The present invention relates to novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell prol...

The present invention is concerned with diazaspiroalkanone substituted oxazole derivatives that selectively modulate regulate and/or inhibit signal transduction mediated by certain native and/or mutant protein kinases implicated in a variety of human and animal diseases such as cell proliferative metabolic autoimmun...

The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R R R A Q W and X are as defined in the description. These compounds selectively modulate regulate and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a...

The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic,...

The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (I) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an a...

The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (l)that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell prolifera...

The present invention is concerned with substituted azole derivatives that selectively modulate  regulate  and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative  metabolic  allergic  and degenerativ...

The present invention relates to novel compounds selected from 2-(3substitutedaryl)amino-4-aryl-thiazoles that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, ...

This application relates to a polymorph form of the compound (IX), which remains dry at 80% relative humidity and thermodynamically stable at temperatures below 200°C. characterized by an X-ray diffraction pattern comprising characteristic peaks approximately 7.269, 9.120, 11.038, 13.704, 14.481, 15.483, 15.870,...

The present invention relates to compounds of general formula (I) wherein A represents an optionally substituted heterocycle group B represents an aryl or heteroaryl group and wherein X R1 R2 R3 R4 and R5 are as defined in the description. Compounds of formula (I) are useful to destroy inhibit or prevent the growth ...

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein B is an aryl or a five- or six-membered heteroaryl, and R1-R5, V, W, Y and Z may be various groups. The compounds according to the invention are useful as tubulin polymerization inhibitors...