DESC:FIELD OF THE INVENTION
The present invention relates to an agrochemical composition. In particular, the present disclosure pertains to a novel composition comprising a mixture of two insecticides, to a method of controlling insects and/or pests using such composition and to a process for preparing such composition.

BACKGROUND OF THE INVENTION
Insecticides and pesticides are extensively and frequently used in commercial agriculture, leading to significant increases in crop yields and product quality. This, in turn, provides farmers with substantial economic benefit and simplifies farming activities.
Combining insecticides is a strategy employed to broaden the spectrum of insect control, enhance pest management through synergistic effect, and reduce the required dosage, thereby minimizing environmental impact. By targeting both chewing and sucking insects simultaneously, these combinations decrease the likelihood of resistance development and aid in resistance management. Additionally, they enhance residual control, reducing the need for frequent applications and lowering the overall pesticidal load in the ecosystem.
Despite the benefits of combining insecticides, there is still room for improvement. Prolonged use of single active ingredient has led to resistance in certain pests. With the emergence of resistant pest populations, there is a pressing need for more effective combinations that can reduce the risk of resistance while enhancing the spectrum of insect-pest control. Inventors of present invention worked on one or more insecticides with various modes of action, which can effectively address existing challenges and can be easily prepared without involving complex manufacturing processes.
Profenofos, chemically known as O-4-bromo-2-chlorophenyl O-ethyl S-propyl phosphorothioate, is a widely used organophosphate insecticide. This substance appears as a pale yellow to amber liquid and emits a garlic-like odor. First registered in the United States in 1982, Profenofos has not been approved for use in the European Union as of 2015. It is applied to various crops, including cotton, maize, potatoes, soybeans, and sugar beets. Like other organophosphates, Profenofos works by inhibiting the acetylcholinesterase enzyme.

Profenofos
Fenpropathrin, chemically known as [Cyano-(3-phenoxyphenyl)methyl] 2,2,3,3-tetramethylcyclopropane-1-carboxylate, is a commonly used pyrethroid insecticide in both agricultural and household settings. It acts as a synthetic pyrethroid through ingestion and contact, disrupting the function of voltage-gated sodium channels, leading to paralysis and death of the target pests. Fenpropathrin is particularly effective in paddy and cotton farming.

Fenpropathrin
US4,374,833 relates to mixtures of profenofos and certain pyrethroid insecticides that exhibit enhanced pesticidal activity against acarids.
WO2020049493A1 relates to a method of stabilizing an agrochemical composition comprising an organo-phosphorus active ingredient or its combination with a pyrethroid active ingredient. The method includes addition of a stabilizer such as urea or its derivatives to the agrochemical composition.
However, the existing literature does not identify the specific combination of Profenofos and Fenpropathrin in pesticidally effective amounts or the precise ratio necessary to achieve optimal efficacy and synergy. The prior art lacks any discussion of the synergistic effect or efficacy exhibited by a composition comprising these two pesticides, and there are no documented field studies to support such synergism. As a result, there is no known pesticidal composition in the field that includes this specific combination, capable of delivering broad-spectrum pesticidal activity while overcoming the limitations associated with previously known combinations.
This gap is effectively addressed by the present invention, which introduces a stable and synergistic combination of Profenofos and Fenpropathrin, designed to meet these needs, deliver superior performance and contributes in Pesticidal resistance management.

SUMMARY OF THE INVENTION
The present invention relates to a synergistic agrochemical composition comprising Profenofos and Fenpropathrin. The inventors have unexpectedly discovered that the combination of Profenofos and Fenpropathrin exhibits synergistic effect, despite their differing modes of action.
The present invention relates to a synergistic agrochemical composition comprising an effective amount of Profenofos, an effective amount of Fenpropathrin; and at least one agrochemically acceptable excipient.
The present invention relates to a synergistic agrochemical composition comprising Profenofos in the range of 0.1% to 80% by weight of the total composition, Fenpropathrin in the range of 0.1% to 50% by weight of the total composition and at least one excipient in the range of 0.05% to 80% by weight of the total composition.
The present invention relates to a synergistic agrochemical composition comprising Profenofos in the range of 0.1% to 80% by weight of the total composition, Fenpropathrin in the range of 0.1% to 50% by weight of the total composition and at least one excipient in the range of 0.05% to 80% by weight of the total composition; wherein the weight ratio of Profenofos to Fenpropathrin is 1:20 to 20:1.
The invention also relates to a process for preparing the synergistic agrochemical composition comprising Profenofos in the range of 0.1% to 80% by weight of the total composition, Fenpropathrin in the range of 0.1% to 50% by weight of the total composition and at least one excipient in the range of 0.05% to 80% by weight of the total composition.
According to another embodiment, the invention also relates to a method for controlling pests and diseases, protection of crop or improving its health or yield, by treating at least one of a plant, crop, or parts thereof, a plant propagation material, seed, seedling or surrounding soil with a pesticidal composition comprising an effective amount of Profenofos; an effective amount of Fenpropathrin; and at least one agrochemically acceptable excipient.

DESCRIPTION OF THE INVENTION
The present invention can be more readily understood by reading the following detailed description of the invention and study of the included examples. In describing the embodiment of the invention, specific terminology is used for clarity. However, the invention is not intended to be confined to these particular terms. It should be understood that these terms encompass all technical equivalents that function in a similar way to achieve a similar purpose. It is understood that any numerical range recited herein is intended to include all subranges subsumed.
The terms “a” or “an”, as used herein, are defined as one or more than one. The terms “including” and/or “having”, as used herein, are defined as comprising (i.e., open language).
As used herein, the term “composition”, as in agrochemical composition, is intended to encompass a product comprising combination of Profenofos and its salts, esters, solvates, polymorphs, derivatives, enantiomers or mixtures thereof; Fenpropathrin and its salts, esters, solvates, polymorphs, derivatives, enantiomers or mixtures thereof, and the other agrochemically acceptable excipients. Such agrochemical compositions are synonymous with “formulation” and “dosage form.”
As used herein, the term “about” means±approximately 10% of the indicated value.
The term “w/w” as used herein refers the total weight of the core composition.
Profenofos used in the present invention refers to Profenofos or its salts or derivatives thereof.
Fenpropathrin used in the present invention refers to Fenpropathrin or its salts or derivatives thereof.
The term "synergistic effect ", as used herein, refers to the combined action of two or more active agents mixed together and administered conjointly that is greater than the sum of their individual effects.
The present invention relates to a synergistic combination comprising Profenofos and Fenpropathrin.
The present invention relates to a pesticidal composition comprising an effective amount of Profenofos; an effective amount of Fenpropathrin; and at least one agrochemically acceptable excipient.
In an embodiment, the present invention relates to synergistic agrochemical composition comprising Profenofos in the range of 0.1% to 80% by weight of the total composition, Fenpropathrin in the range of 0.1% to 50% by weight of the total composition; and at least one excipient in the range of 0.05% to 80% by weight of the total composition.
In another embodiment, the present invention relates to the synergistic agrochemical composition wherein Profenofos is in the range of about 10% - 70% w/w and Fenpropathrin is in the range of 0.1-20 % w/w of the total composition.
In yet another embodiment, the present invention relates to the synergistic agrochemical composition wherein Profenofos is in the range of about 20% - 60% w/w and Fenpropathrin is in the range of 1-10 % w/w of the total composition.
In yet another embodiment, the present invention relates to, a synergistic agrochemical composition wherein the weight ratio of Profenofos to Fenpropathrin is 1:20 to 20:1.
The inventors of the present invention have surprisingly found that the composition comprising Profenofos and Fenpropathrin demonstrates synergistic pesticidal activity compared to the activity of the individual active ingredient alone.
The inventors have further surprisingly discovered that the combination of Profenofos and Fenpropathrin not only exhibits synergistic effect but also serves as an excellent crop protectant with non-phytotoxic properties. Additionally, this pesticidal composition aids in managing resistance to older pesticide chemistries and has been shown to enhance crop yield when applied in the field.
The composition described in this invention exhibits excellent physical properties, including enhanced stability, suspensibility, dispersibility, flowability, pourability, and optimized viscosity.
The composition has demonstrated outstanding performance under accelerated storage conditions. In addition to its remarkable efficacy as a crop protection agent, it also functions as a yield enhancer.
In another embodiment, the present invention relates to a synergistic agrochemical composition, wherein the composition is an emulsion concentrate, a suspension concentrate, a microemulsion, a suspoemulsion, an aqueous emulsion, a dispersible oil suspension, a capsule suspension.
According to an embodiment, the synergistic agrochemical composition comprises one or more agrochemically acceptable excipients.
In yet another embodiment, the agrochemically acceptable excipient is selected from one or more surfactants, dispersing agents, binders or binding agents, wetting agents, emulsifiers, disintegrating agents, fillers or carriers or diluents, coating agents, buffers or pH adjusters or neutralizing agents, antifoaming agents or defoamers, chelating or complexing or sequestering agents, solvents, suspending agents or suspension aid agents or anticaking agents or anti-settling agents, tackifier, sticking agents, preservatives, stabilizers, thickener, spreading agents, anti-freezing agent, pigments, colorants, penetrants, UV agents and mixtures thereof. However, those skilled in the art will appreciate that it is possible to utilize additional agrochemically acceptable excipients without departing from the scope of the present invention. The agrochemically acceptable excipients are commercially manufactured and available through various companies.
According to an embodiment, the agrochemically acceptable excipient is in the range of from 1% w/w to 80% w/w of the total composition, preferably in the range of from 1% w/w to 70% w/w of the total composition, more preferably in the range of from 1% w/w to 60% w/w of the total composition.
According to an embodiment, the agrochemically acceptable excipient is in the range of from 1% w/w to 50% w/w of the total composition. According to an embodiment, the agrochemically acceptable excipient is in the range of from 1% w/w to 30% w/w of the total composition. According to an embodiment, the agrochemically acceptable excipient is in the range of from 1% w/w to 20% w/w of the total composition. According to an embodiment, the agrochemically acceptable excipient is in the range of from 1% w/w to 10% w/w of the total composition.
According to an embodiment, the emulsifier that are used in the composition include one or more of anionic and non-ionic.
In an another embodiment, present invention relates to a synergistic agrochemical composition, wherein non-ionic emulsifier are Polyoxyethylene tridecyl ether, polyoxyethylene tristyryl phenyl ether, Tristeryl phenol ethoxylate, polyoxyethylene sorbitol tetraoleate, polyoxyethylene sorbitan ester, polyoxyethylene alkyl ether, polyoxyethylene polycyclic phenyl ether, polyoxyethylene oleic ester, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene castor oil, and/or ethoxylated propoxylated tristyrylphenol.
According to an embodiment, anionic emulsifier are Alkylarylsulfonates, diphenylsulfonates, alpha-olefin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecyl- and tridecylbenzenes, Calcium alkyl benzene Sulfonate, Sulfates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters. Phosphate esters.
According to an embodiment, the composition comprises emulsifiers present in an amount of 0.1%-60% w/w of the total composition; preferably the composition comprises emulsifiers in an amount of from 0.1% w/w to 50% w/w, preferably the composition comprises emulsifiers in an amount of 0.1 to 40% w/w of the total composition, preferably the composition comprises emulsifiers in an amount of from 0.1% w/w to 30% w/w of the total composition, preferably the composition comprises emulsifiers in an amount of from 0.1% w/w to 20% w/w of the total composition, preferably the composition comprises emulsifiers in an amount of from 0.1% w/w to 10% w/w of the total composition, .
According to an embodiment, the dispersing agents that are used in the agrochemical composition include, but are not limited to non-ionic dispersants selected from one or more of polyvinyl pyrrolidone, polyvinyl alcohol, polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ether, ethoxylated fatty acids, aliphatic alcohol ethoxylates, alkyl ethoxylates, EO-PO block and graft copolymers; However, those skilled in the art will appreciate that it is possible to utilize different non-ionic dispersants without departing from the scope of the present invention.
According to an embodiment, the dispersing agent is present in an amount of 0.1%-60% w/w of the total composition; preferably the composition comprises dispersing agent in an amount of from 0.1% w/w to 50% w/w, preferably in an amount of 0.1 to 40% w/w of the total composition, preferably the composition comprises dispersing agent in an amount of from 0.1% w/w to 30, preferably the composition comprises dispersing agent in an amount of from 0.1% w/w to 20, preferably the composition comprises dispersing agent in an amount of from 0.1% w/w to 10% w/w of the composition.
According to an embodiment, the wetting agents used in the said agrochemical composition include, but are not limited to one or more of phenol naphthalene sulphonates, alkyl naphthalene sulfonate, sodium alkyl naphthalene sulfonate, naphthalene sulphonate sodium salt, dibutylnaphthalene sulfonic acid, alkylarylsulfonates, dioctyl sulfosuccinate, polyoxyethoxylated fatty alcohols, alkane sulfonates, alkylbenzene sulfonates, alkyl ether phosphates, alkyl ether sulphates and alkyl sulfosuccinic monoesters, salts or derivatives thereof. According to an embodiment, the wetting agent is present in an amount of 0.1%-40% w/w of the total composition, preferably in an amount of from 0.1% w/w to 30% of the total composition.
According to an embodiment, the antifoaming agents or defoamers which are used in the agrochemical composition include but are not limited to one or more of silica, siloxane, silicone dioxide, poly dimethyl siloxane, alkyl polyacrylates, ethylene oxide/propylene oxide copolymers, silicone oils and magnesium stearate or derivatives thereof. Preferred antifoaming agents include silicone emulsions, long-chain alcohols, fatty acids, fluoro-organic compounds. According to an embodiment, the anti-foaming agent is present in an amount of 0.01% to 30% w/w of the total composition.
According to an embodiment, the pH-adjusters or buffers or neutralizing agents that are used in the composition include both acids and bases of the organic or inorganic type and mixtures thereof. According to a further embodiment, pH-adjusters or buffers or neutralizing agents include, but are not limited to one or more of organic acids, inorganic acids, and alkali metal compounds or salts, derivatives thereof. According to an embodiment, the organic acids include, but are not limited to one or more of citric, malic, adipic, fumaric, maleic, succinic, and tartaric acids, or salts, derivatives thereof, and the mono, di, or tribasic salts of these acids or derivatives thereof. According to an embodiment, the salts of inorganic acids include, but are not limited to one or more of alkali metal salts such as, sodium chloride, sodium nitrate, potassium nitrate, sodium sulfate, potassium sulfate, sodium monohydrogen phosphate, potassium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate and the like. Mixtures can also be used to create pH-adjusters or buffers or neutralizing agents. According to an embodiment, the pH adjuster or buffer is present in an amount of 0.01% to 30% w/w of the total composition.
According to an embodiment, the anticaking agents which are used in the agrochemical composition include, but are not limited to one or more of polysaccharides such as fumed and precipitated silica (white carbon), ester gum, a petroleum resin, sodium stearate, polyoxyethylene (100) stearylether, sodium acetate, sodium metasilicate, sodium alkylsulfosuccinates or derivatives thereof. According to an embodiment, the anticaking agent is present in an amount of 0.1% to 30% w/w of the total composition.
According to an embodiment, the sticking agents that are used in the agrochemical composition include, but are not limited to one or more of paraffin, a polyamide resin, polyacrylate, polyoxyethylene, wax, latex, polyvinyl pyrrolidone, gums such as xanthan gum, vegetable oils such as cottonseed, or inorganic oils, petroleum distillates, modified trisiloxanes, polyglycol, a synthetic resin emulsion or salts or derivatives thereof. According to an embodiment, the sticking agent is present in an amount of 0.01% to 30% w/w of the total composition.
According to an embodiment, antioxidants that are used in the agrochemical composition include but are not limited to one or more of phenol compounds, phosphoric acid compounds, EDTA, sodium sulphites, citric acid, citrates and the like.
According to an embodiment, the stabilizer preferably used in the composition is an epoxidized oil fatty acid or an epoxidized ester of a fatty acid.
According to an embodiment, stabilizer(s) that are used in the agrochemical composition include but are not limited to one or more epoxidized castor oil, epoxidized rapeseed oil, epoxidized soybean oil, epoxidized cotton seed oil, epoxidized canola oil, epoxidized rice bran oil, epoxidized palm oil, epoxidized coconut oil, epoxidized linseed oil, epoxidized sunflower oil, epoxidized peanut oil, epoxidized thistle oil, Butylated Hydroxy Toluene, Catechol, or in combination thereof.
According to an embodiment, the stabilizer used in agrochemical composition is not urea or its derivatives.
According to an embodiment, the percentage by weight of the stabilizer in a formulation of the invention can be between about 0.1% and 60%, between about 1% and 50%, between about 1% and 40%, between about 1% and 30%, between about 1% and 20%, between about 1% and 10% of the composition.
According to an embodiment, the solvent is selected from water miscible solvents, non-polar solvents like an aliphatic hydrocarbon, an aromatic hydrocarbon, or an alkyl ester.
According to an embodiment, the solvent is selected from Aromatic Hydrocarbon solvent of various carbon chains, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200, Xylene mixtures, alkylated naphthalenes or tetrahydronaphthalene, aliphatic or cycloaliphatic hydrocarbons such as paraffins or cyclohexane; alcohols such as ethanol, propanol or butanol; glycols and their ethers and esters such as propylene glycol, dipropylene glycol ether, diethylene glycol or 2-methoxyethanol or 2-ethoxyethanol; ketones such as cyclohexanone, isophorone or diacetone alcohol; strongly polar solvents such as N-methylpyrrolid- 2-one, dimethyl sulfoxide or N,N-dimethylformamide, amides solvent such Mixture of N, N dimethyl decanamide and octanamide, N, N dimethyl decanamide. According to an embodiment, the solvent is present in the range of 0.10 % to 30.00% w/w of the total composition.
In yet another embodiment co-solvent(s) is selected from the group comprising of, but not limited to, polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, dipropylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; aromatic hydrocarbons such as xylene, toluene, naphthene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvesso 100, solvesso 150, solvesso 200; chlorinated aliphatic or aromatic hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, diisopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma-butyrolactone; amides such as dimethylformamide, N-methyl-2-pyrrolidone, N-octylpyrolidone, N,N-dimethyldecanamide; nitriles such as acetonitrile; organosulfur compound such as dimethyl sulfoxide; vegetable oils such as soybean oil, rapeseed oil, cotton seed oil or a combination thereof. According to an embodiment, the co-solvent is present in the range of 0.10 % to 10.00% w/w of the total composition.
According to an embodiment, preservatives are selected from one or more of formic acid, and derivatives of 2H isothiazol-3-one (so-called isothiazolone derivatives) such as alkylisothiazolones (for example 2-methyl-2H-isothiazol-3-one, MIT; chloro-2-methyl-2H-isothiazol-3-one, CIT), benzoisothiazolones (for example 1,2-benzoisothiazol-3(2H)-one, BIT, commercially available as Proxel® types from Arch Biocides Ltd.) or 2-methyl-4,5-trimethylene-2H-isothiazol-3-one (MTIT), Proxel® or Acticide® RS and Kathon® MK, Sodium Propinoate, Sodium Benzoate, Propyl Paraben, Propyl Paraben Sodum, Potassium Sorbate, Potassium Benzoate, Phenyl Mercuric Nitrate, Phenyl Etehyl Alcohol, Sodium, Ethylparaben, Methylparaben, Butylparaben, Benzyl Alcohol, Benzothonium Chloride, Cetylpyridinium Chloride, Antioxidants includes but are not limited to one or more of imidazole and imidazole derivatives (e.g. urocanic acid), 4,4'-thiobis-6-t-butyl-3 -methylphenol, 2,6-di-t-butyl-p-cresol (BHT), penta erythrityl tetrakis[3-(3,5,-di-t-butyl-4-hydroxyphenyl)] propionate; amine antioxidants. According to an embodiment, the preservative is present in the range of 0.01% to 10% w/w of the total composition.
According to an embodiment, the anti-freezing agents or freezing point depressants used in the aqueous suspension composition include, but are not limited to one or more of polyhydric alcohols such as ethylene glycol, diethylene glycol, dipropylene glycol, propylene glycol, butyrolactone, N,N-dimethyl-formamide, glycerol, monohydric or polyhydric alcohols, glycol ethers, glycol ethers, glycol monoethers such as the methyl, ethyl, propyl and butyl ether of ethylene glycol, diethylene glycol, propylene glycol and dipropylene glycol, glycol diethers such as methyl and ethyl diethers of ethylene glycol, diethylene glycol and dipropyleneglycol,, glycerol, isopropanol, propylene glycol monomethyl ether, di- or tripropylene glycol monomethyl ether or cyclohexanol, carbohydrates such as glucose, mannose, fructose, galactose, sucrose, lactose, maltose, xylose, arabinose, sorbitol, mannitol, trehalose, raffinose or derivatives thereof. However, those skilled in the art will appreciate that it is possible to utilize different anti-freezing agents without departing from the scope of the present invention. The anti-freezing agents are commercially manufactured and available through various companies. According to an embodiment, the anti-freezing agent is present an amount of from 0.1% to 20% w/w of the total composition.
According to an embodiment, the pigments and colorants are selected from but are not limited to synthetic chemicals obtained from various manufacturers. The pigments and colorants can be water soluble or water insoluble, in the form of lakes. Dyes can be solvent dyes, acid dyes or basic dyes. However, those skilled in the art will appreciate that it is possible to utilize other conventionally known pigments and colorants without departing from the scope of the present invention. According to an embodiment, the pigment and colorant are present in the range of 0.01% to 5% w/w of the total composition.
One embodiment of the present invention relates to a synergistic agrochemical composition comprising Profenofos in the range of about 0.1% to 80% by weight; Fenpropathrin in the range of 1.0% to 20.0 % w/w; one or more emulsifier in an amount of about 1% to 20% by weight; one or more stabilizer in an amount of about 1% to 10% by weight; and a solvent in an amount of 10% to 80% by weight.
One embodiment of the present invention relates to a synergistic agrochemical composition comprising Profenofos in the range of about 0.1% to 80% by weight; Fenpropathrin in the range of 1.0% to 20.0 % w/w; non-ionic emulsifier in an amount of about 1% to 20% by weight; anionic emulsifier in an amount of about 1% to 20% by weight; a stabilizer in an amount of about 1% to 10% by weight; and a solvent in an amount of 10% to 60% by weight of the total composition.
In one embodiment, the pesticidal composition may optionally include at least one additional active ingredient. This active ingredient can encompass a pesticidal agent, fertilizer, micronutrients, macronutrients, organic acids, or a combination thereof. Further, the pesticidal agent may consist of one or more substances such as insecticides, fungicides, miticides, acaricides, nematicides, pheromones, plant growth regulators, and others. However, experts in the field will understand that other active ingredients can also be incorporated without departing from the scope of this invention.
According to an embodiment, the present invention relates to a process of preparing the pesticidal composition of the present invention comprising Profenofos in the range of 0.1%w/w to 80% w/w of the total composition; Fenpropathrin in the range of 1%w/w to 50% w/w of the total composition; and at least one agrochemically acceptable excipient.
According to a further embodiment the present invention relates to a process for preparing pesticidal composition in the form of an emulsifiable concentrate, , a microemulsion, a suspoemulsion, an aqueous emulsion, a dispersible oil suspension, capsule suspension.
According to an embodiment, the invention relates to a process for preparation of a suspoemulsion pesticidal composition, the process comprising dissolving wetting agent and dispersing agents in water to obtain a mixture followed by addition of humectant, antifoam agent, if required, and Profenofos to obtain a homogenized suspension, which is further milled to obtain desired particle size (First fraction). Fenpropathrin is dissolved in an oil or a solvent, followed by addition of surfactant to prepare a concentrated emulsion with required agrochemical excipients to obtain a second fraction. The two fractions obtained are then mixed using a homogenizer for minutes to obtain the suspoemulsion composition with the desired particle size of 75 microns.
The invention relates to a process for preparation of an emulsion concentrate pesticidal composition, the process comprises the following steps: firstly, forming a mixture comprising the agrochemical active ingredient(s), the aromatic hydrocarbon solvent and then secondly, adding a suitable surfactant emulsificr and/or stabilizer to the mixture. The mixture is then stirred until a homogeneous solution is obtained. The mixing, preferably by dissolving, of the active ingredient in the substantially water- immiscible co-solvent is preferably achieved in the presence of heating up to 60°C.
According to an embodiment, emulsion concentrate composition was prepared by forming an oil phase by adding Profenofos, Fenpropathrin and anionic surfactant in aromatic hydrocarbon solvent at 60°C and then preparing an aqueous phase by adding non-ionic emulsifies and stabilizer in water and the mixture was stirred until a homogeneous solution was obtained. Mixing the oil phase into the aqueous phase or vice-versa to obtain the emulsion composition with the median particle size about 1 µm.
According to an embodiment, the invention further relates to a method of application of the composition.
According to an embodiment, the invention also relates to a method of protecting the crop, controlling insect pests and diseases, improving the crop health and growth, enhancing the crop yield, strengthening the plant, the method comprising treating at least one of a plant, crop, plant propagation material, locus or parts thereof, a seed, seedling or surrounding soil with the pesticidal composition which includes Profenofos in the range of 10% w/w to 60% w/w of the total composition; Fenpropathrin in the range of 1%w/w to 20% w/w of the total composition. The composition may be sprayed directly to the plant, such as its foliage or applied to the plant propagation material, before it is sown or planted, or to the locus thereof.
In an embodiment of the present disclosure, the insecticidal composition may be used for foliar application, ground application or applications to plant propagation materials. The application may be made as a foliar spray at different timings during crop development, with either one or two applications early or late post-emergence.
The rates of application or the dosage of the composition depends on the type of use, the variety of crop, or the form of composition but is such that the pesticidal active ingredient, is in an effective amount to provide the desired action such as crop protection, crop yield.
In an embodiment, the synergistic agrochemical composition is utilized to control insects and/or pests in different varieties, such as cotton, wheat, rice, maize, corn, soybeans or sunflower.
In an embodiment, the synergistic agrochemical composition effectively controls major insects and/or pests, including: Cotton Bollworm (Helicoverpa armigera), Pink Bollworm (Pectinophora gossypiella), Spotted Bollworm (Earias insulana), Cotton Aphid (Aphis gossypii), Silverleaf Whitefly (Bemisia tabaci), Cotton Leafhopper (Amrasca biguttula biguttula), Thrips (Thrips tabaci), Cotton Mealybug (Phenacoccus solenopsis), Spider Mites (Tetranychus urticae) and Black Cutworm (Agrotis ipsilon) Stem Borer (Scirpophaga incertulas) and Leaf Folder (Cnaphalocrocis medinalis) in Rice, Tobacco caterpillar (Spodoptera litura), Pod borer (Helicoverpa armigera), Semilooper (Chrysodeixis acuta) and Girdle beetle (Obereopsis brevis) infesting Soybean. Furthermore, the composition described herein not only enhances crop yields but also improves the physiological parameters of the plants.
It has been observed that the compositions of the present invention exhibit enhanced efficacy and superior performance in the field, even at reduced dosages.
Further, it should be noted that various modifications and adjustments can be made without departing from the core principles and scope of this invention. The specific embodiments provided are not intended to impose any limitations or restrictions.

A. PREPARATION EXAMPLES:
The following examples demonstrate the fundamental methodology and versatility of the composition described in this invention. However, it is important to note that the invention is not confined to these specific examples and extends to the entire claimed concentration range of the components.
Example 1: Profenofos 10% + Fenpropathrin 1% EC
• To 80 parts of Aromatic Hydrocarbon solvent, add 10 parts of Profenofos and 1 part of Fenproapthrin then mix till complete dissolution.
• To above mixture, add 4.5 parts of Tristyryl phenol ethoxylate, 2 parts of Calcium alkyl benzene Sulfonate, 2.5 parts of Epoxydized soyabean oil and then mix till homogenous clear mass.
• The composition has a Profenofos content 10.35% and Fenpropathrin content 1.03%. The composition further demonstrated Profenofos content 10.19% and Fenpropathrin content 1.05% after accelerated storage condition at 54?C, 14 days.

Example 2 to 12: are prepared based on above example 1.
Ingredients (%) Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12
Profenofos a.i. 10.0 20 40 45.0 50.0 60.0 10.0 20 40 45.0 50 60.0
Fenpropathrin a.i. 1.0 2 4 4.5 5.0 6.0 1.0 2 4 4.5 5 6.0
Tristyryl phenol ethoxylate 4.5 7.1 9.1 7.8 9.1 9.0 0.0 0 0 0.0 0 0.0
Castor oil ethoxylate 0.0 0 0 0.0 0.0 0.0 4.5 7.1 7 7.8 9.5 9.5
Calcium alkyl benzene Sulfonate 2.0 2.9 4.9 4.2 4.9 5.0 2.0 2.9 4.9 4.2 4.5 4.5
Epoxydized soyabean oil 2.5 2.5 4 4.5 5.0 5.0 2.5 2.5 4 5.0 5 5.0
Aromatic Hydrocarbon solvent 80.0 65.5 38 34.0 26.0 15.0 80.0 65.5 40.1 33.5 26 15.0
Total 100.0 100 100 100 100 100 100.0 100 100 100 100 100

Specification (Specification)
Description Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment
Profenofos content (% w/w) 9.0-11.0 19.0 - 21.0 38.0 - 42.0 42.75 - 47.25 48.25 - 52.5 58.2 - 63.0 9.0-11.0 19.0 - 21.0 38.0 - 42.0 42.75 - 47.25 48.25 - 52.5 58.2 - 63.0
Fenpropathrin content (% w/w) 0.95 -1.10 Specifiation: 1.90 -2.20 3.80 - 4.40 4.27 - 4.95 4.75 - 5.50 5.70 - 6.60 0.95 -1.10 Specifiation: 1.90 -2.20 3.80 - 4.40 4.27 - 4.95 4.75 - 5.50 5.70 - 6.60
Acidity as H2SO4 (% by mass) Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0
Emulsion stability Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments
Flash point (?C) Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5
Cold test No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur
Analysis (Initial)
Description Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Profenofos
content (% w/w) 10.35 20.22 40.32 45.3 50.54 60.35 10.22 20.33 40.24 45.23 50.24 60.32
Fenpropathrin
content (% w/w) 1.03 2.09 4.1 4.57 5.07 6.09 1.03 2.04 4.04 4.52 5.05 6.12
Acidity as H2SO4 (% by mass) 0.03 0.02 0.02 0.01 0.04 0.04 0.01 0.01 0.02 0.02 0.03 0.03
Emulsion stability Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Flash point (?C) Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Cold test Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Analysis (54?C, 14 days)
Description Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Profenofos
content (% w/w) 10.19 20.18 40.02 45.12 50.27 60.08 10.09 20.12 40.32 45.09 50.11 60.28
Fenpropathrin
content (% w/w) 1.05 2.08 4.09 4.53 5.05 6.11 1.01 2.01 4.02 4.51 5.03 6.12
Acidity as H2SO4 (% by mass) 0.03 0.02 0.02 0.02 0.04 0.03 0.01 0.02 0.02 0.02 0.03 0.03
Emulsion stability Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Flash point (?C) Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Cold test Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Analysis (0?C, 7 days)
Description Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Profenofos
content (% w/w) 10.29 20.23 40.34 45.33 50.5 60.26 10.09 20.25 40.22 45.18 50.3 60.19
Fenpropathrin
content (% w/w) 1.06 2.09 4.09 4.55 5.07 6.1 1.01 2.03 4.01 4.11 5.02 6.08
Acidity as H2SO4 (% by mass) 0.03 0.02 0.02 0.02 0.03 0.02 0.01 0.03 0.02 0.02 0.03 0.03
Emulsion stability Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Flash point (?C) Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies
Cold test Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies Complies

As observed the compositions formulated in Examples 1 to 12 were found to be stable at the end of the accelerated storage stability study.
Preparative example 13: Profenofos 40% + Fenpropathrin 10% EC
33 parts of Aromatic Hydrocarbon solvent is added to 40 parts of Profenofos and 10 part of Fenproapthrin and is mixed till complete dissolution is obtained. To the above mixture, 8.1 parts of Tristyryl phenol ethoxylate, 4.9 parts of Calcium alkyl benzene Sulfonate, 4 parts of Epoxydized soyabean oil is added and then mixed till homogenous clear mass is obtained. The composition has a Profenofos content 40.26% and Fenpropathrin content 10.08%. The composition further demonstrated Profenofos content 40.12% and Fenpropathrin content 10.07% after accelerated storage condition at 54?C, 14 days.

Examples 14 to 18 were based on preparatory Example 13
Ingredients (%) Example 13 Example 14 Example 15 Example 16 Example 17 Example 18
Profenofos a.i. 40.0 20.0 10.0 40.0 20.0 10.0
Fenpropathrin a.i. 10.0 20.0 30.0 10.0 20.0 30.0
Tristyryl phenol ethoxylate 8.1 7.1 8.1 0.0 0.0 0.0
Castor oil ethoxylate 0 0.0 0.0 7.1 6.1 7.0
Calcium alkyl benzene Sulfonate 4.9 2.9 3.9 5.9 3.9 4.0
Epoxydized soyabean oil 4.0 2.0 2.0 4.0 2.0 2.0
Aromatic Hydrocarbon solvent 33.0 48.0 46.0 33.0 48.0 47.0
Total 100.0 100.0 100.0 100.0 100.0 100.0

Specification
Description Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment Stable liquid, free from visible suspended matter and sediment
Profenofos content (% w/w) 38.0 - 42.0 19.0 – 21.0 9.0-11.0 38.0 - 42.0 19.0 – 21.0 9.0-11.0
Fenpropathrin content (% w/w) 9.0-11.0 19.0 – 21.0 28.50 – 31.50 9.0-11.0 19.0 – 21.0 28.50 – 31.50
Acidity as H2SO4 (% by mass) Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0 Max 1.0
Emulsion stability Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments Max. 2 ml Cream/sediments
Flash point (?C) Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5 Min. 24.5
Cold test No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur No turbidity of solid and/or oily matter or both shall occur


Analysis (Initial)

Description Complies Complies Complies Complies Complies Complies
Profenofos
content (% w/w) 40.26 20.21 10.15 40.35 20.27 10.05
Fenpropathrin
content (% w/w) 10.08 20.15 30.16 10.09 20.16 30.26
Acidity as H2SO4 (% by mass) 0.03 0.01 0.02 0.04 0.01 0.01
Emulsion stability Complies Complies Complies Complies Complies Complies
Flash point (?C) Complies Complies Complies Complies Complies Complies
Cold test Complies Complies Complies Complies Complies Complies


Analysis (54?C, 14 days)
Description Complies Complies Complies Complies Complies Complies
Profenofos
content (% w/w) 40.12 20.08 10.05 40.18 20.19 10.09
Fenpropathrin
content (% w/w) 10.07 20.17 30.03 10.04 20.17 30.16
Acidity as H2SO4 (% by mass) 0.03 0.03 0.03 0.03 0.02 0.02
Emulsion stability Complies Complies Complies Complies Complies Complies
Flash point (?C) Complies Complies Complies Complies Complies Complies
Cold test Complies Complies Complies Complies Complies Complies


Analysis (0?C, 7 days)
Description Complies Complies Complies Complies Complies Complies
Profenofos
content (% w/w) 40.11 20.09 10.09 40.18 20.19 10.09
Fenpropathrin
content (% w/w) 10.09 20.12 30.03 10.04 20.17 30.09
Acidity as H2SO4 (% by mass) 0.02 0.02 0.03 0.02 0.01 0.03
Emulsion stability Complies Complies Complies Complies Complies Complies
Flash point (?C) Complies Complies Complies Complies Complies Complies
Cold test Complies Complies Complies Complies Complies Complies

As observed the compositions formulated in Examples 13 to 18 were found to be stable at the end of the accelerated storage stability study.
B. FIELD STUDY:
Field trial was conducted to evaluate the bio-efficacy of profenophos 50% + fenpropathrin 5% EC against pink bollworm population on cotton crop.
Popular variety Jadoo seeds was dibbled in a plot size of 6.30 × 6.60 m with spacing of 90 × 60 cm at the Raichur.
The experiment was laid out in a Randomized Complete Block Design with seven treatments having three replications. The crop was raised with recommended package of practices excluding plant protection measures.
The test chemical, profenophos 50% + fenpropathrin 5% EC was tested at four doses viz., 500 + 50, 750 + 75, 1000 +100 and 1500 +150 g a.i/ha. Wherein, the highest dose of 1500 +150 g a.i/ha of test compound was tested for phytotoxicity and all these dosages were compared with standard check treatments viz., profenophos 50% EC @ 750 g a.i/ha, fenpropathrin 10 % EC @ 100 g a.i/ha and chlorpyriphos 50 % + cypermethrin 5 % EC @ 500 +50 g a.i/ha along with untreated check.
First imposition of treatments was made, when the pest population reached the Economic Threshold Level (ETL), with a high volume knapsack sprayer using 500 litres of spray fluid per hectare.
Observations recorded
Five plants were selected randomly in each plot per replication and from each plant top three leaves were selected for pre-treatment count of the pests’ viz., pink bollworm. Similarly, the post-treatment observation at 3, 7, 10 and 14 days after spray was made for above mentioned sucking pests.
Observations on phytotoxicity of test compound on cotton crop was scored on 0, 1, 3, 5, 7 and 10 days after spray by recording the injury to leaf tips, leaf surface, wilting, vein clearing, necrosis, epinasty and hyponasty graded by adopting below mentioned zero to 10 scale.

Phytotoxicity rating scale:
Rating Phytotoxicity %
0 No phytotoxicity
1 1 – 10
2 11 – 20
3 21 – 30
4 31 – 40
5 41 – 50
6 51 – 60
7 61 – 70
8 71 – 80
9 81 – 90
10 91 – 100

Seed cotton yield - The total cotton kapas yield was recorded separately from each plot at each picking and finally the total yield was computed by adding the kapas yield from all pickings and was expressed per hectare basis.
Further, the percentage increase in yield over UTC was calculated using the following formula:
Increase (%) = [(Crop yield in treated plot – Crop yield in control plot) / Crop yield in control plot] X 100.

Table 1: Bio-efficacy of Profenophos 50% + Fenpropathrin 5% EC against pink bollworm larvae on cotton during kharif-2019- 20
Treatments Dosage
(g a.i/ha) PTC* Mean PBW larvae/ 20 green bolls
After 1st spray PTC After 2nd spray
7 DAS % ROC
Reduction 14 DAS % ROC
Reduction 7 DAS % ROC
Reduction 14 DAS % ROC
Reduction
T1= Profenophos 50% + Fenpropathrin 5% EC 500 + 50 13.39 (3.71) 6.64 (2.67) 56.98 7.50 (2.82) 58.44 16.72 (4.14) 6.50 (2.62) 66.00 7.90 (2.80) 64.41
T2= Profenophos 50% + Fenpropathrin 5% EC 750 + 75 13.30 (3.70) 4.85 (2.31) 70.02 5.31 (2.41) 70.46 17.07 (4.08) 5.47 (2.42) 71.06 6.46 (2.62) 70.19
T3= Profenophos 50% + Fenpropathrin 5% EC 1000 +100 13.17 (3.67) 4.60 (2.26) 70.83 5.17 (2.37) 71.88 17.28 (4.18) 5.27 (2.37) 72.39 5.97 (2.51) 72.79
T4= Profenophos 50% EC 750 14.60 (3.86) 8.02 (2.92) 48.58 9.72 (3.17) 43.35 17.97 (4.23) 8.38 (2.98) 54.92 9.29 (3.07) 57.71
T5= Fenpropathrin 10% EC 100 12.70 (3.62) 7.87 (2.87) 52.69 9.71 (3.19) 45.52 16.43 (4.09) 8.47 (2.95) 54.67 9.06 (3.07) 57.72
T6= Chlorpyriphos 50% + Cypermethrin 5% EC 500 +50 13.71 (3.74) 8.98 (3.06) 42.99 11.06 (3.39) 40.16 17.06 (4.19) 8.85 (3.05) 52.54 8.85 (3.05) 58.70
T7= Untreated control -- 13.80 (3.75) 16.33 (4.09) 0.00 18.46 (4.34) 0.00 17.47 (4.22) 18.74 (4.38) 0.00 21.44 (4.68) 0.00
S. Em. ± NS 0.10 0.11 NS 0.09 0.11
CD at 5% NS 0.32 0.33 NS 0.27 0.35
* PTC - Pre-treatment count of PBW larvae/20 green bolls bolls,
Figures in parenthesis are square root transformed values DAS= Day/days after spray NS=Non-significant, % ROC – Reduction over control

Table 2: Bio-efficacy of Profenophos 50% + Fenpropathrin 5% EC against pink bollworm larvae on cotton during kharif-2020-21
Treatments Dosage
(g a.i/ha) PTC* Mean PBW larvae/ 20 green bolls
After 1st spray PTC After 2nd spray
7 DAS % ROC
Reduction 14 DAS % ROC
Reduction 7 DAS % ROC
Reduction 14 DAS % ROC
Reduction
T1= Profenophos 50% + Fenpropathrin 5% EC 500 + 50 11.59 (3.46) 4.60 (2.24) 66.53 5.27 (2.37) 67.24 15.02 (3.90) 7.13 (2.76) 60.98 7.40 (2.81) 61.29
T2= Profenophos 50% + Fenpropathrin 5% EC 750 + 75 11.27 (3.41) 4.16 (2.15) 70.05 4.81 (2.28) 70.21 15.07 (3.89) 5.73 (2.48) 68.95 5.70 (2.47) 70.33
T3= Profenophos 50% + Fenpropathrin 5% EC 1000 +100 10.17 (3.26) 3.90 (2.09) 71.57 4.53 (2.21) 72.78 15.51 (3.97) 5.20 (2.38) 71.24 5.40 (2.43) 71.65
T4= Profenophos 50% EC 750 11.57 (3.45) 5.80 (2.51) 57.38 6.13 (2.57) 61.99 14.90 (3.89) 8.50 (3.00) 53.35 10.10 (3.22) 47.54
T5= Fenpropathrin 10% EC 100 9.20 (3.07) 5.77 (2.50) 57.54 6.10 (2.57) 62.39 14.57 (3.86) 8.05 (2.91) 56.37 9.53 (3.12) 50.86
T6= Chlorpyriphos 50% + Cypermethrin 5% EC 500 +50 11.28 (3.39) 6.37 (2.62) 53.01 6.87 (2.71) 57.27 14.93 (3.89) 7.57 (2.83) 58.74 9.07 (3.05) 53.06
T7= Untreated control -- 11.00 (3.38) 13.74 (3.77) 0.00 16.34 (4.10) 0.00 15.73 (4.02) 18.28 (4.33) 0.00 19.11 (4.43) 0.00
S. Em. ± NS 0.06 0.10 NS 0.08 0.11
CD at 5% NS 0.20 0.31 NS 0.23 0.34

Figures in parenthesis are square root transformed values DAS= Day/days after spray NS=Non-significant, % ROC – Reduction over contro

Table 3: Impact of Profenophos 50% + fenpropathrin 5% EC on seed cotton yield during kharif 2019-20 & 2020 - 21
Treatment Details Dosage
(g a.i/ ha) 2019-20
Seed cotton yield
(q/ha) 2019-20
Yield increase over UTC (%) 2020 - 21
Seed cotton yield
(q/ha) 2020 - 21
Yield increase over UTC (%)
T1= Profenophos 50% + Fenpropathrin 5% EC 500 + 50 15.16 84.65 17.23 101.05
T2= Profenophos 50% + Fenpropathrin 5% EC 750 + 75 17.02 107.31 19.98 133.14
T3= Profenophos 50% + Fenpropathrin 5% EC 1000 +100 17.73 115.96 20.01 133.49
T4= Profenophos 50% EC 750 15.01 82.83 17.2 100.70
T5= Fenpropathrin 10% EC 100 14.31 74.30 15.63 82.38
T6= Chlorpyriphos 50% + Cypermethrin 5% EC 500 +50 14.90 81.49 16.11 87.98
T7= Untreated control -- 8.21 - 8.57 -
S.Em (±) 0.39 0.48
CD @ 5 % 1.18 1.43
Table 4. Phytotoxic effect of synergistic composition of the present invention (Profenophos 60% +Fenpropathrin 10% EC) on Cotton 2019-20
T. No Treatments Dosage
(g a.i/ ha) Leaf injury on tips and leaf surface Wilting, Vein clearing and necrosis Epinasty and Hyponasty
T1 Profenophos 50% + Fenpropathrin 5% EC 500 + 50 0 0 0
T2 Profenophos 50% + Fenpropathrin 5% EC 750 + 75 0 0 0
T3 Profenophos 50% + Fenpropathrin 5% EC 1000 +100 0 0 0
T4 Profenophos 50% EC 750 0 0 0
T5 Fenpropathrin 10 % EC 100 0 0 0
T6 Chlorpyriphos 50 % + Cypermethrin 5 % EC 500 +50 0 0 0
T7 Untreated control -- 0 0 0

Table 5. Phytotoxic effect of synergistic composition of the present invention (Profenophos 60% +Fenpropathrin 10% EC) on Cotton 2020-21

T. No Treatments Dosage
(g a.i/ ha) Leaf injury on tips and leaf surface Wilting, Vein clearing and necrosis Epinasty and Hyponasty
T1 Profenophos 50% + Fenpropathrin 5% EC 500 + 50 0 0 0
T2 Profenophos 50% + Fenpropathrin 5% EC 750 + 75 0 0 0
T3 Profenophos 50% + Fenpropathrin 5% EC 1000 +100 0 0 0
T4 Profenophos 50% EC 750 0 0 0
T5 Fenpropathrin 10 % EC 100 0 0 0
T6 Chlorpyriphos 50 % + Cypermethrin 5 % EC 500 +50 0 0 0
T7 Untreated control -- 0 0 0

The synergistic insecticidal composition of the present invention gave good control of pink bollworm. Further, the use of the synergistic insecticidal composition resulted in no phytotoxic symptoms on the Cotton. The above data provides phytotoxic effect of the synergistic composition on cotton. This Product combination is not phytotoxic on Cotton.
,CLAIMS:1. A synergistic agrochemical composition comprising:
a. Profenofos in the range of 0.1% to 80% by weight of the total composition;
b. Fenpropathrin in the range of 0.1% to 50% by weight of the total composition; and
c. at least one agrochemically acceptable excipient in the range of 0.05% to 80% by weight of the total composition.
2. The synergistic agrochemical composition as claimed in Claim 1, wherein the weight ratio of Profenofos to Fenpropathrin is 1:20 to 20:1.
3. The synergistic agrochemical composition as claimed in claim 1, wherein the composition is an emulsion concentrate, a microemulsion, a suspoemulsion, an aqueous emulsion, a dispersible oil suspension, or a capsule suspension.
4. The synergistic agrochemical composition as claimed in claim 1, wherein the at least one excipient is selected from the group comprising of wetting agent, thickener, sticking agent, anti-freezing agent, dispersant, anti-foam agent, defoamer, buffering agent, emulsifiers, stabilizers, surfactants, solvents, and mixtures thereof.
5. The synergistic agrochemical composition as claimed in claim 4, wherein the emulsifier is a non-ionic emulsifier, an anionic emulsifier or a mixture thereof.
6. The synergistic agrochemical composition as claimed in claim 5, wherein the non-ionic emulsifier is selected from non-ionic emulsifier Polyoxyethylene tridecyl ether, polyoxyethylene tristyryl phenyl ether, Tristeryl phenol ethoxylate, polyoxyethylene sorbitol tetraoleate, polyoxyethylene sorbitan ester, polyoxyethylene alkyl ether, polyoxyethylene polycyclic phenyl ether, polyoxyethylene oleic ester, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene castor oil, and ethoxylated propoxylated tristyrylphenol.
7. The synergistic agrochemical composition as claimed in claim 5, wherein the anionic emulsifier is selected from alkylarylsulfonates, diphenylsulfonates, alpha-olefin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecyl- and tridecylbenzenes, Sulfates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters, and phosphate esters.
8. The synergistic agrochemical composition as claimed in claim 4, wherein the stabilizer is selected from an epoxidized oil fatty acid or an epoxidized ester of a fatty acid.
9. The synergistic agrochemical composition as claimed in claim 4, wherein the solvent is selected from a group comprising of water miscible solvents, non-polar solvents like an aliphatic hydrocarbon, an aromatic hydrocarbon, and an alkyl ester.
10. A method for controlling pests and diseases, wherein the method comprises applying the composition as claimed in claim 1 to control insects and/or pests in different crop varieties, such as cotton, wheat, rice, maize, corn, soybeans or sunflower.