Disposed herein is a process for the preparation of methyl phenidate hydrochloride (Formula 1), comprising the steps of; hydrolyzing α-pherryl-α-pipyridyl acetamide (Formula II) in presence of mineral acid at reflux temperature and subsequent neutralization to yield threo -a-phenyl-a-pipyridyl-2-acetic acid (Formula...

The present invention discloses an improved process for preparing 2-[3-cyano4-(2-methylpropoxy) phenyl]-4-methylthiazole-5-carboxylic acid of formula-I and its crystalline form-G.

The present invention provides a novel process for preparing Alogliptin free base and its benzoate salt which comprises insitu condensation process to produce protected Alogliptin by reacting 6-chloro-3-methylpyrimidine-2, 4(1H, 3H)-dione with 2-(halo methyl) benzonitirle in presence of a base, aprotic solvent follo...

The present invention discloses a process for preparing (R)-2-[[6-(3-Aminopiperidin-l-yl)-3-methyl-2, 4-dioxo-3, 4-dihydropyrimidin-l(2H)-yl] methyl]-4-fluorobenzonitrile succinate known as Trelagliptin succinate of formula-II.

The present invention describes an improved process for preparing highly pure (S)-1-[N-(3-hydroxy-l-adamantyl) glycyl] pyrrolidine-2-carbonitrile known as Vildagliptin. Also the present invention discloses a novel insitu process for preparing an intermediate (2S)-l-(chloroacetyl)pyrrolidine-2-carbonitrile. Further, ...

The present invention describes an advantageous, economically viable process for preparing 5-[4-[4-(5-Cyanoindole-3-yl)butyl]Piperazine-1-yl]benzofuran-2-carboxamide free base (Formula-I) and its hydrochloride salt. The instant invention also describes process for preparing 2-benzofurancarboxamide, 5-[4-[4-(5cyano-1...

ABSTRACT: The present invention discloses the process for preparation of (2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol and its stable amorphous hemihydrate form.

ABSTRACT: The present invention discloses the process for preparation of (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol and its amorphous form.

The present invention discloses the process for preparation of 1-¬Azoniabicyclo[2.2.2]octane,3-[(hydroxydi-2-thienylacetyl)oxy]-1-(3¬phenoxypropyl)-, bromide, (3R)- and its novel crystalline form-I.

The present invention discloses industrially feasible process for preparation of 7-[(3R)-3-amino-1-oxo-4-(2,4,5trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Hydrochloride monohydrate.

In accordance with the present invention, an improved process for the preparation of crystalline choline fenofibrate using a single organic solvent, comprises steps of (a) hydrolyzing the choline chloride in an organic solvent at ambient temperature, leaving choline base free in the solution; (b) reacting the cholin...

ABSTRACT: The present invention discloses an improved process for preparing Lurasidone free base and its hydrochloride salt.

The present invention discloses the process for preparation of Anagliptin and its novel crystalline form-H.

The present invention discloses the process for preparation of 7-[(3R)-3-amino-1-oxo-4-(2,4,5trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate.

Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula J), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basification and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (F...

The present invention discloses the process for preparation of (2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol and its pipecolic acid co-crystal. The invention also discloses novel intermediate, acetic acid 4, 5-diacetoxy-6-acetoxymethyl-2...

The present invention discloses the process for preparation of (2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-trioland its amorphous form. The invention further discloses novelco-crystals of dapagliflozin,and process for preparation thereof. The invention further di...

Disclosed herein is a convenient single-pot method for the preparation of highly pure di-n-propyl malonic acid (Formula I), a key intermediate of valproic acid, salts and derivative thereof, wherein the process comprises the alkylation of diethyl malonate with alkyl halide in presence of sodium metal in a suitable o...

The Method involves (i) reacting 2-methyl-2-propyl 1,3-propanediol in chlorosolvcnt selected from Dichloromethane or dichloroethane, with alkali metal cyanate preferably sodium or potassium cyanate and HCI at low temperature till completion of reaction, (ii) quenching the reaction with water, isolating the product b...

Disclosed herein is a one-pot process for the preparation of pharmaceutically active cyclobenzaprine hydrochloride (Formula I) which comprises, reacting 5-dibenzosuberenone with Grignard reagent derived from 3-dimethylaminopropyl chloride. The reaction mass undergoes hydrolysis and dehydration reaction without isola...

The invention discloses a process for divalproex sodium comprising (i) Producing esters of diethyl/ di-n-propyl malonic acid from diethyl malonate, sodium alkoxide particularly sodium t- butoxide or n-propoxide and n-propyl halide, (ii) hydrolysing the esters of diethyl/ di-n-propyl malonic acid to di-n-propyl malon...

The present invention provides economically feasible process for commercial production of fumarate salt of N-(2-Hydroxy-5-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-formamide i.e. Formoterol fumarate dehydrate of formula II. Formula II

The present invention discloses the process for preparation of 1 H-Purine-2,6-dione, 8-[(3R)-3-amino-l-piperidinyl]-7-(2-butyn-l-yl)-3,7-dihydro-3-rnethyl-l-[(4-methyl-2quinazolinyl) methyl] (Forumula-l)

Disclosed herein is an efficacious process for preparation of highly purified Glycopyrrolate tosylate in high yield. The process is being cost effective, environment friendly and easily scalable to high volume industrial production.

The present invention, discloses optically pure compounds of l-Norepinephrine and its acid addition salts and hydrates and process for the preparation thereof. Specifically, the present invention discloses optically pure compounds of l-Norepinephrine bitartrate, its process of preparation and pharmaceutical composit...

Disclosed herein is a process for the preparation and purification of Valsartan. The process according to the invention is capable of removing the toxic nitroamine impurities and providing substantially pure Valsartan.

The present invention, in general, discloses pharmaceutical composition of oral multiunit pellets comprising one or more pharmaceutical active ingredients or pharmaceutically acceptable salt, solvates or polymorphs thereof, specifically, present invention discloses pharmaceutical composition of multiunit pellet s...

The present invention discloses a method for resolving cyclohexylphenyl glycolic acid and the preparation of optically active phenylcyclohexyl glycolate esters. More particularly, the invention provides a process for preparation of optically active R-oxybutynin hydrochloride with high enantiomeric purity of greater ...

The present invention discloses an improved process for the preparation of Imeglimin & salts thereof. More particularly, the present invention discloses chiral resolution of Racemic Imeglimin and its salts which is industrially advantageous and economically significant.

The present invention discloses processes for the preparation of 7-(4,7-Diazaspiro[2,5] octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-pyrido[1,2-a]pyrimidin-4-one i.e. Risdiplam of Formula-1 via novel intermediates namely 7-Benzyl-1-formyl-4,7-Diazaspiro[2,5]octane (Formula-2), 1-Formyl-4,7-Diazaspiro[2,5...

The present invention discloses a novel crystalline form of Risdiplam of structural formula-1 and process for preparation thereof. The present invention further discloses pharmaceutical composition comprising the said crystalline form and their use as pharmaceutically active compounds. Particularly, the present inve...

Disclosed herein is an improved process for preparation of Remimazolam and salts thereof The present invention ameliorates the use of costly reagents, cumbersome process steps employed in the art by virtue of which the present process is cost effective and industrially viable.

The present invention discloses a process for purification of Risdiplam wherein the pure product obtained is characterized by the impurities Des Fluoro Impurity i.e. 2-(2,8-dimethylimidazo[1,2-b] pyridazin-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one (Formula 1) and 2-(2,8-dimethylimidazo[1,2-b] pyridazin-6-yl)-7-(4,7-diaz...