Abstract
A PROCESS FOR THE PREPARATION OF 2-CYANOIMINO-l, 3-THIAZOLIDINE USING AN INORGANIC CARBONATE
The present invention relates to a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of Formula-I
by cyclization of dimethyl N-cyanoiminodithiocarbona...
A process for the preparation of l-[2-(dimethylamino)-l-(4-methoxyphenyl) ethyl] cyclohexanol of Formula-II, which is substantially free from a spiro compound 5-(4-methoxyphenyl)-3-methyl-3-aza-l-oxaspiro(5.5)- undecane and acid addition salts thereof by dissolving an acid addition salt of l-[2-amino-l-(4-methoxyphe...
ABSTRACT
A process for the preparation of 2-cyanoimino-l, 3-thiazolidine using aqueous ammonia
The present invention relates to a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of Formula-1
by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the s...
The present invention relates to crystalline forms of gabapentin and processes for preparing the same. The present invention particularly relates to crystalline forms of gabapentin form II and Form IIB.
The invention also relates to gabapentin form IA and form IB. The gabapentin forms IA and IB are hydrated forma...
The present invention relates to a commercially viable novel process for manufacturing Vildagliptin in high yield with high chemical and chiral purity.
The present invention discloses a process for the preparation of dibenzothiazepinone compounds of Formula I.
The process for preparation of a dibenzothiazepinone compound of Formula I comprises reaction of compound of formula II in the presence of an acid catalyst comprising phosphorus pentoxide and methanesulfo...
The present invention describes a process for the preparation of l,2-dialkoxy-3-fluorobenzene compounds of formula I
Picture I
wherein:
R3 and R4 are each independently a linear or a branched C1-C20 alkyl, a C3-C8 cycloalkyl, a C7-C15 alkylaryl or a C4-C7 cycloalkyl alkyl; said process comprising: halogenating 2...
The present disclosure relates to a process for the preparation of pregabalin of formula 1;
said process comprises the steps of; obtaining 2-Cyano-5-methyl-hex-2-enoic acid alkyl ester of formula II, by reacting isovaleraldehyde and alkyl cyanoacetate, in presence of salts of weak acid and weak base or weak base...
ABSTRACT
A process for the preparation of 2-cyanoiinino-l, 3-thiazoIidine using an alkali metal
alkoxide
The present invention relates to a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of
by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or th...
A process for the preparation of 1 -[2-(dimethylamino)-1 -(4-methoxyphenyl)ethyl]cyclohexanol (venlafaxin) of formula (4) (R=OMe, R]=Me), said process comprising the steps of; dissolving compound (3) (R=OMe) or its acid addition salt in an alcohol, to form an alcoholic solution of compound (3), adding formaldehyde t...
A process for the preparation of compound of formula (3) (R=OMe, OH) said process comprising the steps of: dissolving the substituted phenylacetonitrile (2) (R=OMe, OH) in an alcohol and ammonium salt to obtain a reaction mixture, and treating the reaction mixture with hydrazine hydrate in the presence of a noble me...
The present invention relates to a process for the preparation of l-[2-amino-l-(4-substituted phenyl)ethyl]cyclohexanol (3) (where R is OMe, OH), said process comprising the steps of; subjecting a reaction mixture of substituted phenylacetonitrile (2) in alcohol, an organic acid, and a hydrogenating catalyst in th...
The present invention relates to compounds trans (E) and cis (Z) stereoisomers of 4-t-butyl gabapentin of formula (11) and (12) and a process for the preparation of the said stereoisomers.
The invention describes an improved method for producing halo-dialkoxybenzenes of formula (I) such as 1-fluoro-2. 3-dialkoxybenzene as well as 2-fluoro-1. 4-dialkoxybenzene.
by reacting commercial 2-fluorophenol is reacted with an allyl halide in N-methylpyrrolidone (NMP) followed by rearranging the resultant 2-...
The present invention relates to a process for the preparation of a pharmaceuticallly acceptable acid addition salt of l-amino-3, 5-dimethyl adamantane of Formula-A,
said process comprising: reacting l-halo-3, 5-dimethyl adamantane with acetonitrile in the presence of an organic acid to obtain N-acetamido-3, 5-d...
A Process for the Preparation of Valproic Acid
The present invention relates to a process for the preparation of valproic acid of Formula-I,
said process comprising hydrolysing epoxy nitrile of Formula-II, in presence of a phase transfer catalyst, water and optionally an alkali or alkaline earth metal halide.
...
The present invention relates to a process for the preparation of substantially pure 1-(aminomethyl)-l-cyclohexane acetic acid hydrochloride of formula (II) viz. gabapentin hydrochloride through gabalactam (I) which in turn arises from 3,3-pentamethylene glutarimide of formula (IV). The imide, 3,3-pentamethylene glu...
Abstract
"A process for the preparation of l-benzyl-4-[(5,6-dimethoxy-l-indanon)-2-yl]methylpiperidine and acid addition salts thereof
The present invention relates to a process for preparing donepezil, l-benzyl-4-[(5, 6-dimethoxy-l-indanon)-2-yl] methylpiperidine, of Formula-II and acid addition salts thereof,
...
The present invention relates to a process for the preparation of tetrahydrocarbazolone derivatives in the absence of solvent, more particularly for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl)- 1H-imidazole-1 -yl)methyl]-4H-carbazol-4-one free from exomethylene carbazolone in the absence of solvent....
A process for preparation of E-isomer of l-(4-methylphenyl)-l-(2-pyridyl)-3-pyrrolidinoprop-1 -ene (Formula-1), and acid addition salts thereof, said process comprising; dehydrating l-(4-methylphenyl)-l-(2-pyridyl)-3-pyrrolidinopropan-l-ol (Formula III) followed by adding a base solution to obtain a mixture of E and...
The present invention relates to provide an improved and novel process for the preparation of Apixaban (I), which is simple, economical, metal-free, efficient, user and environment friendly, moreover commercially viable.
ABSTRACT
DIOXANE SOLVATE OF PROTHIOCONAZOLE AND PROCESS FOR PREPARATION THEREOF
The present invention relates to a stable crystalline dioxane solvate of prothioconazole formula (I) and process for preparation thereof. The present invention also relates to crystalline 1,4-dioxane solvate of prothioconazole (II)...
ABSTRACT
PROCESS FOR PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE
The present invention relates to a process for preparation of 5-bromo-1,2,3-trichlorobenzene of formula (I) in simple, economical manner with high yield. The 5-bromo-1,2,3-trichlorobenzene of formula (I)is used in preparation of 1-(3,4,5-trichl...
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF THIABENDAZOLE
The present invention relates to an improved process for preparing thiabendazole of formula (I) with high yield, high purity, in economical and commercially viable manner for agricultural and pharmaceutical use.
(I)
ABSTRACT
CONTINUOUS PROCESS FOR THE PREPARATION OF
GABAPENTIN SALT
The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the Hofm...
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF A KEY INTERMEDIATE OF GEMFIBROZIL
The present invention relates to an improved process for the preparation of 5-bromo-2,2-dimethyl-pentanoic acid isobutyl ester of formula (I), a key intermediate of gemfibrozil, in an environment friendly and commercially via...
The invention relates to a commercially viable process for manufacturing 4-cyanothiazole (I) from 4-methylthiazole (II) using a novel ammoxidation catalyst composed of oxides of Antimony, Calcium, Chromium, Iron, Potassium, Titanium, Vanadium and Zirconium is disclosed with high selectivity and chemical purity.
...
The present invention relates to a commercially viable novel process for manufacturing sitagliptin of formula (I) in high chemical & chiral purity alongwith higher yield.
Sitagliptin (I)
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention relates to provide an improved process for the preparation of sitagliptin (I) and its pharmaceutical acceptable salts thereof, which is simple, economical, efficient, user and env...
The present invention relates to an improved process for the preparation of trifloxystrobin of formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity.
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF ERTUGLIFLOZIN AND INTERMEDIATE THEREOF
The present invention relates to an improved process for the preparation of ertugliflozin of formula (I) and intermediate thereof, in an environment friendly and commercially viable manner with safer conditions in high y...
ABSTRACT
PROCESS FOR THE PREPARATION OF 2-AMINO-N-(2,2,2-TRIFLUOROETHYL) ACETAMIDE AND SALTS THEREOF
The present invention relates to an improved process for the preparation of 2-amino-N-(2,2,2-trifluoroethyl) acetamide of formula (I) and salts (IA) thereof, in an environment friendly and commercially viable m...
ABSTRACT
Process for the preparation of a key intermediate of Gemfibrozil
The present invention relates to an improved process for the preparation of 5-bromo-2,2-dimethyl-pentanoic acid isobutyl ester of formula (I), a key intermediate of Gemfibrozil, by using radical initiator in an environment friendly and c...
The present invention relates to an economical, enzyme catalyzed and commercially viable greener process for manufacturing pregabalin of formula (I) in high yield with high chemical and chiral purity.
ABSTRACT
SUBSTANTIALLY PURE CLARITHROMYCIN 9-OXIME AND ITS PREPARATION THEREOF
The present invention relates to substantially pure Clarithromycin 9-oxime more particularly Clarithromycin 9(E)-oxime having purity more than 98% and corresponding (Z)-isomer not more than 1%. The present invention further relates ...
ABSTRACT
PROCESS FOR PURIFICATION OF FLURALANER
The present invention relates to a process for purification of Fluralaner of formula (I). The present invention further relates to a process for purification of Fluralaner of formula (I) with purity more than 99%, in simple, economic and commercially viable manne...
ABSTRACT
AN INDUSTRIAL SCALE PROCESS FOR THE PREPARATION OF PROTHIOCONAZOLE
The present invention relates to an industrial scale process for the preparation of Prothioconazole (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and greater ...
ABSTRACT
AN INDUSTRIAL PROCESS FOR RESOLUTION OF CHLOCYPHOS
The present invention relates to a process for resolution of Chlocyphos of Formula (I) to obtain corresponding (S)- or (R)-isomers. The present invention further relates to a process of obtaining (S)-Chlocyphos using (R)-(+)-a-methylbenzylamine and (R...
ABSTRACT
PROCESS FOR THE PREPARATION OF 3,5-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE
The present invention relates to an improved process for the preparation of 3,5-Dichloro-2,2,2-Trifluoroacetophenone of formula (I). The present invention further provides an improved process for the preparation of Fluralaner usin...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF DAPAGLIFLOZIN PROPANEDIOL MONOHYDRATE
The present invention relates to an improved process for preparation of Dapagliflozin propanediol monohydrate of formula (I). The invention further relates to an improved process for the preparation of substantially pure inte...
ABSTRACT
“A SIMPLE PROCESS FOR THE PREPARATION OF FAVIPIRAVIR AND ITS INTERMEDIATES THEREOF”
The present invention relates to a simple process for the preparation of Favipiravir of Formula (I). The present invention further relates to an improved process for the preparation of substantially pure 2-aminomalonam...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF EMPAGLIFLOZIN AND ITS CRYSTALLINE POLYMORPH
The present invention relates to an improved process for preparation of Empagliflozin of formula (I). The invention further relates to preparation of crystalline form of Empagliflozin and its particle size having coarse...
ABSTRACT
IMPROVED PROCESS FOR PREPARATION OF R,S-ESTER INTERMEDIATE OF PREGABALIN
The present invention relates to an improved process for preparation of R,S-ester of formula (I) using proline or substituted proline. The present invention further provides an improved process for the preparation of Pregabalin u...
ABSTRACT
“A PREPARATION OF SITAGLIPTIN HYDROCHLORIDE MONOHYDRATE”
The present invention relates to an improved process for the preparation of Sitagliptin hydrochloride monohydrate of formula (I). The invention further relates to Sitagliptin hydrochloride monohydrate of formula (I) which is prepared from phosph...
ABSTRACT
AN EFFICIENT PROCESS FOR THE PREPARATION OF ERTUGLIFLOZINL-PYROGLUTAMIC ACID AND INTERMEDIATES THEREOF
The present invention relates to an efficient process for the preparation of Ertugliflozin L-pyroglutamic acid of formula (I) and intermediate thereof, in environment friendly conditions. The present...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF PROHEXADIONE AND ITS CALCIUM SALT
The present invention relates to an improved and efficient process for the preparation of Prohexadione and its calcium salt of formula (I). The present invention further relates to a one step process for preparation of ethyl 3,5-...
ABSTRACT
INDUSTRIAL METHOD OF PRODUCING BENZISOTHIAZOLINONE
The present invention relates to an industrial method for the preparation of Benzisothiazolinone formula (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and chemical purity.
...
ABSTRACT
SUBSTANTIALLY PURE VILDAGLIPTIN AND A PROCESS THEREOF
The present invention relates to substantially pure Vildagliptin having an imine N-oxide impurity not more than 0.15% and a process for the preparation thereof. The invention further relates to a process for the preparation of substantially pure Vi...
ABSTRACT
INDUSTRIAL METHOD FOR PRODUCING 2-BUTYL-1,2-BENZISOTHIAZOL-3-ONE
The present invention relates to an industrial method for the preparation of 2-Butyl-1,2-benzisothiazol-3-one of formula (I) in an environment friendly and commercially viable manner with high yield and high chemical purity.
...
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIATE OF TRIFLOXYSTROBIN IN SINGLE ISOLATION STAGE
The present invention relates to an improved process for the preparation of intermediate of Trifloxystrobin in single isolation stage. The present invention provides an improved process for the prepara...
ABSTRACT
AN INDUSTRIAL PROCESS FOR THE PREPARATION OF 3-BROMO-1-(3-CHLOROPYRIDIN-2-YL)-1H-PYRAZOL-5-CARBOXYLIC ACID
The present invention relates to an industrial process for the preparation of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-carboxylic acid of formula (I). The present invention further involves ...
ABSTRACT
AN INDUSTRIALY SCALABLE PROCESS FOR THE PREPARATION OF OLMESARTAN MEDOXOMIL
The present invention relates to a process for the preparation of Olmesartan Medoxomil of formula (I) using single solvent in robust and industrially scalable manner.
ABSTRACT
A SCALABLE PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE GLYCINE TERT-BUTYL ESTER AND ITS SALT THEREOF
The present invention relates to a scalable and efficient process for the preparation of substantially pure Glycine tert-butyl ester.The invention further relates to preparation of substantially ...
The present invention relates to a process for the preparation of 4-acetyl-1-naphthoic acid or its derivatives of formula (I) where R is hydrogen or C1-C4 alkyl, using novel compounds. The invention further relates to use of compound (I) for the preparation of Afoxolaner.
ABSTRACT
SUBSTANTIALLY PURE (5-BROMO-2-CHLOROPHENYL) (4-ETHOXYPHENYL) METHANONE AND PREPARATION THEREOF
The present invention relates to substantially pure (5-bromo-2-chlorophenyl) (4-ethoxyphenyl) methanone of formula (IV) having undesired isomer of formula (IVA) less than 1%. The invention further relates to...
ABSTRACT
A PROCESS FOR THE PREPARATION OF VENLAFAXINE HYDROCHLORIDE HAVING COARSER PARTICLE SIZE
The present invention relates to a process for the preparation of venlafaxine hydrochloride having coarser particle sized90 not less than 300 microns, d50 not less than 50 microns, and d10 not less than 20 microns....
ABSTRACT
AN INDUSTRIAL PROCESS FOR THE PREPARATION OF SUBSTANTIALLY PURE 2,3-O-ISOPROPYLIDENE-D-RIBOFURANOSE
The present invention relates to an industrial process for the preparation of 2,3-O-Isopropylidene-D-ribofuranose of formula (I). The intermediate of formula (I) is used for the preparation of Varitriol...
ABSTRACT
PROCESS FOR THE PREPARATION OF BUPROPION HYDROBROMIDE FORM-II
The present invention relates to the preparation of crystalline bupropion hydrobromide form - II by treating bupropion hydrobromide in an aqueous alcoholic solvent.
ABSTRACT
A PREPARATION AND PURIFICATION OF CRYSTALLINE SITAGLIPTIN PHOSPHATE MONOHYDRATE
The present invention relates to a process for the preparation and/or purification of crystalline Sitagliptin phosphate monohydrate of formula (I). The invention further relates to preparation of crystalline Sitagliptin ph...
ABSTRACT
A PROCESS FOR THE PREPARATION OF ISOXAZOLINE-SUBSTITUTED AMIDE COMPOUNDS AND ITS INTERMEDIATES THEREOF
The present invention relates to a process for the preparation of isoxazoline-substituted amide compounds and its intermediates thereof.
The present invention, particularly, relates to a process ...
ABSTRACT
“A 5-(CHLOROMETHYL)-2,4-DIFLUOROPYRIDINE AND PREPARATION THEREOF”
The present invention relates to a process for preparation of 5-(chloromethyl)-2, 4-difluoropyridine of formula (I).
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF 4-ACETYL-2-METHYL-BENZONITRILE
The present invention relates to an improved process for the preparation of 4-acetyl-2-methyl-benzonitrile of formula (I). The present invention further provides an improved process for the preparation of isoxazoline derivatives...
ABSTRACT
A NOVEL POLYMORPH OF SITAGLIPTIN HYDROCHLORIDE AND PROCESS FOR ITS PREPARATION THEREOF
The present invention provides a novel polymorphic form of Sitagliptin hydrochloride and processes for its preparation thereof.
ABSTRACT
“AN IMPROVED PROCESS FOR THE PREPARATION OF
ETHYL (Z)-2-CHLORO-2-(2-(4-METHOXYPHENYL) HYDRAZINYLIDENE) ACETATE”
The present invention relates to an improved process for the preparation of ethyl (z)-2-chloro-2-(2-(4-methoxyphenyl) hydrazinylidene) acetate formula (I).
ABSTRACT
“A PROCESS FOR THE PREPARATION OF1-(4-NITROPHENYL) PIPERIDIN-2-ONE”
The present invention relates to a process for the preparation of 1-(4-Nitrophenyl) piperidin-2-one of formula (I). The present invention further relates to a process for the preparation of 1-(4-Nitrophenyl) piperidin-2-one by oxidati...
ABSTRACT
A PROCESS FOR THE PREPARATION OF EDOXABAN AND ITS INTERMEDIATE
The present invention relates to a process for preparation of Edoxaban intermediate namely alkyl 2-[(5-chloropyridin-2-yl)amino]-2-oxoacetate compound of Formula-I.
The present invention also relates to a process for the preparation of ...