DESC:FIELD OF THE INVENTION:
The present invention relates to synergistic agrochemical compositions comprising bioactive amounts of (A) Isocycloseram; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators and micronutrients or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.

BACKGROUND OF THE INVENTION:
Combination of insecticides and plant health additives are used to broaden the spectrum of control of insect–pests and mites, to improve the pest control with synergistic effect, to mitigate the effect of biotic and abiotic stress on crop plants, to reduce dosage, thereby reducing environmental impact, decrease chances of resistance development and to enhance residual control so lesser the number of sprays for crop protections and minimizing the pesticidal load in ecosystem. The combination of insecticides and plant health additives at times demonstrate an additive or synergistic effect that results in an improved control on the insect-pests and mite.
Insecticides and plant health additives in combination are used widely and very frequently in commercial agriculture and have enabled an enormous increase in crop yields and product quality which ultimately increased the ease to farmers in term of economic advantage as well as ease of farming activities.
There are many combinations of Isocycloseram along with other insecticide known in the art for the control of insect-pests. For example, WO2023282140A1 relates to a kind of composition comprising Group (A): the group consisting of Broflanilide, Nicofluprole, Fluxametamide and Isocycloseram; Group (B): the group consisting of imiprothrin and tetramethrin; Group (C): the group consisting of permethrin, cypermethrin, phenothrin, cyphenothrin, cyfluthrin, deltamethrin and cyhalothrin containing a control compound and a weight ratio of 1:1000:1000 to 1:0.001:0.001.
AR125244A1 relates to a bait composition comprising an insecticidally effective amount of isocycloseram and a bait material comprising an insect food attractant and/or an insect food flavoring. Furthermore, the present invention relates to a method of controlling an insect pest or population of insect pests comprising applying an insecticidally effective amount of said bait composition to a site or environment of known or probable insect activity.
WO2022009224A1 relates to an insecticidal composition for pest control comprising: a) an insecticide from diacylhydrazines group present in amount of 1% - 30 % by weight; b) an insecticide from diamide or pyridylpyrazole group is selected from is selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, cyproflanilide, flubendiamide, tetraniliprole, tetrachlorantraniliprole, broflanilide, fluxametamide and isocycloseram present in amount of 1 % - 20 % by weight; c) an insecticide selected from group of different insecticides present in amount of 0.5 % - 50 % by weight; d) an inactive formulation excipients.
There is however a need for improvement of these combinations. Single active combinations used over a long period of time has resulted in resistance. With the onset of resistance to certain pests, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of control over insect-pests and mite.
However still there is a need for a composition comprises Isocycloseram; an insecticide selected from various groups or mixture thereof; and a plant health additive selected from bio-stimulants, plant growth regulators and micronutrients or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive formulation excipients and formulation thereof which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
In general use, the pesticide actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism. However, most active pesticide compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.
Therefore, one object of the present invention is to provide improved compositions of insecticides and plant health additives for the control of insect-pests and mites. Another object of the present invention is to provide a method and a composition for controlling insect-pests and mites.
Yet another object of the present invention is to provide improved compositions of insecticides and plant health additives that promote plant health and to increase plant or crop yield.
Another object of the present invention is to provide a pesticidal formulation that gives broad spectrum control of insect-pests and mites in one shot application.
Further object of the present invention is to provide a pesticidal formulation that gives residual control i.e. longer duration of control.
Another object of the present invention is to provide a pesticidal formulation which prevents or causes delayed development of resistance to insects against insecticides with a specific site/ mode of action.
Further object of the present invention is to provide a pesticidal formulation that gives synergistic control; i.e. grams of active ingredients required are less to achieve desired level of control.
Another object of the present invention is to provide a pesticidal formulation that gives immediate protection to crops.
Further object of the present invention is to provide a pesticidal formulation that has improved rain-fastness properties.
Another object of the present invention is to provide a pesticidal formulation with environment-friendly formulations; i.e. formulations are without organic solvent as carrier.
Yet another object of the present invention is to provide a pesticidal formulation that is safe to the crops.
Still another object of the present invention is to provide a process for preparing a stable and non-phytotoxic formulation.
Embodiment of the present invention can ameliorate one or more of the above mentioned problems.
Inventors of the present invention have surprisingly found that the novel synergistic
agrochemical composition of Isocycloseram; an insecticide selected from various groups or mixture thereof; and a plant health additive or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive formulation excipients and formulation thereof as described herein which can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION
Therefore an aspect of the present invention provides a synergistic agrochemical composition comprising bioactive amounts of (A) Isocycloseram; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators and micronutrients or mixture thereof.
Further aspect of the present invention provides a synergistic agrochemical compositions comprising bioactive amounts of (A) Isocycloseram present in an amount of 4 to 30%w/w; (B) an insecticide selected from carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb, acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos, ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole, bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin, acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin, sulfoxaflor, flupyradifurone, triflumezopyrim, dichloromezotiaz, fenmezoditiaz, bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, spinosad, spinetoram, abamectin, emamectin benzoate, ivermectin, lepimectin, milbemectin, hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen, chloropicrin, dazomet, metam, pymetrozine, pyrifluquinazon, afidopyropen, flonicamid, clofentezine, hexythiazox, diflovidazin, etoxazole, bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, buprofezin, cyromazine, Bacillus thuringiensis and insecticidal proteins, chlorfenapyr, DNOC, sulfluramid, methoxyfenozide, tebufenozide, halofenozide, fufenozide, chromafenozide, amitraz, diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, tetradifon, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin, cyenopyrafen, cyflumetofen, pyflubumide, hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin, indoxacarb, metaflumizone, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, granuloviruses, nucleopolyhedrosis viruses, acynonapyr, azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin and ledprona present in an amount of 1 to 30%w/w; and (C) a plant health additive from a plant health additive from kojic acid, carboxylic acid (acetic acid, benzoic acid, formic acid, chloroacetic acid, propionic acid, butyric acid, valeric acid, pelargonic acid, lauric acid, lactic acid, tridecylic acid, palmitic acid, arachidic acid), acetyl thioproline, alginate, cellulose, starch, cyclodextrin, d-limonene, strigolactone, laminarin, polyamines, nitrobenzene, anisiflupurin, or mixture thereof present in an amount of 0.001 to 20% w/w.
Accordingly, in a further aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against insect-pests damage by applying to the plant propagation material a composition comprising a pesticidal composition defined in the first aspect.
As per one embodiment formulation for the agrochemical composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Wettable granule/Water dispersible granule (WG/WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR) and one or more customary formulation adjuvants such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides e) anti-freezing agent f) suspending agent g) thickener h) coating agent and i) buffering agent.
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.
Accordingly, in a first aspect, the present invention provides a synergistic agrochemical compositions comprising bioactive amounts of (A) Isocycloseram; (B) an insecticide selected from different groups or mixture thereof; and (C) a plant health additive or mixture thereof; and one or more customary formulation adjuvants; shows synergistic activity.

DETAILED DESCRIPTION OF THE INVENTION:
The term "synergistic", as used herein, refers the combined action of two or more active
agents blended together and administered conjointly that is greater than the sum of their
individual effects.
"Bioactive amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.
Therefore an aspect of the present invention provides a synergistic agrochemical composition comprising bioactive amounts of (A) Isocycloseram; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected from bio-stimulants, plant growth regulators, and micronutrients or mixture thereof.
In an embodiment of the present invention an insecticide from the class of carbamates (AChE-acetylcholine esterase inhibitors) is selected from carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb; from the class of organophosphates (AChE-acetylcholine esterase inhibitors) is selected from acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos; from the class of phenylpyrazoles-fiproles (GABA-gated chloride channel blockers) is selected from ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole; from the class of pyrethroids (sodium channel modulators) is selected from bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (pyrethrum); from the class of nicotinic insecticides (nicotinic acteylcholine receptor (nAChR) competitive modulators) is selected from acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin; sulfoximines-sulfoxaflor; butenolides- flupyradifurone; mesoionics- triflumezopyrim, dichloromezotiaz, fenmezoditiaz; from the class of nereistoxin analogues (nicotinic acetylcholine receptor (nAChR) channel blockers) is selected from bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium; from the class of spinosyns (nicotinic acteylcholine receptor (nAChR) allosteric modulators-Site I) is selected from spinosad, spinetoram; from the class of avermectins and milbemycins (glutamate-gated chloride channel (GluCl) allosteric modulators) is selected from avermectins- abamectin, emamectin benzoate, ivermectin, lepimectin; milbemycins- milbemectin; from the class of juvenile hormone mimics is selected from hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen; from the class of non-specific multi-site inhibitors is selected from chloropicrin, dazomet, metam; from the class of chordotonal organs modulators is selected from pymetrozine, pyrifluquinazon, afidopyropen, flonicamid; from the class of mite growth inhibitors affecting CHS1 is selected from clofentezine, hexythiazox, diflovidazin or etoxazole; from the class of benzoylureas (inhibitors of the chitin biosynthesis affecting CHS1: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron; from the class of buprofezin (inhibitors of the chitin biosynthesis type 1): buprofezin; from the class of cyromazine (moulting disruptors for dipteran): cyromazine; from the class of microbial disruptors of insect midgut membrane: Bacillus thuringiensis and insecticidal proteins they product; from the class of uncouplers of oxidative phosphorylation: chlorfenapyr, DNOC, or sulfluramid; from the class of diacylhydrazines (ecdyson receptor agonists): diacylhydrazines- methoxyfenozide, tebufenozide, halofenozide, fufenozide or chromafenozide; from the class of octopamin receptor agonists: amitraz; from the class of inhibitors of mitochondrial ATP synthase:- diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, or tetradifon; from the class of METI (mitochondrial complex I) inhibitors: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin; from the class of METI (mitochondrial complex II) inhibitors: cyenopyrafen, cyflumetofen, -pyflubumide; from the class of METI (mitochondrial complex III) inhibitors:-hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin; from the class of METI (mitochondrial complex IV) inhibitors:-phosphides and cyanides; from the class of voltage-dependent sodium channel blockers: indoxacarb, metaflumizone; from the class of inhibitors of the lipid synthesis, inhibitors of acetyl CoA carboxylase: spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen; from the class of baculoviruses:- granuloviruses and nucleopolyhedrosis viruses; from the class of calcium activated potassium channel (KCa2) modulators:- acynonapyr; Compounds of unknown or uncertain mode of action:- azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin, sulfiflumin, ledprona.
In an embodiment of the present invention a plant health additive selected from kojic acid, carboxylic acid (acetic acid, benzoic acid, formic acid, chloroacetic acid, propionic acid, butyric acid, valeric acid, pelargonic acid, lauric acid, lactic acid, tridecylic acid, palmitic acid, arachidic acid), acetyl thioprolinealginate, cellulose, starch, cyclodextrin, d-limonene, strigolactone, laminarin, polyamines, nitrobenzene, or mixture thereof.
Isocycloseram
Isocycloseram is an isoxazoline insecticide and acaricide with activity against lepidopteran, hemipteran, coleopteran, thysanopteran and dipteran pest species. Isocycloseram selectively targets the invertebrate Rdl GABA receptor at a site that is distinct to fiproles and organochlorines. The widely distributed cyclodiene resistance mutation, A301S, does not affect sensitivity to isocycloseram, either in vitro or in vivo, demonstrating the suitability of isocylsoseram to control pest infestations with this resistance mechanism.
Isocycloseram is a diastereoisomeric mixture containing 80-100% of the (4R, 5S)-isomer and 0-20% of (4R, 5R)-, (4S,5R)-, and (4S, 5S)-isomers. It is a broad-spectrum insecticide and acaricide developed by Syngenta Crop Protection that is active against several pest species including lepidopteran, hemipteran, and dipteran pest species. It has a role as an insecticide, an acaricide, a GABA-gated chloride channel antagonist and an agrochemical. It contains a (4R, 5S)-isocycloseram, a (4R, 5R)-isocycloseram, a (4S, 5R)-isocycloseram and a (4S, 5S)-isocycloseram.
Isocycloseram is having IUPAC name as 4-[5-(3, 5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-N-(2-ethyl-3-oxoisoxazolidin-4-yl)-2- methylbenzamide.

Plant growth regulators:
Plant Growth Additives or Regulators are defined as small, simple chemicals produced naturally by plants to regulate their growth and development.
Plant Growth Regulators can be of a diverse chemical composition such as gases (ethylene), terpenes (gibberellic acid) or carotenoid derivatives (abscisic acid). They are also referred to as plant growth substances, phytohormones or plant hormones.
Kojic acid
Kojic acid is a kind of faintly acid compound that utilizes starch sugar raw material aerobic fermentation to produce by microorganism, chemical name 2-methylol-5-hydroxyl-?-pyrones, its structure is similar to glucose, confirm that through isotope experiment the biosynthesis pathway of kojic acid is to be formed by glucose direct oxidation dehydration. Chemical composition and molecular structure according to kojic acid, that kojic acid has is antibacterial, anti-oxidant, suppress character such as polyphenol oxidase, chelated metal ions, can be used as the antibiotic antiseptic of food, fruits and vegetables prevent the antistaling agent of enzymatic browning, the antioxidation and color-protecting agent of meat products, aquatic products, the brightening, dispelling spots, dispelling function base-material of skin-lightening cosmetic. The organic acid plant growth regulator is widely used in agricultural production, but prior art is promoting crop yield and improving aspect the quality not ideal enough.
D-limonene
Limonene appears to be a key mediator of the interaction between GT22 and plants. Overall, our findings provide evidence that fungal VCs can promote plant growth and enhance both biotic and abiotic tolerance.
Laminarin
Laminarin as an accelerator of seed germination and plant growth. Laminarin is a brown algae reserve polymer made up of polysaccharides with slightly different structures depending on the nature of the alga. Laminarin (Lam), has an established role on induction of plant disease resistance. In this study, application of Laminarin increased Arabidopsis fresh weight and enhanced tolerance to salt and heat stress by stabilizing chloroplast under adverse environment. Transcriptome analysis indicated that, in addition to induced a large number of genes associated with the host defense, genes involved in the regulation of abiotic stress tolerance mostly the heat stress response constituted the largest group of the up-regulated genes. Laminarin induced expression of IRT1, ZIP8, and copper transporters involved in transport of Fe, Zn, Cu ions associated with the activity of chloroplast antioxidant system. Laminarin also up-regulated genes involved in the synthesis of terpenoid, a plastidial-derived secondary metabolite with antioxidant activity.
Anisiflupurin
Anisiflupurin is a novel cytokinin plant growth regulator which is a 6-anilinopurine derivative. It is not widely approved for use.
Nitrobenzene
Nitrobenzene is a plant energiser and flower stimulant. The main advantages of nitrobenzene it helps the plant to increase CN ratio significantly, it increases plant size and helps for flowering, it enhances the plant canopy and induces flowering and increases the yield, it can be used in all major agriculture crops through foliar application, it is compatible with pesticide and fungicides. It is applicable in foliar spray and other forms of applications also as a plant nutrient.
The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of insect pest and mites control and has surprisingly improved plant vigour and yield. Also providing residual control, i.e. longer duration of control and thereby reducing the number of applications. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The synergistic agrochemical composition of specific active ingredient has the special advantage of being highly active against insect pests and mites. The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combinations of the present invention allow for a broad spectrum of pest control and has surprisingly improved plant vigour and yield. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The synergistic composition has very advantageous pesticidal properties for protecting cultivated plants against insect-pests and mites. As has been mentioned, said active ingredient composition can be used to inhibit or destroy the insect-pests and mites that occur on plants or parts of plants of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such insect-pests and mites.
The synergistic composition of pesticide are used to protect the crops and plants from insect-pests and mites. The lists of the major crops includes but are not limited to GMO (Genetically Modified Organism) and Non GMO traits, hybrids and conventional varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Groundnut/Peanut (Arachis hypogaea), Sunflower (Helianthus annuus), Mustard (Brassica juncea), Rape seed (Brassica napus), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Red gram (Cajanus cajan), French bean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Bell pepper (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Black Pepper (Piper nigrum), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).
Crops are to be understood as also including those crops which have been rendered tolerant to herbicides or classes of herbicides (e.g. ALS-, GS-, EPSPS-, PPO-, ACCase- and HPPD-inhibitors) by conventional methods of breeding or by genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding is Clearfield® summer rape (canola). Examples of crops that have been rendered tolerant to herbicides by genetic engineering methods include e.g. glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady® and LibertyLink®.
Crops are also to be understood as being those which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt maize (resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and also Bt potatoes (resistant to Colorado beetle). Examples of Bt maize are the Bt 176 maize hybrids of NK® (Syngenta Seeds). The Bt toxin is a protein that is formed naturally by Bacillus thuringiensis soil bacteria. Examples of toxins, or transgenic plants able to synthesise such toxins, are described in EP-A-451 878, EP-A-374 753, WO 93/07278, WO 95/34656, WO 03/052073 and EP-A-427 529. Examples of transgenic plants comprising one or more genes that code for an insecticidal resistance and express one or more toxins are KnockOut® (maize), Yield Gard® (maize), NuCOTIN33B® (cotton), Bollgard® (cotton), NewLeaf® (potatoes), NatureGard® and Protexcta®. Plant crops or seed material thereof can be both resistant to herbicides and, at the same time, resistant to insect feeding (“stacked” transgenic events). For example, seed can have the ability to express an insecticidal Cry3 protein while at the same time being tolerant to glyphosate.
Crops are also to be understood to include those which are obtained by conventional methods of breeding or genetic engineering and contain so-called output traits (e.g. improved storage stability, higher nutritional value and improved flavour).
Other useful plants include turf grass for example in golf-courses, lawns, parks and roadsides, or grown commercially for sod, and ornamental plants such as flowers or bushes.
The synergistic combination of the present invention used to control the insects-pests and mites.
The major insects pests are belongs to the order Hemiptera, for example, rice leafhopper/green leaf hopper (GLH) Nephotettix nigropictus, rice brown plant hopper (BPH) Nilaparvata lugen, rice backed plant hopper (WBPH) Sogatella furcifera , Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, aphid Aphis gossypii, jassid Amrasca biguttula biguttla, mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp. ; order Lepidoptera, army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar Achea janata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer Diatraea saccharalis, sugarcane early shoot borer Chilo infuscatellus tobacco budworm Heliothis virescens, tomato fruitworm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, fall armyworm Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza nivella, Tryporyza incertulas, Tuta absoluta.
from the order Coleoptera, for example, apple twig borer Amphicerus spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc; from the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.; from the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci, Thirps parvispinus and Scirtothrips dorsalis; termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis; from the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp., from the order Hymenoptera, for example, Solenopsis spp. ; from the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp., the mites from the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, Tetranychus cinnabarinus;
The term "health of a plant" or "plant health" is defined as a condition of the plant and/or its products. As a result of the improved health, yield, plant vigor, quality and tolerance to abiotic or biotic stress are increased. Noteworthy, the health of a plant when applying the method according to the invention, is increased independently of the pesticidal properties of the active ingredients used because the increase in health is not based upon the reduced pest pressure but instead on complex physiological and metabolic reactions which result for example in an activation of the plant's own natural defense system. As a result, the health of a plant is increased even in the absence of pest pressure. Accordingly, in an especially preferred embodiment of the method according to the invention, the health of a plant is increased both in the presence and absence of biotic or abiotic stress factors. The above identified indicators for the health condition of a plant may be interdependent or they may result from each other. An increase in plant vigor may for example result in an increased yield and/or tolerance to abiotic or biotic stress. One indicator for the condition of the plant is the yield. "Yield" is to be understood as any plant product of economic value that is produced by the plant such as grains, fruits in the proper sense, vegetables, nuts, grains, seeds, wood (e.g. in the case of silviculture plants) or even flowers (e.g. in the case of gardening plants, ornamentals). The plant products may in addition be further utilized and/or processed after harvesting.
In an especially preferred embodiment of the invention, the yield of the treated plant is increased.
In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.
Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased biomass such as higher overall fresh weight (FW), increased number of flowers per plant, higher grain yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index.
According to the present invention, the yield is increased by at least 4 %, preferable by 5 to 10 %, more preferable by 10 to 20 %, or even 30 to 50 % or even more, compared to the untreated control plants or plants treated with known conventional pesticides. In general, the yield increase may even be higher.
A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention, is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, improved stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant.
The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the mixture or active ingredients (components).
Another indicator for the condition of the plant is the "quality" of a plant and/or its products.
In an especially preferred embodiment of the invention, the quality of the treated plant is increased.
In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, enhanced quality means that certain plant characteristics such as the content or composition of certain ingredients are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the application of the mixtures of the present invention. Enhanced quality can be characterized, among others, by following improved properties of the plant or its product: increased nutrient content, increased protein content, increased content of fatty acids, increased metabolite content, increased carotenoid content, increased sugar content, increased amount of essential amino acids, improved nutrient composition, improved protein composition, improved composition of fatty acids, improved metabolite composition, improved carotenoid composition, improved sugar composition, improved amino acids composition, improved or optimal fruit color, improved leaf color, higher storage capacity, higher process ability of the harvested products.
Another indicator for the condition of the plant is the plant's tolerance or resistance to biotic and/or abiotic stress factors. Biotic and abiotic stress, especially over longer terms, can have harmful effects on plants. Biotic stress is caused by living organisms while abiotic stress is caused for example by environmental extremes. According to the present invention, "enhanced tolerance or resistance to biotic and/or abiotic stress factors" means (1.) that certain negative factors caused by biotic and/or abiotic stress are diminished in a measurable or noticeable amount as compared to plants exposed to the same conditions, but without being treated with a mixture according to the invention and (2.) that the negative effects are not diminished by a direct action of the mixture according to the invention on the stress factors, e.g. by its fungicidal or insecticidal action which directly destroys the microorganisms or pests, but rather by a stimulation of the plants' own defensive reactions against said stress factors.

Formulation of the present invention can be in any of the formulations selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Wettable granule/Water dispersible granule (WG/WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).

Further agrochemical composition comprising (A) Isocycloseram; (B) an insecticide selected from various groups or mixture thereof; (C) a plant health additive selected or mixture thereof are present in the said composition in specific fixed ratio.

In further aspect the present invention relates to the synergistic agrochemical composition comprising bioactive amounts of (A) is 4% to 30% w/w of the composition; (B) is 1% to 30% w/w of the composition; and (C) is 0.001% to 20% w/w of the composition.
Compound A Compound B Compound C
Composition Isocycloseram One or more insecticides Plant health additives
% Ratio (w/w) 4% to 30% w/w 1% to 30% w/w 0.001% to 20% w/w
The composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to Super Wetting-spreading-penetrating agent, solvents, dispersant or dispersing agent, anti-freezing agent, emulsifying agent, anti-foam agent, preservatives and buffering agent.
A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules.
Examples Super wetting-spreading-penetrating agent used herein for OD (Oil Dispersion) formulation include but not limited to Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples wetting agent used herein for OD (Oil Dispersion) formulation include but not limited to ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate.
Examples of dispersants or dispersing agent used herein for Oil dispersion (OD) formulation includes but not limited to alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol poly glycol ether), block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.
Emulsifying agent used herein for the Oil dispersion (OD) formulation includes but not limited to castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkyl ammonium salts of alkylbenzene sulphonate, alkyl sulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, polyoxyethylenesorbitan monolaurate, Polyoxyethylene sorbitol hexaoleate.
Examples of Antifoaming agent used herein for Oil dispersion (OD) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.
Examples of Anti-freezing agent used herein for Oil dispersion (OD) formulation include but not limited to ethylene glycol, propane diols, glycerine or the urea, glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride etc.
Preservative used herein for the Oil dispersion (OD) formulation include but not limited to 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.
Examples of Stabiliser or rheology modifier used herein for Oil dispersion (OD) formulation stabilizer is selected from hectorite clay, aluminium magnesium silicate, bentonite clay, silica, attapulgite clay.
Example of solvents used herein for the Oil dispersion (OD) formulation includes but not limited to vegetable oil (plant, seed or tree) or its alkylated or ethoxylated or esterified. The alkylated vegetable oil may be methylated vegetable oil or ethylated vegetable oil. The vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil. The alkyl ester of vegetable oils includes methyl ester, ethyl ester, propyl ester or butyl ester of vegetable oils. Some of the examples are methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane alkyl phenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil butyl ester, cotton seed oil propyl ester, tall oil fatty acids esters-tallow methyl ester, tallow ethyl ester, tallow propyl ester, bio-diesel, mineral oil (aromatic solvents, isoparaffin, base solvent), fatty acid amides (e.g. C1 -C3 amines, alkylamines or alkanolamines with C6–C18 carboxylic acids), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyate, alkyl benzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols. The above oil based carrier/diluting agents may be used as solo or mixture of two or more if desired.
Co-solvent used herein for the Oil dispersion (OD) formulation includes but not limited to Cyclohexanone, Acetophenone, NMP, Dimethyl sulfoxide, Benzyl alcohol, Butanol, N-octanol, N-Propanol, 2-ethyl hexanol, Tetrahydro furfuryl alcohol, Isophorone, Fatty acid dimethyl amide, 2-hexylethyl lactate, Propylene carbonate.
Examples of Wetting agent used herein for Suspension Concentrate (SC) formulation include but not limited to ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a super wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, Methylated seed oil polyalkyleneoxide modified trisiloxane, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, trisiloxane ethoxylate, polyoxyethylene methyl polysiloxane, polyether polymethyl siloxane copolymer, polyether modified polysiloxane; may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples of Dispersing agent used herein for Suspension Concentrate (SC) formulation include but not limited to Naphthalene sulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide;
Examples of Suspending agent used herein for Suspension Concentrate (SC) formulation include but not limited to aluminum magnesium silicate, bentonite clay, silica, attapulgite clay.
Examples of Antifoaming agent used herein for Suspension Concentrate (SC) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.
Examples of Anti-freezing agent used herein for Suspension Concentrate (SC) formulation include but not limited to ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride etc.
Examples of Preservatives used herein for Suspension Concentrate (SC) formulation include but not limited to 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one
Examples of Thickeners used herein for Suspension Concentrate (SC) formulation include but not limited to xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum;
Examples of Humectant used herein for Suspension Concentrate (SC) formulation include but not limited to urea, humic acid, glycerol, lactose.
In another aspect of the present invention, an inactive excipient green solvent selected from n-hexanol (1-hexanol), n-butanol (1-butanol), isobutanol (2-methyl-1-propanol), lactate esters, cyclopentylmethylethe, methyl tertbutyl ether, hexylene glycol, dipropyleneglycol, gamma butyrolactone, acetophenone, 1-methoxy-2-propanol, white mineral oil, g-valerolactone, 2-methyltetrahydrofuran, propylene carbonate, polyethylene glycol, oleic acid, fatty acid methyl ester, Tris (2-ethylhexyl) phosphate, mixture of octanoic acid, decanoic acid, N,N-dimethylamide, 2-ethylhexyl acetate, n-octyl-2-pyrrolidone, pentanol mixture of isomer, isobutanol, lactic acid dimethyl amide, 3-methoxy-N, N-dimethyl propionamide.
In another aspect of the present invention, an inactive excipient emulsifier/surfactant [surface-active emulsifying agent] may be selected from Sorbitan esters (sorbitan fatty acids esters SFAE) - their polyoxyethylene derivatives as polysorbates- polysorbate 20 (polyoxyethylene sorbitan monolaurate-Tween 20), polysorbate 60 (polyoxyethylene sorbitan monostearate-Tween 60), polysorbate 65 (polyoxyethylene sorbitan tristearate-Tween 65), polysorbate 80 (polyoxyethylene sorbitan monolaurate-Tween 80).
In further aspect of the present invention, an inactive excipient an emulsifier is a Glycerides-monoglycerides, diglycerides, triglycerides. Examples are monoglycerides (ACETEM), lactylated monoglycerides (LACTEM), diacetyl tartaric acid monoglycerides (DATEM) and citric acid esters of monoglycerides (CITREM), 1,2-diacylglycerols and 1,3-diacylglycerols, succinylated monoglyceride, ethoxylated monoglyceride, diacetyl tartaric acid esters of mono- and diglyceride, polyglyceryl-3 caprylate, polyglyceryl-3 acetyl ether; sucrose esters, sucrose stearate, propylene glycol esters, sodium stearoyl-2-lactylate, calcium stearoyl-2-lactylate, glycerol monolaurate.
In a further aspect of the present invention, an inactive or formulation excipients Super-Wetting-spreading-penetrating agent is blend of methylated seed oil-organo silicon compound.
The blend methylated seed oil-organo silicon compound comprises methylated seed oil present in an amount of 70% to 90% and organo-silicon surfactants are present in amount of 10% to 40% of the blend.
The preferred combination for the said blend of methylated seed oil and organo-silicon surfactants is selected from 84 % Methylated seed oil, 15% polyalkyleneoxide modified trisiloxane; 90% Methylated seed oil, 10% polyalkyleneoxide modified polydimethylsiloxane; 80% Methylated seed oil, 20% trisiloxane ethoxylate; 70% Methylated seed oil, 30% polyoxyethylene methyl polysiloxane; 60% Methylated seed oil, 40% polyether polymethyl siloxane copolymer.
Methylated seed oil is a kind of fatty acid from seed oil esterified with methyl alcohol. For oil-based adjuvant, droplet spread on application surface for example leaf surfaces; and active agent penetration; are the two predominant factors regarding the mechanism of the enhancement in herbicide efficacy.
Organosilicon compounds have been found to be significantly useful as agricultural adjuvants because of their unique wetting properties. These surfactants provide surface tension values significantly lower than conventional non-ionic surfactants and can provide highly efficient uptake of agricultural chemicals into the plant. The spreading of aqueous solutions due to the organosilicon compounds gives total wetting as measured by low contact angle on leaf surfaces while conventional surfactants provide for less spreading as indicated by higher contact angles. In addition, the organosilicon compounds have been shown to increase the speed and amount of uptake of agricultural active ingredients into plants, resulting in enhanced efficacy of the agricultural active ingredients, including in some cases, like rain fastness.
The present invention relates to blends of Methylated seed oil with organosilicon surfactants, which are useful as agricultural adjuvants for the present suspension concentrate agrochemical composition.
In a further aspect of the present invention, an inactive or formulation excipients Super-Wetting-spreading-penetrating agent is blend of methylated seed oil-organic silicone compound may be selected from methylated seed oil-polyalkyleneoxide modified trisiloxane, methylated seed oil-polyalkyleneoxide modified polydimethylsiloxane, methylated seed oil-trisiloxane ethoxylate, methylated seed oil-polyoxyethylene methyl polysiloxane, methylated seed oil-polyether polymethyl siloxane copolymer, methylated seed oil-polyether modified polysiloxane.
The seed oil may be any one or mixture of two or more selected from soybean (Glycine max) oil, groundnut (Arachis hypogaea) oil, rapeseed (Brassica napus subspecies) oil, mustard (Brassica juncea) oil, sesame (Sesamum indicum) oil, Corn (Zea mays) oil, rice (Oryza sativa) bran oil, castor (Ricinum communis) seed oil, cotton (Gossypium hirsutum) seed oil, linseed (Linum usitatissimum), coconut (Cocos nucifera) oil, Kapok (Ceiba pentandra) oil, Papaya (Carica papaya) seed oil, Tea seed (Camellia oleifera) oil, sunflower (Helianthus annuus) oil, safflower (Carthamus tinctorius) seed oil, Eucalyptus (Eucalyptus globulus) oil, Olive (Olea europaea) oil, Jatropha (Jatropha curcas) oil, Garlic acid (Allium sativum), Ginger oil (Zingiber officinale), D-limonene, Citronella oil or Ceylon ironwood (Mesua ferrea) oil.
The preferred seed oils are sunflower oil, soybean oil, rapeseed oil, cotton seed oil or their blend.

Examples of Wetting agents used herein for WG (Wettable Granule) formulation include but not limited to sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples of Antifoaming agent used herein for WG (Wettable Granule) formulation include but not limited to polydimethylsiloxane.
Examples of Carrier used herein for WG (Wettable Granule) formulation include but not limited to china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
Examples of Humectant used herein for WG (Wettable Granule) formulation include but not limited to humic acid, glycerol, lactose, Sodium sulphate anhydrous.
Examples of Wetting agents used herein for Emulsifiable concentrate (EC) formulation include but not limited to Blend of alcohol ethoxylate and alkyl phenol ethoxylate.
Examples of Solvent used herein for Emulsifiable concentrate (EC) formulation include but not limited to Mixture of heavy aromatic hydrocarbons / C IX, xylene, n-butanol, solvent C-9, N-methyl 2-pyrrolidine, methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, Paraffinic hydrocarbons, cyclohexanone, isophorone and ester solvents such as methyloleate, dimethylamide and morpholineamide derivatives of C6-C16 fatty acids, and mono-alkylene carbonates such as ethylene carbonate, propylene carbonate and butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons and/or aliphatic hydrocarbons, one or more dimethylamides, such as C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP); dimethylformamide (DMF); dimethylisosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidonone; lactate esters; dimethyl and diethylcarbonates; alcohols including methanol; ethanol; iso-propanol; n-propanol; n-butanol; iso-butanol; and tert-butanol; Methyl L-lactate, 2-Ethylhexyl L-lactate, Ethyl L-lactate, n-Butyl L-lactate, Octyl phenyl ethoxylates.
Examples of Emulsifier used herein for Emulsifiable concentrate (EC) formulation include but not limited to salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates Calcium alkyl benzene sulfonate, and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. of sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkylsulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol; fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyletherphosphates; alkylphenoletherphosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkylsulphonate, an alkylethersulphonate, an ether sulphate, or an ether phosphate such as an alkyletherphosphate, nonylphenol polyethoxy ethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol.
Examples of Sticker, surface tension reducer, binder used herein for Emulsifiable concentrate (EC) formulation include but not limited to Polyvinylpyrrolidone.
Examples of Spreader, sticker, penetrant, surface tension reducer used herein for Emulsifiable concentrate (EC) formulation include but not limited to Alkyl polyethylene glycol ether.
The synergistic agrochemical composition comprising bioactive amounts of (A) Isocycloseram present in an amount of 4 to 30%w/w; (B) an insecticide selected from carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb, acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos, ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole, bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin, acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin, sulfoxaflor, flupyradifurone, triflumezopyrim, dichloromezotiaz, fenmezoditiaz, bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, spinosad, spinetoram, abamectin, emamectin benzoate, ivermectin, lepimectin, milbemectin, hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen, chloropicrin, dazomet, metam, pymetrozine, pyrifluquinazon, afidopyropen, flonicamid, clofentezine, hexythiazox, diflovidazin, etoxazole, bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, buprofezin, cyromazine, Bacillus thuringiensis and insecticidal proteins, chlorfenapyr, DNOC, sulfluramid, methoxyfenozide, tebufenozide, halofenozide, fufenozide, chromafenozide, amitraz, diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, tetradifon, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin, cyenopyrafen, cyflumetofen, pyflubumide, hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin, indoxacarb, metaflumizone, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, granuloviruses, nucleopolyhedrosis viruses, acynonapyr, azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin and ledprona present in an amount of 1 to 30%w/w; and (C) a plant health additive from a plant health additive from kojic acid, carboxylic acid (acetic acid, benzoic acid, formic acid, chloroacetic acid, propionic acid, butyric acid, valeric acid, pelargonic acid, lauric acid, lactic acid, tridecylic acid, palmitic acid, arachidic acid), acetyl thioproline, alginate, cellulose, starch, cyclodextrin, d-limonene, strigolactone, laminarin, polyamines, nitrobenzene, anisiflupurin, or mixture thereof present in an amount of 0.001 to 20% w/w shows
• Synergistic control of insect-pests and mites with one shot application;
• Residual control i.e. longer duration of control with immediate crop protection;
• Delay in development of resistance and effective control of hard to kill and resistant insect-pests and mites;
• Increase in yield of treated plants (cereals, pulses, oilseeds, fiber crop, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamentals etc.);
• Increase in yield due to protection against insect-pests and mites;
• Increase in yield due to plant growth regulation, increase in reproductive parts of plant;
• Increase in yield due to more number of tillers, more branches and sub branches, more number of flowers, more number of fruits;
• Increase plant vigor
• Increase tolerance to biotic stress, i.e. insect-pests, mite damage;
• Increase tolerance to abiotic stress, i.e. the weather stress, moisture stress;
• Prevents lodging in susceptible plants (lodging due to biotic and abiotic factors, like heavy rains, winds, insects and diseases damage).
• Improves quality (means visual appearance, color, size, shape etc.) in grains, fruits, fiber, flowers, tuber, bulb, rhizomes, straw, leaves and other plant parts and plant products;
• Improves keeping quality of produce, increase post-harvest life, storage life, and protection from post-harvest insect-pests.

The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.
These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.
EXAMPLE 1:
Isocycloseram 12%+Spinetoram 10%+Laminarin 10% SC
Chemical composition Content (% w/w)
Isocycloseram a.i. 12.00
Spinetoram a.i. 10.00
Laminarin a.i. 10.00
Methylated seed oil, polyalkyleneoxide modified trisiloxane (super wetting-spreading-penetrating agent) 5.00
Ethylene-propylene oxide block copolymer
(dispersing agent I) 4.75
Sodium naphthalene sulphonate formaldehyde
condensates (dispersing agent II) 1.25
Aluminum magnesium silicate (suspending agent) 0.50
Polydimethylsiloxane (anti foaming agent) 0.30
sodium benzoate (preservative) 0.20
Polypropylene glycol (anti freezing agent) 5.00
Xanthan gum (thickner) 0.20
Diluent water 50.80
Total 100.00

Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 12%+Spinetoram 10%+Laminarin 10% SC
Laboratory storage stability for 14 days
Parameters Specification Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 11.40 to 12.60 12.50 12.15 12.50
Spinetoram a.i. 9.50 to 10.50 10.35 10.21 10.35
Laminarin a.i. 9.50 to 10.50 10.40 10.25 10.4
Isocycloseram suspensibility (%) 80 98.60 98.10 98.50
Spinetoram suspensibility (%) 80 98.50 98.30 98.50
Laminarin suspensibility (%) 80 98.70 98.20 98.45
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.15 7.05
Pourability (%) 95 98.20 98.00 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 530 550 550
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.7 2.1,8.7
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specification Initial 1 month 6 month 12 month
Isocycloseram a.i. 11.40 to 12.60 12.50 12.50 12.49 12.45
Spinetoram a.i. 9.50 to 10.50 10.35 10.35 10.34 10.33
Laminarin a.i. 9.50 to 10.50 10.40 10.4 10.4 10.38
Isocycloseram suspensibility (%) 80 98.60 98.50 98.50 98.40
Spinetoram suspensibility (%) 80 98.50 98.50 98.50 98.40
Laminarin suspensibility (%) 80 98.70 98.70 98.60 98.60
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.05 7.05 7.10
Pourability (%) 95 98.20 98.20 98.20 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 530 530 530 535
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.5 2.1,8.5 2.1,8.6
Persistent foam in ml (after 1 minute) max. 60 nil nil nil nil
The composition of Isocycloseram 12%+Spinetoram 10%+Laminarin 10% SC meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing process for 100 kg batch of Isocycloseram 12%+Spinetoram 10%+Laminarin 10% SC
Step 1: Preparation of 2% Gum Solution: Charge Xanthan gum (2.0 kg) and 1,2-benzisothiazoline-3-one (2.0 kg) into 96.0 kg water and homogenize. It should be made 12-18 hour prior to use.
Step 2: Charge DM water (40.8 kg) and 1,2-propylene glycol (5 kg) into designated vessel and ix thoroughly.
Step 3: Add Sodium naphthalene sulphonate formaldehyde condensates (1.25 kg), Ethylene-propylene oxide block copolymer (4.75 kg) and Aluminum magnesium silicate (0.5 kg) into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4: Then add Isocycloseram technical (12 kg), Spinetoram technical (10 kg) and Laminarin technical (10.0 kg) to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5: Before grinding half the quantity of Polydimethylsiloxane (0.15 kg) was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6: Add remaining Polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7: Finally add 10.0 kg of 2% Xanthum gum solution and 5.0 kg of Methylated seed oil, polyalkyleneoxide modified trisiloxane to this formulation and homogenized for 30 minutes.
Step 8: Send this final formulation to QC for quality check.

EXAMPLE 2:
Composition of Isocycloseram 5%+Profenofos 30%+d- limonene 1% EC
Chemical composition content (% w/w)
Isocycloseram a.i. 5.00
Profenofos a.i. 30.00
d- limonene a.i. 1.00
Polyoxyethylene sorbitol 5.00
Calcium alkyl benzene sulfonate 5.00
Castor oil ethoxylate 36 moles 2.00
Cyclohexanone 10.00
Aromatic Solvent c-9 42.00
Total 100.00

Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 5%+Profenofos 30%+d- limonene 1% EC
Laboratory storage stability for 14 days
Parameters Specification Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 4.75 to 5.50 5.20 5.10 5.2
Profenofos a.i. 28.50 to 31.50 30.50 30.30 30.50
d- limonene a.i. 0.95 to 1.10 1.09 1.06 1.09
pH (5% in DM water) 6.0 - 8.0 6.10 6.20 6.10
Emulsion stability Max. 2ml creaming or sediment after 1 hour 0.1 ml 0.2 ml 0.15 ml
Cold test Any separation or creaming max. 2 ml after 1 hour Nil Nil Nil
Flash point Above 24.5 0C 65.00 65.00 65.00
Specific gravity 0.90-1.00 0.95 0.95 0.95
Room temperature storage stability up to 12 months
Parameters Specification Initial 1 month 6 month 12 month
Isocycloseram a.i. 4.75 to 5.50 5.20 5.20 5.2 5.18
Profenofos a.i. 28.50 to 31.50 30.50 30.50 30.48 30.45
d- limonene a.i. 0.95 to 1.10 1.09 1.09 1.08 1.08
pH (5% in DM water) 6.0 - 8.0 6.10 6.10 6.10 6.10
Emulsion stability Max. 2ml creaming or sediment after 1 hour 0.1 ml 0.1 ml 0.15 ml 0.1 ml
Cold test Any separation or creaming max. 2 ml after 1 hour Nil Nil Nil Nil
Flash point Above 24.5 0C 65.00 65.00 65.00 65.00
Specific gravity 0.90-1.00 0.95 0.95 0.95 0.95

The composition of Isocycloseram 5%+Profenofos 30%+d-limonene 1% EC meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).

Manufacturing process for 100 kg batch of Isocycloseram 5%+Profenofos 30%+ d- limonene 1% EC
Step 1: Charge 42.0 kg of Aromatic Solvent c-9 and 10.0 kg of Cyclohexanone into a designated vessel for EC production.
Step 2: Add 5.0 kg of Isocycloseram technical, 30.0 kg of Profenofos technical and 1.0 kg of D-limonene technical, into this premix and homogenized for 30-45 minutes
Step 3: Now add 5.0 kg of Polyoxyethylene sorbitol hexaoleate, 5.0 kg of Calcium alkyl benzene sulfonate and 2 kg of castor oil ethoxylate 36 moles and homogenize the contents for 45 – 60 minutes using high shear homogeniser.
Step 4: Send this final formulation to QC for quality check

EXAMPLE 3:
Isocycloseram 12%+Triflumezopyrim 5%+Kojic acid 1.5% OD
Chemical composition content (% w/w)
Isocycloseram a.i. 12.00
Triflumezopyrim a.i. 5.00
Kojic acid a.i. 1.50
Polyoxyethylene sorbitol hexaoleate (Oil Emulsifier) 10.00
Salts of polyolefin condensates (Non-Aqueous dispersant) 2.50
Ethoxylated sorbitan ester (Co-Emulsifier) 8.50
Bentonite clay (Rheology modifier) 1.50
Styrene acrylic polymer (Aqueous dispersant) 1.50
Methylated seed oil (Oil continuous phase) 57.50
Total 100.00

Active ingredients on the basis of 100% purity.
Storage stability: Isocycloseram 12%+Triflumezopyrim 5%+Kojic acid 1.5% OD
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 11.40 to 12.60 12.50 12.13 12.50
Triflumezopyrim a.i. 4.75 to 5.50 5.25 5.12 5.25
Kojic acid a.i. 1.43 to 1.65 1.60 1.54 1.60
Isocycloseram suspensibility (%) 80 98.90 98.10 98.80
Triflumezopyrim suspensibility (%) 80 99.00 98.50 98.90
Kojic acid suspensibility (%) 80 98.80 98.10 98.80
pH range (1% aq. Suspension) 5.5 to 8.0 6.90 7.05 6.90
Pourability (%) 95 98.20 98.10 98.20
Specific gravity 1.00-1.10 1.03 1.03 1.03
Viscosity at spindle no.62,20 rpm 350-800 cps 510 520 510
Particle size (micron) D50<3, D90<10 2.1,8.0 2.1,8.2 2.1,8.1
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specifications Initial 1 month 6 month 12 month
Isocycloseram a.i. 11.40 to 12.60 12.50 12.50 12.49 12.47
Triflumezopyrim a.i. 4.75 to 5.50 5.25 5.25 5.24 5.23
Kojic acid a.i. 1.43 to 1.65 1.60 1.60 1.58 1.54
Isocycloseram suspensibility (%) 80 98.90 98.90 98.80 98.80
Triflumezopyrim suspensibility (%) 80 99.00 98.90 98.90 98.80
Kojic acid suspensibility (%) 80 98.80 98.80 98.70 98.70
pH range (1% aq. Suspension) 5.5 to 8.0 6.90 6.90 6.90 6.95
Pourability (%) 95 98.20 98.20 98.20 98.20
Specific gravity 1.00-1.10 1.03 1.03 1.03 1.03
Viscosity at spindle no. 62, 20 rpm 350-800 cps 510 510 510 515
Particle size (micron) D50<3, D90<10 2.1,8.0 2.1,8.1 2.1,8.1 2.1,8.1
Persistent foam in ml (after 1 minute) max. 60 nil nil nil nil

The composition of Isocycloseram 12%+Triflumezopyrim 5%+Kojic acid 1.5% OD meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing Process for 100 kg batch of Isocycloseram 12%+ Triflumezopyrim 5%+Kojic acid 1.5% OD
Step 1: 15% Bentonite clay Solution Preparation:
Add 15 kg of Precipitated Bentonite in to 85 kg of Methylated seed oil and also and homogenized till it gets completely dissolved. It must be kept for 12-18 hour prior to use.
Step 2: OD Premix:
Charge 47.5 kg of Methylated seed oil into a designated vessel for OD production.
Step 3: Now add 10.0 kg of Polyoxyethylene sorbitol hexaoleate, 1.50 kg of Styrene acrylic polymer,8.50 kg of Ethoxylated sorbitan ester,2.50 kg of Salts of polyolefin condensates and 0.15 kg of Polydimethyl siloxane homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4: Add 12.0 kg of Isocycloseram technical, 5.0 kg of Triflumezopyrim technical and 1.5 kg of Kojic acid technical, into this premix and homogenized for 30-45 minutes.
Step 5: Add remaining 0.15 kg of Silicon antifoam and 10 kg of 15% Betonite solution after milling to avoid foaming.
Step 6: Send this final formulation to QC for quality check.

EXAMPLE 4:
Isocycloseram 4%+Cartap hydrochloride 30%+Kojic acid 1% WG
Chemical composition Percent (w/w)
Isocycloseram a.i. 4.00
Cartap hydrochloride a.i. 30.00
Kojic acid a.i. 1.00
Modified Sodium lignosulphonate (dispersing agent I) 7.00
Modified polyacrylate copolymer (dispersing agent II) 3.00
Sodium isopropyl naphthalene sulfonate (wetting agent) 5.00
Polydimethylsiloxane (Antifoaming Agent) 1.00
Lactose anhydrous 20.00
Sodium Sulfate Anhydrous 29.00
Total 100.00
Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 4%+Cartap hydrochloride 30%+Kojic acid 1% WG
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 3.80 to 4.40 4.25 4.10 4.25
Cartap hydrochloride a.i. 28.5 to 31.5 30.50 30.20 30.50
Kojic acid a.i. 0.95 to 1.10 1.10 1.07 1.1
Isocycloseram suspensibility (%) 70 98.40 97.30 98.20
Cartap hydrochloride suspensibility (%) 70 98.20 97.50 98.20
Kojic acid suspensibility (%) 70 98.80 97.40 98.60
pH range (1% aq. Suspension) 3 to 5 4.50 4.50 4.50
Wettability Max 30 s 10 12 10
Wet Sieve(45 micron) Mini 98.5% 99.5 99.4 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.2 1.4
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specifications Initial 1 month 6 month 12 month
Isocycloseram a.i. 3.80 to 4.40 4.25 4.25 4.24 4.22
Cartap hydrochloride a.i. 28.5 to 31.5 30.50 30.50 30.30 30.20
Kojic acid a.i. 0.95 to 1.10 1.10 1.1 1.1 1.09
Isocycloseram suspensibility (%) 70 98.40 98.40 98.40 98.30
Cartap hydrochloride suspensibility (%) 70 98.20 98.20 98.10 98.10
Kojic acid suspensibility (%) 70 98.80 98.80 98.80 98.70
pH range (1% aq. Suspension) 3 to 5 4.50 4.50 4.50 4.51
Wettability Max 30 s 10 10 10 11
Wet Sieve(45 micron) Mini 98.5% 99.5 99.5 99.5 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.4 1.4 1.3
Persistent foam ml (after 1 minute) max. 60 nil nil nil nil

The composition of Isocycloseram 4%+Cartap hydrochloride 30%+Kojic acid 1% WG meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing process for 100 kg batch of Broflanilide 5%+Chlorantraniliprole 10%+Prothioconazole 25% WG
Step 1: Charge the 29.0 kg sodium sulfate anhydrous, 20.0 kg Lactose anhydrous, 0.5 kg silicone antifoam, 5 kg of Sodium isopropyl naphthalene sulfonate, 3 kg Modified polyacrylate copolymer and 7.0 kg of Modified Sodium lignosulphonate blend into a ribbon or premix blender and homogenization for 30 minutes.
Step 2: Now charge 4.0 kg Isocycloseram technical, 30 kg Cartap hydrochloride technical and 1.0 kg Kojic acid technical and again homogenize for 30 minutes and now this Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx 1.5 hr)
Step 3: Finely grinded powder is mixed with 10 kg of water having 0.5 kg silicone antifoam to form extrudable dough.
Step 4: Dough is passed through extruder to get granules of required size.
Step 5: Wet granules are passed through Fluidized bed drier to remove 10 kg extra water added and further graded using vibrating screens.
Step 6: Final product is sent for QC approval.
Step 7: After approval material is packed in required pack sizes.

EXAMPLE 5:
The preferred compositions for present invention are:
Compound A Compound B Compound C Active ingredients (%) Formulation Strength (%) Formulation
A B C
Isocycloseram profenofos d-limonene 5 30 1 36.00 EC
Isocycloseram quinalphos d-limonene 5 30 1 36.00 SE
Isocycloseram fipronil d-limonene 10 12 2 24.00 SE
Isocycloseram bifenthrin d-limonene 10 10 2 22.00 EC
Isocycloseram fenpropathrin d-limonene 10 10 2 22.00 EC
Isocycloseram cypermethrin d-limonene 10 10 2 22.00 EC
Isocycloseram lambda cyhalothrin d-limonene 10 5 2 17.00 EC
Isocycloseram clothianidin kojic acid 16 20 4 40.00 WG
Isocycloseram cartap hydrochloride kojic acid 4 30 0.5 34.50 WG
Isocycloseram thiocyclam hygroen oxalate kojic acid 4 30 0.5 34.50 WG
Isocycloseram flupyrimin kojic acid 12 20 1.5 33.50 OD
Isocycloseram triflmezopyrim kojic acid 12 5 1.5 18.50 OD
Isocycloseram chlorantraniliprole d-limonene 12 8 3 23.00 OD
Isocycloseram cyantraniliprole d-limonene 12 12 3 27.00 OD
Isocycloseram cyclaniliprole d-limonene 12 12 3 27.00 OD
Isocycloseram tetraniliprole d-limonene 12 10 3 25.00 OD
Isocycloseram flubendiamide d-limonene 12 10 3 25.00 OD
Isocycloseram broflanilide d-limonene 12 4 3 19.00 OD
Isocycloseram fluxametamide d-limonene 12 8 3 23.00 OD
Isocycloseram emamectin benzoate laminarin 12 2 10 24.00 SC
Isocycloseram methoxyfenozide laminarin 6 21 5 32.00 SC
Isocycloseram indoxacarb laminarin 6 7.5 5 18.50 OD
Isocycloseram novaluron laminarin 6 7.5 5 18.50 SE
Isocycloseram spinosad laminarin 12 15 10 37.00 WG
Isocycloseram spinetoram laminarin 12 10 10 32.00 SC
Isocycloseram dinotefuran anisiflupurin 12 5 0.2 17.20 OD
Isocycloseram nitenpyram anisiflupurin 12 8 0.2 20.20 OD
Isocycloseram thiamethoxam anisiflupurin 12 10 0.2 22.20 OD
Isocycloseram sulfoxaflor anisiflupurin 6 12 0.1 18.10 OD
Isocycloseram etoxazole kojic acid 20 10 1 31.00 SC
Isocycloseram cyenopyrafen kojic acid 10 12 0.5 22.50 SC
Isocycloseram spiromesifen kojic acid 5 8 0.25 13.25 SC
Isocycloseram pyriproxyfen nitrobenzene 6 10 5 21.00 EC
Isocycloseram hexythiazox nitrobenzene 12 6 10 28.00 EC
Isocycloseram fenpyroximate nitrobenzene 12 6 10 28.00 EC
Isocycloseram abamectin nitrobenzene 12 1.8 10 23.80 OD

Active ingredients on the basis of 100% purity.
Biological Examples:
The synergistic pesticidal action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) or tank mix of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components.
In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:

The objective of the present studies is to study the synergism, residual control, spectrum of activity and benefits of compositions comprising of isocycloseram, an insecticide and a plant health additive.

Bio-Example 1: Control of insect-pests in Okra crop.
Crop : Okra
Location : Pansora, Nadiad, Gujarat
No. of Treatments : 9
Crop age : 70 days after sowing.
Spray water volume : 400 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Red spider mite (Tetranychus urticae) control (%): Count the number of live/motile stages of mites per spot (microscopic lense area), record the observations from 4 spots per leaf, 3 leaves per plant and 10 plants per plot.

Table 1: Treatment details.
Treatment Number Treatment compositions gram actives ingredients per hectare
T1 isocycloseram 20%+etoxazole 10%+kojic acid 1% SC 50+25+2.5
T2 isocycloseram 10%+cyenopyrafen 12%+kojic acid 0.5% SC 50+60+2.5
T3 isocycloseram 5%+spiromesifen 8%+kojic acid 0.25% SC 50+80+2.5
T4 isocycloseram 20% SC 50
T5 kojic acid 5% WP 2.5
T6 etoxazole 10% SC 15
T7 cyenopyrafen 30% SC 24
T8 spiromesifen 24% SC 30
T9 Untreated Check (UTC) -
T1 to T3-present compositions, T5 to T8- market available products.
Table 2: Red spider mite control in okra crop.
Treatment Number Red spider mite control (%)
at 5 DAA at 10 DAA
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 98.2 93.4 1.05 Y 88.6 84.2 1.05 Y
T2 96.8 92.9 1.04 Y 86.4 83.0 1.04 Y
T3 99.0 93.8 1.06 Y 90.4 84.7 1.07 Y
T4 72.4 60.6
T5 24.6 10.2
T6 68.2 55.4
T7 65.8 52.0
T8 70.2 56.8
T9 0.0 0.0
DAA-days after application, Y-yes, N-no.
All the present compositions (T1 to T3) provide synergistic control of red spider mite in okra crop on 5th and 10th day after application.

Bio-Example 2: Control of insect-pests in cotton crop.
Crop : Cotton
Location : Gondal, Rajkot, Gujarat
No. of Treatments : 11
Crop age : 82 days after sowing.
Spray water volume : 500 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Jassid (Amrasca biguttulla biguttula) control (%): Count the number of live insects per leaf, record the observations from 3 leaves per plant and 10 plants per plot.

Table 3: Treatment details
Treatment Number Treatment compositions gram actives ingredients per hectare
T1 isocycloseram 12%+dinotefuran 5%+anisiflupurin 0.2% OD 36+15+0.6
T2 isocycloseram 12%+nitenpyram 8%+anisiflupurin 0.2% OD 36+24+0.6
T3 isocycloseram 12%+thiamethoxam 10%+anisiflupurin 0.2% OD 36+30+0.6
T4 isocycloseram 6%+sulfoxaflor 12%+anisiflupurin 0.1% OD 36+72+0.6
T5 isocycloseram 10% DC 36
T6 anisiflupurin 1% EC 0.6
T7 dinotefuran 20% SG 15
T8 nitenpyram 25% WP 24
T9 thiamethoxam 25% WG 30
T10 sulfoxaflor 24% SC 30
T11 Untreated Check (UTC) -

T1 to T4-present compositions, T5 to T10-market available products.
Table 4: Residual control of jassid in cotton.
Treatment Number jassid control (%)
at 3 DAA at 10 DAA
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 99.2 88.1 1.13 Y 89.8 81.1 1.11 Y
T2 97.4 86.7 1.12 Y 85.4 78.6 1.09 Y
T3 96.2 85.5 1.13 Y 83.8 76.8 1.09 Y
T4 98.8 87.6 1.13 Y 85.2 78.5 1.09 Y
T5 68.2 60.4
T6 4.2 1.2
T7 60.8 51.8
T8 56.4 45.4
T9 52.4 40.8
T10 59.4 45.0
T11 0.0 0.0

All the present compositions (T1 to T4) provide excellent control of jassid on 3rd and 10th days, provides excellent protection which directly contributed to the yield.

Bio-Example 3: Pod borer larval control in redgram crop.
Crop : Red gram
Location : Savli, Vadodara, Gujarat
No. of Treatments : 16
Crop age : 100 days after sowing.
Spray water volume : 500 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Pod borer (Helicoverpa armigera) larval control (%): Count the number of live larvae per plant, record the observations from 10 plants per plot. Calculate larval control (%) as observed value.
Healthy pod count: Count the number of healthy (undamaged) pods per plant. Record the observations from 10 plants per plot.

Table 5: Treatment details.
Treatment Number Treatment compositions gram actives ingredients per hectare
T1 isocycloseram 12%+chlorantraniliprole 8%+d-limonene 3% OD 48+32+12
T2 isocycloseram 12%+cyantraniliprole 12%+d-limonene 3% OD 48+48+12
T3 isocycloseram 12%+cyclaniliprole 12%+d-limonene 3% OD 48+48+12
T4 isocycloseram 12%+tetraniliprole 10%+d-limonene 3% OD 48+40+12
T5 isocycloseram 12%+flubendiamide 10%+d-limonene 3% OD 48+40+12
T6 isocycloseram 12%+broflanilide 4%+d-limonene 3% OD 48+16+12
T7 isocycloseram 12%+fluxametamide 8%+d-limonene 3% OD 48+32+12
T8 isocycloseram 10% DC 48
T9 d-limonene 5% EC 12
T10 chlorantraniliprole 20% SC 32
T11 cyantraniliprole 10% OD 48
T12 cyclaniliprole 10% DC 48
T13 tetraniliprole 20% SC 40
T14 flubendiamide 20% WG 40
T15 broflanilide 20% SC 16
T16 fluxametamide 10% EC 32
T17 Untreated Check (UTC) -
T1 to T7-present compositions.

Table 6: Pod borer larval control in red gram.
Treatment Number Pod borer larval control (%)
at 5 DAA at 15 DAA
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 100.0 92.8 1.08 Y 94.8 84.2 1.13 Y
T2 100.0 92.0 1.09 Y 91.2 82.4 1.11 Y
T3 100.0 91.9 1.09 Y 91.0 81.8 1.11 Y
T4 100.0 92.3 1.08 Y 92.4 82.7 1.12 Y
T5 100.0 91.4 1.09 Y 90.6 81.1 1.12 Y
T6 100.0 92.8 1.08 Y 93.8 83.6 1.12 Y
T7 100.0 92.4 1.08 Y 92.6 82.7 1.12 Y
T8 69.6 57.8
T9 20.2 8.0
T10 70.4 59.2
T11 67.2 54.6
T12 66.8 53.0
T13 68.2 55.4
T14 64.6 51.2
T15 70.4 57.8
T16 68.6 55.4
T17 0.0 0.0

Table 7: Healthy pod count
Treatment Number Number of healthy pods per plant Increase (%) in healthy pods over UTC (T17)

T1 168.4 122.8
T2 163.9 116.8
T3 162.5 114.9
T4 165.2 118.5
T5 161.9 114.2
T6 167.7 121.8
T7 165.1 118.4
T8 138.1 82.7
T9 104.8 38.6
T10 140.5 85.8
T11 132.4 75.1
T12 129.3 71.0
T13 134.7 78.2
T14 128.8 70.4
T15 137.8 82.3
T16 135.3 79.0
T17 75.6 0.0

All the present compositions (T1 to T7) provide synergistic control of pod borer larvae and also yielded higher number of healthy pods per plant.

Bio-Example 4: Pod borer larval control in gram/chickpea crop.
Crop : chickpea gram
Location : Ratlam, Madhya Pradesh
No. of Treatments : 15
Crop age : 88 days after sowing.
Spray water volume : 400 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Pod borer (Helicoverpa armigera) larval control (%): Count the number of live larvae per plant, record the observations from 10 plants per plot. Calculate larval control (%) as observed value.
Healthy pod count: Count the number of healthy (undamaged) pods per plant. Record the observations from 10 plants per plot.

Table 8: Treatment details.
Treatment Number Treatment compositions gram actives ingredients per hectare
T1 isocycloseram 12%+emamectin benzoate 2%+laminarin 10% SC 48+8+40
T2 isocycloseram 6%+methoxyfenozide 21%+laminarin 5% SC 48+168+40
T3 isocycloseram 6%+indoxacarb 7.5%+laminarin 5% OD 48+60+40
T4 isocycloseram 6%+novaluron 7.5%+laminarin 5% SE 48+60+40
T5 isocycloseram 12%+spinosad 15%+laminarin 10% WG 48+60+40
T6 isocycloseram 12%+spinetoram 10%+laminarin 10% SC 48+40+40
T7 isocycloseram 10% DC 48
T8 laminarin 3.7% SL 40
T9 emamectin benzoate 5% SG 8
T10 methoxyfenozide 24% SC 168
T11 indoxacarb 15% SC 60
T12 novaluron 10% EC 60
T13 spinosad 45% SC 60
T14 spinetoram 11.9% SC 40
T15 Untreated Check (UTC) -
T1 to T6-present compositions.
Table 9: Synergistic larval control of pod borer infesting gram/chickpea crop.
Treatment Number Pod borer larval control (%)
at 5 DAA at 15 DAA
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 100.0 91.6 1.09 Y 98.2 83.7 1.17 Y
T2 100.0 92.6 1.08 Y 99.2 85.2 1.16 Y
T3 100.0 92.7 1.08 Y 97.6 85.0 1.15 Y
T4 100.0 91.4 1.09 Y 96.4 82.8 1.16 Y
T5 100.0 91.6 1.09 Y 96.2 82.4 1.17 Y
T6 100.0 92.2 1.09 Y 95.8 82.7 1.16 Y
T7 72.8 65.2
T8 8.2 1.8
T9 66.4 52.4
T10 70.2 56.8
T11 70.6 56.2
T12 65.4 49.8
T13 66.2 48.6
T14 68.6 49.4
T15 0.0 0.0

All the present compositions (T1 to T6) provide synergistic control of pod borer larvae infesting gram/chickpea crop.

Bio-Example 5: Control of Thirps in chilli crop.
Crop : Chilli
Location : Umreth, Gujarat
No. of Treatments : 17
Crop age : 88 days after sowing.
Spray water volume : 400 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Thrips (Scirtothrips dorsalis): Count the number of live thrips by shaking the twigs on black piece of paper. Record the observations from 3 twigs per plant and 10 plants per plot on 7 and 14 DAA (days after application). Calculate thrips control (%) as observed control and apply colby’s formula to calculate syngergism.

Table 10: Treatment details.
Treatment Number Treatment compositions gram actives ingredients per hectare
T1 isocycloseram 5%+profenofos 30%+d-limonene 1% EC 50+300+10
T2 isocycloseram 5%+quinalphos 30%+d-limonene 1% EC 50+300+10
T3 isocycloseram 10%+fipronil 12%+d-limonene 2% EC 50+60+10
T4 isocycloseram 10%+bifenthrin 10%+d-limonene 2% EC 50+50+10
T5 isocycloseram 10%+fenpropathrin 10%+d-limonene 2% EC 50+50+10
T6 isocycloseram 10%+cypermethrin 10%+d-limonene 2% EC 50+50+10
T7 isocycloseram 10%+lambda cyhalothrin 5%+d-limonene 2% EC 50+25+10
T8 isocycloseram 10% DC 50
T9 d-limonene 5% EC 10
T10 profenofos 50% EC 300
T11 quinalphos 25% EC 300
T12 fipronil 5% SC 60
T13 bifenthrin 10% EC 50
T14 fenpropathrin 10% EC 50
T15 cypermethrin 25% EC 50
T16 lambda cyhalothrin 5% EC 25
T17 Untreated Check (UTC) -
T1 to T7-present compositions.
Table 11: Synergistic control of Thrips infesting chilli crop.
Treatment Number Thrips control (%)
at 7 DAA at 14 DAA
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 100.0 90.7 1.10 Y 97.4 83.9 1.16 Y
T2 98.8 91.1 1.08 Y 94.2 84.3 1.12 Y
T3 100.0 92.1 1.09 Y 98.6 85.7 1.15 Y
T4 97.6 90.5 1.08 Y 92.8 83.5 1.11 Y
T5 96.6 90.4 1.07 Y 90.2 83.5 1.08 Y
T6 95.2 88.9 1.07 Y 89.8 81.3 1.10 Y
T7 98.8 89.2 1.11 Y 92.2 81.1 1.14 Y
T8 72.6 65.8
T9 18.8 12.4
T10 58.4 46.2
T11 60.2 47.6
T12 64.6 52.2
T13 57.4 45.0
T14 56.8 44.8
T15 50.2 37.6
T16 51.4 36.8
T17 0.0

All the present compositions (T1 to T7) provide synergistic control of thrips infesting chilli crop.
Bio-Example 6: Stem borer control in Rice crop.
Crop : Rice
Location : Kurud, Chhattishgarh
No. of Treatments : 16
Crop age : 30 days after transplanting.
Spray water volume : 400 liter per hectare
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
The infestation by stem borer was observed as dead heart (DH) during vegetative stage. Count the number of healthy tillers and infested tillers (dead heart) from randomly selected 10 hills per plot.
The incidence of stem borer recorded as per below formula.


Table 12: Treatment details.
Treatment Number Treatment compositions gram actives ingredients per hectare
T1 isocycloseram 4%+thiocyclam hydrogen oxalate 30%+kojic acid 0.5% WG 48+360+6
T2 isocycloseram 4%+cartap hydrochloride 30%+kojic acid 0.5% WG 48+360+6
T3 isocycloseram 12%+flupyrimin 20%+kojic acid 1.5% WG 48+80+6
T4 isocycloseram 12%+triflumezopyrim 5%+kojic acid 1.5% WG 48+20+6
T5 isocycloseram 4%+thiocyclam hydrogen oxalate 30% WG 48+360
T6 isocycloseram 4%+cartap hydrochloride 30% WG 48+360
T7 isocycloseram 12%+flupyrimin 20% WG 48+80
T8 isocycloseram 12%+triflumezopyrim 5% WG 48+20
T9 isocycloseram 4%+kojic acid 1.5% WG 48+6
T10 isocycloseram 10% DC 48
T11 kojic acid 5% WP 6
T12 thiocyclam hydrogen oxalate 50% WP 360
T13 cartap hydrochloride 50% WP 360
T14 flupyrimin 10% SC 80
T15 triflumezopyrim 20% SC 20
T16 Untreated Check (UTC) -

T1 to T4-present compositions.
Table 13: Control of stem borer in rice crop.
Treatment Number Stem borer control (%)
at 15 DAA (dead heart symptoms) at 30 DAA (dead heart symptoms)
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 100.0 96.7 1.03 Y 95.8 89.2 1.07 Y
T2 100.0 96.1 1.04 Y 94.2 88.0 1.07 Y
T3 100.0 95.5 1.05 Y 92.8 88.3 1.05 Y
T4 100.0 93.9 1.06 Y 90.2 87.0 1.04 Y
T5 98.8 96.3 1.03 Y 87.6 88.7 0.99 N
T6 97.4 95.5 1.02 Y 85.2 87.4 0.97 N
T7 96.6 94.9 1.02 Y 86.6 87.7 0.99 N
T8 95.2 93.1 1.02 Y 85.0 86.3 0.98 N
T9 87.8 84.7 1.04 Y 70.6 72.5 0.97 N
T10 82.6 71.2
T11 12.2 4.6
T12 78.6 60.6
T13 74.2 56.4
T14 70.8 57.4
T15 60.2 52.6
T16 0.0 0

All the present compositions (T1 to T4) provide synergistic control of stem borer (in terms of dead heart during vegetative stage) on 30th day after application, in comparison with their prior art mixtures (T5 to T8).
,CLAIMS:CLAIMS
We claim;

[CLAIM 1]. A synergistic agrochemical composition comprising:
a. Isocycloseram present in an amount of 4 to 30%w/w;
b. an insecticide is selected from carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb, acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos, ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole, bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin, acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin, sulfoxaflor, flupyradifurone, triflumezopyrim, dichloromezotiaz, fenmezoditiaz, bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, spinosad, spinetoram, abamectin, emamectin benzoate, ivermectin, lepimectin, milbemectin, hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen, chloropicrin, dazomet, metam, pymetrozine, pyrifluquinazon, afidopyropen, flonicamid, clofentezine, hexythiazox, diflovidazin, etoxazole, bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, buprofezin, cyromazine, Bacillus thuringiensis and insecticidal proteins, chlorfenapyr, DNOC, sulfluramid, methoxyfenozide, tebufenozide, halofenozide, fufenozide, chromafenozide, amitraz, diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, tetradifon, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin, cyenopyrafen, cyflumetofen, pyflubumide, hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin, indoxacarb, metaflumizone, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, granuloviruses, nucleopolyhedrosis viruses, acynonapyr, azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin and ledprona present in an amount of 1 to 30%w/w; and
c. a plant health additive is selected from kojic acid, carboxylic acid (acetic acid, benzoic acid, formic acid, chloroacetic acid, propionic acid, butyric acid, valeric acid, pelargonic acid, lauric acid, lactic acid, tridecylic acid, palmitic acid, arachidic acid), acetyl thioproline, alginate, cellulose, starch, cyclodextrin, d-limonene, strigolactone, laminarin, polyamines, nitrobenzene, anisiflupurin, or mixture thereof present in an amount of 0.001 to 20% w/w.

[CLAIM 2]. The synergistic agrochemical composition as claimed in claim 1, wherein the formulation for the said composition is selected from Suspension concentrate (SC), Emulsion Concentrate (EC), Wettable Granule (WG) and Oil dispersion (OD).

[CLAIM 3]. The synergistic agrochemical composition as claimed in claim 1, wherein the preferred combinations of active ingredients in the composition for the Suspension concentrate (SC) formulation comprises:
i. Isocycloseram 12% +spinetoram 10% + laminarin 10%;
ii. Isocycloseram 12%+ emamectin benzoate 2% + laminarin 10%;
iii. Isocycloseram 6%+ methoxyfenozide 21%+ laminarin 5%;
iv. Isocycloseram 20%+ etoxazole 10% + kojic acid 1%;
v. Isocycloseram 10%+ cyenopyrafen 12%+ kojic acid 0.5%;
vi. Isocycloseram 5%+ spiromesifen 8%+ kojic acid 0.25%.

[CLAIM 4]. The synergistic agrochemical composition as claimed in claim 2, wherein, the Suspension concentrate (SC) comprises:
i. Isocycloseram present in an amount of 4 to 30%w/w;
ii. an insecticide selected from spinetoram, emamectin benzoate, methoxyfenozide, etoxazole, cyenopyrafen, spiromesifen present in an amount of 1 to 30%w/w; and
iii. a plant health additive from a plant health additive selected from kojic acid, laminarin or mixture thereof present in an amount of 0.001 to 20% w/w;
iv. super wetting-spreading-penetrating agent in an amount of 2 to 6 % by weight;
v. dispersing agent I in an amount of 1 to 6 % by weight;
vi. dispersing agent II in an amount of 1 to 3 % by weight;
vii. suspending agent in an amount of 0.2 to 4.0 % by weight;
viii. antifoaming agent in an amount of 0.1 to 1.5 % by weight;
ix. preservative in an amount of 0.1 to 0.5 % by weight;
x. anti-freezing agent in an amount of 2 to 6 % by weight;
xi. thickner in an amount of 0.1 to 1.0 % by weight;
xii. diluent water in an amount of 40 to 70 % by weight.

[CLAIM 5]. The synergistic agrochemical composition as claimed in claim 4, wherein wetting-spreading-penetrating agent is selected from ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate, organosilicons surfactants (as a wetting-spreading-penetrating agent) includes trisiloxane ethoxylate, Methylated seed oil, polyalkyleneoxide modified trisiloxane, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, trisiloxane ethoxylate, polyoxyethylene methyl polysiloxane, polyether polymethyl siloxane copolymer, polyether modified polysiloxane; may or may not be in modified form, may be liquid or powder form or mixture thereof.

[CLAIM 6]. The synergistic agrochemical composition as claimed in claim 4, wherein dispersing agent is selected from Naphthalenesulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide.

[CLAIM 7]. The synergistic agrochemical composition as claimed in claim 4, wherein suspending agent is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay.

[CLAIM 8]. The synergistic agrochemical composition as claimed in claim 4, wherein antifoaming agent is selected from silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.

[CLAIM 9]. The synergistic agrochemical composition as claimed in claim 4, wherein anti-freezing agent is selected from ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride.

[CLAIM 10]. The synergistic agrochemical composition as claimed in claim 4, wherein preservative is selected from 1, 2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1, 3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

[CLAIM 11]. The synergistic agrochemical composition as claimed in claim 1, wherein preferred combinations of active ingredients in the composition of the Wettable Granule formulation comprises
i. Isocycloseram16%+Clothianidin 20% + kojic acid 4%;
ii. Isocycloseram 4%+ cartap hydrochloride 30%+ kojic acid 0.5%;
iii. Isocycloseram 4%+ thiocyclam hygroen oxalate 30% + kojic acid 0.5%;
iv. Isocycloseram 12%+ spinosad 15% + laminarin 10 %.

[CLAIM 12]. The synergistic agrochemical composition as claimed in claim 2, wherein, the Wettable Granule formulation comprises
i. Isocycloseram present in an amount of 4 to 30%w/w;
ii. an insecticide selected from Clothianidin, Cartap hydrochloride, thiocyclam hygroen oxalate, spinosad present in an amount of 1 to 30%w/w; and
iii. a plant health additive from a plant health additive selected from kojic acid, laminarin or mixture thereof present in an amount of 0.001 to 20% w/w;
iv. wetting agent in an amount of 2 to 6 % % by weight;
v. dispersing agent in an amount of 2 to 8 % by weight;
vi. antifoaming agent in an amount of 0.1 to 2.0 % by weight;
vii. carrier in an amount of 20 to 40 % by weight.

[CLAIM 13]. The synergistic agrochemical composition as claimed in claim 12, wherein dispersing agent is selected from sodium polycarboxylate (sodium polyacrylate), naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, calcium lignosulfonate, lignin sulfonate sodium salt, alkyl naphthalene sulfonate, sodium salt.

[CLAIM 14]. The synergistic agrochemical composition as claimed in claim 12, wherein wetting agent is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane.

[CLAIM 15]. The synergistic agrochemical composition as claimed in claim 12, wherein antifoaming agent is polydimethylsiloxane.

[CLAIM 16]. The synergistic pesticidal composition as claimed in claim 12, wherein carrier is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels.

[CLAIM 17]. The synergistic agrochemical composition as claimed in claim 1, wherein preferred combinations of active ingredients in the composition of Oil dispersion (OD) formulation comprises
i. Isocycloseram 12%+ flupyrimin20%+kojic acid 1.5%;
ii. Isocycloseram 12%+ triflmezopyrim 5%+ kojic acid 1.5%;
iii. Isocycloseram 12%+ chlorantraniliprole 8% + d-limonene 3%;
iv. Isocycloseram 12%+cyantraniliprole 12%+d-limonene 3%;
v. Isocycloseram 12% + cyclaniliprole 12% + d-limonene 3%;
vi. Isocycloseram 12 % + tetraniliprole 10% + d-limonene 3%;
vii. Isocycloseram 12 %+flubendiamide 10% + d-limonene 3%;
viii. Isocycloseram 12 % + broflanilide 4% + d-limonene 3%;
ix. Isocycloseram 12 % + fluxametamide 8% +d-limonene 3%;
x. Isocycloseram 6%+ indoxacarb 7.5%+ laminarin 5%;
xi. Isocycloseram 12%+ Dinotefuran 5%+ anisiflupurin 0.2%;
xii. Isocycloseram 12%+ nitenpyram 8%+ anisiflupurin 0.2%;
xiii. Isocycloseram 12%+ thiamethoxam 10%+ anisiflupurin 0.2%;
xiv. Isocycloseram 6%+ sulfoxaflor 12%+ anisiflupurin 0.1%;
xv. Isocycloseram 12%+ Abamectin 1.8%+ nitrobenzene 10%.

[CLAIM 18]. The synergistic agrochemical composition as claimed in claim 2, wherein, Oil dispersion (OD) formulation comprises:
i. Broflanilide is present in amount of 1% to 20% w/w;
ii. a diamide group of insecticide cyantraniliprole present in amount of 0.01% to 30% w/w;
iii. a compound selected from Fluxametamide, Isocycloseram present in amount of 0.001% to 50% w/w;
iv. solvent in an amount of 40 to 70 % w/w;
v. dispersing agent in an amount of 8 to 12 % w/w;
vi. emulsifying agent in an amount of 2 to 8 % w/w;
vii. antifoaming agent in an amount of 0.1 to 1.5% w/w;
viii. stabilizer in an amount of 0.5 to 3.0 % w/w;
ix. co-solvent in an amount of 0.1 to 1.0 % w/w.

[CLAIM 19]. The synergistic agrochemical composition as claimed in claim 18, wherein dispersing agent is selected from alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkyl phenol alkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol poly glycol ether), block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.

[CLAIM 20]. The synergistic agrochemical composition as claimed in claim 18, wherein solvent is selected from vegetable oil in its alkylated or ethoxylated or esterified form selected from olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil. The alkyl ester of vegetable oils includes methyl ester, ethyl ester, propyl ester or butyl ester of vegetable oils. Some of the examples are methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane alkylphenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil butyl ester, cotton seed oil propyl ester, tall oil fatty acids esters-tallow methyl ester, tallow ethyl ester, tallow propyl ester, bio-diesel, mineral oil (aromatic solvents, isoparaffin, base solvent), fatty acid amides (e.g. C1 -C3 amines, alkylamines or alkanolamines with C6–C18 carboxylic acids), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyate, alkyl benzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols.

[CLAIM 21]. The synergistic agrochemical composition as claimed in claim 18, wherein stabilizer is selected from hectorite clay, aluminium magnesium silicate, bentonite clay, silica, attapulgite clay.

[CLAIM 22]. The synergistic agrochemical composition as claimed in claim 18, wherein emulsifying agent is selected from Polyoxyethylene sorbitol hexaoleate castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide.

[CLAIM 23]. The synergistic agrochemical composition as claimed in claim 1, wherein preferred combinations of active ingredients in the composition for the Emulsion Concentrate (EC) formulation comprises:
i. Isocycloseram 5%+ profenofos 30% + d-limonene 1%;
ii. Isocycloseram 10%+ bifenthrin 10%+ d-limonene 2%;
iii. Isocycloseram 10%+ fenpropathrin 10%+ d-limonene 2%;
iv. Isocycloseram 10%+ cypermethrin 10%+ d-limonene 2%;
v. Isocycloseram 10%+ lambda cyhalothrin 5%+d-limonene 2%;
vi. Isocycloseram 6%+ pyriproxyfen 10%+ nitrobenzene 5%;
vii. Isocycloseram 12%+ hexythiazox 6%+ nitrobenzene 10%;
viii. Isocycloseram 12%+ fenpyroximate 6%+ nitrobenzene 10%.

[CLAIM 24]. The synergistic agrochemical composition as claimed in claim 2, wherein the Emulsion Concentrate (EC) formulation comprises:
i. Isocycloseram present in an amount of 4 to 30%w/w;
ii. an insecticide selected from profenofos, bifenthrin, fenpropathrin, cypermethrin, lambda cyhalothrin, pyriproxyfen, hexythiazox, fenpyroximate present in an amount of 1 to 30%w/w; and
iii. a plant health additive from a plant health additive selected from nitrobenzene, d-limonene or mixture thereof present in an amount of 0.001 to 20% w/w;
iv. wetting agent in an amount of 0.5 to 0.8% by weight;
v. emulsifier in an amount of 2 to 8% by weight; and
vi. solvent in an amount of 10 to 50% by weight.

[CLAIM 25]. The synergistic agrochemical composition as claimed in claim 24, wherein wetting agent is selected from Blend of alcohol ethoxylate and alkyl phenol ethoxylate.

[CLAIM 26]. The synergistic agrochemical composition as claimed in claim 24, wherein Solvent is selected from Mixture of heavy aromatic hydrocarbons / C IX, xylene, n-butanol, solvent C-9, N-methyl 2-pyrrolidine, methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, Paraffinic hydrocarbons, cyclohexanone, isophorone and ester solvents such as methyloleate, dimethylamide and morpholineamide derivatives of C6-C16 fatty acids, and mono-alkylene carbonates such as ethylene carbonate, propylene carbonate and butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons and/or aliphatic hydrocarbons, one or more dimethylamides, such as C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP); dimethylformamide (DMF); dimethylisosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidonone; lactate esters; dimethyl and diethylcarbonates; alcohols including methanol; ethanol; iso-propanol; n-propanol; n-butanol; iso-butanol; and tert-butanol; Methyl L-lactate, 2-Ethylhexyl L-lactate, Ethyl L-lactate, n-Butyl L-lactate, Octyl phenyl ethoxylates.

[CLAIM 27]. The synergistic agrochemical composition as claimed in claim 24, wherein Emulsifier is selected from salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates Calcium alkyl benzene sulfonate, and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. of sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkyl sulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol; fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyletherphosphates; alkylphenoletherphosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkylsulphonate, an alkylethersulphonate, an ether sulphate, or an ether phosphate such as an alkyletherphosphate, nonylphenol polyethoxy ethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol.

Dated this 09th day of April 2024