The invention concerns a continuous process for the production of compounds having the general formula (6) comprising providing to a reaction zone a continuous stream of an alkyl acetate and a continuous stream of an alkali metal or alkaline earth metal amide base and contacting the continuous streams together in th...

The present invention relates to a reactor comprising a plurality of reaction zones, a first reaction zone being configured to provide a first residence time for a reaction mixture passing therethrough at a particular flow rate, and a second reaction zone connected in series with the first reaction zone and configur...

The present relation to a continuous process for the cyanation of hydrogenated β-ketoesters in a cyanation zone maintained under conditions of temperature and pressure effective for cyanation of a hydrogenated R-ketoesters. A substrate comprising a hydrogenated β-ketoesters is continuously supplied to the cyanation ...

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The invention concerns a process for the manufacture of substituted propionic acids comprising providing a substrate of formula (I): And subjecting the substrate to enantioselective hydrogenation under enantioselective hydrogenation conditions in the presence of an enantioselective hydrogenation catalyst comprising ...

The present invention concerns a metallocene-based phosphine ligand for use in enantioselective catalysis, the ligand having the Formula (I): Wherein M is a metal; Z is P or As; L is a suitable linker; R1 is selected from alkyl, alkoxy, alkylamino, cycloalkyl, cycloalkoxy, cycloalkylamino carbocyclic aryl, substitut...

The present invention concerns a catalytic composition comprising a catalyst effective for catalysing asymmetric hydrogenation reactions, which catalyst requires acid activation, an acidic material effective for activating the catalyst, and a buffering compound or composition capable of forming, in the presence of t...

The invention relates to a process for the production of chloramines comprising supplying a first reagent stream comprising chlorine gas and a second reagent stream comprising ammonia gas to a reaction zone maintained at a temperature of less than 275° C and configured to allow expansion of the first and second reag...

The invention provides a process for the manufacture of Hl 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with bis(methylsulphonoxymethyl) ether in a suitable solvent to form an intermediate compound, contacting said intermediate compound with isonicotinamide to form an O-protec...

The present invention provides a method of preparing a sulfonyl ether comprising the steps of: v) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate; vi) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at le...

The present invention relates to process for the production of chiral ligands comprising providing a starting material of Formula (A): wherein X is a chiral or achiral directing group; and (1) is an optionally substituted mono-or polycyclic aryl or cycloalkyl group; ortholithiating the substrate; converting the orth...

The present invention relates to metallocene-based phosphine ligands having chirality at phosphorus and at least one other element of chirality (planar chirality and/or chirality at carbon); and to the use of such ligands in asymmetric transformation reactions to generate high enantiomeric excesses of formed compoun...