A novel high-shear wet granulation process was invented for modified release formulation of active ingredients, which involves addition of a granulating fluid into the powder dry mixture of API with or without additives other than release retarding polymer to prepare a semisolid mass. Addition of release retarding p...
Wherein R1 is Cyano group and R2 is amino group.
The present invention relates to a process of preparing amino pyridine compounds represented by structural formula V comprising reacting cyano pyridine compounds represented by structural formula IV with an oxidizing agent in the absence of base.
Wherein R1 is Cya...
A method of preparing sustained release pharmaceutical composition of 1buprofen comprising a) mixing coprocessed guar gum and sugar with Ibuprofen, at least one filler, granulating agent/binder, glident and one lubricant to form tabletting mixture; b) compressing tabletting mixture into tablets and c) coating tablet...
The present invention relates to intermediates 2-isopropoxy-4,5-dimethoxybenzoic acid compound represented by structural formula I and ethyl 2-[(2-isopropoxy-4,5-dimethoxybenzoyl)amino] thiazole-4-carboxylate compound represented by structural formula XXI and their use in the preparation of acotiamide hydrochloride ...
The invention relates to improved process for making 5-(2-chlorophenyI)-l,3-dihydro-7-nitrobenzo(l,4)-diazepin-2-one namely Clonazepam from reacting 2-(2-chloroacetamido)-5-2'-nitrobenzophenone with hexamine to from 2-(2-chloroacetamido)-5-2'-nitrobenzophenone -Hexamine complex which further treated in presence of a...
A novel process for preparation of Flupentixol comprising the condensation of
Condensation of 2-(trifluoromethyl)-9H-thioxanthen-9-one with grignard of
N,N"dimethyl aminopropyl magnesium chloride in mixture of toluene and
tetrahydrofuron to give 9[3-(dimethylamino)propyl]-2-(trifluoromethyl)-9H-thioxanthen-
9-ol...
The present invention provided a process for obtaining Flupentixol E/Z isomer ratio about 1:1 to 1: 1.4, comprising; treating Flupentixol isomeric mixture containing predominately E-isomer or Z-isomer, with base in organic solvent at a temperature ranging from 0 to 120°C.
The present invention relates to a crystalline form B of Metopimazine. The present invention further relate to a processes of preparing crystalline form B of Metopimazine and pharmaceutical composition thereof.
The present invention relates to a crystalline form E of Temazepam. The present invention further relate to a processes of preparing crystalline form E of Temazepam and pharmaceutical composition thereof.
The present invention relates to a novel intermediate compounds represented by structural formula I and their uses for the preparation of substantially pure Milnacipran hydrochloride compound represented by structural formula II.
The present invention provide an improved process of preparing Loprazolam mesylate comprises reacting a compound of structural formula II with an alkyl chloroformate compound of structural formula III to get a compound of structural formula IV and then converting compound of structural formula IV into Loprazolam mes...
A cost effective with commercially viable process for Isonipecotamide provided by catalytic hydrogenation of isonicotinamide in presence of platinum group elements on carbon formed by reacting palladium with organochlorine, in alcohol solvents at a temperature in the range of 25-50 °C, and isolates the product In no...
The present invention relates to a novel polymorph of Brexpiprazole, a process of preparation of crystalline Form C & pharmaceutical composition thereof.
The present invention relates to a process for the preparation of 2-Methyl sulphonyl phenothiazine compound of structural formula (I) which is intermediate of Metopimazine compound of structural formula (II).
Present invention provides a stable monohydrate form of loxapine hydrochloride compound represented by structural formula (I) and process of preparing thereof
The present invention relates to a novel crystalline form C of Fluphenazine hydrochloride. The present invention further relate to a processes of preparing novel crystalline form C of Fluphenazine hydrochloride.
The novel method related to preparation of pure Zuclopenthixol using mandelic acid by formation of mandelate salt. The method comprises dissolving a mixture of E and Z-Clopenthixol into an organic solvent, added mandelic acid to form mandelate salt, crystallized in organic solvent, subsequently carrying out alkali...
Abstract
An improved process for the preparation of substituted 3-(Acetyloxy)-7-chloro-l,3-
dihydro-5-phenyl-2H-l,4-benzodiazepin-2-one
The present invention relates to a process for preparation of substituted 3-(Acetyloxy)-7-chloro-l,3-dihydro-5-phenyl-2H-l,4-benzodiazepin-2-one, the compound represented by stru...
The present invention relates to a crystalline form C of Fludiazepam. The present invention further relate to a processes of preparing crystalline form C of Fludiazepam.
The present invention relates to the process of preparation of Z-Flupentixol Decanoate, compound represented by structural formula (I) by resolution of E/Z mixture of compound of structural formula (II) through the preparation of mandelate salt of Z-Flupentixol which can be used for the preparation of the compound o...
Present invention provides one pot process forpreparing 2-(chloromethyl)-4-methyl-quinazoline compound represented by structural formula (I) which is an intermediate of linagliptin compound represented by structural formula (II).
Present invention provides a process for preparation of sitagliptin compound represented by structural formula (I) through a novel mix anhydride compound represented by structural formula (IX).
wherein R is group selected from C1 to C5 alkyl, substituted C1 to C5 alkyl, phenyl or substituted phenyl.
...
Present invention provides a process for preparation of diamino benzazepine derivative compound represented by structural formula (I) by reduction of dinitro benzazepine derivative compound represented by structural formula (II) using metal/acid as a reagent.
Wherein R is a group selected from H, -COH, -COCH3, -...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF QUINAZOLINE COMPOUND
AND APPLICATION THEREOF
The present invention provides an improved process for the preparation of Quinazoline compound represented by structural formula I with high yield and high purity, is an important intermediate for synthesis of various Act...