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Pyrazole Derivatives As Ret Kinase Inhibitors

Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
01 June 2023
Publication Number
30/2024
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application

Applicants

ELI LILLY AND COMPANY
Lilly Corporate Center Indianapolis, Indiana 46285

Inventors

1. ANDERSON, Erin, D.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
2. ANDREWS, Steven, W.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
3. BOLDRON, Christopher, Pierre, Albert, Jean
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
4. CONDROSKI, Kevin, R.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
5. IRVIN, Thomas, C.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
6. KOLAKOWSKI, Gabrielle, R., a/k/a Jody, Gabrielle, Rustmann, KOLAKOWSKI
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
7. KUMAR, Manoj
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
8. MCFADDIN, Elizabeth, A.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
9. MCKENNEY, Megan, L.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
10. MCLEAN, Johnathan, Alexander
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
11. MOURET, Tiphaine
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
12. MUNCHHOF, Michael, J.
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
13. PANCALDI, Thomas, Pierre, Dino
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
14. Michael Alexander PILKINGTON-MIKSA
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288
15. PINTO, Marta
c/o Eli Lilly and Company P.O. Box 6288 Indianapolis, Indiana 46206-6288

Specification

Documents

Application Documents

# Name Date
1 202317037743-STATEMENT OF UNDERTAKING (FORM 3) [01-06-2023(online)].pdf 2023-06-01
2 202317037743-Sequence Listing in txt [01-06-2023(online)].txt 2023-06-01
3 202317037743-Sequence Listing in PDF [01-06-2023(online)].pdf 2023-06-01
4 202317037743-REQUEST FOR EXAMINATION (FORM-18) [01-06-2023(online)].pdf 2023-06-01
5 202317037743-PROOF OF RIGHT [01-06-2023(online)].pdf 2023-06-01
6 202317037743-POWER OF AUTHORITY [01-06-2023(online)].pdf 2023-06-01
7 202317037743-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [01-06-2023(online)].pdf 2023-06-01
8 202317037743-FORM 18 [01-06-2023(online)].pdf 2023-06-01
9 202317037743-FORM 1 [01-06-2023(online)].pdf 2023-06-01
10 202317037743-DECLARATION OF INVENTORSHIP (FORM 5) [01-06-2023(online)].pdf 2023-06-01
11 202317037743-COMPLETE SPECIFICATION [01-06-2023(online)].pdf 2023-06-01
12 202317037743-CLAIMS UNDER RULE 1 (PROVISIO) OF RULE 20 [01-06-2023(online)].pdf 2023-06-01
13 202317037743.pdf 2023-06-16
14 202317037743-RELEVANT DOCUMENTS [19-07-2023(online)].pdf 2023-07-19
15 202317037743-FORM 13 [19-07-2023(online)].pdf 2023-07-19
16 202317037743-FORM 3 [16-11-2023(online)].pdf 2023-11-16