The present invention relates to the bicalutamide active ingredient substantially free of the impurities 4-Cyano-N-methacryloyl-3-trifluoromethylaniline (BIC-0) and 4-cyano-3-(trifluoromethyl) benzamido-2-methyl-l,2-epoxide (BIC-1). The invention also relates to a novel analytical method for estimation of impurities...

The invention disclosed in this applications relates to improved process for the preparation of 5-Carboxy phthalide useful as an intermediate for the preparation of Citalopram which comprises adding Terephthalic acid to Chloromethyl chlorosulphate, heating, adding water portion wise, filtering, centrifuging and wash...

The invention relates to an improved process for production of Bicalutamide useful in the treatment of prostate cancer by oxidizing N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methyl propanamide with Hydrogenperoxide in the presence of ethylacetate as solvent, methanesulfonic acid and ...