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This invention relates to chemoenzymatically biologically active compounds. This invention also relates to process for the preparation of the chemoenzymatically hydrolysable biologically active compounds.

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Hydroxyalkyl derivatives of biologically active compounds represented by the formula VII R2 I HO—L—Z'—D Formula - VII wherein R2 = H, C1-12 alkyl, C6-12 aryl, or -OH and D = Biologically active agent having functional groups such as L = spacer comprising (un)substituted alkyl, hydr...

The process of recovery of Pt/C catalyst from the hydrogenation of 6,9-imino ether is carried out by isolating spent Pt/C by filtration, reactivating the wet spent Pt/C with strong acid like perchloric acid and recycling the reactivated catalyst along with fresh catalyst in the weight ratio of 98:2 in next cycle of ...

A simple and economical process for the preparation of amorphous atorvastatin calcium in high purity and good yield from crystalline atorvastatin sodium without forming crystalline atorvastatin calcium is disclosed.

Process for preparing Clarithromycin of formula and also 6-O-methyl1-2’, 4"-O-bis (trimethylsilyl) erythromycin A 9-[O- (1-methoxy -1-methylethyl) oxime] of formula is carried out by selective methylation of 2’, 4"-O-bis (trimethylsilyl) erythromycin A 9-[O (1-methoxy-1-methylethyl) oxime] of formula with methylatin...

A synthetic bulk laxative which comprises a crosslinked graft polymer. It is formed of a hydrophilic monomer partially neutralised upto 75%, a polysaccharide gum upto 3% by weight and crosslinker upto 2% by weight.

A process for preparing 6,9-Imino ether from Erythromycin thiocyanate without isolating Erythromycin base and Erythromycin oxime and Beckmann's rearrangement if erythromycin oxime is carried in the presence biphasic solvent system comprising methylene chloride and water in the presence of triethylamine along with so...

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Disclosed herein is an improved process for synthesis of Ticagrelor, its intermediates in good yield and purity. The present invention further discloses novel crystalline Ticagrelor polymorph depicted in Fig 1.

A process for preparing 9-Deoxo-9a-aza-9a-homoerythromycin A which is an intermediate of Azithromycin dihydrate is carried out by hydrogenating 6,9-Imino ether in methanol as solvent to which 70% perchloric acid is added to adjust the pH to 5.5 in the presence of wet Pt/C catalyst at temperature in therange of 30º-5...

Disclosed herein is an improved and cost effective process for preparation of Nitroxoline (5-nitro-8-oxyquinoline) free from process related genotoxic impurities. The process of the present invention significantly controls the formation of the undesired side-product i.e. 7-Nitro nitroxoline during oxidation of 5-nit...

The present invention discloses a method for purification of crude beta blocker drugs such as atenolol, propranolol, metoprolol and bisoprolol etc. to improve the impurity profile of the same.