The present invention provides an alternate simple, one pot reaction for the larger scale manufacture of Linagliptin (I) by reaction of alkylidenepiperidin-3-amine rcprcscntcd by a general formuIa( XIV) with l-[(4-methyl-quinazolin-2-yl) methyl]-3-methyl-7-(2-butyn-l-yl)-8-haloxanthine (VIII), using suitable solvent...

The present invention relates to a simple and cost effective improved process for the synthesis of Apronal (compound of formula 1) and of related intermediate alkyl 2-isopropyl-4-pentenoate of Formula (4) is used in the synthesis of Apronal namely allyl isopropyl acetyl urea of Formula (1). The process comprises of ...

The present invention relates to a single pot process for the manufacture of Linagliptin (I) by reacting 8-bromo-7-(but-2-ynyl)-1H-purine-2,6(3H,7H)-dione (XII) with 2-(chloromethyl)-4-methylquinazoline (XIII) followed by amination using (R)-piperidine-3-amine or HCI salt thereof in the presence of base in polar org...

The present invention provides an alternate simple, single stream process for the larger-scale manufacture of (S)-2-aminobutanamide hydrochloride (II) comprising of; (S)-2-amino butanoic acid represented by general formula (I-A) with Thionyl Chloride, using lower alcoholic solvent, without any catalyst to get a corr...

A method for the large-scale manufacture of [.evetiracetam (I) comprising reaction of (S)-2-Amino butyric acid (II A) with aliphatic alcohol in presence of Thinly Chloride to form a corresponding ester intermediate (Nil). Further, the ester intermediate (III), without isolation, reacts with Ammonia to form amide int...