[[2 (Amino 3,4 Dioxo 1 Cyclobuten 1 Yl) Amino] Alkyl] Acid Derivatives

[[2 (Amino 3,4 Dioxo 1 Cyclobuten 1 Yl) Amino] Alkyl] Acid Derivatives For The Treatment Of Pain

Abstract: This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are -CH2CH2-, -CH2C(R6)(R7)CH2- or -CH2C(R8) (R9)-C(R10) (R11)CH2-, where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-l,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula(I).

Patent Information

Application #

Filing Date

04 June 2007

Publication Number

32/2007

Publication Type

INA

Invention Field

PHARMACEUTICALS

Status

Email

Parent Application

Applicants

WYETH

FIVE GIRALDA FARMS, MADISON, NJ

Inventors

1. BRANDT MICHAEL RICHARD

16 LENAPE ROAD, FLEMINGTON, NJ 08822

2. ZALESKA MARGARET MARIA

843 BRYN MAWR AVENUE, NARBERTH, PA 19072

3. MOYER JOHN ALLEN

6274 INGHAM ROAD, NEW HOPE, PA 18938

Specification

This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are -CH2CH2-, -CH2C(R6)(R7)CH2- or -CH2C(R8) (R9)-C(R10) (R11)CH2-, where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-l,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula(I).

Documents

Application Documents

#	Name	Date
1	abstract-02017-kolnp-2007.jpg	2011-10-07
2	2017-KOLNP-2007-OTHERS 1.1.pdf	2011-10-07
3	2017-KOLNP-2007-FORM 18.pdf	2011-10-07
4	2017-KOLNP-2007-FORM 18-1.1.pdf	2011-10-07
5	2017-KOLNP-2007-CORRESPONDENCE.pdf	2011-10-07
6	2017-KOLNP-2007-CORRESPONDENCE OTHERS 1.2.pdf	2011-10-07
7	02017-kolnp-2007-priority document.pdf	2011-10-07
8	02017-kolnp-2007-priority document 1.1.pdf	2011-10-07
9	02017-kolnp-2007-gpa.pdf	2011-10-07
10	02017-kolnp-2007-form 5.pdf	2011-10-07
11	02017-kolnp-2007-form 3.pdf	2011-10-07
12	02017-kolnp-2007-form 3 1.1.pdf	2011-10-07
13	02017-kolnp-2007-form 2.pdf	2011-10-07
14	02017-kolnp-2007-form 1.pdf	2011-10-07
15	02017-kolnp-2007-description complete.pdf	2011-10-07
16	02017-kolnp-2007-correspondence others.pdf	2011-10-07
17	02017-kolnp-2007-correspondence others 1.1.pdf	2011-10-07
18	02017-kolnp-2007-claims.pdf	2011-10-07
19	02017-kolnp-2007-assignment.pdf	2011-10-07
20	02017-kolnp-2007-abstract.pdf	2011-10-07
21	2017-KOLNP-2007-(28-03-2016)-FORM-27.pdf	2016-03-28
22	2017-KOLNP-2007_EXAMREPORT.pdf	2016-06-30
23	2017-KOLNP-2007 FIRST EXAMINATION REPORT.pdf	2017-08-30
24	2017-KOLNP-2007 ABANDONED LETTER.pdf	2017-08-30
25	2017-KOLNP-2007-PRIORITY DOCUMENT-1.2.pdf	2018-09-14
26	2017-KOLNP-2007-FIRST EXAMINATION REPORT-1-1.pdf	2018-11-06