A process for preparation of clear aqueous composition of propofol suitable for parenteral administration is described. The compositions essentially consist of an inclusion complex of propofol with 2-hydroxypropyl-β-cyclodextrin. Complexation of propofol with 2-hydroxypropyl-β-cyclodextrin produces a clear aqueous c...
A process for manufacture of a low toxicity sterile Amphotericin B aqueous composition suitable for parenteral administration containing phospholipids and atleast 0.1% w/v sodium chloride; the process for manufacture comprising,
(i) dissolving one or more phospholipids in a single solvent or in a mixture of solvent...
The present invention provides stable, clear, aqueous Ifosfamide compositions for parenteral administration having reduced dose dependent toxicities of Ifosfamide. Also the compositions have reduced urotoxicity over and above the concomitant use of the uroprotective agent, Mesna. Aqueous compositions of Ifosfamide c...
A sterile, low toxicity, stable, aqueous, oxazaphosphorine-containing composition with mesna for parenteral administration has been described. The invention describes compositions that are stable and have low urotoxicity
Monoglycerides, especially Monolaurin, are used to protect intravenously administrable oil-in -water emulsion composition against growth of E. coli, P.aeruginosa S.aureus and C. albicans. The compositions can be medicaments containing lipophilic drugs, especially propofol, and/ or total intravenous nutritional compo...
The invention discloses a stable intravenous Propofol oil-in-water emulsion composition having mixed preservatives of low toxicity that is capable of withstanding accidental contamination of bacteria and fungi.The preservative system employed comprising of monoglyceryl ester of lauric acid(Monolarurin)and a member s...
The invention discloses an aqueous anaesthetic Propofol composition that is stable, autoclave sterilized, suitable for parental administration, having reduced incidence of pain upon injection. The composition comprises propofol, 2-hydroxypropyl-β-cyclodextrin and a local anaesthetic, Lignocaine.
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The present invention provides an injectable oil-in-water nanoemulsion having average particle size less than 200nm comprising: water insoluble drugs in the concentration of at least 0.01% w/v; oils selected from one or more vegetable oils such as Soya oil, olive oil; MCT oil or mixture thereof, in a concentration o...
The present invention discloses Propofol oil-in-water emulsion composition comprising capric and / or its water soluble alkali salts as preservative to prevent proliferation of microorganisms due to any accidental contamination of the composition during prolonged intravenous administration.
A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing , a plunger means having a plunger rod configured for stage wi...
The present invention is disclosing an automated and end of content blocking disposable injector system comprising a housing having an injection container with injecting content for delivery at a dispensing end, an injecting content pusher means in axial operative communication with the injection container for dosag...
The present invention relates to an improved purification process for isolating anti-Rhesus D monoclonal antibodies and their antigen-binding fragments. The improved process involves a series of purification techniques, including affinity chromatography, low pH inactivation, anion exchange and cation exchange chroma...