Anti N3 Pglu Amyloid Beta Antibodies And Uses Thereof

Abstract: The invention is directed to treatment or prevention of a disease characterized by deposition of Aß in the brain using anti-N3pGlu Aß antibodies. The diseases that can be treated or prevented include, e.g., Alzheimer's disease, Down's syndrome, and cerebral amyloid angiopathy. The invention, in some aspects, is related to doses and dosing regimens useful for such treatments. The invention is also related to, in some aspects, human subjects who are responsive to treatment or prevention of a disease characterized by deposition of Aß in the brain using anti-N3pGlu Aß antibodies. The invention is also related to human subject who have one or two alleles of APOE4.

Patent Information

Application #

Filing Date

14 July 2023

Publication Number

47/2023

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

ELI LILLY AND COMPANY

Lilly Corporate Center Indianapolis, Indiana 46285

Inventors

1. FLEISHER, Adam S.

c/o ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206-6288

2. MINTUN, Mark

c/o ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206-6288

3. SIMS, John Randall II

c/o ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206-6288

4. SPARKS, JonDavid

c/o ELI LILLY AND COMPANY P.O. Box 6288 Indianapolis, Indiana 46206-6288

Specification

Documents

Application Documents

#	Name	Date
1	202317047393-STATEMENT OF UNDERTAKING (FORM 3) [14-07-2023(online)].pdf	2023-07-14
2	202317047393-Sequence Listing in txt [14-07-2023(online)].txt	2023-07-14
3	202317047393-Sequence Listing in PDF [14-07-2023(online)].pdf	2023-07-14
4	202317047393-REQUEST FOR EXAMINATION (FORM-18) [14-07-2023(online)].pdf	2023-07-14
5	202317047393-POWER OF AUTHORITY [14-07-2023(online)].pdf	2023-07-14
6	202317047393-FORM 18 [14-07-2023(online)].pdf	2023-07-14
7	202317047393-FORM 1 [14-07-2023(online)].pdf	2023-07-14
8	202317047393-DRAWINGS [14-07-2023(online)].pdf	2023-07-14
9	202317047393-DECLARATION OF INVENTORSHIP (FORM 5) [14-07-2023(online)].pdf	2023-07-14
10	202317047393-COMPLETE SPECIFICATION [14-07-2023(online)].pdf	2023-07-14
11	202317047393-FORM-26 [17-07-2023(online)].pdf	2023-07-17
12	202317047393-FORM 3 [19-07-2023(online)].pdf	2023-07-19
13	202317047393-Proof of Right [28-09-2023(online)].pdf	2023-09-28