The invention provides a protein composition derived from silk fibroin which composition possesses enhanced solubility and stability in aqueous solutions. The primary amino acid sequence of native fibroin is modified in the SDP such that cysteine disulfide bonds between the fibroin heavy and fibroin light protein ch...

A biotherapeutic ophthalmic solution that may include a silk-derived protein as an active ingredient. Ophthalmic formulations are critical to the delivery of dosage forms, user requirements, and maintaining product stability. The formulations described herein are ophthalmic solutions that are comfortable to the user...

Described herein are methods for reducing inflammation by administration of an effective amount of silk-derived proteins (SDP) or a fraction thereof to a subject having an inflammatory condition. The methods include the treatment of inflammatory conditions and wounds, including corneal wounds, comprising the topical...