LC/MS data generated by an LC/MS system is analyzed to determine groupings of ions associated with originating molecules. Ions are grouped initially according to retention time, for example, using retention time or chrornatographic peaks in mass chromatograms. After initial groupings are determined based on retentio...

Embodiments of the present invention are directed to devices, methods and apparatus for performing separations in which particulates are separated or removed from a fluid stream flowing to a column. In one embodiment directed to a device, the invention comprises a body having a first surface and a second surface and...

Abstract of the Disclosure A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not inter...

A method (100) for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a pepride in the sample (110) , separating the precursors to determine values associated with retention times of the separated precursors (120), ionizing the separated precursors to form precurs...

A method (100) for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each includes potions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions (110, and associating precursor ions observed via LC/...

Absolute quantitation of protein in a sariple is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performe...

A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor io...

Methods and apparatus for LGTMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data.

Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily r...

Protein identification in a complex sample begins by selecting a database having proteins likely to be in the sample. In-silico digestion is performed on the proteins in the database to produce peptides. A target peptide is selected from the produced peptides. The masses of the Y- and B-ion fragments of the targe...

Novel particles and materials for chromatographic separations, processes for preparation and separations devices containing the chromatographic particles and materials are provided by the instant invention. In particular, the invention provides a porous inorganic/organic hybrid particle, wherein the inorganic portio...

A process for achieving zero industrial liquid discharge for textiles dyeing wastewater, the brine obtained from the wastewater is treated for re-use in the textile dye baths, said treatment comprising the steps of subjecting the brine to biological processes with decolourant resin filter to reduce COD and colour to...