Analytical Hplc

Abstract: The present invention concerns a HPLC separation method useful in the synthesis of [18F]-labelled compounds, including positron emission tomography (PET) tracers. The method of the invention addresses constraints of previous methods imposed by the needs of free 5 [18F]fluoride. The present invention provides a simplified process that enables rapid separation and analysis of free [18F]fluoride and chemical impurities in the synthesis of [18F]-labelled compounds.

Patent Information

Application #

Filing Date

11 October 2023

Publication Number

38/2024

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

GE HEALTHCARE LIMITED

Pollards Wood Nightingales Lane Chalfont St. Giles Buckinghamshire HP8 4SP

Inventors

1. CLARKE, Alan

c/o GE Healthcare AS Nycoveien 1 P.O. Box 4220 Nydalen 0401 Oslo

2. ENGELBRECHT, Hendrik, Petrus

8 Red Fern Circle Johnson City, Tennessee 37604

3. GRIGG, Julian

c/o GE Healthcare Limited Pollards Wood Nightingales lane Chalfont St. Giles Buckinghamshire HP8 4SP

4. KHAN, Imtiaz Ahmed

c/o GE Healthcare Limited Pollards Wood Nightingales Lane Chalfont St. Giles Buckinghamshire HP8 4SP

5. WIKENE, Kristine

c/o GE Healthcare AS Nycoveien 1 P.O. Box 4220 Nydalen 0401 Oslo

6. MCROBBIE, Graeme

c/o GE Healthcare Limited Pollards Wood Nightingales lane Chalfont St. Giles Buckinghamshire HP8 4SP

Specification

Documents

Application Documents

#	Name	Date
1	202317068337-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [11-10-2023(online)].pdf	2023-10-11
2	202317068337-STATEMENT OF UNDERTAKING (FORM 3) [11-10-2023(online)].pdf	2023-10-11
3	202317068337-PROOF OF RIGHT [11-10-2023(online)].pdf	2023-10-11
4	202317068337-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [11-10-2023(online)].pdf	2023-10-11
5	202317068337-FORM 1 [11-10-2023(online)].pdf	2023-10-11
6	202317068337-DRAWINGS [11-10-2023(online)].pdf	2023-10-11
7	202317068337-DECLARATION OF INVENTORSHIP (FORM 5) [11-10-2023(online)].pdf	2023-10-11
8	202317068337-COMPLETE SPECIFICATION [11-10-2023(online)].pdf	2023-10-11
9	202317068337-FORM-26 [26-10-2023(online)].pdf	2023-10-26
10	202317068337-FORM 3 [15-03-2024(online)].pdf	2024-03-15
11	202317068337-MARKED COPIES OF AMENDEMENTS [12-03-2025(online)].pdf	2025-03-12
12	202317068337-FORM 18 [12-03-2025(online)].pdf	2025-03-12
13	202317068337-FORM 13 [12-03-2025(online)].pdf	2025-03-12
14	202317068337-Annexure [12-03-2025(online)].pdf	2025-03-12
15	202317068337-AMMENDED DOCUMENTS [12-03-2025(online)].pdf	2025-03-12