Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6.alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, - CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)pO(CH2)qOR2 wherein each R2 is in...

Compounds of general formula (1) wherein R', R2, R3 and R4 are independently hydrogen, halo.C1-C6 alkyl, -OC1-C6 alkyl), -CON(RU)2 , -SO11, -SO2R11 –SO1N(R11)2, -N(R11)2, -NR11COR11, -CO2R11, -COR11, -SR11, -OH, -NO2 or -CN; each Ru is independently hydrogen or C1 -C6 alkyl; R5 and R6 are each independently hydrogen...

The invention relates to a microcrystalline form of a compound which is an inhibitor of PGD2 at the CRTH2 receptor. The microcrystalline form is obtained from a simple chemical reaction without the need for a milling process.

Compounds of general formula (I) wherein R is phenyl optionally substituted with one or more halo substituents ; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhini...

Compounds of general formula (I) and their pharmaceutically acceptable salts, hydrates, solvates, complexes and prodrugs are useful in the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

Compounds of general formula: (1) wherein R' is halo or cyano; R2 is C,-C4 alkyl; and R is phenyl substituted with one or more siibslilnenls chosen from C1 C-V, alkyl, halo or -SO2Crd alkyl); or a pharmaceutically acceptable salt, hydrate, solvate, complex 01 prodrug (hereof; arc usclul in the treatment of d...

The potassium, sodium, ammonium, lysine, diethylamine, tromethamine (TRIS), piperazine, ethylenediamine and ethanolamine salt of a compound of general formula (I): wherein R' is halo or cyano; R2 is C1-C4 alkyl; and R3 is quinolyl or phenyl substituted with methane sulfonyl; can be synthesised by a novel method and ...