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The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion protein may further comprise a linker sequence or hinge portion which joins the Fc receptor binding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typ...

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The present invention relates to methods for the production of heat shock protein complexes for use in vaccine compositions. In particular there is provided a method for increasing the level and immunogenicity of heat shock protein complexes produced in cells by subjecting the cells to specific stress inducing stimu...

The present invention provides an improved method for the purification of a mixture of complexes comprising a stress protein complexed to a peptide or peptide fragment from a source mixture  typically a cell lysate. The method of the invention provides for protein complexes to be purified using ion exchange chromato...

The present invention relates to a method for producing and isolating specific immunogenic heat shock protein from cancer cells or virally infected or recombinant cells and vaccines prepared from such proteins.

VACCINE AGAINST INTRA-CELLULAR PATHOGENSABSTRACTThe present invention relates to a method for producing and isolating specific immunogenic heat shock proteins induced by heat or tumour necrosis factor treatment of cells infected by intra-cellular pathogens; and vaccines prepared from such protein...