ABSTRACT: The present invention provides novel processes for the preparation of N-(5- Chloro-2-pyridinyl)-2-{[4-(N,N-dimethylcarbamimidoyl)benzoyl] amino}-5-methoxy benzamide i.e., Betrixaban or salts thereof and novel intermediates useful for preparing the same. Also, provided are amorphous and/or crystalline s...

ABSTRACT: The present invention provides improved, industrially viable processes for the preparation of N-(5-chloro-2-pyridinyl)-2-{[4-(N,N-dimethylcarbamimidoyl)benzoyl]am -ino}-5-methoxybenzamide i.e., Betrixaban or salts thereof. Also the process of present invention provides novel compounds useful as intermedia...

A commercially viable, cost-effective one pot process for the preparation of triphenylphosphine (TPP) in high degree of yield, wherein triphenylphosphine oxide (TPPO) is treated with triphosgene in the presence of a halogenated solvent to form a solution containing triphenylphosphine dichloride (TPPCl2), which is fu...

Abstract The present invention describes a new process for the synthesis of (S)-6-chloro-4(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, that is efavirenz, with advantages over reported methods like low cost, high yield, better optical purity and industrial feasibility. Also disclos...

Abstract The present invention relates to a novel, cost-effective industrially scalable process for the preparation of sacubitril or stereoisomers thereof represented by a compound of formula VIII. The present invention also relates to novel intermediates useful for the synthesis of sacubitril and preparation proc...

The present invention relates to a new process for the preparation of empagliflozin, useful as a SGLT-2 inhibitor in the treatment of type 2 diabetes. More particularly, the present invention relates to a new process comprising reacting a compound of formula VII with a reducing agent to yield empagliflozin. Als...

The present invention provides novel process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl] oxy] phenyl] methyl] phenyl]-D-glucitol i.e., Empagliflozin or salts thereof. Also, provided are amorphous solid dispersions/solutions with pharmaceutically acceptable polymers, amorp...

Abstract The present invention provides novel processes for the synthesis of (±) Difluoromethyl ornithine, known as eflornithine or acid addition salts thereof. Also provided are novel compounds obtainable from the processes of the present invention, useful as intermediates for synthesis of eflornithine. The pre...

The present invention provides novel, improved process for the synthesis of tapentadol (1), a central analgesic used in the treatment of moderate to severe acute pain and salts thereof. The present process has proven to be robust, user friendly, simple, economic, environment sustainable and commercially viable metho...

The present invention relates to an improved process for preparing (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol i.e. Dapagliflozin or stereoisomers, solvates or hydrates thereof. Also, the products obtained from the present invention may be used for the preparation of medicaments for t...

The present invention provides improved, cost-effective, industrially viable processes for preparing ß-aminosulfone compounds, particularly 1-(3-ethoxy-4-methoxyphenyl)-2-methyl sulfonylethylamine (3), a key intermediate useful for the preparation of Apremilast in high yields and purity, by way of using Turbo-grigna...

The present invention relates to an improved process for the preparation of 3-Methyl-4-nitroiminoperhydro-1,3,5-oxadiazine (I) (MNIO) which is economical and commercially feasible. MNIO prepared in accordance with the present invention may be used as an intermediate to manufacture a broad-spectrum insecticide, ...

Abstract An improved, commercially feasible process for preparing N, N’-bis(2-aminoethyl)-1,2-ethanediamine dihydrochloride (VI) comprising reacting triethylenetetramine free base with alcoholic hydrochloric acid, avoiding direct addition of molar excess of hydrochloric acid and higher reaction temperatures. More p...

ABSTRACT The present invention relates to an alternative, cost-efficient, industrially viable process for the preparation of 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-piperidine i.e., Pitolisant and it pharmaceutical acceptable salts, through a novel intermediate 3-(4-chlorophenyl)propyl pivalate represented as follo...