The process for the preparation of a combination of Polymorphs 1 and 2 Desloratadine (8-chloro-11-piperidin-4-ylidene-6, 11-dihydro-5H-benzo [5,6][cyclohepta[1,2-b]pyridine):
(a) dissolving Loratadine (ethyl 4-(8-chloro-5, 6-dihydro-11H-benzo[5,6]cyclohepta [1,2-b]pyridin-11-ylidene)piperidine-1-carboxylate in an a...
A process for the preparation of a combination of Desloratadine Polymorphs 1 & 2 in Equal Proportion by crystallization comprising the following steps: i. Dissolving crude Desloratadine in Acetonitrile in the ratio of 1 : 5 to 1 : 15 under reflux conditions. ii. Cooling the solution of step (i) to a temperature of 5...
A process for the preparation of Ebastine by crystalization having desired particle size comprising the following steps: i. mixing Ebastine (crude) with alcoholic solvent in the ratio of 1:2 to 1:5 w/v; ii. heating the mixture of step (i) at temperature 64 to 66°C to get a clear solution; iii. adding activated carbo...
A process for the preparation of a combination of Famotidine [(N-Sulfamyl - 3-(2-guanidinothiazole-4-yl-methylthio) proionamidine] Polymorphs A and B comprising the following steps:-
(a) dissolving Famotidine crude in methanol at a ratio 1:50 to 1:70 under heating and stirring to form a solution;
(b) adding 20 g a...
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[Class : 5] Drugs And Pharmaceutical Products, Chemical Preparations And Chemical Reagents For Medicinal And Pharmaceutical Purposes, Chemico Pharmaceutical Preparations And Intermediates, Bulk Drugs.