The present invention relates to an improved process for the synthesis of (Z)-2-
(dibutylam ino)-1-(2,7-dichloro-9-(4-chlorobenzyl idene)-9H-fluoren-4-yl)ethanol, commonly known as Lumefantrine, an antimalarial drug.
More particularly, the present invention relates to improved processes for the selective synthesi...
The present invention relates to a novel process for preparation of bitter-less Erythromycin ethyl succinate using organic solvent selected from esters or ethers in formation of Erythromycin ethyl succinate from erythromycin base or in purification of Erythromycin ethyl succinate. The present invention also relates ...
The present invention relates to a process for preparation of substantially pure N-9 alkylated isomer N2-Acetyl-9-(l,3-diacetoxy-2-propoxymethyl)guanine and to use this intermediate for the preparation of Ganciclovir of sufficient purity.
The present invention relates to an improved process for the preparation of Azithromycin monohydrate. More particularly, the present invention relates to a simple and industrially scalable process for preparation of stable Azithromycin monohydrate having residual solvent content between 0 to 200 ppm.
...
The present invention relates to a simple, eco friendly and an improved process for preparation of Sarpogrelate of Formula I and its salts employing water as a solvent.
The present invention provides an improved and commercially viable process for preparation of famciclovir of compound of formula (I), in high purity and good yield
which comprises,
isolation of desired N9 isomer of triester of formula (II)
by precipitating it with a suitable solvent followed by direct reduc...
The present invention provides an improved process for preparation of Maraviroc of Formula I by reductive amination using ammonium salt as a reducing agent.
The present invention relates to an improved in-situ process for the preparation of Valsartan intermediate, N-[2"-(lH-tetrazol-5yI) biphenyl-4-yl) methyl] N-valeryl-(L)-valine benzylester. More particularly, the present invention relates to an improved, cost effective and industrially feasible in-situ process for th...
The present invention relates to an improved process for preparation of stable and pure Clopidogrel bisulfate polymorphic form I from Clopidogrel base.
The present invention is to provide a novel process for the preparation of ethers of dihydroartemisinin, more particularly artemether and arteether containing more than 99% of P- isomer in higher yield with a simple isolation procedure and by using a pro-acid catalyst in very small amount.
A process for preparation of telmisartan comprising the steps of
condensing 2-n-propyl-4-methyl-6-(1"-methylbenzimidazole-2-yl)benzimidazole
with alkyl ester of 4"-bromomethylbiphenyl-2-carboxylic acid in presence of a
base and an alcoholic solvent to obtain a telmisartan alkylester intermediate and further hy...
The present invention discloses a process for the preparation of substituted aryl alkylamine compounds comprising the step of,reducing the substituted aryl acetonitrile substrate using Raney nickel catalyst at lower substrate/catalyst ratio of 20:1 to 6:1 with higher sybstrate concentration, at ramped temperature/ p...
The present invention relates to an efficient one pot process for the synthesis of (Z)-2-(dibutyiamino)-1 -(2, 7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl) ethanol of formula-I, commonly known as lumefantrine (formerly known as Benflumetol). More particularly, the present invention provides an improved one po...
The present invention relates to an improved process for the preparation of Sartans and pharmaceutically acceptable salts thereof from the cyano compounds.
A novel process for the production of valproic acid of Formula I, comprising, heating a reaction mixture comprising di-n-propylmalonic acid of Formula (II), metal catalyst in the form of its salt or oxide, and (3) a polar organic solvent, alone or in combination with one another, at 60° to 100°C for 6 to 15 hours to...
A process for the preparation of unsymmetrical biaryl compounds of Formula I wherein, R is alkyl, R’ is cyano, protected or unprotected tetrazole, or –H/C=NR” wherein, R” is alkyl, aryl, aralkyl or alkoxy, said process comprising, reacting Grignard reagent of Formula II wherein, R is alkyl; X is halogen with an aryl...
The present invention relates to a novel process for the synthesis of piperaquine base of formula IV and its intermediate 7-chloro-4-(piperazin-l-yl)quinoline. The present invention also relates to an improved process for the synthesis of piperaquine tetraphosphate tetrahydrate of formula I.
The present invention f...
The present invention relates to a novel process for preparation of eszopiclone of
formula (II) by reacting racemic zopiclone with an optically active acid in presence of water. The present invention also relates to a process for the purification of dextroisomer of optically active salt of zopiclone and eszopiclon...
The present invention provides an improved process for the preparation of mercaptocarboxylates of trimethylolpropane and pentaerythritol (polythiols) comprising reacting mercaptoalkanoic acid with trimethylolpropane and pentaerythritol respectively in the presence of a cation exchange resin as a catalyst in a suitab...
The present invention relates to a novel process for effective alkylation of key drug intermediates or their salts using substituted or unsubstituted Imidazole moiety as a catalyst.
Disclosed herein is process for the separation of 4-bromomethyl-2’-substituted biphenyls of Formula II from 4,4-dibromomethyl-2’-substituted biphenyls of Formula III and 4-methyl-2’-substituted biphenyl of Formula I by stirring a crude reaction mixture comprising compounds of formula I, II and III in suitable orga...
The present invention relates to an improved and efficient process for the preparation of 2-n-butyl-3-[[2"-(lH-tetrazol-5-yl)[l,l"-biphenyl]-4-yl]methyl]-l,3-diazaspiro[4.4]non-l-en-4-one of formula I, also known as "Irbesartan".
H3C
Formula I
In particular, the present invention provides an improved process f...
The present invention relates to a novel water based process for the preparation of racemic, levorotatory or dextrorotatory diphenylmethyl piperazines.
ABSTRACT
The present invention relates to a novel process for preparation of heterocyclic N-substituted alkylamines of formula I, by reacting appropriate amine with protected halo-substituted alkyl amine salt in the presence of catalyst and water as a solvent. The present invention also relates to a novel one-pot p...
The present invention relates to an improved process for the preparation of
ethers of dihydroartemisinin, more particularly artemether and arteether
containing more than 99% of β isomer from dihydroartemisinin by reacting
dihydroartemisinin with trialkyl orthoformate in the presence of a dry cation
exchange ...
The present invention relates to a novel process for desalination of Lisinopril (N2-t(S)-l-Carboxy-3-phenylpropyI]-L-lysyI-L-proline) of formula I, which is a very useful antihypertensive agent.
In particular, there is provided a novel process for removing the salts from Lisinopril of formula I by partitioning t...
The present invention relates to an improved and commercially viable process for preparation of L-valine benzyl ester p-toluenesulfonate wherein said product is isolated employing anti-solvent selected from a cycloalkane or branched aliphatic ether.
The present invention relates to a novel one pot process for preparation of N-carbamate of 3-oxopiperazine of formula I, particularly benzyl-3-oxopiperazine-l-carboxylate and tert-butyl-3-oxopiperazine-l-carboxylate, from ethylene diamine,
wherein R represents a benzyl group or a tert-butyl group.
...
The present invention relates to a novel process for the preparation of 4-(2-(dimethylamino)-l-(l-hydroxycyclohexyl) ethyl) phenol, commonly known as O-desmethylvenlafaxine of formula I and its pharmaceutically acceptable salts thereof.The present invention also relates to the novel process for the preparation of O-...
The present invention relates to a novel process for the liberation of Erythromycin from Erythromycin salts such as Erythromycin thiocyanate using water as a solvent in presence of a base. Erythromycin obtained by processes of present invention has purity of more than 95%.
A novel single step process for the synthesis of venlafaxine of formula I and N-desmethylvenlafaxine of formula II from 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile [cyano-intermediate] of formula V comprising reacting 2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile with an alkylamine and/or its s...
The present relates to an improved and commercially viable in-situ process for preparation of N- [2" -(1 -triphenylmethyl-tetrazol-5-yl) biphenyl-4-yl)methyl-N-valeryl-(L)-valine benzyl ester, an intermediate of Valsartan (Formula I).
The present invention further relates to an improved process for preparation o...
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