The present invention related to a process for the preparation of filgrastim of higher purity and yield using a novel multi steps liquid chromatographic method after the over-expression of the protein in prokaryotic cells. This invention makes use of a combination of ion exchange chromatographic resins in series hav...
The present invention relates to pharmaceutical compositions of tenecteplase that are safe and effective in the treatment of acute ischemic stroke compared with the known compositions. The advantages of the invention are its safety and efficacy over the known formulations in the treatment of acute ischemic stroke in...
The present invention relates to a process for the preparation of TNK-tPA by inoculating said seed culture for production phase in a perfusion mode/batch using adherent type Chinese Hamster Ovary cell with packed bed technology comprising of a modified CHO-S-SFM II production medium; wherein the residual glucose lev...
The present invention relates to a process for the preparation of a glycoprotein using adherent type substrate in perfusion-mode, wherein in the production phase, the monosaccharide content in the perfusing medium is 7 gm/day to 137.5 gm/day.
The present invention relates to a process for the preparation of rhGM-CSF by growing the yeast cells expressing rhGM-CSF in a suitable medium, which comprises of glycerol as a carbon source to yield the biomass and inducing the grown yeast cells capable of expressing the protein using alcohol in an incremental orde...
The present invention pertains to an ophthalmic composition of Bevacizumab, in a single use prefilled syringe which is safe, non-toxic and efficacious for administration during the shelf life, characterised in that the ophthalmic solution is controlled with respect to the number of sub-visible particulate matter wit...
The present invention relates to a novel, economically viable, storage stable, lyophilized composition of pegaspargase. The composition comprises pegaspargase, a cryoprotectant, a bulking agent, a buffer and may optionally contain other pharmaceutically acceptable excipients including but not limited to a salt. The ...
The present invention discloses a naïve antibody phage display library (APDL) a process for producing the same and a method of obtaining manufacturable antibodies as soluble Fabs from the antibody phage display library.
The present invention relates to a novel process of isolating and purifying tissue plasminogen activator and its variants more specifically TNK tPA from CHO cells and describes an industrially applicable simple cost effective robust and highly efficient process of TNK tPA purification.
The present invention pertains to an economic packed-bed perfusion system for the production of pharmaceutical grade of recombinant TNK-tPA. The present invention involves a cell culture process utilizing CHO cells more specifically in a micro/macro carriers based packed-bed perfusion system. The process of the pres...
The disclosed invention relates to a method for purifying a recombinant protein produced in the bacterial protein expression system. Specifically, it relates to the efficient purification of a therapeutic recombinant protein by removing the impurities from a complex liquid mixture containing said recombinant protein...
Lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. The present invention relates to lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. It particularly provides a method for lyophilisation of liquid formulations of mRNA adsorbed onto lipid nano-emulsion particles ...
RNA adsorbed onto lipid nano-emulsion particles and its formulations. The present invention relates, a method of preparing a liquid formulation of RNA complexed with lipid nano-emulsion particles or nano-carriers. It particularly provides a method for preparation of the RNA adsorbed onto lipid nano-emulsion particle...
A lyophilised COVID-19 vaccine formulation. The present invention relates, a method of preparing a lyophilized formulation of mRNA complexed onto lipid nano-emulsion particles or nano-carriers for intradermal application. It particularly provides a method for preparation of the mRNA adsorbed onto lipid nano-emulsion...
[Class : 5] Pharmaceutical And Medicinal Preparations; Ayurvedic Preparations; Dietary Food Supplements For Medical Use; Dietetic Food Supplements Adapted For Medical Purposes; Health Food Supplements For Persons With Special Dietary Requirements; Medicated Food Supplements.
[Class : 5] Pharmaceutical And Medicinal Preparations; Ayurvedic Preparations; Dietary Food Supplements For Medical Use; Dietetic Food Supplements Adapted For Medical Purposes; Health Food Supplements For Persons With Special Dietary Requirements; Medicated Food Supplements.