Immunotoxins platform to prevent HIV mediated AIDS progression and other autoimmune diseases is disclosed. AIDS is characterized by a progressive decline of CD4+ immune cells in the host"s system. Existing antiretroviral drug therapies are effective in containing the viral replication and thus bring up the CD4+ T ce...

Fusion proteins for the treatment of Multiple Sclerosis and other autoimmune diseases are disclosed. Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disease of the central nervous system. MS is triggered by the body"s own immune system attacking the myelin sheath around the axons. Current medical...

Adeno-associated virus 2/8 - microRNA-101 (AAV2/8-miR-101) therapy for liver cancer is provided. In particular, the invention provides a recombinant AAV 2/8 vector, comprising mutated capsid, for the enforced expression of pre-miR-101 and for the treatment of liver cancer.

Antibody for targeted induction of Apoptosis, CDC and ADCC mediated killing of Cancer cells, TBL-CLN1, is disclosed. The antibodies, TBL-CLN1, are monoclonal antibodies which can specifically target and bind to the epitope of SEQ ID NO: 1 expressed on cancer cells which further leads to killing of cancer cells. TBL-...

Adeno-associated virus EzH2 shRNA (AAV 2-EzH2 shRNA) based treatment, incorporating targeted gene silencing of cancer metastasis promoting gene EzH2, through RNA interference (RNAi), mediated by recombinant adeno-associated virus vector, is provided. The present invention provides an efficient and safe therapeutic c...

Exemplary aspects of the present invention disclosure relates to a novel pharmaceutical formulation and a process for oral delivery of biotherapeutic peptides and proteins like insulin conjugated with biotin to form a complex and encapsulated by a polymer for binding to its own as well as biotin receptors of the gas...

A method for the production of Docosahexaenoic acid (DHA) by batch fermentation is disclosed. The production of DHA from sources such as sea food and algae are already known. However, sources such as sea food and algae have disadvantages such as uneven product quality and un-assured product safety. The production of...

A method for treating type 1 and type 2 diabetes by administering an oral pharmaceutical formulation which comprises of insulin or its analogues amalgamated with suitable encapsulating agents and pharmaceutical excipients. The encapsulated pharmaceutical oral formulation protects insulin or its analogues from harsh ...

ABSTRACT “FORMULATION FOR NASAL DELIVERY OF INSULIN AND OTHER PROTEINS AND PEPTIDES” The present invention relates to a pharmaceutical preparation for nasal insulin administration in diabetic population comprising a polypeptide hormone insulin, or an analogue thereof, and a quaternised and thiolated Chitosan ...

The present invention is in the field of oncolytic viruses. The invention provides new poxviruses which are engineered to be defective for the function encoded by the M2L locus (ie, m2 function). Such poxviruses lack a functional m2 binding activity to at least one or both of CD80 and CD86 co-stimulatory antigens. S...