The present disclosure relates to methods of decreasing lactate production in cell culture using divalent transitional metallic salts. The present disclosure also relates to a method of producing polypeptide by adding divalent transitional metallic salt to the cell culture medium for reducing lactate accumulation fo...

The present invention relates to production of Human Insulin methyl ester by enzymatic reaction. The present invention further relates to production and enhancement of purity of Human Insulin Methyl ester.

The present disclosure relates to a method of reducing heterogeneity in antibodies during culturing, wherein the heterogeneity is due to proportion of charge variant of the antibody. The disclosure also comprises a process of growing cells in a cell culture system that results in antibodies with the reduced heteroge...

The present invention relates to pharmaceutical composition comprising: (a) Liraglutide as active drug substance; (b) Buffer selected from the group consisting of Sodium citrate arginine disodium hydrogen phosphate glycine or any combination thereof; (c) tonicity modifier selected from glycerol mannitol propylene gl...