The invention discloses a process for preparation of highly pure dialkyl pemetrexed by reacting a 2-(4-hydroxy-6-aminopyrrolo(2,3-d)pyrimidin-3-y])ethylbenzoic acid with a glutamatic acid diester or its salt in presence of a safe, mild, inexpensive, non-oxidative and easy to handle reagent such as substituted triphe...
Disclosed herein is a freeze dried composition of atracurium besylate comprising atracurium besylate; an acid to adjust the pH and a co-solvent along with water as a principle solvent.
Disclosed herein is stable freeze dried composition of atracurium besylate which comprises atracurium besylate; an acid to adjust the pH and polyvinyl Pyrolidone.
The invention discloses a novel process for highly chemoselective reactions of substituted anilines without any detectable reaction at aromatic amino group. The invention also relates to a novel process for preparation of neostigmine methylsulphate via chemoselective reaction of 3-amionphenol and aryl dimethylcarbam...
The invention discloses a novel method for preparing neuromuscular blocking agents using aryl esters as a reagent of di-acylation as well as highly regioselective mono-acylation of androstane-diols.
The invention discloses a novel process for quaternization of (2β,3α,5α, 16β, 17β)-2,16-bispiperidino-3,17-diacetoxy-5-androstane with methyl bromide in presence of a cyclic ether. The invention further discloses purification of quaternary salt to provide highly pure vecuronium bromide with unspecified impurity leve...
The invention discloses compositions of clear injectable solution which comprises Midazolam, pentazocine, tonicity agent, chelating agent, and acids to adjust pH.
The invention discloses a process for enantiomeric enrichment of 2",6"-pipecoloxylidide using a chiral carbamoyl benzoic acid to provide (S)-enantiomer in high yield and high enantiomeric purity. The invention also discloses novel intermediates formed in the process of enantiomeric enrichment of 2",6"-pipecoloxyIidi...
The invention discloses a novel process for preparation of succinylcholine chloride via transesterification of succinic acid diester with choline chloride.
The present invention discloses solid oral formulation of etoposide, i.e. 4'-demethylepipodophillotoxin-9-(4,6-O-ethylidene-p-D-glucopyranoside ), comprising free flowing granules of Etoposide in hard gelatin capsules with good oral bioavailability.
The invention discloses a one-pot economical process for preparation of highly pure 6-[(l-methyl-4-nitro-lH-imidazol-5-yl)thio]-lH-purine by reacting 6-mercaptopurine with 5-halo-l-methyl-4-nitro-lH-imidazole in presence of a base in aqueous medium.
Disclosed herein is a stable aqueous injectable pharmaceutical composition comprising Diclofenac sodium as an active ingredient in an amount of 2.5% to 2.625%, a chelating agent in an amount of 0.01% 0.02% and other pharmaceutically acceptable excipients, wherein the said formulation is free of propylene glycol.
...
Disclosed herein is a stable aqueous injectable pharmaceutical composition of 75mg of Diclofenac Sodium in I ml solution having viscosity of 0.5 to 1.5 mm2 / sec, wherein said composition is characterized by comprising a single co-solvent/solubilizer in an amount of 20 to 60% and water as principle solvent.
...
The invention discloses a novel process for preparation of highly pure 3-dimethylaminophenyl dimethylcarbamate via formation of aryl dimethylcarbamate which can be easily obtained from diaryl carbonate and dimethylamine.
The invention discloses a process for preparation of (dl)-norepinephrine salt by reacting 3,4-dihydroxy-a-haloacetophenone with hexamethylenetetramine to provide hexamine salt; followed by hydrolysis and hydrogenation. The invention also discloses a novel intermediate formed in the process and its synthesis.
...
The present invention discloses a pharmaceutical composition comprising non-sticky, free flowable, dried granules of essential phospholipid as active ingredient along with pharmaceutically acceptable excipients encapsulated into hard gelatin capsules and to the process of preparation thereof.
A highly stabilized, economic and less viscous (after reconstitution), lyophilized injectable composition of Lorazepam is disclosed. The composition of the present invention is very stable for longer period at room temperature with optimum bioavailability and desirable pharmaceutical properties.
...
This invention discloses new stable lyophilized preparations of Cyclophosphamide for injection with excellent storage stability, less reconstitution time and to a process for their preparation. The invention further discloses Cyclophosphamide for injection obtained by reconstitution of the lyophilized products descr...
Disclosed herein are free flowable, nonsticky essential phospholipid granules with optimum stability, good compressibility suitable for preparation of solid oral tablet formulation. The formulation comprises essential phospholipid derived from soya lecithin as an active ingredient preferably with Adsorbent, Binder, ...
The present invention discloses an improved process for preparation of highly pure cyclopentyl mandelic acid derivative of formula (I), an intermediate of glycopyrrolate, without using hazardous chemicals.
The present invention discloses an improved process for preparation of substantially pure pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxy-1H-isoquinoline-2-propionate), a compound of formula I and its acid addition salts in good yields. Pentamethylene bis(1-(3,4-dimethoxybenzyl)-3,4-dihydro-6,7-...