The invention relates to a new process for the synthesis of 6, 7-bis(2-methoxyethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine hydrochloride (erlotinib hydrochloride) of
formula-I
Formula-I
by reacting 6,7-bis(2-methoxyethoxy)-4-chloroquinazoline of formula-II
Formula-II
with 3-aminophenylacetylen...
The invention relates to stable, free flowing and non-hygroscopic a-crystalline form of methane sulfonic acid salt of 4-(4-methyl piperazin-1-yl methyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl amino)phenyl]-benzamide (imatinib mesylate). A process for the preparation of the a-crystal polymorph is also described...
[Class : 5] Medicinal And Pharmaceutical Preparations.
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