Disclosed herein is an improved, safe and novel method for the elimination of nitrosamine impurities during the preparation of sartan class of drugs containing tetrazole ring structure represented by general formula I, more particularly valsartan drug molecule of formula II. In particular, process of the present inv...

Recyclable Biocatalytic Process for Preparation of Sitagliptin comprising reuse of at least once used enzyme for the preparation of compound of Formula I in a biphasic solvent system comprising water and water immiscible organic solvent for stereoselective conversion of keto group of 4-Oxo-4-[3-(trifluoromethyl)-5...

Process for the preparation of carcinogenic azido impurities free Losartan and salts thereof Comprising using sartan catalyst that alleviates or minimizes carcinogenic impurities preferably Losartan azido of Formula III up to pharmaceutically acceptable limit.

ABSTRACT EFFICIENT PROCESS FOR PREPARATION OF APIXABAN HAVING CRYSTALLINE PARTICLES WITH D90 GREATER THAN 89 ?M A cost-efficient process for the preparation of Apixaban of Formula I having crystalline particles size distribution D90 greater than 89 µm comprising insitu slow cooling crystallization without is...