Method For Preparing A Chelating Ligand Derived From Pcta

Abstract: The present invention relates to a method for preparing the macrocyclic ligand of formula (L) comprising i) decomplexing the complex of formula (II) consisting of at least 80% of a diastereoisomeric excess comprising a mixture of isomers ll-RRR and ll-SSS of formulae (IISSS) (II-RRR), ii) eliminating the gadolinium salt formed during step i), for example by filtration, and iii) recovering the free macrocyclic ligand of formula (L). The present invention also relates to a composition comprising the diastereoisomerically enriched complex of formula (II) and the macrocyclic ligand of formula (L).

Patent Information

Application #

Filing Date

01 February 2023

Publication Number

15/2024

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

GUERBET

15, rue des Vanesses 93420 VILLEPINTE

Inventors

1. CERF, Martine

17 rue de l'Ancien Relais 17870 BREUIL-MAGNÉ

2. LE GRENEUR, Soizic

140A, rue Charles de Gaulle 91440 BURES SUR YVETTE

3. CHÉNEDÉ, Alain

16 rue de l'Ébeaupin 17140 LAGORD

4. FRANÇOIS, Bruno

Le Moulin de l'Angle 17170 SAINT JEAN DE LIVERSAY

Specification

Documents

Application Documents

#	Name	Date
1	202317006437.pdf	2023-02-01
2	202317006437-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [01-02-2023(online)].pdf	2023-02-01
3	202317006437-STATEMENT OF UNDERTAKING (FORM 3) [01-02-2023(online)].pdf	2023-02-01
4	202317006437-POWER OF AUTHORITY [01-02-2023(online)].pdf	2023-02-01
5	202317006437-FORM 1 [01-02-2023(online)].pdf	2023-02-01
6	202317006437-DECLARATION OF INVENTORSHIP (FORM 5) [01-02-2023(online)].pdf	2023-02-01
7	202317006437-COMPLETE SPECIFICATION [01-02-2023(online)].pdf	2023-02-01
8	202317006437-certified copy of translation [16-02-2023(online)].pdf	2023-02-16
9	202317006437-FORM 3 [15-03-2023(online)].pdf	2023-03-15
10	202317006437-Proof of Right [11-04-2023(online)].pdf	2023-04-11
11	202317006437-FORM 18 [18-04-2024(online)].pdf	2024-04-18