Therapeutic Inhibitors Of Gdf15 Signalling

Abstract: This invention relates to antibodies that bind to and inhibit the activity of glial cell-derived neurotrophic factor family receptor alpha like (GFRAL) protein. The invention also relates to the GDF15-GFRAL signalling pathway as a therapeutic target for states of cachexia and conditions involving reduction in food intake and reduction in muscle and fat mass.

Patent Information

Application #

Filing Date

23 October 2023

Publication Number

36/2024

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

CAMBRIDGE ENTERPRISE LIMITED

The Old School Trinity Lane Cambridge CAMBRIDGESHIRE CB2 1TN

KYMAB LIMITED

The Bennet Building (B930) Babraham Research Campus CAMBRIDGE CB22 3AT

Inventors

1. O’RAHILLY, Stephen

Cambridge Enterprise Limited The Old Schools Trinity Lane CAMBRIDGE CB2 1TN

2. COLL, Anthony Patrick

Cambridge Enterprise Limited The Old Schools Trinity Lane CAMBRIDGE CB2 1TN

3. CIMINO, Irene

Cambridge Enterprise Limited The Old Schools Trinity Lane CAMBRIDGE CB2 1TN

4. LEE, E-Chiang

The Bennet Building (B930) Babraham Research Campus CAMBRIDGE CB22 3AT

5. LIU, Hui

The Bennet Building (B930) Babraham Research Campus CAMBRIDGE CB22 3AT

6. CARPENTER, Adam

The Bennet Building (B930) Babraham Research Campus CAMBRIDGE CB22 3AT

Specification

Documents

Application Documents

#	Name	Date
1	202317072310-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [23-10-2023(online)].pdf	2023-10-23
2	202317072310-STATEMENT OF UNDERTAKING (FORM 3) [23-10-2023(online)].pdf	2023-10-23
3	202317072310-Sequence Listing in txt [23-10-2023(online)].txt	2023-10-23
4	202317072310-Sequence Listing in PDF [23-10-2023(online)].pdf	2023-10-23
5	202317072310-FORM 1 [23-10-2023(online)].pdf	2023-10-23
6	202317072310-DRAWINGS [23-10-2023(online)].pdf	2023-10-23
7	202317072310-DECLARATION OF INVENTORSHIP (FORM 5) [23-10-2023(online)].pdf	2023-10-23
8	202317072310-COMPLETE SPECIFICATION [23-10-2023(online)].pdf	2023-10-23
9	202317072310-FORM-26 [01-01-2024(online)].pdf	2024-01-01
10	202317072310-Proof of Right [29-03-2024(online)].pdf	2024-03-29
11	202317072310-FORM-26 [29-03-2024(online)].pdf	2024-03-29
12	202317072310-FORM 3 [29-03-2024(online)].pdf	2024-03-29
13	202317072310-FORM 18 [05-02-2025(online)].pdf	2025-02-05