ABSTRACT
NOVEL POLYMORPHS OF DOLUTEGRAVIR AND SALTS THEREOF
The present invention relates to novel crystalline forms of dolutegravir, process for its preparation and pharmaceutical composition comprising them.
ABSTRACT:
The present invention generally relates to crystalline forms of Lumacaftor, processes for its preparation and pharmaceutical compositions thereof. The present invention also relates to an improved process for preparation of Lumacaftor.
The present invention relates to a process tor the preparation of disodium salt of pyrroloquinoline quinone. Also relates to novel polymorphic form of pyrroloquinoline quinone disodium salt and process for its preparation.
The present invention relates to a process for the preparation of carbamoylpyridone HIV integrase inhibitors and pharmaceutically acceptable salts thereof. The present invention specifically relates to a process for the preparation of carbamoylpyridone HIV integrase inhibitors such as dolutegravir, cabotegravir and ...
The present invention generally relates to novelsolid forms of lumacaftor, including amorphous form, solvates and/or polymorphs, processes for their preparation, pharmaceutical compositions containing the same and to their use in therapy.
The present invention relates to solid forms of empagliflozin, in particular empagliflozin co-crystals, solvates and/or their polymorphs, processes for their preparation and a pharmaceutical composition containing the same.
Methods for particle size reduction of Pirfenidone.
The present invention provides the process for particle size reduction of pirfenidone by wet
milling techniques selected from colloid mill, ultrasonicator or high speed homogenizer.
A process for preparing 0- ketoester of formula (m) comprises; (a)condensing alkyl 3-formylbenzoate with 7-Chloroquinaldine to give alkyl 3-[((7-chloro-2-quinolinyl) ethenyl)] benzoate; and (b) reacting alkyl 3-[((7-chloro-2-quinolinyl) ethenyl)] benzoate with an alkyl ester in presence of metal hydride/metal alkoxi...
The present invention provides solid forms of SGLT2 inhibitors, to processes for their preparation and their use in the purification of SGLT2 inhibitors and also provided pharmaceutical compositions comprising them and their use in therapy.
ABSTRACT
PROCESS FOR PREPARATION OF CHLORANTRANILIPROLE OR A SALT THEREOF
The present invention generally relates to a process for preparation of chlorantraniliprole or a salt thereof by reaction of formula II with methyl amine, wherein “R” is selected from straight or branched chain C1-6 alkyl group.
Fo...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF CHLORANTRANILIPROLE OR A SALT THEREOF
The present invention generally relates to a process for preparation of chlorantraniliprole or a salt thereof. Further, the present invention relates to an improved process for preparation of intermediate of chlorantranilipro...
ABSTRACT
“PROCESSES FOR PURIFICATION OF BICTEGRAVIR INTERMEDIATES”
The present invention generally relates to a process for purification of (2R,5S,13aR)-8-methoxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5] pyrazino [2,1-b] [1,3] oxazepine-10-carboxylic acid of Formula I and (2R,5S,13aR...
ABSTRACT
PROCESS FOR THE PREPARATION OF AMORPHOUS CANAGLIFLOZIN SUBSTANTIALLY FREE OF HYDROPEROXIDE IMPURITY
The present invention provides process for the preparation of amorphous canagliflozin substantially free of hydroperoxide impurity. The present invention also provides pharmaceutical compositions compri...
The present invention relates to granules containing pirfenidone and a sugar alcohol, and, furthermore, to the use of the granules for the preparation of an immediate-release tablet or capsule.
ABSTRACT
AN IMPROVED PROCESS FOR 3-(4-METHYL-1H-IMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL) ANILINE
The present invention relates to an improved process for the preparation of 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) aniline of Formula (I).
ABSTRACT
PROCESS FOR PREPARATION OF 2-AMINO-5-HYDROXY PROPIOPHENONE
The present invention relates to a process for preparation of 2-Amino-5-hydroxy propiophenone, a key intermediate for the synthesis of camptothecin analogs including 7-Ethyl-10-hydroxycamptothecin (SN-38).
ABSTRACT
NOVEL PROCESSES FOR PREPARATION OF TEZACAFTOR
The present invention generally relates to processes for preparation of Tezacaftor and pharmaceutical composition comprising the same. The present invention also encompasses novel intermediates of tezacaftor, processes for its preparation and use of said i...
ABSTRACT
POLYMORPHIC FORMS OF VENETOCLAX AND ITS PREPARATION THEREOF
The present invention provides novel crystalline polymorphic forms of venetoclax and its processes for preparation thereof. The present invention also relates to processes for preparation of amorphous form of venetoclax and pharmaceutical com...
ABSTRACT
CRYSTALLINE FORM OF NILOTINIB HYDROCHLORIDE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
The present invention relates to novel crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical composition comprising the same.
...
The present invention relates to a process for preparation of dolutegravir intermediate compound of formula V, wherein R represents alkyl, aryl or aralkyl group;
Formula V
The present invention generally relates to an improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof and preparation thereof. The present invention also relates to crystalline forms of monophenyl PMPA an important intermediate of tenofovir alafenamide and their pre...
The present invention generally relates to a process for preparation of 9-halo-3-(2-haloacetyl)- 10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one of Formula I, which is an intermediate in the preparation of Hepatitis C Virus (HCV) inhibitors.
ABSTRACT
The present invention relates to stable pharmaceutical composition of canagliflozin comprises one diluent, one disintegrant and one or more pharmaceutically acceptable excipients and also process for preparing the composition.
The present invention generally relates to an improved process for preparation of velpatasvir or a pharmaceutically acceptable salt thereof of Formula I.
ABSTRACT
METHOD FOR PREPARATION OF PYRAZOLE-CARBOXYLATE INTERMEDIATES
The present invention generally relates to an improved process for preparation of pyrazole-carboxylate intermediate of Formula II, an intermediate for preparation of certain anthranilamide compounds, for example chlorantraniliprole and cyantrani...
The present invention relates to novel polymorph of eluxadoline namely Form A. The present invention also relates to novel solvates of eluxadoline and process for the preparation and use thereof in the preparation of eluxadoline Form Aand its pharmaceutical composition comprising the same.
“An improved process for preparation of lopinavir and its intermediates thereof”
The present invention generally relates to an improved process for preparation of lopinavir
and its intermediates through formation of tartrate salt of compound of Formula III.
N
NH2
OH
Formula III
ABSTRACT
A PROCESS FOR THE PREPARATION OF PALBOCICLIB
The present invention relates to a process for the preparation of palbociclib, especially a process for the preparation of palbociclib having specific surface area greater than 2 m2/g.
ABSTRACT
A PROCESS FOR PURIFICATION OF PROTECTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVES
The present invention relates to a process for purification of protected polycyclic carbamoylpyridone derivatives and its conversion to polycyclic carbamoylpyridone derivatives or its pharmaceutically acceptable salts the...
ABSTRACT
“POLYMORPHIC FORMS OF APALUTAMIDE AND ITS PREPARATION THEREOF”
The present invention relates to novel crystalline polymorphic forms of apalutamide. The present invention also relates to processes for preparation of amorphous form of apalutamide and pharmaceutical composition containing the same.
...
ABSTRACT
PURIFICATION METHOD OF CARFILZOMIB
The present invention relates to a process for purification of carfilzomibfree from its impurities using preparative high performance liquid chromatography (prep-HPLC).
ABSTRACT
“PROCESS AND POLYMORPHIC FORMS OF BICTEGRAVIR AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS OR CO-CRYSTALS THEREOF”
The present invention generally relates to polymorphic forms of bictegravir, its salts, co-crystals, solvates or hydrates thereof and process for the preparation of the same and also relates...
ABSTRACT
PURIFICATION METHOD OF CABAZITAXEL
The present invention relates to a process for purification of cabazitaxel free from its impurities using preparative high performance liquid chromatography (HPLC).
The present invention relates to stable amorphous form of sacubitril valsartan trisodium complex and its solid dispersion compounds, processes for their preparation and pharmaceutical composition comprising the same. The present invention also relates to an improved process for the preparation of sacubitril sodium a...
ABSTRACT
SOLID FORMS OF TEZACAFTOR, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
The present invention relates to solid forms of Tezacaftor, including its co-crystals, solvates, hydrates and/or polymorphs, processes for their preparation, pharmaceutical compositions containing the sa...
ABSTRACT
ORAL FILM OF HIV DRUGS
The present invention provides oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof, which is useful for the treatment of HIV infections. Further the present invention provides composition and process for preparing oral film of HIV/Anti-retrovi...
The present invention relates to process for the preparation of Empagliflozin or its co- crystals, solvates and/or polymorphs thereof. The present invention also relates to novel intermediates used therein, and process for the preparation thereof. The present invention further relates to process for preparation of a...
The present invention relates to stable amorphous form of sacubitril valsartan trisodium complex and its solid dispersion compounds, processes for their preparation and pharmaceutical composition comprising the same. The present invention also relates to an improved process for the preparation of sacubitril sod...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF 2-AMINO-5-CHLORO-N-3-DIMETHYL BENZAMIDE
The present invention generally relates to an improved one-pot process for preparation of 2-amino-5-chloro-N-3-dimethylbenzamide of Formula IV, an intermediate for preparation of chlorantraniliprole.
Formula IV
...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF 2-AMINO-5-CHLORO-N-3-DIMETHYL BENZAMIDE
The present invention generally relates to an improved one-pot process for preparation of 2-amino-5-chloro-N-3-dimethylbenzamide of Formula IV, an intermediate for preparation of chlorantraniliprole.
Formula IV
...
ABSTRACT
PROCESS AND CRYSTALLINE FORMS OF LUMACAFTOR
The present invention generally relates to crystalline forms of Lumacaftor, processes for its preparation and pharmaceutical compositions thereof. The present invention also relates to an improved process for preparation of Lumacaftor.
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF TRIGONELLINE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention generally relates to an improved process for the preparation of Trigonelline or pharmaceutically acceptable salts thereof and to processes for its purification.
...
ABSTRACT
PROCESS FOR PREPARATION OF CABOTEGRAVIR
The present invention relates to a process for preparation cabotegravir and its intermediates thereof. The present invention further relates to a process for purification cabotegravir and its pharmaceutical composition thereof.
ABSTRACT
PURIFICATION OF (2R,5S,13AR)-8-METHOXY-7,9-DIOXO-N-[(2,4,6-TRIFLUOROPHENYL)METHYL)]-2,3,4,5,7,9,13,13A-OCTAHYDRO2,5-METHANOPYRIDO-[1’,2':4,5]PYRAZINO[2,1-B][1,3]-OXAZEPINE-10-CARBOXAMIDE
The present invention generally relates to a process for purification of (2R,5S,13aR)-8-methoxy7,9-dioxo-N-[(2,4,6-trif...
ABSTRACT
“A PROCESS FOR PURIFICATION OF VENETOCLAX OR ITS PHARMACEUTICALLY ACCEPTABLE SALT THEREOF”
The present invention relates to a process for purification of venetoclax or its pharmaceutically acceptable salt thereof and pharmaceutical composition containing the same.
ABSTRACT
A PROCESS FOR PURIFICATION OF POLYCYCLIC-PYRIDONE COMPOUNDS
The present invention generally relates to a process for purification of polycyclic-pyridone compounds, specifically compound of Formula XI, an intermediate for preparation of cabotegravir.
Formula XI
wherein “Y” -represents hydrogen, c...
ABSTRACT
“A NOVEL INTERMEDIATE OF DOLUTEGRAVIR AND A METHOD OF PREPARATION THEREOF”
The present invention relates to a process for preparation of dolutegravir intermediate compound of formula VII, wherein R represents alkyl, aryl or aralkyl group; R1 and R2 independently represent an alkyl.
...
The present invention relates to a process for preparation of dolutegravir intermediate compound of formula IV, wherein R represents alkyl, aryl or aralkyl group.
Formula IV
ABSTRACT
MONOLAYER TABLET OF DOLUTEGRAVIR AND LAMIVUDINE
The present invention relates to a monolayer tablet composition comprising a) Dolutegravir and b) lamivudine and one or more pharmaceutically acceptable excipients. Specifically present invention relates to a monolayer tablet comprising Dolutegravir and ...
ABSTRACT
POLYMORPHIC FORMS OF MOLNUPIRAVIR AND ITS PREPARATION THEREOF
The present invention relates to solid forms of molnupiravir, including its co-crystals, solvates, hydrates and/or polymorphs, processes for their preparation, pharmaceutical compositions containing the same.
ABSTRACT
A PROCESS FOR PREPARATION OF CABOTEGRAVIR OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention generally relates to a process for preparation of cabotegravir or its pharmaceutically acceptable salts thereof using a stable compound of Formula II; wherein R1 and R2 represents C1-6 a...
ABSTRACT
ORAL FILM OF CFTR MODULATOR(S)
The present invention provides oral film(s) of Cystic fibrosis transmembrane conductance regulator (CFTR) modulator(s) or a pharmaceutically acceptable salt thereof. Further the present invention provides composition and process for preparing oral film(s) comprising Cyst...
ABSTRACT
PROCESS FOR PREPARATION OF POLYMORPHIC FORM OF CABOTEGRAVIR SODIUM
The present invention generally relates to a process for preparation of polymorphic form of cabotegravir sodium and pharmaceutical composition thereof. Specifically, the present invention relates to a process for preparation of crystal...
ABSTRACT
ORAL FILMS OF ANTI-EMETIC DRUGS
The present invention relates to new oral dosage forms of Anti-emetic drugs and its pharmaceutically acceptable salts thereof for veterinary use, such as for oral administration to animals. More specifically the present invention provides compositions and process for pr...
ABSTRACT
ORAL FILMS OF ANTIPRURITIC DRUGS
The present invention relates to new oral dosage forms of Antipruritic drug(s) and its pharmaceutically acceptable salts thereof for veterinary use, such as for oral administration to animals. More specifically the present invention provides compositions and process fo...
ABSTRACT
ORAL FILMS OF ANTI-PARASITIC DRUGS
The present invention relates to new oral dosage forms of Anti-parasitic drugs and its pharmaceutically acceptable salts thereof for veterinary use, such as for oral administration to animals. More specifically the present invention provides compositions and process ...
ABSTRACT
ORAL FILMS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
The present invention relates to new oral dosage forms of Non-steroidal anti-inflammatory drugs (NSAIDs) and its pharmaceutically acceptable salts thereof for veterinary use, such as for oral administration to animals. More specifically the present i...
ABSTRACT
ORAL FILM OF HIV DRUGS
The present invention provides oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof, which is useful for the treatment of HIV infections. Further the present invention provides composition and process for preparing oral film of HIV/Anti-retrovi...
ABSTRACT
ORAL FILM OF HIV DRUGS
The present invention provides oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof, which is useful for the treatment of HIV infections. Further the present invention provides composition and process for preparing oral film of HIV/Anti-retrovi...
ABSTRACT
ORAL FILM OF HIV DRUGS
The present invention provides oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof, which is useful for the treatment of HIV infections. Further the present invention provides composition and process for preparing oral film of HIV/Anti-retrovi...
ABSTRACT
ORAL FILM OF HIV DRUGS
The present invention provides oral film of HIV/Anti-retroviral drugs and its pharmaceutically acceptable salt thereof, which is useful for the treatment of HIV infections. Further the present invention provides composition and process for preparing oral film of HIV/Anti-retrovi...
ABSTRACT
“PROCESS FOR PREPARATION OF AZABICYCLO [3.1.0] HEXANE INTERMEDIATES”
The present invention generally relates to a process for preparation of azabicyclo [3.1.0] hexane intermediate of Formula-I, an intermediate for preparation of certain antiviral compounds for example boceprevir and nirmatrelvir.
...
ABSTRACT
AN IMPROVED PROCESS FOR THE PREPARATION OF TENOFOVIR ALAFENAMIDE MONOFUMARATE
The present generally relates to an improved process for the preparation of tenofovir alafenamide monofumarate by treating tenofovir alafenamide with fumaric acid having particle size less than 120 µm.
...
ABSTRACT
AN IMPROVED PROCESS FOR PREPARATION OF CYANTRANILIPROLE OR A SALT THEREOF
The present invention relates to process for preparation of 2-amino-5-cyano-N, 3-dimethyl benzamide of Formula V, an intermediate for preparation of cyantraniliprole or a salt thereof. The present invention further relates to an...
ABSTRACT
A PROCESS FOR PURIFICATION OF SITAGLIPTIN OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
The present invention relates to an improved process for the preparation of pure Sitagliptin or pharmaceutically acceptable salts thereof, particularly sitagliptin hydrochloride or sitagliptin phosphate substantiall...