethylene glycol, Diethylehe glycol etc.

18. The composition as claimed in claim 10, wherein the anti bacterial agent is selected from benzisothiazol group (Clariant), Bromo nitro alcohol (Navdeep) etc.

19.The composition as claimed in claim 11, wherein the foaming agent is selected from group consisting of Polydimethylsiloxane powder (Dow corning 1920) and (Polydimethylsiloxane liquid) (Dow corningLDC 120A), Reliance and BASF.

20.The composition as claimed in claim 12, wherein the rheology modifier is selected from xanthane gum suspension, precipitated silica, attagel clay mineral, Bentone clay etc.
21.A process for preparing a synergistic herbicidal composition having (a) Quizalofop-p-ethyl (b) Fomesafen Sodium as active ingredients comprising the steps :
a. blending Quizalofop-p-ethyl and Fomesafen, with atleast one adjuvant
selected from the group consisting of wetting agents, suspending agents,
anti-foaming agent, anti-bacterial agent, anti-freezing agent, and water, to
obtain a mixture;
b. grinding the said mixture by atleast one process selected from the group
consisting of pulverizing and wet milling, to obtain a slurry mixture;
c. adding atleast one natural oil to the said slurry mixture, and

d. adding atleast one rheology modifier to obtain the stable formulation of
synergistic herbicide composition.

22.The process as claimed in claim 21, wherein the said slurry has a particles size
in the range of 0.1 to 2 microns.

23.The process as claimed in claim 22, wherein the said slurry has a solid content
in the range of 10 to 60% and preferably in the range 10 to 50%.