A process for the preparation of Sorafenib i.e. 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt, with improved yield and purity.

The invention relates to a process for preparation of Regorafenib tosylate (VI), comprising reacting 4-(4-amino-3-fluorophenoxy)-N- methylpicolinamide (IV) with 4-chloro-3-(trifluoromethyl)phenylisocyanate (V) in an organic solvent or mixture of organic solvent at temperature ranging from about 25 - 50 °C; addition ...