DESC:FORM 2

THE PATENTS ACT, 1970
(SECTION 39 OF 1970)
&
The Patents Rules, 2003

COMPLETE SPECIFICATION
(Section 10 and Rule 13)

SYNERGISTIC HERBICIDAL COMPOSITION OF BIXLOZONE AND OXYFLUORFEN

We, COROMANDEL INTERNATIONAL LIMITED,
an Indian company incorporated under Companies Act of 1956, having its principal place of business at Coromandel House, Sardar Patel Road, Secunderabad – 500 003, Telangana, India.

The following specification particularly describes the invention and the manner in which it is to be performed.

FIELD OF THE INVENTION

The present invention relates to a synergistic herbicidal composition comprising of bixlozone, and oxyfluorfen with suitable agrochemical additives. The present invention further relates to a process for preparing and method of using such composition effectively for controlling the growth of undesirable vegetation, particularly in crops.

BACKGROUND OF THE INVENTION

Enhancement of agricultural produce requires the protection of the crops and its produce from pest damage and unwanted vegetation. Various chemicals and their formulations have been developed and are in use currently for the effective management of the same.

Herbicides are also used extensively away from the farm, in areas such as industrial sites, roadsides, ditch banks, irrigation canals, fence lines, recreational areas, lawns, railroad embankments, and power line rights-of-way. Herbicides remove undesirable plants that might cause damage, present fire hazards, or impede work crews. They also reduce costs of labour for mowing. These are classed as selective when they are used to kill weeds without harming the crop and as nonselective when the purpose is to kill all vegetation. Both selective and nonselective materials can be applied to weed foliage or to soil containing weed seeds and seedlings, depending on the mode of action, and intended use pattern.

Another classification of herbicides includes either contact or translocated categories. Contact herbicides kill the plant parts onto whose surfaces the chemical is applied and are most effective against annuals, those weeds that germinate from seeds and grow to maturity each year. Complete coverage is essential in weed control with contact materials. Translocated herbicides are absorbed either by roots or above-ground parts of plants and are circulated within the plant system to distant tissues. Translocated herbicides may be effective against all weed types; however, their greatest advantage is in the control of established perennials, those weeds that continue their growth from year to year. Uniform application is a key requirement in achieving good weed control with translocated herbicides.

Herbicides are also classed according to timing of application, i.e., growth stage of crop or weed development. What constitutes the best timing varies by chemical class of the material and its persistence, the crop, and its tolerance to the herbicide, weed species, cultural practices, climate, and soil type and condition. The three primary categories of application timing are preplanting, preemergence, and post emergence.

Preplanting applications for control of annual weeds are made to an area before the crop is planted, within a few days or weeks of planting and often includes a step to incorporate the herbicide in the soil. In recent years such preplant uses have included making fall applications of herbicides to suppress early weed growth the next spring before corn is planted. Preemergence applications are completed prior to emergence of the crop or weeds, depending on definition, after planting. Postemergence applications are made after the crop or weed emerges from the soil.

Herbicide application based on the area covered involves four categories: band, broadcast, spot treatments, and directed spraying. A band application treats a continuous strip, as along or in a crop row. Broadcast application covers the entire area, including the crops. Spot treatments are confined to small areas of weeds. Directed sprays are applied to crop stems, selected weeds or to the soil to avoid contact with crop foliage.

Active compounds having different mechanisms of action are combined to delay the generation of resistance and reduce the amount of application and prevention and treatment costs. Consequently, research is being conducted to produce herbicides and combinations of herbicides that are safer, that have better performance, that require lower dosages, that are easier to use, and that cost less.

Accordingly, there is a need in the art to provide synergistic herbicidal compositions which are environmentally safer and stable product during storage.

Bixlozone is a new herbicide from the isoxazolidinone family, and provides a unique selective residual weed control solution in a wide range of crops including, cereals, corn, legumes, oilseed rape, rice, and sugarcane, and will offer a new mode of action herbicide solution for many of these crops. Bixlozone provides both systemic and contact activity, with residual control and can be applied pre-emergence, early post-emergence or incorporated by sowing, across a wide range of agronomic environments. It controls major problem grass weeds including ryegrass and blackgrass, and several key broadleaf weeds by inhibiting 1-deoxy-D-xylulose 5-phosphate synthase resulting in the disruption of plastid isoprenoid biosynthesis. It is proposed to be classified as an HRAC Group F4 and will offer a new rotational product tool for resistance management. It will be an ideal complementary mixing partner for broadleaved herbicides as it can extend the utility of existing molecules by expanding the weed spectrum in many cases at reduced use rates.

Oxyfluorfen is a selective pre- and post-emergent herbicide used to control broadleaf and grassy weeds in a variety of nut, tree fruit, vine, and field crops, especially wine grapes and almonds. It is also used for residential weed control. It is a contact herbicide and light are required for it to affect target plants. It is available in emulsifiable concentrate and granular formulations.

The present invention is based on the synergistic effect of bixlozone, and oxyfluorfen when applied in combination.

The synergistic herbicidal composition of the present invention shows enhanced herbicide action in comparison with the herbicide action of solo bixlozone, and oxyfluorfen against undesirable vegetation. Moreover, the composition of the invention shows a persistent herbicidal activity, even under difficult weathering conditions, and minimizes the risk of weeds escaping. The composition is generally non-toxic or of low toxicity against mammals.

The synergistic herbicidal composition of the present invention may also show an accelerated action on harmful plants, i.e., they may affect damage of the harmful plants more quickly in comparison with solo applications of the at least two herbicides involved.

OBJECT OF THE INVENTION

The main object of the present invention is to provide a synergistic herbicidal composition of bixlozone, and oxyfluorfen.

In one object of the present invention is to provide an herbicidal composition comprising bixlozone, and oxyfluorfen with suitable agrochemical additives.
In another object of the present invention is to provide synergistic herbicidal composition that enable efficient and reliable control of grass and broad-leaf weeds.

In another object of the present invention is to provide synergistic herbicidal composition for wheat crops through pre-emergent application for the control of grass and broad-leaf weeds.

In another object of the present invention is to provide synergistic herbicidal composition for crops through pre-emergent and post-emergent application for the control of grass and broad-leaf weeds.

In another objective of the present invention to provide an herbicidal composition having persistent herbicidal activity to achieve weed control over a sufficiently long in effect duration and safe to the environment.

Yet another object of the present invention is to provide process for the preparation of an herbicidal composition comprising bixlozone, and oxyfluorfen.

SUMMARY OF THE INVENTION

The present invention is to provide a synergistic herbicidal composition comprising of bixlozone, and oxyfluorfen with suitable agrochemical additives.

In an aspect of the present invention is to provide a synergistic herbicidal composition comprising of a) bixlozone is present in a range from 35% (w/w) to 45% (w/w); b) oxyfluorfen is present in a range from 5% (w/w) to 15% (w/w); and c) agrochemical additives.

According to the present invention, the suitable agrochemical additives are selected from the group comprising a wetting agent, a dispersing agent, a disintegration agent, a defoamer, an anticaking agent, and a filler.

According to the present invention, the wetting agent is selected from the group comprising of sodium isopropyl naphthalene sulfonate, naphthalene sulfonic acid and phenol sulphonic acid sodium salt, sodium alkyl naphthalene sulfonate blend, iso decyl alcohol ethoxylates, sodium lauryl sulphate, present in a range from 1% to 3% (w/w).
According to the present invention, the dispersing agent is selected from the group comprising of alkyl naphthalene sulfonate formaldehyde condensate, sodium ligno sulphonates, kraft lignin polymer, mixture of naphthalene sulfonic acid and phenol sulphonic acid condensate sodium salt, modified styrene acrylic polymer, alkyl naphthalene sulphonate sodium salt, kraft lignin sulphonate, and combination thereof, present in a range from 1% to 10% (w/w).

According to the present invention, the disintegration agent is selected from ammonium sulphate, and sodium sulfate, present in a range from 10% to 25% (w/w).

According to the present invention, the defoamer is polydimethyl siloxane or silicone emulsion, present in a range from 0.1% to 2% (w/w).

According to the present invention, an anti-caking agent is silicon dioxide, present in a range from 0.1% to 5% (w/w).

According to the present invention, the filler is selected from china clay, starch, and aluminium hydroxide, present in Q.S.

In an aspect of the present invention, the composition is formulated as water dispersible granule (WDG).

In another aspect of the present invention is to provide process for the preparation of an herbicidal composition comprising bixlozone, and oxyfluorfen.

In another aspect of the present invention is to provide a synergistic herbicidal composition comprising of bixlozone, and oxyfluorfen with an improved stability and ready to use herbicidal composition, having superior bio-efficacy compared to the individual formulations.

In another aspect of the present invention is to provide synergistic herbicidal composition for wheat crops through pre-emergent application for the control of grass and broad-leaf weeds.

Yet another aspect of the present invention is to provide synergistic herbicidal composition that enable efficient and reliable control of grass and broad-leaf weeds.

The present invention relates to herbicidal composition with synergistic activity. The composition contains three components that mutually complement each other when used together and exhibit activity that is greater than the activities of individual components when used alone.

DETAILED DESCRIPTION OF THE INVENTION

The term "comprising", which is synonymous with "including", "containing", or "characterized by" here is defined as being inclusive or open-ended, and does not exclude additional, unrecited elements or method steps, unless the context clearly requires otherwise.

It is to be noted that, as used in the specification, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to a composition containing “a compound” includes a mixture of two or more compounds. It should also be noted that the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.

As used herein, the terms "crops" and "vegetation" can include, for instance, dormant seeds, germinant seeds, emerging seedlings, plants emerging from vegetative propagules, immature vegetation, and established vegetation.

As used herein, immature vegetation may be understood to include small vegetative plants prior to reproductive stage, and mature vegetation may be understood to include vegetative plants during and after the reproductive stage.

As used herein, the terms “herbicide” may be understood as a substance that is toxic to plants, used to destroy unwanted vegetation.

As used herein, the term “synergistic composition” may be understood to include effective combination of more than one agrochemical that allows the application of the said agrochemical in a much lower dosage, which results in a less dosage treatment for the crops.

As used herein, the term “agrochemical additives” may be understood to include a range of surfactants, dispersing agents, pigments, solvents, co-solvents, defoamers, emulsions, crystallization inhibitors, viscosity modifiers, suspending agents, dyes, antioxidants, light absorbers, mixing aids, neutralizers or pH adjusting substances and buffers, corrosion inhibitors, fragrances, wetting agents, absorption enhancers, micronutrients, plasticizers, lubricants, thickeners, anti-freezing agents, sterilization agents, biocide, adjuvant among others.

The herbicidal composition of the present invention may be formulated as capsule suspension (CS), dispersible concentrate (DC), dustable powder (DP), powder for dry seed treatment (DS), emulsifiable concentrate (EC), emulsifiable granule (EG), emulsion water in-oil (EO), emulsifiable powder (EP), emulsion for seed treatment (ES), emulsion oil-in-water (EW), flowable concentrate for seed treatment (FS), granules (GR), micro-emulsion (ME), oil-dispersion (OD), oil miscible flowable concentrate (OF), oil miscible liquid (OL), oil dispersible powder (OP), suspension concentrate (SC), suspension concentrate for direct application (SD), suspo-emulsion (SE), water soluble granule (SG), soluble concentrate (SL), spreading oil (SO), water soluble powder (SP), water soluble tablet (ST), ultra-low volume (ULV), tablet (TB), water dispersible granules (WG or WDG), wettable powder (WP), water dispersible powder for slurry seed treatment (WS), water dispersible tablet (WT), a mixed formulation of CS and SC (ZC), a mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW) among others. Preferably, the composition of the present invention is in form of water dispersible granule (WDG).

The present invention provides a synergistic herbicidal composition comprising of bixlozone, and oxyfluorfen with suitable agrochemical additives.

In an embodiment, the present invention provides a synergistic herbicidal composition comprising of a) bixlozone is present in a range from 35% (w/w) to 45% (w/w); b) oxyfluorfen is present in a range from 5% (w/w) to 15% (w/w); and c) agrochemical additives.

According to the present embodiment, the suitable agrochemical additives are selected from the group comprising a wetting agent, a dispersing agent, a disintegration agent, a defoamer, an anticaking agent, and a filler.

Wetting is the first stage of dispersion, in which the air surrounding the granular composition is substituted with water. Wetting of the herbicidal composition with water cannot occur if the surface tension of the liquid is very high. Hence, it is recommended to add a wetting agent to the herbicidal composition to facilitate the process of dispersion of the granules in the liquid.

Accordingly, the composition of the present invention contains a wetting agent selected from the group comprising of sodium isopropyl naphthalene sulfonate, naphthalene sulfonic acid and phenol sulphonic acid sodium salt, Sodium alkyl naphthalene sulfonate blend, iso decyl alcohol ethoxylates, sodium lauryl sulphate, present in a range from 1% to 3% (w/w).

It is generally observed that solid particles in a liquid undergo spontaneous aggregation to form lumps. Hence it is recommended to add a dispersant or a dispersing agent which prevents aggregation of solid particles and keeps them suspended in the fluid.

Accordingly, the composition of the present invention contains a dispersing agent is selected from the group comprising of alkyl naphthalene sulfonate formaldehyde condensate, sodium ligno sulphonates, kraft lignin polymer, mixture of naphthalene sulfonic acid and phenol sulphonic acid condensate sodium salt, modified styrene acrylic polymer, alkyl naphthalene sulphonate sodium salt, kraft lignin sulphonate, and combination thereof, present in a range from 1% to 10% (w/w).

Disintegrating agent are additive that can be some time useful for improving dispersibility of herbicide formulation. Accordingly, the composition of the present invention contains a disintegrating agent is selected from ammonium sulphate, and sodium sulfate, present in a range from 10% to 25% (w/w).

Defoamer is a chemical reagent developed for defoaming and foam suppression based on the principle of foaming. The defoamer suitable for the purpose of the present invention is polydimethyl siloxane or silicone emulsion, present in a range from 0.1% to 2% (w/w).

An anti-caking agent is an additive used in the pesticide industry to avoid the formation of lumps. The anti-caking agent suitable for the purpose of the present invention is silicon dioxide, present in a range from 0.1% to 5% (w/w).

A “filler” refers to solid chemicals that are added to an herbicide formulation to aid in the delivery of the active ingredient. Accordingly, the composition of the present invention contains a filler is selected from china clay, starch, and aluminium hydroxide, present in Q.S.

In another embodiment, the present invention, the composition is formulated as water dispersible granule (WDG).

In another embodiment, the present invention provides a synergistic herbicidal composition for wheat crops through pre-emergent application for the control of grass and broad-leaf weeds.

In another embodiment, the present invention provides a process for the preparation of an herbicidal composition comprising bixlozone, and oxyfluorfen.

In yet another embodiment, the present invention provides a synergistic herbicidal composition of bixlozone, and oxyfluorfen with an improved stability and ready to use herbicidal composition, having superior bio-efficacy compared to the individual formulations.

The composition of the present invention and method provided may be utilized to control weeds or battle undesired vegetation in crops or other settings, including but not limited to turf, citrus, grapes, olives, sugarcane, maize, soyabeans, wheat, triticale, potatoes, barley, asparagus, tomatoes, peas, lentils, non-cropped areas, and industrial vegetation management. Preferably, the undesirable vegetation includes species from the families of broadleaved and grass weeds, more preferably from the families of Aeschynomene, Ageratum, Amaranthus, Bidens, Brachiaria, Cenchrus, Cyperus, Digitaria, Echinochloa, Eclipta, Eleusine, Eragrostis Fimbristylis, Galinsoga, Ischaemum, Leptochloa, Monochoria, Panicum, Paspalum, Polygonum, Portulaca, Richardia, Sesbania, Setaria, Sida, Sorghum, most preferably Echinochloa, Leptochloa, Ischaemum, Monochoria, and Cyperus, or combinations thereof.

The composition achieves improved biological activity by enhancing overall control of weeds over a shorter period. Additional benefits of using the herbicidal composition of the present invention includes reduced risk of occupational hazard, lower cost of application, better cost, reduced fuel, and labour cost, saving in applicator’s time and loss caused by mechanical damage to the crop and soil.

The present compositions can be applied to the undesirable weeds or their locus using conventional ground or aerial dusters, sprayers, and granule applicators, by addition to irrigation or paddy water, and by other conventional means known to those skilled in the art.

The process for preparing the present agrochemical composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the composition. However, all such variation and modification are still covered by the scope of present invention.

Examples:
Example 1: Bixlozone 40%+ Oxyfluorfen 10% WDG
S. No. Composition Function Charge in (%)
1. Bixlozone Active ingredient 40.0
2. Oxyfluorfen Active ingredient 10.0
3. Sodium isopropyl naphthalene sulfonate Wetting agent 3.0
4. Alkyl naphthalene sulfonate formaldehyde condensate Dispersing agent 4.0
5. Ammonium sulphate Disintegrating Agent 15.0
6. Polydimethyl siloxane emulsion Defoamer 0.5
7. Silicon dioxide Anti caking agent 3.0
8. China clay Filler Q.S.

The process for manufacture of the composition is as follows: 40.0 gm of Bixlozone, 10.0 gm of Oxyfluorfen, 3.0 gm of sodium isopropyl naphthalene sulfonate, 4.0 gm of alkyl naphthalene sulfonate formaldehyde condensate, 15.0 gm of ammonium sulphate, 0.5 gm of polydimethyl siloxane emulsion, 3.0 gm of silicon dioxide, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 12 microns). Collecting the milled material and post blending the material for 1 hour. Extruding the granule at 35 rpm (1.0 mesh), collecting the water dispersible granules, and drying at 50 °C for 30 min (moisture content it should be < 5%) followed by packing the material in a suitable package.

Example 2: Bixlozone 35%+ Oxyfluorfen 5% WDG

S. No. Composition Function Charge in (%)
1. Bixlozone Active ingredient 35.0
2. Oxyfluorfen Active ingredient 5.0
3. Sodium isopropyl naphthalene sulfonate Wetting agent 3.0
4. Alkyl naphthalene sulfonate formaldehyde condensate Dispersing agent 4.0
5. Ammonium sulphate Disintegrating Agent 20.0
6. Polydimethyl siloxane emulsion Defoamer 0.5
7. Silicon dioxide Anti caking agent 3.0
8. China clay Filler Q.S.

The process for manufacture of the composition is as follows: 35.0 gm of Bixlozone, 5.0 gm of Oxyfluorfen, 3.0 gm of sodium isopropyl naphthalene sulfonate, 4.0 gm of alkyl naphthalene sulfonate formaldehyde condensate, 20.0 gm of ammonium sulphate, 0.5 gm of polydimethyl siloxane emulsion, 3.0 gm of silicon dioxide, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 12 microns). Collecting the milled material and post blending the material for 1 hour. Extruding the granule at 35 rpm (1.0 mesh), collecting the water dispersible granules, and drying at 50 °C for 30 min (moisture content it should be < 5%) followed by packing the material in a suitable package.

Example 3: Bixlozone 45%+ Oxyfluorfen 15% WDG

S. No. Composition Function Charge in (%)
1. Bixlozone Active ingredient 45.0
2. Oxyfluorfen Active ingredient 15.0
3. Isodecyl alcohol ethoxylates Wetting agent 3.0
4. Modified styrene acrylic polymer Dispersing agent 4.0
5. Alkyl naphthalene sulphonate sodium salt Dispersing agent 25.0
6. Silicone emulsion Defoamer 0.5
7. Silicon dioxide Anti caking agent 3.0
8. China clay Filler Q.S.

The process for manufacture of the composition is as follows: 45.0 gm of Bixlozone, 15.0 gm of Oxyfluorfen, 3.0 gm of Isodecyl alcohol ethoxylates, 4.0 gm of Modified styrene acrylic polymer, 25.0 gm of Alkyl naphthalene sulphonate sodium salt, 0.5 gm of silicone emulsion, 3.0 gm of silicon dioxide, and required quantity of china clay were weighed in the pre-blender reactor and mixed for 1 hour. The mixture was milled through air jet mill instrument (Inlet pressure 2-3 kg/cm2, grinding pressure 6 kg/ cm2) to obtain the desired particle size (D90 < 12 microns). Collecting the milled material and post blending the material for 1 hour. Extruding the granule at 35 rpm (1.0 mesh), collecting the water dispersible granules, and drying at 50 °C for 30 min (moisture content it should be < 5%) followed by packing the material in a suitable package.

Evaluation of synergistic effect of Bixlozone + Oxyfluorfen herbicidal combination:
Field and synergy studies:
Wheat is the main cereal crop in India. In India, it is grown on an area of 31.6 million hectare with an annual production of 106.84 million tonnes. Successful weed control is most important factor for fruitful wheat production because losses due weeds have been one of the major limiting factors in wheat production. Weeds compete with crop for light moisture and nutrients. It was concluded that weeds exhibit the economic yield losses to the wheat crop, which may range from 24-39.95% and these must be controlled during the full growing season of the crop for achieving satisfactory crop yields. Traditionally, weed control in India has been largely dependent on manual weeding. However, increased labour scarcity and costs are encouraging farmers to adopt to use herbicides.
The field studies were conducted to compare the weed controlling activity of the combination of Bixlozone & Oxyfluorfen. The active ingredient Bixlozone in the combination, belongs to chemical family “Isoxazolidinone” with mode of action of INHIBITION OF DEOXY-D-XYLULOSE PHOSPHATE SYNTHASE inhibitors, & Oxyfluorfen belongs to chemical family “Aryloxy phenoxy-propionates” with PPO (protoporphyrinogen oxidase) inhibitor mode of action. Combination has the potential of controlling the cross-spectrum weeds (broad leaf weeds & grassy weeds) in wheat at the pre-emergence (0-3 DAS) application timing. All the molecules are safe to wheat when applied at their recommended dose rate in pre-emergence (0-3 DAS) application timing.
The weed control activity of the individual herbicides of the invention and their combinations were evaluated on weeds such as Phalaris minor, Chenopodium album, Vicia sativa & Lathyrus aphaca. Trials were conducted with randomized block design with net plot size of 5 m x 6 m. Each trial was replicated four times and conducted under GEP guidelines. Spraying was done with manual operated backpack knapsack sprayer with 300 L of water spray volume per hectare at pre-emergence application timing. Such field trials were carried out at various locations to generate independent data, the locations were chosen randomly across India.
Visual observations were recorded on percent weed control for individual weeds on whole plot basis at 30 days after application. These observations are to be taken from entire plot.
Appropriate analysis of plant response to herbicide combination is critical in determining the type of activity observed. The most widely used model is one Gowing* derived and Colby** modified. Gowing described a mathematical formula for calculating the predicting response values for herbicide mixtures. He suggested the expected (E) percent inhibition of growth induced by herbicide A plus herbicide B is as follows, *(Jerry Flint et al, 1988) ***

AB
Expected (E) = A + B –
100
Where:
A = observed efficacy of active ingredient A at the same concentration as used in the mixture.
B = observed efficacy of active ingredient B at the same concentration as used in the mixture.

When the percentage of pesticidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed)

Reference:
*Gowing, D. P. 1960. Comments on tests of herbicide mixtures. Weeds 8:379–391.
**Colby, S. R. 1967. Calculating synergistic and antagonistic responses of herbicide combinations. Weeds 15:20–22
*** Jerry Flint et al, 1988. Analysing Herbicide Interactions: A Statistical Treatment of Colby's Method. Weed Technology 2: 304-309

The field trials were carried out in India at various locations. The percentage efficacy was calculated after 30 days of application. The target weed was Phalaris minor, Chenopodium album, & Lathyrus aphaca. The synergy effect of two-way combination of Bixlozone, and Oxyfluorfen on weeds in pre-emergence application window are as follows:
Table 1:

Active Dose (GAH) % Weed Control of Phalaris minor % Weed Control of Chenopodium album % Weed Control of Vicia sativa % Weed Control of Lathyrus aphaca
Expected Observed Expected Observed Expected Observed Expected Observed
Bixlozone 40% SC 400 45 00 5 10
Oxyfluorfen 23.5% EC 100 70 80 80 80
Bixlozone 40% + Oxyfluorfen 10% WDG 500 83.5 90 80 82 81 85 82 85
Ratio of O/E 1.07 1.02 1.04 1.03

Table 2:

Active Dose (GAH) % Weed Control of Phalaris minor % Weed Control of Chenopodium album % Weed Control of Vicia sativa % Weed Control of Lathyrus aphaca
Expected Observed Expected Observed Expected Observed Expected Observed
Bixlozone 40% SC 350 40 00 00 5
Oxyfluorfen 23.5% EC 150 80 85 85 85
Bixlozone 35% + Oxyfluorfen 15% WDG 500 88 90 85 85 85 85 85.75 88
Ratio of O/E 1.02 1.00 1.00 1.02

Table 3:

Active Dose (GAH) % Weed Control of Phalaris minor % Weed Control of Chenopodium album % Weed Control of Vicia sativa % Weed Control of Lathyrus aphaca
Expected Observed Expected Observed Expected Observed Expected Observed
Bixlozone 40% SC 450 45 15 15 20
Oxyfluorfen 23.5% EC 50 50 65 70 65
Bixlozone 45% + Oxyfluorfen 5% WDG 500 72.5 74 70.25 72 74.5 77 72 75
Ratio of O/E 1.02 1.02 1.03 1.04
SC – Suspension concentrate; EC – Emulsion concentrate; WDG – Water dispersible powder; GAH – Gram active per hectare.
The results in tables 1 to 3 clearly demonstrates synergy between of two-way combination of Bixlozone + Oxyfluorfen WDG against weeds like, Phalaris minor, Chenopodium album, & Lathyrus aphaca. The higher ratio of the observed and the expected efficacy clearly demonstrates the synergistic effect of the combination.

We claim:

1. A synergistic herbicidal composition comprising bixlozone and oxyfluorfen with agrochemical additives.

2. The herbicidal composition as claimed in claim 1, wherein the composition bixlozone is present in a range from 35% (w/w) to 45% (w/w); oxyfluorfen is present in a range from 5% (w/w) to 15% (w/w); and agrochemical additives.

3. The herbicidal composition as claimed in claim 1, wherein the agrochemical additives are selected from a wetting agent, a dispersing agent, a disintegration agent, a defoamer, an anticaking agent, and a filler.

4. The herbicidal composition as claimed in claim 3, wherein the wetting agent is selected from the group comprising of sodium isopropyl naphthalene sulfonate, naphthalene sulfonic acid and phenol sulphonic acid sodium salt, sodium alkyl naphthalene sulfonate blend, iso decyl alcohol ethoxylates, sodium lauryl sulphate, present in a range from 1% to 3% (w/w).

5. The herbicidal composition as claimed in claim 3, wherein the dispersing agent is selected from the group comprising of alkyl naphthalene sulfonate formaldehyde condensate, sodium ligno sulphonates, kraft lignin polymer, mixture of naphthalene sulfonic acid and phenol sulphonic acid condensate sodium salt, modified styrene acrylic polymer, alkyl naphthalene sulphonate sodium salt, kraft lignin sulphonate, and combination thereof, present in a range from 1% to 10% (w/w).

6. The herbicidal composition as claimed in claim 3, wherein the disintegration agent is ammonium sulphate, present in a range from 10% to 25% (w/w).

7. The herbicidal composition as claimed in claim 3, wherein the defoamer is polydimethyl siloxane or silicon emulsion, present in a range from 0.1% to 2% (w/w).

8. The herbicidal composition as claimed in claim 3, wherein the anti-caking agent is silicon dioxide, present in a range from 0.1% to 5% (w/w).

9. The herbicidal composition as claimed in claim 3, wherein filler is china clay, present in Q.S.

10. The herbicidal composition as claimed in claim 1, wherein the composition is formulated as water dispersible granules (WDG) form.

Dated this Fourth (4th) day of May 2024

Sahadev Katam,
General Manager, Legal-IPR,
Coromandel International Limited,
Registered Indian Patent Agent (IN/PA/5560)
,CLAIMS:We claim:

1. A synergistic herbicidal composition comprising bixlozone and oxyfluorfen with agrochemical additives.

2. The herbicidal composition as claimed in claim 1, wherein the composition bixlozone is present in a range from 35% (w/w) to 45% (w/w); oxyfluorfen is present in a range from 5% (w/w) to 15% (w/w); and agrochemical additives.

3. The herbicidal composition as claimed in claim 1, wherein the agrochemical additives are selected from a wetting agent, a dispersing agent, a disintegration agent, a defoamer, an anticaking agent, and a filler.

4. The herbicidal composition as claimed in claim 3, wherein the wetting agent is selected from the group comprising of sodium isopropyl naphthalene sulfonate, naphthalene sulfonic acid and phenol sulphonic acid sodium salt, sodium alkyl naphthalene sulfonate blend, iso decyl alcohol ethoxylates, sodium lauryl sulphate, present in a range from 1% to 3% (w/w).

5. The herbicidal composition as claimed in claim 3, wherein the dispersing agent is selected from the group comprising of alkyl naphthalene sulfonate formaldehyde condensate, sodium ligno sulphonates, kraft lignin polymer, mixture of naphthalene sulfonic acid and phenol sulphonic acid condensate sodium salt, modified styrene acrylic polymer, alkyl naphthalene sulphonate sodium salt, kraft lignin sulphonate, and combination thereof, present in a range from 1% to 10% (w/w).

6. The herbicidal composition as claimed in claim 3, wherein the disintegration agent is ammonium sulphate, present in a range from 10% to 25% (w/w).

7. The herbicidal composition as claimed in claim 3, wherein the defoamer is polydimethyl siloxane or silicon emulsion, present in a range from 0.1% to 2% (w/w).

8. The herbicidal composition as claimed in claim 3, wherein the anti-caking agent is silicon dioxide, present in a range from 0.1% to 5% (w/w).

9. The herbicidal composition as claimed in claim 3, wherein filler is china clay, present in Q.S.

10. The herbicidal composition as claimed in claim 1, wherein the composition is formulated as water dispersible granules (WDG) form.

Dated this Fourth (4th) day of May 2024

Sahadev Katam,
General Manager, Legal-IPR,
Coromandel International Limited,
Registered Indian Patent Agent (IN/PA/5560)