The present disclosure relates to a methodology that identifies the underlying mechanisms that lead to hepatotoxicity. This is done by using the alterations in cellular metabolite profiles obtained before and after therapy/drug treatment in combination with a model of liver metabolism. Subsequently, by using a covar...

Apparatuses (including devices and systems) and methods for determining if a patient will respond to a variety of cancer drugs.

This invention proposes a method and system to draw the structure of a compound ("query"), to run a similarity search against compounds in an interactions database, to define target compounds similar to the query compound, and then to check the interactions of these target compounds. This method allows for checking ...

The present invention relates to a method and system for elucidating, enriching, compiling, analyzing, storing and retrieving pathophysiological mechanisms of a drug induced toxicological phenomena using a combination of text-mining, network building and biological significance algorithms. It provides a map, the uni...

The attached disclosure provides a systems approach based on mathematical modelling of the kinetics of essential biochemical pathways involved in organ homeostasis. When this in silico model is coupled with in-vitro and/ or in-vivo measurements to quantify drug-induced perturbations, a powerful platform that allows ...

METHOD FOR DETECTING CANCER THROUGH CELL-FREE DNA METHYLATION PATTERNS IN SUBJECT AND DIAGNOSTIC DEVICE THEREFOR ABSTRACT The present disclosure provides at least one method for detecting at least one cancer through cell-free DNA (cfDNA) methylation patterns in a subject. Method comprises: obtaining a plurality of ...