The present invention discloses an improved process for the preparation of thebaine from oripavine including the steps of; (a) adding an alkoxide prior to methylation of oripavine solution in inert organic solvent with a suitable methylating agent, (b) extracting the reaction mass in said inert organic solvent and w...
The present invention discloses an improved, simple, efficient, selective process for the preparation of NAL derivatives of formula II, its acid addition salts in high yield and purity from noroxymorphone. The Nal derivatives of formula II are known to possess narcotic agonist/antagonist properties with very low sid...
The invention discloses naltrexone implantable tablets which are devoid of metal salts and corticosteroids, and which provide consistent and controlled amount of naltrexone for 3 months or more; also disclosed is methods of treatment comprising the implants and methods of sterilization of the implants.
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This invention discloses stable, small volume parenteral dosage form with higher systemic bio-availability and lower toxicity of sodium aminosalicylate. This lyophilized formulation comprises combination of sodium aminosalicylate, polyvinyl pyrrolidone and stabilizers. The formulation is stable at temperature l...
Described herein is a process for the preparation of nalbuphine or its pharmaceutically acceptable salts which is substantially free from the undesirable β- epimer. Also disclosed are the novel intermediates viz N-ethoxycarbonyl- 10-acetoxynorcodeinone (III), N-ethoxycarbonyl 14-acetoxynorcodeine(lV), N-ethoxy carbo...
Disclosed herein is a process for the preparation of 4,5 α-epoxy-3,14-dihydroxynormorphinan-7-ene-6-one (Formula V) including the steps of; (i) N-demethylating 4,5 a-epoxy-3,34-diacetoxy-17-methyl morphinan-7-ene-6-one of Formula III to form N-ethoxycarbonyl-4,5 a-epoxy-3,14-diacetoxy normorphinan-7-ene-6-one of For...
The present invention discloses an efficient industrial process for the preparation of 21-cyclopropyl-7a-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydro-oripavine, i.e Buprenorphine of Formula-I in high yield and purity, with enhanced safety and eco-friendly norms. The invention further relates...
The present invention discloses a short, simplified and eco-friendly process for producing Nalbuphine or its pharmaceutically acceptable salts thereof. In particular, the process of the present invention avoids use of any hazardous, corrosive and pyrophoric chemicals and the product formed is substantially free of i...
[Class : 5] Pharmaceutical, Medicinal And Ayurvedic Preparations And Substances; Dietetic Food And Substances Adapted For Medical Use, Dietary Supplements For Humans; Nutritional Supplements; Nutraceutical Preparations For Therapeutic Or Medical Purposes; Nutraceuticals For Use As Dietary Supplements
[Class : 5] Pharmaceutical, Medicinal And Ayurvedic Preparations And Substances; Dietetic Food And Substances Adapted For Medical Use, Dietary Supplements For Humans; Nutritional Supplements; Nutraceutical Preparations For Therapeutic Or Medical Purposes; Nutraceuticals For Use As Dietary Supplements