The present invention relates to stable microemulsion composition comprising Amphotericin B alongwith suitable excipients for intravenous administration, which is capable of providing safe, stable and an efficient formulation obtained by simple and rapid process.

Disclosed herein is stable, microemulsion injectable composition of anti cancer drug, paclitaxel for painless intravenous and intramuscular administration with suitable excipients like appropriate solubilizer, compatible pH stabilizer, and chelating agent which are very safe and improve the dissolution of poorly sol...

The present invention provides a commercially viable and stable lyophilized parenteral formulation and a method for preparing a pharmaceutical composition for intravenous administration. The invention provides lyophilized parenteral formulation comprising Rifampicin along with pharmaceutical acceptable excipients su...

The present invention relates to a process for the preparation of highly pure Lomoxicam. The crude Lornoxicam is reacted with solution of potassium hydroxide or potassium carbonate, sodium carbonate or sodium hydroxide, whereby high purity Lomoxicam salt is produced. This salt is subsequently converted into Lomoxica...

Disclosed herein is a synthetic method for preparation of Gefitinib which comprises i) reacting isovanilline with hydroxylamine hydrochloride in a suitable solvent in presence of dehydrating agent to convert aldehyde group into cyano- group to obtain compound (1); reacting compound (1) with 3-Morpholino-l- chlor...

Disclosed herein is a process for preparation N,N"-4,10-dioxa-3,11-dioxotridecylene-K 13-bis-tetrahydropapaverine(III), a precursor of Atracuriurn Besylate and its conversion to Atracurium Besylate, a neuro-muscular blocking agent. The novel method involving condensation of N-(2-carboxyethyl)-l-(3,4-dimethoSybenzyl)...

Disclosed herein is a process for the synthesis of Exemestane involving oxidation of 6-Methyleneandrost-4-ene-3, 17-dione (11) with systematic mode of addition of DDQ in the presence of organic carboxylic acid and a buffer. Rapid adsorption-desorption column chromatography combined with recrystallisation gave pharma...

A process for the preparation of Gemcitabine Hydrochloride (I) comprising: i) reacting 2,3-O-isopropylidene-D-glyceraldehyde and chiral auxiliary (1) by Evans and Crimmins asymmetric aldol reaction to obtain (2); ii) protecting hydroxyl group at 3’-position in compound (2) to give (3); iii) hydrolsing acetonide moie...

The present invention discloses a new improved synthetic process for the preparation of Erlotinib Hydrochloride involving 3,4-dihydroxybenzaldehyde as raw material which comprises reaction of 3,4-dihydroxybenzaldehyde with hydroxylamine hydrochloride to obtain cyano compound; which is further reacted with l-chloro-2...

Disclosed herein is stable intravenous microemulsion comprising propofol; wherein said microemulsion is characterized by comprising a surfactant, non-ionic polyoxyethylene-polyoxypropylene copolymer; a co-surfactant, non-ionic polyethylene glycol 660 hydroxystearate in a range of 0.2%-5% and 2%-25% respectively alon...

Disclosed herein is a stable pharmaceutical compositions comprising a core containing Chlorambucil as an active ingredient and a moisture resistance coat of 2 to 4 % of total tablet weight surrounding said core comprising one or more polymers in the range of 10 to 60% and plasticizer in the range of 5 to 15% along w...

Disclosed herein an improved process for the preparation of pure Pipecuronium bromide comprises passing of methyl bromide gas through a stirred solution of compound of formula (1) in an organic solvent at ambient temperature, followed by purification step. H,C. N CH3 (1)

Disclosed herein is a process for preparation of imatinib free base which comprises condensing 4-Methyl-N-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-l,3-diamine with 4-(4-Methyl-piperazin-l-ylmethy])-benzoic acid ester in the presence of base including organic bases and inorganic bases in an organic solvent to form ima...

The present invention provides a high yielding process for the preparation of Oxaliplatin by reacting (SP-4-2)-dichloro-[(lR,2R)-l,2-cyclohexanediamine-N,N"]platinum (II) with silver sulfate in water to form more stable diaqua sulfate salt of platinum (II), followed by treating with oxalic acid. Further, the present...

The present disclosure relates generally to an improved process for the preparation of Anastrozole, compound of formula (I). Anastrozole, compound of formula (I) is an anti-estrogenic anti-cancer drug which is used along with other medications in treatment and prevention of breast cancers. The disclosed process is f...

The present disclosure relates generally to an improved process for the preparation of Gemcitabine Hydrochloride, compound of formula (I). Gemcitabine Hydrochloride, compound of formula (I) is a nucleoside analog and used in chemotherapy of cancers. The disclosed process is best suited for an industrial production o...