The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of inflammatory pain and/or symptoms of inflammatory pain, and to a method of treating and/or preventing inflammatory pain and/or symptoms of inflammatory pain using an anti-CGRP antibody.

The present invention relates to compounds of formula (I) to pharmaceutically acceptable salts therefore and to pharmaceutically acceptable solvates of said compounds and salts wherein the substituents are defined herein; to compositions containing such compounds; and to the uses of such compounds in the treatment o...

The invention relates to a process for the preparation of compounds of formula (I) wherein Q is a group selected from formulae (II) & (HI) and a group *-NR6 -Q -A or, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof, as well as intermediates u...

The invention relates to a dose unit for a dry powder inhaler comprising: - a dose carrier including a plurality of pockets (17) each adapted to contain a dose of medication powder suitable for inhalation, said pockets being sequentially arranged such that the content of the pockets (17) can be sequentially exposed ...

The present invention relates to solid molecular dispersion of fesoterodine hydrogen fumarate and a polymeric binder. The invention also relates to an inert core bead or particle which is coated with said solid molecular dispersion and to pharmaceutical formulations comprising such coated beads or particles. ...

An apparatus and method for heat sealing a lidding sheet to a base, wherein the apparatus including a press for pressing a lidding sheet onto a sealing surface of a base, the press including a relatively flexible face plate and the apparatus further including a system for applying pressure to the lidding sheet with ...

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular ...

The invention relates to imidazole derivatives to their use in medicine to compositions containing them to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new imidazole Na1.8 modulators of formula (I) or a pharmaceutically acceptable salt t...

The present invention relates to the xinafoate salt of N4-[(2,2-difluoro-4H-benzo[1,4]oxazin-3-one)-6-yl]-5-fluoro-N2-[3-(methylaminocarbonylmethylene oxy)phenyl]-2,4-pyrimidinediamine. This compound is a suitable drug substance and is useful in the treatment of conditions inc uding asthma.

A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R1 and R2 each Independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from ...

Chemical Compounds The present invention relates to imidazopyridazme derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5- c]pyridazine derivatives of formula (I) and pharmaceutically acceptable salts thereof, wherein R 1,R , R3, R4 and R5 are as defined in the description. The imidazopyrid...

This invention relates to novel glucocorticoid receptor agonists of formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their...

The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers therof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of...

DEVICE FOR DISPENSING A PLURALITY OF UNITARY DOSES (2) OF DRY POWDER, COMPRISING AT LEAST ONE SUPPORT COMPRISING CONDUITS EACH DEFINING A FLOW PATH FOR AN AIRSTREAM CARRYING ONE OF THE UNITARY DOSE (2), THE SUPPORT HAVING FIRST (26) AND SECOND (27) MEMBERS SECURED TO ONE ANOTHER SO THAT A FIRST CONDUIT PORTION (29) ...

The invention relates to an anti-CGRP antibody for use in the prevention and/or treatment of chronic pain and/or symptoms of chronic pain, and to a method of treating and/or preventing chronic pain and/or symptoms of chronic pain using an anti-CGRP antibody.

The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts wherein the substituents are as described herein and their use in medicine in particular as Trk antagonists.

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particul...

Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.

The invention provides compounds of formula (I): (I) wherein: m is 0, 1 or 2; X is O, S or N-CN; R is F, CI or CN; A is a C3.6 cycloalkylene group optionally substituted with aCH alkyl group; and B is a single bond or a C1-2alkylene group; or a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof....

A compound of Formula (II: or a pharmaccuticaliv and/or vet.n narily acceptable derivative thereof, wherein R , R , R , R , R . and R art as defined above.

This invention relates to synergistic combinations of non-steroidal anti- inflammatory drugs, particularly carprofen, with alpha-2-delta ligands, such as gabapentin or pregabalin, for veterinary treatment of pain and/or inflammation, particularly in dogs, cats and horses.

The invention provides a process for the production of a compound of formula (I), wherein Y is selected from CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX is hydroxy or O- M+, in which M+ is a cation selected from Li+, Na+ and K+, and Y is as defined...

A method and apparatus for filling with powder (4) a container (8) having an open end, including positioning an outlet of a hopper (2) containing powder above, the open end of the container (8), mechanically agitating the hopper so as to cause powder (4) to he transferred from the hopper to the container and mechani...

The invention relates to a new combination of an anti-MAdCAM antibody with an anti-fibrotic agent, such as a protease inhibitor, preferably a caspase inhibitor. The invention also relates to pharmaceutical compositions comprising the combination of the invention, and the use of the combination for the treatment of l...

The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain. ...

Compounds of formula (1), or a pharmaceufccally acceptable derivative thereof, wherein R and R independently represent H, C1-6alky], C3.gcycloalkyl, or halogen; R represents C1-6allcy], CF3 or aryl; a represents 1 or 2; R , R , R and R independently represent H, C1-6alkyl,C1-6a]kylaxy, CN or halogen, or R and R , or...

The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1 , R2 , R3 , R4 and R5 are each independently selected from H, halo, CN, CF3 and CONH2; compositions containing such compounds and th...

An apparatus lor dispensing small quantities of powder into a receptacle, the apparatus comprising a hopper (1), the hopper in use containing powder 10 be dispensed therefrom, a support for the hopper whereby the hopper can in use he held above a receptacle (8) into which the dispensed powder is to be received, at l...

An apparatus for dispensing small quantities of particles, the apparatus comprising a hopper (20) provided with a sieve at a bottom portion thereof, the hopper defining • powder-containing zone above The sieve which in use contains powder 10 be dispensed therefrom through (he sieve, a support (35) for the hopper, th...

A weighing apparatus comprising a weighing pan (20) for supporting on an upper surface the colof an object (21) lo be weighed, a support for the weighing pan (20'), (he support contacting a lower surface or the weighing pan and comprising an elongate member (23) extending downwardly from the weighing pan (.20), the ...

This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceuti-cally acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

The present invention relates to a polymorphic form B of A/-[3-tert-butyl-l-(3- chloro-4-hydroxyphenyl)-l H-pyrazol-5-yl]-N-(2-[(3-{2-[(2-hydroxyethyl)sulfanyl] phenyl}[l,2.4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]benzyl}urea (I) as defined herein. This polymorph is useful in the treatment of various conditions, parti...

The present invention relates is a class of melanocortin MCR4 agonists of genera! formula (1), wherein the variables and substitutes are as defined tierein and especially to selective MCR4 agonist compounds, to their use in medicine. particularly in the treatment of sexual dysfunction and obesity, to intermediates u...

The present invention relates to the use of a phosphodiesterase 7 (PDE7) inhibitor in the manufacture of a medicament for the treatment of neuropathic pain and to a method of treating neuropathic pain using an inhibitor of PDE7.

The invention relates to compounds of Formula (1) and to intermediates in the preparation of, compositions containing and uses of such derivatives. The compounds according to the present invention are P2 adrenergic receptor agonists and M3 muscarine receptor antagonists useful in numerous diseases, disorder and cond...

A device for dispensing individual doses of powder from respective pockets of a pair of carriers, the device including: a support for two disc shaped carriers, each disc shaped carrier having at least one substantially planar first side surface having an annular array of cavities in which respective pockets are form...

This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.

Use of anti-MAdCAM antibodies for the treatment of coeliac disease and tropical sprue The application relates to the use of an anti-MAdCAM antibody for the manufacture of a medicament for the treatment of coeliac disease and/or tropical sprue. Methods of treatment for coeliac disease and/or tropical sprue using a th...

The present invention relates to immune response modifiers of Formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions containing said inhibitors. These inhibitors have utilit...

The present invention relates to a method of treating pain using a compound of formula (I) wherein R1 , R2 , R3 and R4 are as defined herein. The invention also relates to certain novel derivatives of formula (I).

The present invention relates to the use of an anti-NGF antibody in the treatment or prevention of pain and/or a lower urinary tract symptom (LUTS) associated with interstitial cystitis and/or painful bladder syndrome and/or bladder pain syndrome.

The invention relates to compounds of formula processes and intermediates for their preparation, their use as muscarinic antagonists and pharmaceutical compositions containing them.

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, L and n are as defined in the specification. These compounds are useful as MC4 agonists.

This invention relates to a class of pyrrolidine compounds of formula (I), and pharmaceutically acceptable derivatives thereof, to their use in medicine, to compositions containing them, and to processes for their preparation. It also relates to intermediates used in the preparation of such compounds and derivatives...

This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. The present invention provides compounds of formula (I) wherein R1 R2, R3, R9, Rsa and Y are defined in the description. More particularly, the present invention relates to the use of ...

This invention relates to a range of 1-aryl-4-cyclopropylpyrazoies in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides. ...

The present invention relates to an inhaled formulation comprising a compound selected from a particular class of 5,6-dihydro-9$i(H)-pyrazolo[3,4-c]-1,2,4- triazolo[4,3-a]pyridines which is capable of delivering the compound as fine, solid particles to the lung and the use of such a formulation in the treatment of c...

A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective dcaggregation How paths for each pocket, split airstreams allowing improved entrainmen...

The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.

The invention provides 4 [2 (5 amino 1H pyrazol 4 yl) 4 chlorophenoxy] 5 chloro 2 fluoro N (1 3 thiazol 4 yl)benzenesulfonamide or a pharmaceutically acceptable salt thereof for the treatment of a disease associated with elevated blood uric acid levels such as hyperuricemia or gout. In another aspect the invention p...

This invention relates to the hydrochloride salt of 5-[3-(3-hydroxyphenoxy)azetidin-l-yl]-5- methyl-2,2-diphenyl-hexanamide or derived form thereof and its use as a medicament.

The invention relates to a novel crystallisation process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronisation. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then add...

The present invention relates to compounds of formula (I): wherein R1 R2, R3a R3b, R3c R3d and R100 are as defined in the specification These compounds act as 5-HT2C agonists.

The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds for the treatment of pain. ...

DEVICE FOR DISPENSING A PLURALITY OF UNITARY DOSES OF DRY POWDER, COMPRISING: - FIRST (25A) AND SECOND (25B) SUPPORTS, - AN INDEXING MECHAN ISM ADAPTED TO MOVE THE FIRST AND SECOND SUPPORTS (25), THE INDEXING MECHANISM AND THE SUPPORTS (25A, 25B) BEING CONFIGURED SO THAT IN A FIRST DISPENSING STATE OF THE DEVICE, TH...

An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pHwithin the range of 5.5 to 7, when measured as a 20 wt% aqueous slurry. The stability can also be aided by making the pharmaceuticalcomposition from amlodipine maleate particles having an ave...

The present invention relates to a class of EP2 antagonist azetidines of general formula (1) wherein the variables and substituents are as defined herein, and especially to EP2 antagonist compounds, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids (leiomyomata) and to ...

This invention relates to novel glucocorticoid receptor agonists of formula (I) and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their u...

The invention relates to a method for producing retinal pigment epithelial cells.