Provided herein is a process for synthesis of tiotropium bromide and a process for synthesis of scopine starting from a dimethyl tartarate compound. The synthetic sequence comprises a double Mannich reaction (Robinson-Schopf reaction).

Provided herein are processes for preparation of glycopyrronium bromide comprising reaction of N-methylpyrrolidin-3-ol with compounds of Formula I or Formula II followed by additional steps.

Provided herein is a process for synthesis of tiotropium bromide wherein the coupling of scopine with 2, 2-dithienyl glycolate is achieved by a two step process under mild conditions.

Provided herein is a process for synthesis of aclidinium bromide and intermediates thereof, wherein the process for the preparation of aclidinium bromide increases the % yield of aclidinium bromide by about 70% to 90%.

The present invention relates to a process for preparing a chiral compound having formula (XXXVI) comprising reacting a compound of formula (XXXIV) with a chiral sulfide compound of formula (XXXV) in presence of a first base and a first solvent.                   Formula (XXXIV) Formula (XXXV)                Form...

ABSTRACT A PROCESS FOR THE PREPARATION OF UMECLIDINIUM BROMIDE AND INTERMEDIATES THEREOF Provided herein is a process for the preparation of umeclidinium bromide and intermediates thereof, wherein pure form of umeclidinium bromide is achieved by a two step process under mild conditions.

ABSTRACT A PROCESS FOR PREPARATION OF VILANTEROL AND INTERMEDIATE THEREOF The present invention discloses a process of preparing vilanterol. The process of as disclosed herein is a simple process resulting in formation of vilanter...

A PROCESS FOR PREPARING BATEFENTEROL AND INTERMEDIATES THEREOF The present invention relates to a process for preparation of Batefenterol of Formula (I) or pharmaceutically acceptable salts thereof, and the process for the preparation of the chiral intermediate compounds including compound of Formula (VII) by chira...

A PROCESS FOR PREPARING NAVAFENTEROL AND INTERMEDIATES THEREOF The present invention relates to a process for preparation of Navafenterol of Formula (I) and intermediate compounds of Formula (VII) and Formula (XIII) by chiral sulfide mediated epoxidation. The process involves preparation of the intermediate compoun...

A PROCESS FOR PREPARING ABEDITEROL AND INTERMEDIATES THEREOF The present invention relates to a process for preparation of Abediterol of the Formula (I) or its pharmaceutically acceptable salts, and intermediate compounds including the compound of the Formula (VII) by chiral sulfide mediated epoxidation. The proces...

METHOD OF SYNTHESIZING AN AMINE DERIVATIVE OF 2-(TERT5 BUTYLDIMETHYLSILYL) OXY 2-(3-CHLOROPHENYL) The present invention relates to an improved method of synthesizing an amine derivative intermediate 2-(tert-butyl dimethylsilyl) oxy 2-(3-chlorophenyl) formula (V) from formula (A). Specifically 1,1'-biphenyl deriva...