TITLE OF THE INVENTION: ATTENUATION OF CYTOKINE RELEASE SYNDROME IN IMMUNOTHERAPY The present invention discloses a recombinant nucleic acid molecule encoded at least by an ORF (100, 100a) to lower a cytokine storm during immunotherapy. The recombinant nucleic acid molecule includes at least one first hairpin loop...

TITLE OF THE INVENTION: ATTENUATION OF CYTOKINE RELEASE SYNDROME IN IMMUNOTHERAPY The present invention discloses a recombinant nucleic acid molecule encoded at least by an ORF (100, 100a, 100b) to lower a cytokine storm during immunotherapy. The recombinant nucleic acid molecule includes at least one hairpin loop...

TITLE OF THE INVENTION: ATTENUATION OF CYTOKINE RELEASE SYNDROME IN IMMUNOTHERAPY The present invention discloses a recombinant nucleic acid molecule encoded at least by an ORF (100, 100a) to lower a cytokine storm during immunotherapy. The recombinant nucleic acid molecule includes at least one hairpin loop struc...

TITLE OF THE INVENTION: ATTENUATION OF CYTOKINE RELEASE SYNDROME IN IMMUNOTHERAPY The present invention discloses a recombinant nucleic acid molecule encoded at least by an ORF (100, 100a) to lower a cytokine storm during immunotherapy. The recombinant nucleic acid molecule includes at least one hairpin loop struc...

TITLE OF THE INVENTION: ATTENUATION OF CYTOKINE RELEASE SYNDROME IN IMMUNOTHERAPY The present invention discloses a recombinant nucleic acid molecule encoded at least by an ORF (100, 100a) to lower a cytokine storm during immunotherapy. The recombinant nucleic acid molecule includes at least one first hairpin loop ...

TITLE OF THE INVENTION: DELIVERY SYSTEM AND METHOD OF PREPARATION THEREOF The present disclosure discloses particle (100) including at least one bi-layer outer membrane (110), a plurality of vacuoles (130) and at least one payload (150). The bi-layer outer membrane (110) defining a lumen (110a) including an outer l...

TITLE OF THE INVENTION: SYNTHETIC DELIVERY SYSTEMS AND CONJUGATES THEREOF A synthetic delivery system (100) for targeted delivery of an agent (200) including a tetravalent atom/moiety, at least one first spacer (120), at least one linker (130), one or more second spacers (140), and a plurality of ligands (150). The...

TITLE OF THE INVENTION: CRISPR-MEDIATED GENE EDITING TO INDUCE FETAL HEMOGLOBIN The present disclosure discloses a gene editing system (100) to induce expression of fetal hemoglobin (HbF) in hematopoietic stem cells (HSCs). The gene editing system (100) includes a guide RNA (gRNA 110) extending between a 5’end and ...

TITLE OF INVENTION: DELIVERY SYSTEM FOR CRISPR CAS COMPONENTS The present disclosure discloses particle (100) including at least one bi-layer outer membrane (110), a plurality of vacuoles (130) and at least one payload (150). The bi-layer outer membrane (110) defining a lumen (110a) including an outer layer (111) a...

TITLE OF THE INVENTION: ATTENUATION OF CYTOKINE RELEASE SYNDROME IN IMMUNOTHERAPY The present invention discloses a recombinant nucleic acid molecule encoded at least by an ORF (100, 100a, 100b) to lower a cytokine storm during immunotherapy. The recombinant nucleic acid molecule includes at least one hairpin loop ...

TITLE OF THE INVENTION: MRNA BASED ENZYME PRECURSOR AND PREPARATION METHOD THEREOF The present disclosure discloses a recombinant construct including a vector and a recombinant nucleic acid molecule (1). The vector including at least one promoter region (13). The recombinant nucleic acid molecule (1) is encoded at ...

TITLE OF THE INVENTION: SURFACE MODIFICATION OF LENTIVIRAL PARTICLE AND PRODUCER CELL THEREOF The present disclosure discloses a genetic cassette (100) including one or more promoters (103), and one or more genes disposed downstream of the one or more promoters (103). The one or more genes including at least one of...