The present invention discloses a process for preparation of Ethyl-dec-9-ynoate (III). More particularly, the invention relates to highly pure Ethyl-dec-9-ynoate (III), wherein, the process impurities such as 1-Decanoic acid ethyl ester (VI) and Ethyl non-8-ynoate (VIII) are controlled to less than 0.5%. ...

“NOVEL PROCESS FOR THE SYNTHESIS OF PALBOCICLIB” ABSTRACT:                Disclosed herein is a novel process for synthesis of 6-bromo-2-chloro-8-cyclopentyl-5-methylpyrido [2, 3-d]pyrimidin-7(8H)-one (V), useful as a key intermediate in the synthesis of Palbociclib (I) and further conversion of the same into ...

Disclosed herein is a novel process for the synthesis of 3-methyl-8-aminocarbomyl-imidazo[5,l-d]-l,2,3,5-tetrazin-4(3H)-one, an antitumor compound from 8-carboxy-3-methyl-[3H]-imidazo[5,l-d]-l,2,3,5-tetrazin-4-one by three step synthesis via acid chloride, then converting to its N-tert-butyl carboxamide followed by ...

Disclosed herein is a compound of formula A, its salts, enantiomers, and diastereomers thereof; wherein, R1 and R2 can be (C1-C6) alkyl groups, a phenyl group, a (C5-C7) cycloalkyl groups; X and Y individually selected from H, -N02, -NH2, -OH, -halo, -CHO, -COOH, -COOR, boronic acid-potassium bifluoride bor...

A PROCESS FOR PREPARING INTERMEDIATES OF 10-PROPARGYL-10-DEAZAAMINOPTERIN (PRALATREXATE) SYNTHESIS AND THE INTERMEDIATES THEREOF A process for preparation of 4-(1-(2 4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid and other key intermediates in synthesis of 10-propargyl-10-deazaaminopterin (Pralatrexate) and t...

SULPHUR CONTAINING POLYUREA FOR USE IN METAL SCAVENGING, REMOVAL AND RECOVERY ABSTRACT: The present invention discloses sulphur functionalized polyurea composite of Formula (I) and Formula (II) that provides an insoluble solid support for effective removal of metal residues from solvent streams and other reser...

A PROCESS FOR SELECTIVE PREPARATION OF PURE 4-FLUORO-2-METHOXY-5-NITROANILINE ABSTRACT: Disclosed herein is a process for selective preparation of highly pure 4-fluoro-2-methoxy-5-nitroaniline with less than 0.5% of 2-fluoro-4-methoxy-5-nitrobenzenamine and 2,4-dimethoxy-5-nitrobenzenamine impurities. ...

IMPROVED PROCESS FOR SYNTHESIS OF MACITENTAN ABSTRACT: Disclosed herein is an improved and industrially feasible process for synthesis of Macitentan, N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]-N"-propyl sulfamide and its intermediates thereof in good yield and purity. ...

Disclosed herein is an improved process for synthesis of N-(4-fluorobenzyl)-N-(1- methylpiperidin-4-yl) -N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide, Pimavanserin and novel intermediate thereof.

The present invention discloses economical and industrially viable process for the preparation of N-Boc-l,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester (6) via novel intermediates;4-bromo-l,2,3,6-tetrahydropyridine( 13) and its N-protected derivatives (12) and (14) and salt (15) which are used as key interme...

A novel process for making Renin inhibitors like Aliskiren is disclosed. Its novel intermediate compounds and method of making them are also disclosed.

ABSTRACT The present invention relates to a novel process of preparation of an anticancer drug and its novel intermediates. More specifically, the present invention relates to a process for preparation of    4-(4-Methyl-piperazin-l-ylmethy!)-N-{4-methyl-3-[(4-pyridin-3- yl)pyrimidin-2-ylamino]-pbenyl}-benzamide ...

The present invention discloses a process for efficient production of 2-amino-5-hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin and novel intermediates the...

ABSTRACT A novel process for preparing nevirapine comprising the steps of halogenating either 2-amino-4-picoline or 2-acylamino-4-picoline to yield 5-haIo-2"amino-4-picoline or 5-halo-2-acylamino-4-picoline, nitrating the obtained 5-halo derivative to yield 5-halo-3-nitro-2-amino-4-picoline, and treating it with ni...

Disclosed herein is an efficient method for synthesis of beta glycerophosphate disodium salt in high purity and yield, without the need for tedious purification at any step, involving the recovery and reuse of tiglic acid a key reagent/ raw material.

A process for preparation of 10-propargyl-10-deazaaminopterin (Pralatrexate) or its salts comprising coupling a diaminopteridin derivative and a di-alkyl- glutamate  the two key components  using a peptide coupling agent O-(Benzotriazol-1-yl)-N N N′ N′-tetramethyluronium tetrafluoroborate (TBTU) in presence of an or...

AN IMPROVED PROCESS FOR SYNTHESIS OF TICAGRELOR ABSTRACT: The present invention discloses an improved and cost effective process for preparation of Ticagrelor in good yield and purity. The invention further discloses novel Polymorphic Form of Ticagrelor and its process for preparation thereof. ...

The present invention discloses a process for synthesis of (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-Methanesulfonylethylamine (VIII), via novel intermediates viz., 3-Ethoxy-N,4-dimethoxy-N-methylbenzamide (V) and (R)-2-((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamino)-2-phenylethanol (VII) and its further co...

This invention discloses a novel pharmaceutical salt of Lenalidomide. More particularly, the invention discloses crystalline Trifluroacetic acid salt of Lenalidomide; polymorphic forms thereof and process for preparation thereof. The invention further discloses pharmaceutical composition comprising crystalline Trifl...

This invention discloses an industrial process for preparation of Eltrombopag Polymorph I. More specially, the invention relates to process for preparation of Eltrombopag Polymorph I from aliphatic ether solvents.

The present invention disclose an efficient synthesis of 3,6-difluoropyrazine-2-carbonitrile, which is a key intermediate, in the preparation of Favipiravir. The invention further discloses synthesis of Favipiravir.

Disclosed herein is an improved and industrially feasible process for synthesis of Macitentan, N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]-ethoxy]-4-pyrimidinyl]-N′-propyl sulfamide in good yield and purity.

The present invention discloses an improved process for preparation of Lenalidomide and crystalline polymorphic forms thereof. More particularly, the invention relates to preparation of Lenalidomide with high yields and purity and to preparation of crystalline polymorphic form A and Form B.