Enolate salts of 4 fluoro 2 hydroxymethylene 3 oxobutyrates of formula wherein R is C alkyl R and R are independently hydrogen or fluorine M is an alkali or alkaline earth metal and n is 1 or 2 are prepared from enolate salts of the corresponding 4 fluoro 3 oxobutyrates and carbon monoxide. The enolate salts of form...

Enantiomerically enriched (1 S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene of formula wherein PG1 is an amino-protective group, are prepared from cyclopentadiene via hetero-Diels-Alder cycloaddition with protected 1-C-nitroso-P-D-ribofuranosyl halides of formula wherein X is a halogen atom selected from fluorine, chlori...

The invention relates to a method for the production of L carnitine wherein a ß lactone which is a 4 (halomethyl)oxetane 2 one is converted into carnitine with trimethylamme (TMA) wherein the ß lactone is not subjected to a basic hydrolysis step before being contacted with the trimethylamme. The invention also relat...

The invention relates to a method for the production of L carnitine wherein a chiral ß lactone carnitine precursor is obtained by a [2+2] cycloaddition of ketene with an aldehyde X CH CHO wherein X is selected from CI Br I and trimethylamine in the presence of a chiral catalyst.

The invention relates to an isolated nucleic acid sequence comprising a promoter, which is a native sequence of Pichia pastoris comprising the nucleic acid sequence of pCSl of SEQ ID 1, or a functionally active variant thereof which is a size variant, a mutant or hybrid of SEQ ID 1, or a combination thereof, express...

The present invention relates to novel tricyanoborates of the general formula Catn+ [B(CN)3(XR1)]-n, wherein R1 is C1-6 alkyl, C2-6 alkenyl, C6-10 aryl or benzyl; X is oxygen or sulfur; and Catn+ is a cation with n being 1 or 2, which is selected from the group consisting of an inorganic cation and an organic cation...

The invention discloses a method for the preparation of 4-alkoxy- 1,1,1 -trifluorobut-3-en-2-ones from 1,1,1 -trifluoro - acetone.

The present invention relates to a process for preparing cyanoacetic ester of the general formula: in which R is C1-10-alkyl, C3-10-alkenyl or ary-C1-4-alkyl, characterized in that an alkali metal cyanoacetate is reacted in an aqueous/organic two-phase system in the presence of a phase-transfer catalyst with...

The invention relates to a method for the preparation of bis(fluorosulfonyl) imide and its derivatives at elevated temperature.

The invention relates to a method for the preparation of bis(fluorosulfonyl)-imide, the method starts from bis(chlorosulfonyl)-imide or its respective derivatives, which is reacted with HF in the presence of chlorosulfonyl isocyanate, and uses a certain extraction step for extraction of bis(fluorosulfonyl)-imide fro...