DESC:FIELD OF THE INVENTION:
The present invention relates to a synergistic insecticidal compositions comprising of (A) Isocycloseram; (B) at least one insecticide compound selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; (C) at least one more insecticide. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.

BACKGROUND OF THE INVENTION:
Combination of insecticides and Isocycloseram are used to broaden the spectrum of control of insect–pests and mites, to improve the pest control with synergistic effect, to reduce dosage, thereby reducing environmental impact, decrease chances of resistance development and to enhance residual control so lesser the number of sprays for crop protections and minimizing the insecticidal load in ecosystem. The combination of insecticides and Isocycloseram at times demonstrate an additive or synergistic effect that results in an improved control on the insect-pests and mite.
There are many combinations of Isocycloseram along with other insecticide known in the prior art for the control of insect-pests. For example, WO2022018745A1 relates to synergistic agrochemical composition, where in active ingredient present in fixed ratio shows synergy in pesticidal activity comprising (A) Diamide group of insecticides like broflanilide, chlorantraniliprole, cyantraniliprole, cyclaniliprole, cyhalodiamide, cyproflanilide, flubendiamide, tetrachlorantraniliprole, tyclopyrazoflor, tetraniliprole fluxametamide or isocyclaseram and mixtures thereof; (B) one compound or more Plant health additives compounds like chitosan, chitin, humic acid, potassium polysaccharides, jasmonic acid (methyl jasmonate), silicon compound-silicic acid (H2Si03) and mixture thereof; (C) one more Insecticide like acetylcholine esterase inhibitors from the class of carbamates, acetylcholine esterase inhibitors from the class of organophosphates, GABA-gated chloride channel antagonists.
A composition comprising: (a) isocycloseram, (b) a polyoxyalkylene copolymer, (c) an acrylic graft copolymer, and (d) an oxygenated hydrocarbon compound. More particularly, this invention relates to millbases, or to formulations such as suspension concentrates (SC), flowable suspensions (FS), suspoemulsions (SE), suspension concentrate-capsule suspension blends (ZC), ready-to-use baits (RB), water soluble granules (SG), water dispersible granules (WG), and water dispersible tablets (WT), to dilutions or dispersions of such formulations more particularly in a farmer's spray-tank; and to use of such a composition to combating and/or control an animal pest.
WO2022207887A1 relates to a bait composition comprising an insecticidally effective amount of isocyloseram and a bait material comprising an insect food attractant and/or an insect food flavorant. Furthermore, the present invention relates to a method for controlling an insect pest or an insect pest population comprising applying an insecticidally effective amount of said bait composition to a locus or environment of known or likely insect activity.
US20230292757A1 relates to a to synergistic insecticidal compositions comprising bioactive amounts of (A) at least one insecticide selected from class of diamide, metadiamides, isoxazolines , isocyloseram or mixture thereof; (B) at least one plant growth regulator or mixture thereof; (C) at least one more insecticide from various groups or mixture thereof. The present invention further relates to process of preparing said composition along with at least one inactive excipients and formulation thereof.
WO2023282140A1 relates to a composition having excellent control efficacy against pests, and a pest control method are provided. The composition contains at least one type of pest control compound selected from group (A), at least one type of pest control compound selected from group (B), and at least one type of pest control compound selected from group (C), in the weight ratio 1:1000:1000 to 1:0.001:0.001. Group (A), group (B) and group (C) are as follows. Group (A): the group consisting of Broflanilide, Nicofluprole, Fluxametamide and Isocycloseram; Group (B): the group consisting of imiprothrin and tetramethrin; Group (C): the group consisting of permethrin, cypermethrin, phenothrin, cyphenothrin, cyfluthrin, deltamethrin and cyhalothrin.
CN110250186A relates to an invention discloses a kind of synergetic pesticide compositions containing pyridine quinazoline, it is A and B containing active constituent, wherein A is selected from pyridine quinazoline, B is selected from fatty acid, Tyclopyrazoflor, benzpyrimoxan, tetraniliprole, dicloromezotiaz, pyriprole, spiropidion, cyclopyinorate, isocycloseram, pleocidin, one of fluorine pyrrole furanone, composition includes usual auxiliaries, active components A and B, A and B has synergistic effect to target after compounding in certain proportion, suitable for preventing and treating pest agriculturally, especially Bemisia tabaci, aphid.
There is however a need for improvement of these combinations. Single active combinations used over a long period of time has resulted in resistance. With the onset of resistance to certain pests, there is a need in the art for a combination of actives that decreases chances of resistance and improves the spectrum of control over insect-pests and mite.
The present invention further relates to process of preparing said composition along with at least one inactive formulation excipients and formulation thereof which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.
In general use, the insecticides actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism. However, most active insecticide compounds that are used as insecticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use. This problem especially occurs and may get worsen if more than one active compound is present in the composition.
Therefore, one object of the present invention is to provide improved compositions of insecticides and Isocycloseram for the control of insect-pests and mites. Another object of the present invention is to provide a method and a composition for controlling insect-pests and mites.
Yet another object of the present invention is to provide improved compositions of insecticides and Isocycloseram that promote insecticidal activity and to increase plant or crop yield.
Still another object of the present invention is to provide a process for preparing a stable and non-phytotoxic formulation.
Embodiment of the present invention can ameliorate one or more of the above mentioned problems.
Inventors of the present invention have surprisingly found insecticidal
composition of Isocycloseram; an insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; and one more insecticide selected from group thereof shows synergistic effect. The present invention further relates to process of preparing said composition along with at least one inactive formulation excipients and formulation thereof as described herein which can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION
Therefore an aspect of the present invention provides an insecticidal composition comprising bioactive amounts of (A) Isocycloseram; (B) at least one insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; group; (C) at least one more insecticide.
Further aspect of the present invention provides synergistic compositions comprising of (A) Isocycloseram; (B) at least one insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; and (C) At least one compound selected from the group of an insecticides.
Insecticidal compound (C) selected from the group consisting of (1) from the class of carbamates (AChE-acetylcholine esterase inhibitors): carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb; (2) from the class of organophosphates (AChE-acetylcholine esterase inhibitors): acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos; (3) from the class of phenylpyrazoles-fiproles (GABA-gated chloride channel blockers): ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole; (4) from the class of metadiamides and isoxazolines (GABA gated chloride channel allosteric modulators): metadiamides-broflanilide, cyproflanilide; isoxazolines-fluxametamide, afoxolaner, esafoxolaner, fluralaner, lotilaner, sarolaner; (5) from the class of pyrethroids (sodium channel modulators): bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (pyrethrum); (6) from the class of nicotinic insecticides (nicotinic acteylcholine receptor (nAChR) competitive modulators): acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin; sulfoximines-sulfoxaflor; butenolides- flupyradifurone; mesoionics- triflumezopyrim, dichloromezotiaz, fenmezoditiaz; (7) from the class of nereistoxin analogues (nicotinic acetylcholine receptor (nAChR) channel blockers); bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium; (8) from the class of spinosyns (nicotinic acteylcholine receptor (nAChR) allosteric modulators-Site I);spinosad, spinetoram; (9) from the class of avermectins and milbemycins (glutamate-gated chloride channel (GluCl) allosteric modulators): avermectins-abamectin, emamectin benzoate, ivermectin, lepimectin; milbemycins- milbemectin; (10) from the class of juvenile hormone mimics: hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen; (11) from the class of non-specific multi-site inhibitors: chloropicrin, dazomet, metam; (12) from the class of chordotonal organs modulators: pymetrozine, pyrifluquinazon, afidopyropen, flonicamid; (13) from the class of mite growth inhibitors affecting CHS1: clofentezine, hexythiazox, diflovidazin or etoxazole; (14) from the class of benzoylureas (inhibitors of the chitin biosynthesis affecting CHS1: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron; (15) from the class of buprofezin (inhibitors of the chitin biosynthesis type 1): buprofezin; (16) from the class of cyromazine (moulting disruptors for dipteran): cyromazine; ( 17) from the class of microbial disruptors of insect midgut membrane: Bacillus thuringiensis and insecticidal proteins they product; (18) from the class of uncouplers of oxidative phosphorylation: chlorfenapyr, DNOC, or sulfluramid; (19) from the class of diacylhydrazines (ecdyson receptor agonists): diacylhydrazines- methoxyfenozide, tebufenozide, halofenozide, fufenozide or chromafenozide; (20) from the class of octopamin receptor agonists: amitraz; (21) from the class of inhibitors of mitochondrial ATP synthase:- diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, or tetradifon; (22) from the class of METI (mitochondrial complex I) inhibitors: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin; (23) from the class of METI (mitochondrial complex II) inhibitors: cyenopyrafen, cyflumetofen, -pyflubumide; (24) from the class of METI (mitochondrial complex III) inhibitors:-hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin; (25) from the class of METI (mitochondrial complex IV) inhibitors:-phosphides and cyanides; (26) from the class of voltage-dependent sodium channel blockers: indoxacarb, metaflumizone; (27) from the class of inhibitors of the lipid synthesis, inhibitors of acetyl CoA carboxylase: spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen; (28) from the class of baculoviruses:- granuloviruses and nucleopolyhedrosis viruses; (29) from the class of calcium activated potassium channel (KCa2) modulators:- acynonapyr; (30) Compounds of unknown or uncertain mode of action:- azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin, sulfiflumin, ledprona.
Accordingly, in a further aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against insect-pests damage by applying to the plant propagation material a composition comprising an insecticidal composition defined in the first aspect.
As per one embodiment formulation for the composition is selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Wettable granule/Water dispersible granule (WG/WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).
The remainder of the aqueous formulation is preferably wholly water but may comprise other materials, such as inorganic salts. The formulation is preferably, completely free from organic solvents.
Accordingly, in a first aspect, the present invention provides synergistic compositions comprising of (A) Isocycloseram; (B) at least one insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; (C) at least one more insecticide.

DETAILED DESCRIPTION OF THE INVENTION:
Therefore an aspect of the present invention provides a composition comprising (A) Isocycloseram; (B) at least one insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; and (C) at least one more insecticide.
In an embodiment of the present invention an insecticide of compound (c) selected from the class (1) from the class of carbamates (AChE-acetylcholine esterase inhibitors): carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb; (2) from the class of organophosphates (AChE-acetylcholine esterase inhibitors): acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos; (3) from the class of phenylpyrazoles-fiproles (GABA-gated chloride channel blockers): ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole; (4) from the class of metadiamides and isoxazolines (GABA gated chloride channel allosteric modulators): metadiamides-broflanilide, cyproflanilide; isoxazolines-fluxametamide, afoxolaner, esafoxolaner, fluralaner, lotilaner, sarolaner; (5) from the class of pyrethroids (sodium channel modulators): bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (pyrethrum); (6) from the class of nicotinic insecticides (nicotinic acteylcholine receptor (nAChR) competitive modulators): acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin; sulfoximines-sulfoxaflor; butenolides- flupyradifurone; mesoionics- triflumezopyrim, dichloromezotiaz, fenmezoditiaz; (7) from the class of nereistoxin analogues (nicotinic acetylcholine receptor (nAChR) channel blockers); bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium; (8) from the class of spinosyns (nicotinic acteylcholine receptor (nAChR) allosteric modulators-Site I);spinosad, spinetoram; (9) from the class of avermectins and milbemycins (glutamate-gated chloride channel (GluCl) allosteric modulators): avermectins-abamectin, emamectin benzoate, ivermectin, lepimectin; milbemycins- milbemectin; (10) from the class of juvenile hormone mimics: hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen; (11) from the class of non-specific multi-site inhibitors: chloropicrin, dazomet, metam; (12) from the class of chordotonal organs modulators: pymetrozine, pyrifluquinazon, afidopyropen, flonicamid; (13) from the class of mite growth inhibitors affecting CHS1: clofentezine, hexythiazox, diflovidazin or etoxazole; (14) from the class of benzoylureas (inhibitors of the chitin biosynthesis affecting CHS1: bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron; (15) from the class of buprofezin (inhibitors of the chitin biosynthesis type 1): buprofezin; (16) from the class of cyromazine (moulting disruptors for dipteran): cyromazine; ( 17) from the class of microbial disruptors of insect midgut membrane: Bacillus thuringiensis and insecticidal proteins they product; (18) from the class of uncouplers of oxidative phosphorylation: chlorfenapyr, DNOC, or sulfluramid; (19) from the class of diacylhydrazines (ecdyson receptor agonists): diacylhydrazines- methoxyfenozide, tebufenozide, halofenozide, fufenozide or chromafenozide; (20) from the class of octopamin receptor agonists: amitraz; (21) from the class of inhibitors of mitochondrial ATP synthase:- diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, or tetradifon; (22) from the class of METI (mitochondrial complex I) inhibitors: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin; (23) from the class of METI (mitochondrial complex II) inhibitors: cyenopyrafen, cyflumetofen, -pyflubumide; (24) from the class of METI (mitochondrial complex III) inhibitors:-hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin; (25) from the class of METI (mitochondrial complex IV) inhibitors:-phosphides and cyanides; (26) from the class of voltage-dependent sodium channel blockers: indoxacarb, metaflumizone; (27) from the class of inhibitors of the lipid synthesis, inhibitors of acetyl CoA carboxylase: spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen; (28) from the class of baculoviruses:- granuloviruses and nucleopolyhedrosis viruses; (29) from the class of calcium activated potassium channel (KCa2) modulators:- acynonapyr; (30) Compounds of unknown or uncertain mode of action:- azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin, sulfiflumin, ledprona.
Isocycloseram

Isocycloseram is an isoxazoline insecticide and acaricide with activity against lepidopteran, hemipteran, coleopteran, thysanopteran and dipteran pest species. Isocycloseram selectively targets the invertebrate Rdl GABA receptor at a site that is distinct to fiproles and organochlorines. The widely distributed cyclodiene resistance mutation, A301S, does not affect sensitivity to isocycloseram, either in vitro or in vivo, demonstrating the suitability of isocylsoseram to control pest infestations with this resistance mechanism.
Isocycloseram is a diastereoisomeric mixture containing 80-100% of the (4R, 5S)-isomer and 0-20% of (4R, 5R)-, (4S,5R)-, and (4S, 5S)-isomers. It is a broad-spectrum insecticide and acaricide developed by Syngenta Crop Protection that is active against several pest species including lepidopteran, hemipteran, and dipteran pest species. It has a role as an insecticide, an acaricide, a GABA-gated chloride channel antagonist and an agrochemical. It contains a (4R, 5S)-isocycloseram, a (4R, 5R)-isocycloseram, a (4S, 5R)-isocycloseram and a (4S, 5S)-isocycloseram.
Isocycloseram is having IUPAC name as 4-[5-(3, 5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-N-(2-ethyl-3-oxoisoxazolidin-4-yl)-2- methylbenzamide.
Cyantraniliprole:

It is an insecticide of the ryanoid class, specifically a diamide insecticide. IUPAC name for cyantraniliprole 4-Bromo-1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-1H-pyrazole-5-carboxamide.
The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combination of the present invention allows for a broad spectrum of insect, pest and mites control. Also providing residual control, i.e. longer duration of control and thereby reducing the number of applications. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The synergistic composition of specific active ingredient has the special advantage of being highly active against insect pests and mites. The present inventors believe that the combination of the present invention surprisingly results in a synergistic action. The combinations of the present invention allow for a broad spectrum of pest control. The broad spectrum of the present combination also provides a solution for preventing the development of resistance.
The synergistic composition has very advantageous insecticidal properties for protecting cultivated plants against insect-pests and mites. As has been mentioned, said active ingredient composition can be used to inhibit or destroy the insect-pests and mites that occur on plants or parts of plants of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such insect-pests and mites.
The synergistic composition of insecticides is used to protect the crops and plants from insect-pests and mites. The lists of the major crops includes but are not limited to GMO (Genetically Modified Organism) and Non GMO traits, hybrids and conventional varieties of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Barley (Hordeum vulgare), Maize (Zea mays), Sorghum (Sorghum bicolor), Oat (Avena sativa), Pearl millet (Pennisetum glaucum), Sugarcane (Saccharum officinarum), Sugarbeet (Beta vulgaris), Soybean (Glycin max), Groundnut/Peanut (Arachis hypogaea), Sunflower (Helianthus annuus), Mustard (Brassica juncea), Rape seed (Brassica napus), Sesame (Sesamum indicum), Green gram (Vigna radiata), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Cowpea (Vigna unguiculata), Red gram (Cajanus cajan), French bean (Phaseolus vulgaris), Indian bean (Lablab purpureus), Horse gram (Macrotyloma uniflorum), Field pea (Pisum sativum), Cluster bean (Cyamopsis tetragonoloba), Lentils (Lens culinaris), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.), Tomato (Solanum lycopersicun), Potato (Solanum tuberosum), Sweet potato (Ipomoea batatas), Chilly (Capsicum annum), Bell pepper (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Bitter gourd (Momordica charantia), Radish (Raphanus sativus), Carrot (Dacus carota subsp. sativus), Turnip (Brassica rapa rapa), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Guava (Psidium guajava), Mango (Mangifera indica), Papaya (Carica papaya), Pineapple (Ananas comosus), Pomegranate (Punica granatum), Sapota (Manilkara zapota), Tea (Camellia sinensis), Coffea (Coffea Arabica), Turmeric (Curcuma longa), Ginger (Zingiber officinale), Cumin (Cuminum cyminum), Black Pepper (Piper nigrum), Mentha ( Mentha spp.), Rose (Rosa spp.), Jasmine (Jasminum spp.), Marigold ( Tagetes spp.), Common daisy (Bellis perennis), Dahlia (Dahlia hortnesis), Gerbera ( Gerbera jamesonii), Carnation (Dianthus caryophyllus).
Crops are to be understood as also including those crops which have been rendered tolerant to herbicides or classes of herbicides (e.g. ALS-, GS-, EPSPS-, PPO-, ACCase- and HPPD-inhibitors) by conventional methods of breeding or by genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding is Clearfield® summer rape (canola). Examples of crops that have been rendered tolerant to herbicides by genetic engineering methods include e.g. glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady® and LibertyLink®.
Crops are also to be understood as being those which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt maize (resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and also Bt potatoes (resistant to Colorado beetle). Examples of Bt maize are the Bt 176 maize hybrids of NK® (Syngenta Seeds). The Bt toxin is a protein that is formed naturally by Bacillus thuringiensis soil bacteria. Examples of toxins, or transgenic plants able to synthesise such toxins, are described in EP-A-451 878, EP-A-374 753, WO 93/07278, WO 95/34656, WO 03/052073 and EP-A-427 529. Examples of transgenic plants comprising one or more genes that code for an insecticidal resistance and express one or more toxins are KnockOut® (maize), Yield Gard® (maize), NuCOTIN33B® (cotton), Bollgard® (cotton), NewLeaf® (potatoes), NatureGard® and Protexcta®. Plant crops or seed material thereof can be both resistant to herbicides and, at the same time, resistant to insect feeding (“stacked” transgenic events). For example, seed can have the ability to express an insecticidal Cry3 protein while at the same time being tolerant to glyphosate.
Crops are also to be understood to include those which are obtained by conventional methods of breeding or genetic engineering and contain so-called output traits (e.g. improved storage stability, higher nutritional value and improved flavour).
Other useful plants include turf grass for example in golf-courses, lawns, parks and roadsides, or grown commercially for sod, and ornamental plants such as flowers or bushes.
Crops are to be understood as also including those crops which have been rendered tolerant to herbicides or classes of herbicides (e.g. ALS-, GS-, EPSPS-, PPO-, ACCase- and HPPD-inhibitors) by conventional methods of breeding or by genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding is Clearfield® summer rape (canola). Examples of crops that have been rendered tolerant to herbicides by genetic engineering methods include e.g. glyphosate- and glufosinate-resistant maize varieties commercially available under the trade names RoundupReady® and LibertyLink®.
Crops are also to be understood as being those which have been rendered resistant to harmful insects by genetic engineering methods, for example Bt maize (resistant to European corn borer), Bt cotton (resistant to cotton boll weevil) and also Bt potatoes (resistant to Colorado beetle). Examples of Bt maize are the Bt 176 maize hybrids of NK® (Syngenta Seeds). The Bt toxin is a protein that is formed naturally by Bacillus thuringiensis soil bacteria. Examples of toxins, or transgenic plants able to synthesise such toxins, are described in EP-A-451 878, EP-A-374 753, WO 93/07278, WO 95/34656, WO 03/052073 and EP-A-427 529. Examples of transgenic plants comprising one or more genes that code for an insecticidal resistance and express one or more toxins are KnockOut® (maize), Yield Gard® (maize), NuCOTIN33B® (cotton), Bollgard® (cotton), NewLeaf® (potatoes), NatureGard® and Protexcta®. Plant crops or seed material thereof can be both resistant to herbicides and, at the same time, resistant to insect feeding (“stacked” transgenic events). For example, seed can have the ability to express an insecticidal Cry3 protein while at the same time being tolerant to glyphosate.
Crops are also to be understood to include those which are obtained by conventional methods of breeding or genetic engineering and contain so-called output traits (e.g. improved storage stability, higher nutritional value and improved flavour).
Other useful plants include turf grass for example in golf-courses, lawns, parks and roadsides, or grown commercially for sod, and ornamental plants such as flowers or bushes.
The present composition used to control following major insect-pests and plant parasitic mites infesting crop plants.
The major insect-pests are belongs to the order Hemiptera, for example, rice leafhopper/green leaf hopper (GLH) Nephotettix nigropictus, rice brown plant hopper (BPH) Nilaparvata lugen, rice backed plant hopper (WBPH) Sogatella furcifera , Apple Mealy bug Phenococcus aceris, bean aphid Aphis fabae, black citrus aphid Toxoptera aurantii, citrus black scale Saissetia oleae, cabbage aphid Brevicoryne brassicae, Lipaphis erysimi, citrus red scale Aonidiella aurantii, yellow scale Aonidiella citrine, citrus mealybug Planococcus citri, corn leaf aphid Rhopalosiphum maidis, aphid Aphis gossypii, jassid Amrasca biguttula biguttla, mealy bug Planococcus spp. And Pseudococcus spp., cotton stainer Dysdercus suturellus, whitefly Bemisia tabaci, cowpea aphid Aphis crassivora, grain aphid Sitobion avenae, golden glow aphid Uroleucon spp., grape mealybug Pseudococcus maritimus, green peach aphid Myzus persicae, greenhouse whitefly Trialeurodes vaporariorum, papaya mealy bug Pracoccus marginatus, pea aphid Acyrthosiphon pisum, sugarcane mealybug Saccharicoccus sacchari, potato aphid Myzus persicae, potato leaf hopper Empoasca fabae, cotton whitefly Bemisia tabaci, tarnished plant bug Lygus lineolaris, wooly apple aphid Eriosoma lanigerum, mango hopper Amritodus atkinsoni, Idioscopus spp.; order Lepidoptera, army worm Mythimna unipuncta, asiatic rice borer Chilo suppressalis, bean pod borer Maruca vitrata, beet armyworm Spodoptera exigua, black cutworm Agrotis ipsilon, bollworm Helicoverpa armigera , cabbage looper Trichoplusia ni, codling moth Cydia pomonella, croton caterpillar Achea janata, diamond backmoth Plutella xylostella, cabbage worm Pieris rapae, pink bollworm Pectinophora gossypiella, sugarcane borer Diatraea saccharalis, sugarcane early shoot borer Chilo infuscatellus tobacco budworm Heliothis virescens, tomato fruit worm Helicoverpa zea, velvet bean caterpillar Anticarsia gemmatalis, yellow stem borer Scirpophaga incertulas, spotted bollworm Earias vittella, rice leaffolder Cnaphalocrocis medinalis, pink stem borer Sesamia spp., tobacco leafeating caterpillar Spodoptera litura; brinjal fruit and shoot borer Leucinodes orbonalis, bean pod borer Maruca vitrata, Maruca testulalis, armyworm Mythimna separata, cotton pinkbollworm Pectinophora gossypiella, citrus leafminer Phyllocnistis citrella, cabbage butterfly Pieris bras-sicae, diamond backmoth Plutella xylostella, paddy stem borer Scirpophaga excerptallis, Scirpophaga incertulas, Scirpophaga innotata, wheat stem borer Sesamia inferens, Sitotroga cerealella, Spilosoma obliqua, fall armyworm Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Trichoplusia ni, Tryporyza nivella, Tryporyza incertulas, Tuta absoluta.
from the order Coleoptera, for example, apple twig borer Amphicerus spp., corn root worm Diabrotica virgifera, cucumber beetle diabrotica balteata, boll weevil Anthonomus grandis, grape flea beetle Altica chalybea, grape root worm Fidia viticola, grape trunk borer Clytoleptus albofasciatus, radish flea beetle Phyllotreta armoraciae, maize weevil Sitophilus zeamais, northern corn rootworm Diabrotica barberi, rice water weevil Lissorhoptrus oryzophilus, Anthonomus grandis, Bruchus lentis, Diabrotica semipunctata, Diabrotica virgifera, Dicladispa armigera, Epila-chna varivestis, various species of white grubs are Holotrichia bicolor, Holotrichia consanguinea, Holotrichia serrata, Leptinotarsa decemlineata, Phyllotreta chrysocephala, Popillia japonica etc; from the order Orthoptera, for example, Gryllotalpa spp., Locusta spp., and Schistocerca is spp.; from the order Thysanoptera, for example, Frankliniella spp., Thrips palmi, Thrips tabaci, Thrips parvispinus and Scirtothrips dorsalis; termites (Isoptera), e.g. Calotermes flavicollis, Coptotermes formosanus, Heterotermes aureus, Leucotermes flavipes, Microtermes obesi, Odontotermes obesus, Reticulitermes flavipes, Termes natalensis; from the order Heteroptera, for example, Dysdercus spp., Leptocorisa spp., from the order Hymenoptera, for example, Solenopsis spp.; from the order Diptera, for example, Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp.
The major plant parasitic mites are from the order Acarina, for example, Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp., Tetranychus urticae, Tetranychus cinnabarinus.
In an especially preferred embodiment of the invention, the yield of the treated plant is increased.
In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention, is increased synergistically.
According to the present invention, "increased yield" of a plant, in particular of an agricultural, silvicultural and/or horticultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the mixture according to the invention.
Increased yield can be characterized, among others, by the following improved proper-ties of the plant: increased plant, weight, increased plant height, increased biomass such as higher overall fresh weight (FW), increased number of flowers per plant, higher grain yield, more tillers or side shoots (branches), larger leaves, increased shoot growth, increased protein content, increased oil content, increased starch content, increased pigment content, increased leaf are index.
A further indicator for the condition of the plant is the plant vigor. The plant vigor becomes manifest in several aspects such as the general visual appearance. In another especially preferred embodiment of the invention, the plant vigor of the treated plant is increased. In another preferred embodiment of the invention, the plant vigor of the plants treated according to the method of the invention, is increased synergistically. Improved plant vigor can be characterized, among others, by the following improved properties of the plant: improved vitality of the plant, improved plant growth, improved plant development, improved visual appearance, improved plant stand (less plant verse/lodging), improved emergence, enhanced root growth and/or more developed root system, enhanced nodulation, in particular rhizobial nodulation, bigger leaf blade, bigger size, increased plant weight, increased plant height, increased tiller number, increased number of side shoots, increased number of flowers per plant, increased shoot growth, increased root growth (extensive root system), increased yield when grown on poor soils or unfavorable climate, enhanced photosynthetic activity (e.g. based on increased stomatal conductance and/or increased C02 assimilation rate), increased stomatal conductance, increased C02 assimilation rate, enhanced pigment content (e.g. chlorophyll content), earlier flowering, earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, improved stress tolerance and resistance of the plants against biotic and abiotic stress factors such as fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress and/or salt stress, less non-productive tillers, less dead basal leaves, less input needed (such as fertilizers or water), greener leaves, complete maturation under shortened vegetation periods, less fertilizers needed, less seeds needed, easier harvesting, faster and more uniform ripening, longer shelf-life, longer panicles, delay of senescence, stronger and/or more productive tillers, better extractability of ingredients, improved quality of seeds (for being seeded in the following seasons for seed production), better nitrogen uptake, improved reproduction, reduced production of ethylene and/or the inhibition of its reception by the plant.
The improvement of the plant vigor according to the present invention particularly means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the insecticidal action of the mixture or active ingredients (components).
Another indicator for the condition of the plant is the "quality" of a plant and/or its products.
In an especially preferred embodiment of the invention, the quality of the treated plant is increased.
In another preferred embodiment of the invention, the quality of the plants treated according to the method of the invention, is increased synergistically.

Formulation of the present invention can be in any of the formulations selected from Capsule suspension (CS), Dispersible concentrate (DC), Emulsifiable concentrate (EC), Emulsion, water in oil (EO), Emulsion, oil in water (EW), Jambo balls or bags (bags in water soluble pouch), Micro-emulsion (ME), Oil dispersion (OD), Oil miscible flowable concentrate (oil miscible suspension (OF), Oil miscible liquid (OL), Suspension concentrate (SC), Suspo-emulsion (SE), Soluble concentrate (SL), Wettable granule/Water dispersible granule (WG/WDG), Water soluble granule (SG), Water soluble powder (SP), Wettable powder (WP), A mixed formulation of CS and SC (ZC), A mixed formulation of CS and SE (ZE), a mixed formulation of CS and EW (ZW), Granule (GR) / Soil Applied Granules (SAG), Controlled release granules (CR).

Further composition comprising (A) Isocycloseram; (B) at least one insecticide selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; group; (C) at least one more insecticide are present in the said composition in specific fixed ratio.

In further aspect the present invention relates to the synergistic composition comprising of (A) is 1% to 20% w/w of the composition; (B) is 0.5% to 30% w/w of the composition; and (C) is 0.5% to 30% w/w of the composition.
Compound A Compound B Compound C
Composition Isocycloseram One or more insecticides One or more insecticides
% Ratio (w/w) 1% to 20% w/w 0.5% to 30% w/w 0.5% to 30% w/w
The composition of the present invention in addition to bioactive amounts of active ingredients further comprises inactive excipients including but not limited to Super Wetting-spreading-penetrating agent, solvents, dispersant or dispersing agent, anti-freezing agent, emulsifying agent, anti-foam agent, preservatives and buffering agent.
A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical formulations: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules.
SC
Examples of Wetting agent used herein for Suspension Concentrate (SC) formulation include but not limited to ethylene oxide/propylene oxide (EO/PO) block copolymer, poly aryl phenyl ether phosphate, polyalkoxylated butyl ether, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate. Ethoxylated alcohol includes natural fatty alcohol (lauryl alcohol ethoxylate, lauryl alcohol alkoxylate), synthetic alcohol ethoxylate (tridecyl alcohol ethoxylate, 2-ethyl hexanol, 2-propylheptanol, isodecyl alcohol.
Examples of Wetting-spreading-penetrating agent used herein for Suspension Concentrate (SC) formulation include but not limited to trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form.
Examples of Dispersing agent used herein for Suspension Concentrate (SC) formulation include but not limited to Naphthalenesulfonic acid, sodium salt condensate with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide.
Examples of Suspending agent used herein for Suspension Concentrate (SC) formulation include but not limited to aluminum magnesium silicate, bentonite clay, silica, attapulgite clay.
Examples of Antifoaming agent used herein for Suspension Concentrate (SC) formulation include but not limited to silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids.
Examples of Anti-freezing agent used herein for Suspension Concentrate (SC) formulation include but not limited to ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride etc.
Examples of Preservatives used herein for Suspension Concentrate (SC) formulation include but not limited to 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one
Examples of Thickeners used herein for Suspension Concentrate (SC) formulation include but not limited to xanthan gum, PVK, carboxymethyl celluloses, polyvinyl alcohols, gelatin, sodium carboxymethylcellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, acacia gum.
Examples of Humectant used herein for Suspension Concentrate (SC) formulation include but not limited to urea, humic acid, glycerol, lactose.

ZC formulation is mixture of Capsule suspension (CS) and Suspension Concentrate Formulation (SC) formulation.

Examples of Wall forming material 1 used herein for Capsule suspension (CS) formulation include but not limited to Tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethene diisocyanate (MDI), polymethylene polyphenylene isocyanate, 2,4,4’-diphenyl ether tri-isocyanate, 3,3’-dimethyl-4,4’-diphenyl diisocyanate, 3,3’-dimethoxy-4,4’-diphenyl diisocyanate, 1,5-naphthylene diisocyanate and 4,4’4"-triphenylmethane tri-isocyanate, toluene diisocyanate or polymethylene polyphenylisocyanate, polyurethane comprising of polyfunctional iso cyanate and a polyamine in polarized form.

Examples of Wall forming material 2 used herein for Capsule suspension (CS) formulation include but not limited to Diethylene triamine, Ammonia, hexamine, ethylenediamine, propylene-1,3-diamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetra ethylene pentamine, pentaethylenehexamine, 4,9-dioxadodecane-1, 12-diamine, 1,3- phenylenediamine, 2,4- and 2,6-toluenediamine and 4,4’-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4'-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4'-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole and 1,4,5,8-tetraminoanthraquinone.

Examples of Dispersing agents used herein for Capsule suspension (CS) formulation include but not limited to Ethoxylated lignosulfonic acid salts, lignosulfonic acid salts, oxidized lignins, lignin salts, salts of styrenemaleic anhydride copolymers, polyvinyl alcohol, salts of partial esters of styrene-maleic anhydride copolymers, partial salts of polyacrylic acid and partial salts of polyacrylic acid terpolymers. the surfactant is lignosulfonate of calcium or sodium or mixtures thereof or a modified kraft lignin with a high sulfonic acid group , dibutylnaphthalenesulfonic acid ,fatty acids, alkyl- and alkylarylsulfonates, alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates, and salts of sulfated hexa-, hepta- and octadecanols and of fatty alcohol glycol ethers, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene or of the naphthalenesulfonic acids with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctyl-, octyl- or nonylphenol, alkyl phenyl polyglycol ethers, tributyl phenyl polyglycol ethers, alkyl aryl polyether alcohols, is tridecyl alcohol, fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulphite waste liquors, and proteins, denatured proteins, polysaccharides , ammonium salts of sulfonates, sulfates, phosphates or carboxylates, alkylarylsulfonates, diphenyl sulfonates, alpha-olefin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of condensed naphthalene, sulfonates of dodecyl- and tridecyl benzenes, sulfonates of naphthalene and alkylnaphthalenes, sulfosuccinates or sulfosuccinates, alkoxylates, N-alkylated fatty acid amides, amine oxides, esters or sugar-based surfactants, alkylphenols, amines (e.g. tallow amine), amides, aryl phenols, fatty acids or fatty acid esters which have been alkoxylated. Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide, polyethylene oxide and polypropylene oxide, polyacids or polybases.

Examples of Wetting agent used herein for Capsule suspension (CS) formulation include but not limited to Ethylene oxide/propylene oxide block copolymer, Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol, Sodium dioctyl sulfosuccinate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, Alkyl naphthalene sulfonate, Octyl phenol ethoxylate, alkyl phenol ethoxylate.

Examples of Wetting-spreading-penetrating agent-used herein for Capsule suspension (CS) formulation include but not limited to Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, 10 mole ethylene oxide adduct of octylphenol, may or may not be in modified form, may be liquid or powder form or mixture thereof etc;

Examples of Solvent used herein for Capsule suspension (CS) formulation include but not limited to Hydrocarbon solvent such a an aliphatic, cyclic and aromatic hydrocarbons (e.g. toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalene or their derivatives, mineral oil fractions of medium to high boiling point (such as kerosene, diesel oil, coal tar oils)); a vegetable oil such as corn oil, rapeseed oil; a fatty acid ester such as C1-C10-alkylester of a C10-C22-fatty acid; or, methyl- or ethyl esters of vegetable oils such as rapeseed oil methyl ester or corn oil methyl ester, acetophenone, 2-Heptanon , 3-heptanone, 2-hexanone, 5-methyl-2-hexanone , 5-methyl-3-heptanone, 3-methyl-2-hexanone , 4-methyl-2-hexanone, 2-methyl-3-hexanone, 4-methyl-3-hexanone , 5-methyl-3-hexanone , 3-ethyl-2-pentanone , 3,3-dimethyl-2-pentanone , 3,4-dimethyl-2-pentanone, 4,4-dimethyl-2-pentanone , 2,2-dimethyl-3-pentanone , 2,4-dimethyl-3-pentanone, 2-octanone , 2,5-dimethyl-3-hexanone , 2,2-dimethyl-3-hexanone , 3,3-dimethyl-2-hexanone, 3,4-dimethyl-2-hexanone, 4,4-dimethyl-3-hexanone , 3-ethyl-4-methyl-2-pentanone , 2-methyl-3-heptanone, 2-methyl-4-heptanone, 3-methyl-2-heptanone, 3-methyl-4-heptanone, 5-methyl-3-heptanone, 6-methyl-2-heptanone , 6-methyl-3-heptanone, 3-octanone, 4-octanone, 2,2,4-trimethyl-3-pentanone , 3-ethyl-3-methyl-2-pentanone, 5-methyl-2-heptanone, isoprene.

Examples of Thickener used herein for Capsule suspension (CS) formulation include but not limited to Xanthan gum ,Carboxy methyl cellulose, Attapulgite clay, Bentonite clay.

Examples of Suspending agent used herein for Capsule suspension (CS) formulation include but not limited to Aluminium Magnesium Silicate, Bentonite clay, Silica, Attapulgite clay.

Examples of Antifoaming agent used herein for Capsule suspension (CS) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, Silicone antifoam emulsion, Dimethyl siloxane, Polydimethyl siloxane, Vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.

Examples of Antifreezing agent used herein for Capsule suspension (CS) formulation include but not limited to ethylene glycol, propane diols, glycerine or the urea, Glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol), Glycerine, Urea, Magnesium sulphate heptahydrate, sodium chloride etc.

Examples of Preservative used herein for Capsule suspension (CS) formulation include but not limited to 1,2-benzisothiazolin-3(2H)-one, sodium salt, Sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, Formaldehyde, Sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

Examples of Buffering agent used herein for Capsule suspension (CS) formulation include but not limited to Sodium hydroxide, potassium hydroxide, acetic acid, sulphuric acid, hydrochloric acid, ortho phosphoric acid, ammonium hydroxide.

Examples wetting agent used herein for OD (Oil Dispersion) formulation include but not limited to ethylene oxide/propylene oxide block copolymer, polyarylphenyl ether phosphate, ethoxylated fatty alcohol, sodium dioctyl sulfosuccinate, sodium lauryl sulfate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonate.
Examples Super wetting-spreading-penetrating agent used herein for OD (Oil Dispersion) formulation include but not limited to Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc.
Examples of dispersants or dispersing agent used herein for Oil dispersion (OD) formulation includes but not limited to alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol poly glycol ether), block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.
Emulsifying agent used herein for the Oil dispersion (OD) formulation includes but not limited to castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, Polyoxyethylene sorbitol hexaoleate, polyoxyethylene sorbitan monolaurate etc.
Examples of Antifoaming agent used herein for Oil dispersion (OD) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane.
Examples of Anti-freezing agent used herein for Oil dispersion (OD) formulation include but not limited to ethylene glycol, propane diols, glycerine or the urea, glycol (Monoethylene glycol, Diethylene glycol, Polypropylene glycol, Polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride etc.
Preservative used herein for the Oil dispersion (OD) formulation include but not limited to 1,2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.
Examples of Stabiliser or rheology modifier used herein for Oil dispersion (OD) formulation stabilizer is selected from hectorite clay, aluminium magnesium silicate, bentonite clay, silica, attapulgite clay.
Example of solvents used herein for the Oil dispersion (OD) formulation includes but not limited to vegetable oil (plant, seed or tree) or its alkylated or ethoxylated or esterified. The alkylated vegetable oil may be methylated vegetable oil or ethylated vegetable oil. The vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil. The alkyl ester of vegetable oils includes methyl ester, ethyl ester, propyl ester or butyl ester of vegetable oils. Some of the examples are methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane alkyl phenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil butyl ester, cotton seed oil propyl ester, tall oil fatty acids esters-tallow methyl ester, tallow ethyl ester, tallow propyl ester, bio-diesel, mineral oil (aromatic solvents, isoparaffin, base solvent), fatty acid amides (e.g. C1 -C3 amines, alkylamines or alkanolamines with C6–C18 carboxylic acids), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyate, alkyl benzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols. The above oil based carrier/diluting agents may be used as solo or mixture of two or more if desired.
Co-solvent used herein for the Oil dispersion (OD) formulation includes but not limited to Cyclohexanone, Acetophenone, NMP, Dimethyl sulfoxide, Benzyl alcohol, Butanol, N-octanol, N-Propanol, 2-ethyl hexanol, Tetrahydro furfuryl alcohol, Isophorone, Fatty acid dimethyl amide, 2-hexylethyl lactate, Propylene carbonate.
Example of Dispersing agents used herein for the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation includes but not limited to alkylnaphthalene sulfonate sodium salt, sodium polycarboxylate, naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkylphenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, polyacrylates and phosphate esters, calcium lignosulfonate, lignin sulfonate sodium salt;

Example of Wetting agents used herein for the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation includes but not limited to sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, may or may not be in modified form, may be liquid or powder form or mixture thereof etc;

Example of Antifoaming agent used herein for the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation includes but not limited to polydimethylsiloxane

Example of Carrier used herein for the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation includes but not limited to china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels; fertilizers such as, for example, ammonium sulphate, ammonium phosphate, ammonium nitrate and urea; natural products of vegetable origin such as, for example, grain meals and flours, bark meals, wood meals, nutshell meals and cellulosic powders; and synthetic polymeric materials such as, for example, ground or powdered plastics and resins, bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.

Example of Disintegrating agent used herein for the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation includes but not limited to citric acid, succinic acid or the sodium bicarbonate.

Example of Humectant used herein for the Wettable Granule (WG)/ Water Dispersible Granule (WDG) formulation includes but not limited to urea, humic acid, glycerol, lactose.

Examples of Solvent used herein for Suspo-Emulsion (SE) formulation include but not limited to water, water soluble alcohols and dihydroxy alcohol ethers. Water soluble alcohol or lower alcohol (1-4 carbon atoms) includes-methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol. Macromolecular alcohol includes polyethylene glycol, sorbitol, glucitol etc., dihydroxy alcohol ethers includes dihydroxy alcohol alkyl ether or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, di-propylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, di-propylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, 5 diethylene glycol phenyl ether, propylene glycol phenyl ether, di-propylene glycol phenyl ether, and the like. Any of the mentioned solvent can be used either alone or in combinations thereof.
Hyrdocarbons includes solvent naphtha, n-pentane, hexane(s), cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylene(s), isophorone and ester solvents such as methyloleate, dimethylamide and morpholineamide derivatives of C6-C16 fatty acids, and mono-alkylene carbonates such as ethylene carbonate, propylene carbonate and butylene carbonates, dimethylsulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, fatty acid dimethyl esters, fatty acid esters, dibasic esters, aromatic hydrocarbons and/or aliphatic hydrocarbons, one or more dimethylamides, such as C8-dimethylamide, C10-dimethylamide, C12-dimethylamide, ethylene glycol, propylene glycol, polyalkylene glycols, aromatic hydrocarbons, methylpyrrolidinone (NMP); dimethylformamide (DMF); dimethylisosorbide (DMI); isophorone; acetophenone; 1,3-dimethyl-2-imidazolidonone; lactate esters; dimethyl and diethylcarbonates; alcohols including methanol; ethanol; iso-propanol; n-propanol; n-butanol; iso-butanol; and tert-butanol; Methyl L-lactate, 2-Ethylhexyl L-lactate, Ethyl L-lactate, n-Butyl L-lactate, Octyl phenol ethoxylates.
Examples of Emulsifier used herein for Suspo-Emulsion (SE) formulation include but not limited to salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. of sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkylsulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol (tristyrlphenol with 16 moles EO), tristyrylphenol-polyglycolether-phosphate, fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyletherphosphates; alkylphenoletherphosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkylsulphonate, an alkylethersulphonate, an ether sulphate, or an ether phosphate such as an alkyletherphosphate, nonylphenol polyethoxy ethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol.
Examples of Stabilizer used herein for Suspo-Emulsion (SE) formulation include but not limited to butylated hydroxytoluene (BHT) and epoxidized soybean oil (ESBO), Epichlorhydrin.
Examples of Anti-freezing agent used herein for Suspo-Emulsion (SE) formulation include but not limited to ethylene glycol, propane diols, glycerine or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerine, urea, magnesium sulfate heptahydrate, sodium chloride.
Examples of Antifoaming agent used herein for Suspo-Emulsion (SE) formulation include but not limited to silicone oil, silicone compound, C10~C20 saturated fat acid compounds or C8~C10 aliphatic alcohols compound, silicone antifoam emulsion, dimethylsiloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids, polyalkyleneoxide modified polydimethylsiloxane etc.
Examples of Antifoaming agent used herein for Suspo-Emulsion (SE) formulation include but not limited to aluminum magnesium silicate, bentonite clay, silica, silicone dioxide, attapulgite clay.

Examples of Wetting agent used herein for Suspo-Emulsion (SE) formulation include but not limited to Ethylene oxide/propylene oxide block copolymer, Polyarylphenyl ether phosphate, Ethoxylated Fatty Alcohol, Sodium dioctyl sulfosuccinate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, Alkyl naphthalene sulfonate, Octyl phenol ethoxylate, alkyl phenol ethoxylate.

Examples of Wetting-spreading-penetrating agent used herein for Suspo-Emulsion (SE) formulation include but not limited to Organosilicone surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, heptamethyl trisiloxane, Polyalkyleneoxide modified heptamethyl trisiloxane, heptamethyl trisiloxane ethoxylate, polyether modified polysiloxane, 10 mole ethylene oxide adduct of octylphenol, may or may not be in modified form, may be liquid or powder form or mixture thereof.

Examples of Preservatives used herein for Suspo-Emulsion (SE) formulation include but not limited to propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2- methyl-4-isothiazolin-3-one, potassium sorbate, para hydroxy benzoates or mixtures thereof.

Examples of Thickeners used herein for Suspo-Emulsion (SE) formulation fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate formulations using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and 15 seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl 20 alcohol and polyethylene oxide or mixtures.

Examples of Dispersing agent used herein for Suspo-Emulsion (SE) formulation include but not limited to polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylic polymers, acrylic graft copolymer, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymers and mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof. The examples of dispersing agents are alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium salt of alkyl naphthalene sulfonate, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.

Examples of Buffering agent used herein for Suspo-Emulsion (SE) formulation include but not limited to calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.

Examples of Humectant used herein for Suspo-Emulsion (SE) formulation include but not limited to urea, humic acid, glycerol, lactose.
The synergistic composition comprising of (A) Isocycloseram present in an amount of 1% to 20% w/w of the composition; (B) at least one insecticide from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole; group (0.5% to 30% w/w) and (C) at least one more insecticide (0.5% to 30%) w/w of the composition shows:
• Synergistic control of insect-pests and mites with one shot application.
• Residual control i.e. longer duration of control with immediate crop protection.
• Delay in development of resistance and effective control of hard to kill and resistant insect-pests and mites.
• Increase in yield of treated plants (cereals, pulses, oilseeds, fibre crop, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamentals etc.)
• Increase in yield due to protection against insect-pests and mites.
• Increase in yield due to more number of tillers, more branches and sub branches, more number of flowers, more number of fruits
• Increase plant vigor
• Increase tolerance to insect-pests and mite damage
The process for preparing the present novel synergistic composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the formulation. However, all such variation and modification is still covered by the scope of present invention.
While the foregoing written description of the invention enables one of ordinary skill to make and use what is considered presently to be the best mode thereof, those of ordinary skill will understand and appreciate the existence of variations, combinations, and equivalents of the specific embodiment, method, and examples herein. The invention should therefore not be limited by the above described embodiment, method, and examples, but by all embodiments and methods within the scope and spirit of the invention. The invention shall now be described with reference to the following specific examples. It should be noted that the example(s) appended below illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the present invention.
These and other aspects of the invention may become more apparent from the examples set forth herein below. These examples are provided merely as illustrations of the invention and are not intended to be construed as a limitation thereof.
EXAMPLE 1:
Isocycloseram 1%+Chlorantraniliprole 0.64%+Cartap hydrochloride 6.4% GR (Granule)
Chemical Composition content (% w/w)
Isocycloseram a.i. 1.00
chlorantraniliprole a.i. 0.64
Cartap hydrochloride a.i. 6.40
phosphoric acid (buffering agent) 0.35
phosphate ester of alcohol 1.50
alcohol alkoxylate 1.50
china clay 2.50
Rhodamine 0.30
River sand (Silica) 85.81
Total 100.00

Active ingredients on the basis of 100% purity.
Storage stability - Isocycloseram 1% + Chlorantraniliprole 0.64% + Cartap hydrochloride 6.4% GR (Granule)
Laboratory storage stability
Parameters Specifications Initial At 54±2 0C At 0±2 0C
isocycloseram a.i. (% w/w) 0.95 to 1.10 1.25 1.15 1.25
chlorantraniliprole a.i. (% w/w) 0.608 to 0.704 0.70 0.68 0.70
cartap hydrochloride a.i. (% w/w) 6.08 to 7.04 7.00 6.90 7.00
pH range (1% aq. Suspension) 3.5 to 5.5 4.00 4.20 4.10
Dustiness < 20 mg 5 5 5
Dry sieve (300 micron) percent by mass min. > 90% 98.00 98.00 98.00
Attrition Resistance (<100 micron) < 5% 2.00 2.00 2.00
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 0.50 0.45 0.50
Room temperature storage stability
Parameters specifications 1 month 6 month 12 month
isocycloseram a.i. (% w/w) 0.95 to 1.10 1.25 1.24 1.23
chlorantraniliprole a.i. (% w/w) 0.608 to 0.704 0.70 0.69 0.68
cartap hydrochloride a.i. (% w/w) 6.08 to 7.04 7.00 6.98 6.90
pH range (1% aq. Suspension) 3.5 to 5.5 4.00 4.10 4.10
Dustiness < 20 mg 5 5 5
Dry sieve (300 micron) percent by mass min. > 90% 98.00 98.00 98.00
Attrition Resistance (<100 micron) < 5% 2.00 2.00 2.00
Bulk density (g/ml) 1.25 to 1.50 1.35 1.35 1.35
Moisture content percent by mass max. max. 2% 0.50 0.45 0.50

The composition of Isocycloseram 1%+Chlorantraniliprole 0.64%+Cartap hydrochloride 6.4% GR (Granule) meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & at 0±2 C for 14 days) and room temperature (for 12 months).

Manufacturing process for preparing 100 kg batch of Isocycloseram 1%+Chlorantraniliprole 0.64%+Cartap hydrochloride 6.4% GR (Granule).
Step 1: Take 85.81 kg of River sand granules in booth mixer
Step 2: In another mixing vessel,add 1.5 kg of phosphate ester of alcohol and 1.50 kg of alcohol alkoxylate, 0.35 kg of phosphoric acid, 0.30 kg of Rhodamine dye and mix for 20-30 minutes
Step 3: Now spray this liquid mix onto these granules and homogenize the blank granules
Step 4: Now add 1.00 kg of Isocycloseram, 0.64 kg of Chlorantraniliprole technical and 6.40 kg of Cartap hydrochloride technical in this vessel and homogenzie for 3-45 minutes till it get homogenous mixture.
Step 5: Finally add China clay onto these wet granules
Step 6: After homogenous mixing and drying to remove the solvent ,checked for quality parameters

EXAMPLE 2:
Composition of Isocycloseram 9%+Chlorantraniliprole 6%+Abamectin 1.8% SC
Chemical composition content (% w/w)
Isocycloseram a.i. 9.00
Chlorantraniliprole a.i. 6.00
Abamectin a.i. 1.80
Methylated seed oil, polyalkyleneoxide modified trisiloxane (super wetting-spreading-penetrating agent) 5.00
Ethylene-propylene oxide block copolymer (dispersing agent I) 4.75
Sodium naphthalene sulphonate formaldehyde condensates (dispersing agent II) 1.25
Aluminum magnesium silicate (suspending agent) 0.50
Polydimethylsiloxane (anti foaming agent) 0.30
sodium benzoate (preservative) 0.20
Polypropylene glycol (anti freezing agent) 5.00
Xanthan gum (thickner) 0.20
Diluent water 66.00
Total 100.00
Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 9%+Chlorantraniliprole 6%+Abamectin 1.8% SC
Laboratory storage stability for 14 days
Parameters Specification Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 8.55 to 9.45 9.30 9.10 9.3
Chlorantraniliprole a.i. 5.70 to 6.60 6.25 6.10 6.24
Abamectin a.i. 1.71 to 1.98 1.95 1.85 1.95
Isocycloseram suspensibility (%) 80 98.60 98.10 98.50
Chlorantraniliprole suspensibility (%) 80 98.50 98.30 98.50
Abamectin suspensibility (%) 80 98.70 98.20 98.45
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.15 7.05
Pourability (%) 95 98.20 98.00 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 530 550 550
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.7 2.1,8.7
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specification 1 month 6 month 12 month
Isocycloseram a.i. 8.55 to 9.45 9.3 9.28 9.25
Chlorantraniliprole a.i. 5.70 to 6.60 6.24 6.22 6.21
Abamectin a.i. 1.71 to 1.98 1.95 1.93 1.91
Isocycloseram suspensibility (%) 80 98.50 98.50 98.40
Chlorantraniliprole suspensibility (%) 80 98.50 98.50 98.40
Abamectin suspensibility (%) 80 98.70 98.60 98.60
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.05 7.10
Pourability (%) 95 98.20 98.20 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 530 530 535
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.5 2.1,8.6
Persistent foam in ml (after 1 minute) max. 60 nil nil nil

The composition of Isocycloseram 9%+Chlorantraniliprole 6%+Abamectin 1.8% SC meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & at 0±2 C for 14 days) and room temperature (for 12 months).

Manufacturing process for 100 kg batch of Isocycloseram 9%+ Chlorantraniliprole 6%+Abamectin 1.8% SC
Step 1: Preparation of 2% Gum Solution: Charge Xanthan gum (2.0 kg) and 1,2-benzisothiazoline-3-one (2.0 kg) into 96.0 kg water and homogenize. It should be made 12-18 hour prior to use.
Step 2: Charge DM water (56.0kg) and 1,2-propylene glycol (5 kg) into designated vessel and ix thoroughly.
Step 3: Add Sodium naphthalene sulphonate formaldehyde condensates (1.25 kg), Ethylene-propylene oxide block copolymer (4.75 kg) and Aluminum magnesium silicate (0.5 kg) into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4: Then add Isocycloseram technical (9 kg), Chlorantraniliprole technical (6 kg) and Abamectin technical (1.8 kg) to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5: Before grinding half the quantity of Polydimethylsiloxane (0.15 kg) was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6: Add remaining Polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7: Finally add 10.0 kg of 2% Xanthum gum solution and 5.0 kg of Methylated seed oil, polyalkyleneoxide modified trisiloxane to this formulation and homogenized for 30 minutes.
Step 8: Now send this final formulation to QC for quality check.

EXAMPLE 3:
Composition of Isocycloseram 7.5%+Cyantraniliprole 7.5%+Tolfenpyrad 12% SC
Chemical composition content (% w/w)
Isocycloseram a.i. 7.50
Cyantraniliprole a.i. 7.50
Tolfenpyrad a.i. 12.00
Polyalkyleneoxide modified trisiloxane (super wetting-spreading-penetrating agent) 5.00
Octylphenol ethoxylate (dispersing agent I) 4.75
polyarylphenyl anionic ether sulfate, ammonium salts (dispersing agent II) 1.25
Bentonite clay (suspending agent) 0.50
Polydimethylsiloxane (anti foaming agent) 0.30
sodium benzoate (preservative) 0.20
Glycerine (anti freezing agent) 5.00
Carboxy methyl cellulose (thickner) 0.20
Diluent water 55.80
Total 100.00
Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 7.5%+Cyantraniliprole 7.5%+Tolfenpyrad 12% SC
Laboratory storage stability for 14 days
Parameters Specification Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 7.125 to 8.25 7.85 7.55 7.85
Cyantraniliprole a.i. 7.125 to 8.25 7.80 7.60 7.80
Tolfenpyrad a.i. 11.40 to 12.60 12.50 12.30 12.49
Isocycloseram suspensibility (%) 80 98.60 98.10 98.50
Cyantraniliprole suspensibility (%) 80 98.50 98.30 98.50
Tolfenpyrad suspensibility (%) 80 98.70 98.20 98.45
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.15 7.05
Pourability (%) 95 98.20 98.00 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 530 550 550
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.7 2.1,8.7
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specification 1 month 6 month 12 month
Isocycloseram a.i. 7.125 to 8.25 7.85 7.84 7.83
Cyantraniliprole a.i. 7.125 to 8.25 7.80 7.78 7.75
Tolfenpyrad a.i. 11.40 to 12.60 12.5 12.49 12.46
Isocycloseram suspensibility (%) 80 98.50 98.50 98.40
Cyantraniliprole suspensibility (%) 80 98.50 98.50 98.40
Tolfenpyrad suspensibility (%) 80 98.70 98.60 98.60
pH range (1% aq. Suspension) 5.5 to 8.0 7.05 7.05 7.10
Pourability (%) 95 98.20 98.20 98.10
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 530 530 535
Particle size (micron) D50<3, D90<10 2.1,8.5 2.1,8.5 2.1,8.6
Persistent foam in ml (after 1 minute) max. 60 nil nil nil

The composition of Isocycloseram 7.5%+Cyantraniliprole 7.5%+Tolfenpyrad 12% SC meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).

Manufacturing process for 100 kg batch of Isocycloseram 7.5%+Cyantraniliprole 7.5%+Tolfenpyrad 12% SC
Step 1: Preparation of 2% Gum Solution: Charge carboxy methyl cellulose (2.0 kg) and 1,2-benzisothiazoline-3-one (2.0 kg) into 96.0 kg water and homogenize. It should be made 12-18 hour prior to use.
Step 2: Charge DM water (45.08 kg) and Glycerine (5 kg) into designated vessel and ix thoroughly.
Step 3: Add Octylphenol ethoxylate (4.75 kg),polyarylphenyl anionic ether sulfate, ammonium salts (1.25 kg) and Bentonite clay (0.5 kg) into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 4: Then add Isocycloseram technical (7.5 kg), Cyantraniliprole technical (7.5 kg) and Tolfenpyrad technical (12.0 kg) to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 5: Before grinding half the quantity of Polydimethylsiloxane (0.15 kg) was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 6: Add remaining Polydimethyl siloxane (0.15 kg) antifoam was added after grinding process completes and before sampling for in process analysis.
Step 7: Finally add 10.0 kg of 2% Xanthum gum solution and 5.0 kg of polyalkyleneoxide modified trisiloxane to this formulation and homogenized for 30 minutes.
Step 8: Now send this final formulation to QC for quality check.

EXAMPLE 4:
Composition of Isocycloseram 5%+Tetraniliprole 10%+Hexythiazox 5% SE
Chemical composition content (% w/w)
Isocycloseram a.i. 5.00
Tetraniliprole a.i. 10.00
Hexythiazox a.i. 5.00
Polyarylphenyl anionic ether sulfate, ammonium salt (emulsifier) 1.50
Solvent naphtha (solvent) 15.00
Acrylic graft copolymer (dispersing agent I) 3.00
Butyl Polyalkylene Oxide block copolymer (dispersing agent II) 4.50
Aluminum magnesium silicate (suspending agent) 0.50
Polydimethylsiloxane (anti foaming agent) 0.20
1,2-benzisothiazolin-3(2H)-one (preservative) 0.15
Polypropylene glycol (anti freezing agent) 5.00
Xanthan gum (thickner) 0.15
Diluent water 50.00
Total 100.00
Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 5%+Tetraniliprole 10%+Hexythiazox 5% SE
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 4.75 to 5.50 5.35 5.15 5.35
Tetraniliprole a.i. 9.50 to 10.50 10.50 10.2 10.49
Hexythiazox a.i. 4.75 to 5.50 5.30 5.12 5.30
Isocycloseram suspensibility (%) 80 98.90 97.50 98.50
Tetraniliprole suspensibility (%) 80 99.00 97.90 98.60
Hexythiazox suspensibility (%) 80 98.50 97.60 98.30
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.00 7.10
Pourability (%) 95 98.20 98.20 97.80
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no.62,20 rpm 350-800 cps 550 560 560
Particle size (micron) D50<3, D90<10 2.1,8.2 2.2,8.5 2.1,8.2
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specification 1 month 6 month 12 month
Isocycloseram a.i. 4.75 to 5.50 5.35 5.34 5.30
Tetraniliprole a.i. 9.50 to 10.50 10.49 10.49 10.45
Hexythiazox a.i. 4.75 to 5.50 5.30 5.29 5.27
Isocycloseram suspensibility (%) 80 98.70 98.70 98.50
Tetraniliprole suspensibility (%) 80 98.90 98.80 98.70
Hexythiazox suspensibility (%) 80 98.40 98.40 98.40
pH range (1% aq. Suspension) 5.5 to 8.0 7.10 7.10 7.08
Pourability (%) 95 98.20 98.20 98.20
Specific gravity 1.05-1.10 1.07 1.07 1.07
Viscosity at spindle no. 62, 20 rpm 350-800 cps 550 550 555
Particle size (micron) D50<3, D90<10 2.1,8.2 2.1,8.2 2.1,8.2
Persistent foam in ml (after 1 minute) max. 60 nil nil nil

The composition of Isocycloseram 5%+Tetraniliprole 10%+Hexythiazox 5% SE meets the all inhouse specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing process for 100 kg batch of Isocycloseram 5%+Tetraniliprole 10%+Hexythiazox 5% SE
Step 1: Preparation of 2% Gum solution: Charge 2 kg Xanthan gum and 2 kg 1,2-benzisothiazoline-3-one into 96 kg water and homogenize and should be made 12-18 hour prior to use.
Step 2: EC premix-Add 15.0 kg of solvent naphtha into other vessel having slow stirring. Now add 5.0 kg of Isocycloseram technical 5.0 kg of Hexythiazox technical and 4.5 kg of Butyl Polyalkylene Oxide block copolymer and mix properly for 30-45 minutes
Step 3: Charge 40.0 kg of DM water and 5 kg of 1,2-propylene glycol into designated vessel and mix thoroughly
Step 4: Add 0.5 kg of Aluminum magnesium silicate, 3.0 kg of Acrylic graft copolymer, 1.50 kg of Polyarylphenyl anionic ether sulfate, ammonium salt and 0.10 kg of Polydimethylsiloxane into the vessel having water and homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Step 5: Then add 10.0 kg of Tetraniliprole technical to this premix slowly and homogenised to get uniform slurry ready for grinding.
Step 6: Before grinding half the quantity of antifoam was added and then material was subjected to grinding in Dyno mill till desired particle size is achieved.
Step 7: Add remaining 0.10 kg of Polydimethyl siloxane antifoam was added after grinding process completes and before sampling for in process analysis.
Step 8: Now mix EC premix to this milled slurry under slow stirring and homogenize for 30-45 minutes
Step 9: Finally add 7.5 kg of 2% gum solution to this formulation and send to QC for quality check.

EXAMPLE 5:
Composition of Isocycloseram 8%+Cyclaniliprole 6.67%+Fluxametamide 5% DC
Chemical composition content (% w/w)
Isocycloseram a.i. 8.00
Cyclaniliprole a.i. 6.67
Fluxametamide a.i. 5.00
Polyalkyleneoxide Modified Heptamethyltrisiloxane 7.00
Sodium Dioctyl Sulfosuccinate 8.00
Polydimethyl siloxane 0.30
Propylene Carbonate 20.00
Propylene glycol 10.00
Dimethyl amide ether type solvents 35.03
Total 100.00
Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 8%+Cyclaniliprole 6.67%+Fluxametamide 5% DC
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 7.60 to 8.80 8.30 8.15 8.35
Cyclaniliprole a.i. 6.336 to 7.337 7.00 6.8 7.00
Fluxametamide a.i. 4.75 to 5.50 5.25 5.15 5.25
pH (5% in DM water) 6.0 - 8.0 6.50 6.70 6.50
Dispersion stability Max. 2ml creaming or sediment after 30 min 0.5ml 0.6 ml 0.5 ml
Cold test Any separation or creaming max. 1 ml after 1 hour 0.2 ml 0.3 ml 0.2 ml
Persistent Foam Max 60 ml after 1 min 2.00 2.00 2.00
Wet sieve (75 microns) Mini 99% 99.50 99.45 99.65
Flash point Above 24.5 0C 45 45 45
Room temperature storage stability up to 12 months
Parameters Specifications 1 month 6 month 12 month
Isocycloseram a.i. 7.60 to 8.80 8.35 8.33 8.29
Cyclaniliprole a.i. 6.336 to 7.337 7.00 6.95 6.9
Fluxametamide a.i. 4.75 to 5.50 5.25 5.24 5.20
pH (5% in DM water) 6.0 - 8.0 6.50 6.48 6.42
Dispersion stability Max. 2ml creaming or sediment after 30 min 0.5 ml 0.5 ml 0.6 ml
Cold test Any separation or creaming max. 1 ml after 1 hour 0.2 ml 0.2 ml 0.3 ml
Persistent Foam Max 60 ml after 1 min 2.00 2.00 2.00
Wet sieve (75 microns) Mini 99% 99.65 99.65 99.45
Flash point Above 24.5 0C 45 45 45

The composition of Isocycloseram 8%+Cyclaniliprole 6.67%+Fluxametamide 5% DC meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & At 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing process for 100 kg batch of Isocycloseram 8%+Cyclaniliprole 6.67%+Fluxametamide 5% DC
Step 1: Charge 20.0 kg of Propylene carbonate, 35.03 kg of Dimethyl amide ether type solvent and 10.0 kg of Propylene glycol into a designated vessel for OD production.
Step 2: Add 8 kg of Isocycloseram technical, 6.67 kg of Cyclaniliprole technical and 5.0 kg of Fluxametamide technical, into this premix and homogenized for 30-45 minutes.
Step 3: Now add 8.0 kg of Sodium dioctyl sulfosuccinate and 0.3 kg of Polydimethyl siloxane.
Step 4: Send this final formulation to QC for quality check.

EXAMPLE 6:
Composition of Isocycloseram 7.5%+Cyantraniliprole 7.5%+Fluxametamide 5% OD
Chemical composition content (% w/w)
Isocycloseram a.i. 7.50
Cyantraniliprole a.i. 7.50
Fluxametamide a.i. 5.00
Polyoxyethylene sorbitol hexaoleate (Oil Emulsifier) 10.00
Salts of polyolefin condensates (Non-Aqueous dispersant) 2.50
Ethoxylated sorbitan ester (Co-Emulsifier) 8.50
Bentonite clay (Rheology modifier/stabiliser) 1.00
Styrene acrylic polymer (Aqueous dispersant) 1.50
Methylated seed oil (Oil continuous phase/ solvent) 56.50
Total 100.00

Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 7.5%+ Cyantraniliprole 7.5%+Fluxametamide 5% OD.
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 7.125 to 8.250 7.90 7.65 7.90
Cyantraniliprole a.i. 7.125 to 8.250 7.85 7.6 7.84
Fluxametamide a.i. 4.75 to 5.50 5.30 5.10 5.30
Isocycloseram suspensibility (%) 80 98.90 98.10 98.80
Cyantraniliprole suspensibility (%) 80 99.00 98.50 98.90
Fluxametamide suspensibility (%) 80 98.80 98.10 98.80
pH range (1% aq. Suspension) 5.5 to 8.0 6.90 7.05 6.90
Pourability (%) 95 98.20 98.10 98.20
Specific gravity 1.00-1.10 1.03 1.03 1.03
Viscosity at spindle no.62,20 rpm 350-800 cps 510 520 510
Particle size (micron) D50<3, D90<10 2.1,8.0 2.1,8.2 2.1,8.1
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specifications 1 month 6 month 12 month
Isocycloseram a.i. 7.125 to 8.250 7.90 7.89 7.88
Cyantraniliprole a.i. 7.125 to 8.250 7.85 7.84 7.8
Fluxametamide a.i. 4.75 to 5.50 5.30 5.29 5.27
Isocycloseram suspensibility (%) 80 98.90 98.80 98.80
Cyantraniliprole suspensibility (%) 80 98.90 98.90 98.80
Fluxametamide suspensibility (%) 80 98.80 98.70 98.70
pH range (1% aq. Suspension) 5.5 to 8.0 6.90 6.90 6.95
Pourability (%) 95 98.20 98.20 98.20
Specific gravity 1.00-1.10 1.03 1.03 1.03
Viscosity at spindle no. 62, 20 rpm 350-800 cps 510 510 515
Particle size (micron) D50<3, D90<10 2.1,8.1 2.1,8.1 2.1,8.1
Persistent foam in ml (after 1 minute) max. 60 nil nil nil

The composition of Isocycloseram 7.5%+Cyantraniliprole 7.5%+Fluxametamide 5% OD meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & at 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing Process for 100 kg batch of Isocycloseram 7.5%+ Cyantraniliprole 7.5%+Fluxametamide 5% OD
Step 1: Preparation of 10% Bentonite clay solution:
Add 10 kg of Bentonite clay in to 90 kg of Methylated seed oil and also and homogenized till it gets completely dissolved. It must be kept for 12-18 hour prior to use.
Step 2: OD Premix:
Charge 46.5 kg of Methylated seed oil into a designated vessel for OD production.
Now add 10.0 kg of Polyoxyethylene sorbitol hexaoleate, 1.50 kg of Styrene acrylic polymer, 8.50 kg of Ethoxylated sorbitan ester and 2.50 kg of Salts of polyolefin condensates homogenise the contents for 45 – 60 minutes using high shear homogeniser.
Add 10 kg of 10% Bentonite solution after milling to avoid foaming
Send this final formulation to QC for quality check

EXAMPLE 7:
Composition of Isocycloseram 12%+Flubendiamide 6%+Pymetrozine 30% WG
Chemical composition content (% w/w)
Isocycloseram a.i. 12.00
Flubendiamide a.i. 6.00
Pymetrozine a.i. 30.00
Modified Sodium lignosulphonate (dispersing agent I) 7.00
Modified polyacrylate copolymer (dispersing agent II) 3.00
Sodium isopropyl naphthalene sulfonate (wetting agent) 5.00
Polydimethylsiloxane (Antifoaming Agent) 1.00
Corn Starch 15.00
China clay 21.00
Total 100.00
Active ingredients on the basis of 100% purity.
Storage stability- Isocycloseram 12%+Flubendiamide 6%+Pymetrozine 30% WG
Laboratory storage stability for 14 days
Parameters Specifications Initial At 54±2 0C At 0±2 0C
Isocycloseram a.i. 11.40 to 12.60 12.50 12.15 12.5
Flubendiamide a.i. 5.70 to 6.60 6.35 6.10 6.34
Pymetrozine a.i. 28.50 to 31.50 30.50 30.20 30.5
Isocycloseram suspensibility (%) 70 98.40 97.30 98.20
Flubendiamide suspensibility (%) 70 98.20 97.50 98.20
Pymetrozine suspensibility (%) 70 98.80 97.40 98.60
pH range (1% aq. Suspension) 5 to 9 7.50 7.60 7.50
Wettability Max 30 s 10 12 10
Wet Sieve(45 micron) Mini 98.5% 99.5 99.4 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.2 1.4
Persistent foam ml (after 1 minute) max. 60 nil nil nil
Room temperature storage stability up to 12 months
Parameters Specifications 1 month 6 month 12 month
Isocycloseram a.i. 11.40 to 12.60 12.5 12.48 12.45
Flubendiamide a.i. 5.70 to 6.60 6.35 6.34 6.33
Pymetrozine a.i. 28.50 to 31.50 30.5 30.5 30.48
Isocycloseram suspensibility (%) 70 98.40 98.40 98.30
Flubendiamide suspensibility (%) 70 98.20 98.10 98.10
Pymetrozine suspensibility (%) 70 98.80 98.80 98.70
pH range (1% aq. Suspension) 5 to 9 7.50 7.50 7.55
Wettability Max 30 s 10 10 11
Wet Sieve(45 micron) Mini 98.5% 99.5 99.5 99.5
Bulk Density 0.45-0.85 0.5 0.5 0.5
Moisture Content Max 2.0% 1.4 1.4 1.3
Persistent foam ml (after 1 minute) max. 60 nil nil nil

The composition of Isocycloseram 12%+Flubendiamide 6%+Pymetrozine 30% WG meets the all in-house specifications for storage stability studies in laboratory (at 54±2 C & at 0±2 C for 14 days) and room temperature (for 12 months).
Manufacturing process for 100 kg batch of Isocycloseram 12%+Flubendiamide 6%+Pymetrozine 30% WG
Step 1: Charge the 21.0 kg China clay, 15.0 kg Corn starch, 0.5 kg silicone antifoam, 5 kg of Sodium isopropyl naphthalene sulfonate, 3 kg Modified polyacrylate copolymer and 7.0 kg of Modified Sodium lignosulphonates blend into a ribbon or premix blender and homogenization for 30 minutes.
Step 2: Now charge 12.0 kg Isocycloseram technical, 6 kg Flubendiamide technical and 30.0 kg Pymetrozine technical and again homogenize for 30 minutes and now this Pre-blended material is then grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx. 1.5 hr).
Step 3: Finely grinded powder is mixed with 10 kg of water having 0.5 kg silicone antifoam to form extrudable dough.
Step 4: Dough is passed through extruder to get granules of required size.
Step 5: Wet granules are passed through Fluidized bed drier to remove 10 kg extra water added and further graded using vibrating screens.
Step 6: Final product is sent for QC approval.
Step 7: After approval material is packed in required pack sizes.

EXAMPLE 8:
The preferred compositions for present invention are:
Compound A Compound B Compound C Active ingredients (%) Formulation Strength (%) Formu-lation
A B C
Isocycloseram Chlorantraniliprole Cartap hydrochloride 1 0.64 6.4 8.04 GR
Isocycloseram Chlorantraniliprole thiocyclam hydrogen oxalate 1 0.64 6.4 8.04 GR
Isocycloseram Chlorantraniliprole Clothianidin 1 0.64 2 3.64 GR
Isocycloseram Chlorantraniliprole fipronil 1 0.64 1.2 2.84 GR
Isocycloseram Chlorantraniliprole emamectin benzoate 1.25 0.8 0.35 2.40 GR
Isocycloseram Chlorantraniliprole Tolfenpyrad 7.5 5 15 27.50 SC
Isocycloseram Chlorantraniliprole Bifenthrin 7.5 5 7.5 20.00 SC
Isocycloseram Chlorantraniliprole lambda cyhalothrin 15 10 5 30.00 SE
Isocycloseram Chlorantraniliprole Abamectin 9 6 1.8 16.80 SC
Isocycloseram Chlorantraniliprole Fipronil 8 6 12 26.00 SC
Isocycloseram Chlorantraniliprole Fipronil 16 12 24 52.00 WG
Isocycloseram Chlorantraniliprole flonicamid 16 12 24 52.00 WG
Isocycloseram Chlorantraniliprole pyriproxyfen 6.4 4.8 10 21.20 SE
Isocycloseram Chlorantraniliprole diafenthiuron 4 3 25 32.00 SC
Isocycloseram Chlorantraniliprole pyrifluquinazon 8 6 20 34.00 WG
Isocycloseram Chlorantraniliprole spiromesifen 4 3 12.5 19.50 SC
Isocycloseram Chlorantraniliprole Fenpyroximate 6 10 5 21.00 SC
Isocycloseram Chlorantraniliprole Hexythiazox 6 10 5 21.00 SE
Isocycloseram Chlorantraniliprole Etoxazole 6 10 6 22.00 SC
Isocycloseram Chlorantraniliprole cyenopyrafen 4.8 8 12 24.80 SC
Isocycloseram Chlorantraniliprole Methoxyfenozide 8 6 25 39.00 WG
Isocycloseram Chlorantraniliprole Methoxyfenozide 5 3 20 28.00 SC
Isocycloseram Chlorantraniliprole Spinosad 10 6 10 26.00 SC
Isocycloseram Chlorantraniliprole Indoxacarb 10 6 10 26.00 SC
Isocycloseram Chlorantraniliprole Emamectin benzoate 12.5 7.5 2.5 22.50 SC
Isocycloseram Chlorantraniliprole Emamectin benzoate 20 15 5 40.00 WG
Isocycloseram Chlorantraniliprole Emamectin benzoate 12.5 7.5 2.5 22.50 OD
Isocycloseram Chlorantraniliprole Flupyrimin 6 3 7.5 16.50 SC
Isocycloseram Chlorantraniliprole Triflumezopyrim 15 7.5 5 27.50 SC
Isocycloseram Chlorantraniliprole Pymetrozine 12 6 30 48.00 WG
Isocycloseram Cyantraniliprole emamectin benzoate 15 15 3 33.00 SC
Isocycloseram Cyantraniliprole Tolfenpyrad 7.5 7.5 15 30.00 SC
Isocycloseram Cyantraniliprole Bifenthrin 7.5 7.5 7.5 22.50 SC
Isocycloseram Cyantraniliprole lambda cyhalothrin 12.5 12.5 5 30.00 ZC
Isocycloseram Cyantraniliprole Abamectin 9 9 1.8 19.80 SC
Isocycloseram Cyantraniliprole Fipronil 8 10 12 30.00 SC
Isocycloseram Cyantraniliprole flonicamid 16 20 24 60.00 WG
Isocycloseram Cyantraniliprole pyriproxyfen 6.4 8 10 24.40 SE
Isocycloseram Cyantraniliprole diafenthiuron 4 5 25 34.00 SC
Isocycloseram Cyantraniliprole pyrifluquinazon 8 10 20 38.00 WG
Isocycloseram Cyantraniliprole spiromesifen 4 5 9 18.00 OD
Isocycloseram Cyantraniliprole Fenpyroximate 6 12 5 23.00 SC
Isocycloseram Cyantraniliprole Hexythiazox 6 12 5 23.00 SE
Isocycloseram Cyantraniliprole Etoxazole 6 12 6 24.00 SC
Isocycloseram Cyantraniliprole cyenopyrafen 4.8 9.6 12 26.40 SC
Isocycloseram Cyantraniliprole Methoxyfenozide 5 5 18 28.00 SC
Isocycloseram Cyantraniliprole Methoxyfenozide 10 10 30 50.00 WG
Isocycloseram Cyantraniliprole Spinosad 5 5 5 15.00 SC
Isocycloseram Cyantraniliprole Indoxacarb 5 5 5 15.00 SC
Isocycloseram Cyantraniliprole Emamectin benzoate 12.5 12.5 2.5 27.50 SC
Isocycloseram Cyantraniliprole Flupyrimin 6 5 7.5 18.50 SC
Isocycloseram Cyantraniliprole Triflumezopyrim 15 12.5 5 32.50 SC
Isocycloseram Cyantraniliprole Pymetrozine 12 10 30 52.00 WG
Isocycloseram Tetraniliprole emamectin benzoate 15 15 3 33.00 SC
Isocycloseram Tetraniliprole Tolfenpyrad 7.5 7.5 12 27.00 SC
Isocycloseram Tetraniliprole Bifenthrin 7.5 7.5 7.5 22.50 SC
Isocycloseram Tetraniliprole lambda cyhalothrin 12.5 12.5 5 30.00 SE
Isocycloseram Tetraniliprole Abamectin 9 9 1.8 19.80 SC
Isocycloseram Tetraniliprole Fipronil 8 8 10 26.00 SC
Isocycloseram Tetraniliprole flonicamid 16 16 20 52.00 WG
Isocycloseram Tetraniliprole pyriproxyfen 6.4 6.4 8 20.80 SE
Isocycloseram Tetraniliprole diafenthiuron 4 4 22 30.00 SC
Isocycloseram Tetraniliprole pyrifluquinazon 8 8 18 34.00 WG
Isocycloseram Tetraniliprole spiromesifen 4 4 10 18.00 SC
Isocycloseram Tetraniliprole Fenpyroximate 5 10 5 20.00 SC
Isocycloseram Tetraniliprole Hexythiazox 5 10 5 20.00 SE
Isocycloseram Tetraniliprole Etoxazole 5 10 6 21.00 SC
Isocycloseram Tetraniliprole cyenopyrafen 4 8 12 24.00 SC
Isocycloseram Tetraniliprole Methoxyfenozide 5 4.5 17.5 27.00 SC
Isocycloseram Tetraniliprole Methoxyfenozide 10 9 30 49.00 WG
Isocycloseram Tetraniliprole Spinosad 10 9 9 28.00 SC
Isocycloseram Tetraniliprole Indoxacarb 10 9 9 28.00 SC
Isocycloseram Tetraniliprole Emamectin benzoate 12.5 11.25 2 25.75 SC
Isocycloseram Tetraniliprole Flupyrimin 10 8 10 28.00 SC
Isocycloseram Tetraniliprole Triflumezopyrim 12.5 10 5 27.50 SC
Isocycloseram Tetraniliprole Pymetrozine 8 8 30 46.00 WG
Isocycloseram Cyclaniliprole cartap hydrochloride 1 0.6 6.4 8.00 GR
Isocycloseram Cyclaniliprole thiocyclam hydrogen oxalate 1 0.6 6.4 8.00 GR
Isocycloseram Cyclaniliprole clothianidin 1 0.6 1.2 2.80 GR
Isocycloseram Cyclaniliprole fipronil 1 0.6 1 2.60 GR
Isocycloseram Cyclaniliprole emamectin benzoate 15 10 3 28.00 SC
Isocycloseram Cyclaniliprole Tolfenpyrad 7.5 5 12 24.50 SC
Isocycloseram Cyclaniliprole Bifenthrin 7.5 5 7.5 20.00 SC
Isocycloseram Cyclaniliprole lambda cyhalothrin 15 10 5 30.00 SE
Isocycloseram Cyclaniliprole Abamectin 9 6 1.8 16.80 SC
Isocycloseram Cyclaniliprole Fipronil 8 6 12 26.00 SC
Isocycloseram Cyclaniliprole flonicamid 16 12 24 52.00 WG
Isocycloseram Cyclaniliprole pyriproxyfen 6.4 4.8 10 21.20 SE
Isocycloseram Cyclaniliprole diafenthiuron 4 3 25 32.00 SC
Isocycloseram Cyclaniliprole pyrifluquinazon 8 6 20 34.00 WG
Isocycloseram Cyclaniliprole spiromesifen 4 3 9 16.00 OD
Isocycloseram Cyclaniliprole Fenpyroximate 6 8 5 19.00 SC
Isocycloseram Cyclaniliprole Hexythiazox 6 8 5 19.00 SE
Isocycloseram Cyclaniliprole Etoxazole 6 8 6 20.00 SC
Isocycloseram Cyclaniliprole cyenopyrafen 4.8 6.4 12 23.20 SC
Isocycloseram Cyclaniliprole Methoxyfenozide 5 3 20 28.00 SC
Isocycloseram Cyclaniliprole Spinosad 5 3 5 13.00 SC
Isocycloseram Cyclaniliprole Indoxacarb 5 3 5 13.00 SC
Isocycloseram Cyclaniliprole Emamectin benzoate 12.5 7.5 2.5 22.50 SC
Isocycloseram Cyclaniliprole Flupyrimin 6 3 7.5 16.50 SC
Isocycloseram Cyclaniliprole Triflumezopyrim 15 7.5 5 27.50 SC
Isocycloseram Cyclaniliprole Pymetrozine 12 6 30 48.00 WG
Isocycloseram Flubendiamide cartap hydrochloride 1 1.3 6 8.30 GR
Isocycloseram Flubendiamide thiocyclam hydrogen oxalate 1 1.3 6 8.30 GR
Isocycloseram Flubendiamide clothianidin 1 1.3 2 4.30 GR
Isocycloseram Flubendiamide fipronil 1 1.3 1 3.30 GR
Isocycloseram Flubendiamide emamectin benzoate 15 10 3 28.00 SC
Isocycloseram Flubendiamide emamectin benzoate 20 10 5 35.00 WG
Isocycloseram Flubendiamide Tolfenpyrad 7.5 5 12 24.50 SC
Isocycloseram Flubendiamide Bifenthrin 7.5 5 7.5 20.00 SC
Isocycloseram Flubendiamide lambda cyhalothrin 15 10 5 30.00 SE
Isocycloseram Flubendiamide Abamectin 9 6 1.8 16.80 SC
Isocycloseram Flubendiamide Fipronil 8 6 12 26.00 SC
Isocycloseram Flubendiamide flonicamid 16 12 24 52.00 WG
Isocycloseram Flubendiamide pyriproxyfen 6.4 4.8 10 21.20 SE
Isocycloseram Flubendiamide diafenthiuron 4 3 25 32.00 SC
Isocycloseram Flubendiamide pyrifluquinazon 8 6 20 34.00 WG
Isocycloseram Flubendiamide spiromesifen 4 3 12.5 19.50 SC
Isocycloseram Flubendiamide Fenpyroximate 6 8 5 19.00 SC
Isocycloseram Flubendiamide Hexythiazox 6 8 5 19.00 SE
Isocycloseram Flubendiamide Etoxazole 6 8 6 20.00 SC
Isocycloseram Flubendiamide cyenopyrafen 4.8 6.4 12 23.20 SC
Isocycloseram Flubendiamide Methoxyfenozide 5 3 20 28.00 SC
Isocycloseram Flubendiamide Methoxyfenozide 10 6 30 46.00 WG
Isocycloseram Flubendiamide Spinosad 5 3 5 13.00 SC
Isocycloseram Flubendiamide Indoxacarb 5 3 5 13.00 SC
Isocycloseram Flubendiamide Emamectin benzoate 12.5 7.5 2.5 22.50 SC
Isocycloseram Flubendiamide Flupyrimin 6 3 7.5 16.50 SC
Isocycloseram Flubendiamide Triflumezopyrim 15 7.5 5 27.50 SC
Isocycloseram Flubendiamide Pymetrozine 12 6 30 48.00 WG
Isocycloseram Chlorantraniliprole Broflanilide 15.0 12.0 6.0 33.00 SC
Isocycloseram Cyantraniliprole Broflanilide 7.5 10.0 3.0 20.50 SC
Isocycloseram Tetraniliprole Broflanilide 15.0 15.0 6.0 36.00 SC
Isocycloseram Cyclaniliprole Broflanilide 15.0 15.0 6.0 36.00 SC
Isocycloseram Flubendiamide Broflanilide 15.0 15.0 6.0 36.00 SC
Isocycloseram Chlorantraniliprole Fluxametamide 7.50 6.0 7.5 21.00 SC
Isocycloseram Cyantraniliprole Fluxametamide 6.0 8.0 6.0 20.00 OD
Isocycloseram Tetraniliprole Fluxametamide 6.0 6.0 6.0 18.00 SC
Isocycloseram Cyclaniliprole Fluxametamide 6.0 6.0 6.0 18.00 DC
Isocycloseram Flubendiamide Fluxametamide 6.0 6.0 6.0 18.00 SC
Isocycloseram Chlorantraniliprole Acetamiprid 15.0 7.5 15.0 37.50 WG
Isocycloseram Cyantraniliprole Acetamiprid 15.0 15.0 10.0 40.00 WG
Isocycloseram Tetraniliprole Acetamiprid 15.0 12.0 20.0 47.00 WG
Isocycloseram Cyclaniliprole Acetamiprid 15.0 12.0 20.0 47.00 WG
Isocycloseram Flubendiamide Acetamiprid 15.0 15.0 15.0 45.00 WG
Active ingredients on the basis of 100% purity.
Biological Examples:
The synergistic pesticide action of the inventive mixtures can be demonstrated by the experiments below. A synergistic effect exists wherever the action of a combination (ready-mix) or tank mix of active ingredient is greater than the sum of the action of each of the components alone. Therefore, a synergistically effective amount or an effective amount of a synergistic composition or combination is an amount that exhibits greater pesticide activity than the sum of the pesticide activities of the individual components.
In the field of agriculture, it is often understood that the term “synergy” is as defined by Colby S.R. in an article entitled “ Calculation of the synergistic and antagonistic responses of herbicide combinations” published in the journal Weeds, 1967, 15, p.20-22, incorporated herein by reference in its entirety. The action expected for a given combination of two or three active components can be calculated as follows:

The objective of the present studies was to study the synergism and benefits of present compositions.
Example 1: Bio efficacy against insect-pests infesting chilli crop.
Crop : Chilli
Location : Warangal, Telangana
Number of Treatments: 28
Plot size : 50 sq.m. (m2)
Crop stage : 92 days after transplanting.
Method of application : foliar spray with battery operated backpack sprayer.
Water volume : 520 liter per hectare
Observation Methods:
Thrips (mixed infestation of Scirtothrips dorsalis and Thrips parvispinus): Count the number of live thrips by shaking the twigs on black piece of paper. Record the observations from 3 twigs per plant and 10 plants per plot on 7th and 14th DAA (days after application). Calculate thrips control (%) as observed value and apply Colby’s formula to calculate synergism.

Fruit borer (Helicoverpa armigera) larvae: Count the number of live larvae per plant. Record observations from 10 plants per plot, calculate larval control (%) by using given
Formula.

Healthy Fruit count: Count the number of healthy marketable fruits per plant. Record the observations from 10 plants per plot and calculate increase (%) in healthy marketable fruits over UTC (untreated check).

Table 1: Treatment details
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 15%+chlorantraniliprole 10%+lambda cyhalothrin 5% SE 45+30+15
T2 isocycloseram 9%+chlorantraniliprole 6%+abamectin 1.8% SC 45+30+9
T3 isocycloseram 7.5%+chlorantraniliprole 5%+tolfenpyrad 15% SC 45+30+90
T4 isocycloseram 7.5%+chlorantraniliprole 5%+bifenthrin 7.5% SC 45+30+45
T5 isocycloseram 12.5%+cyantraniliprole 12.5%+lambda cyhalothrin 5% ZC 45+45+18
T6 isocycloseram 9%+cyantraniliprole 9%+abamectin 1.8% SC 45+45+9
T7 isocycloseram 7.5%+cyantraniliprole 7.5%+tolfenpyrad 15% SC 45+45+90
T8 isocycloseram 7.5%+cyantraniliprole 7.5%+bifenthrin 7.5% SC 45+45+45
T9 chlorantraniliprole 10%+lambda cyhalothrin 5% SE 30+15
T10 chlorantraniliprole 6%+abamectin 1.8% SC 30+9
T11 chlorantraniliprole 5%+tolfenpyrad 15% SC 30+90
T12 chlorantraniliprole 5%+bifenthrin 7.5% SC 30+45
T13 cyantraniliprole 12.5%+lambda cyhalothrin 5% ZC 45+18
T14 cyantraniliprole 9%+abamectin 1.8% SC 45+9
T15 cyantraniliprole 7.5%+tolfenpyrad 15% SC 45+90
T16 cyantraniliprole 7.5%+bifenthrin 7.5% SC 45+45
T17 isocycloseram 15%+lambda cyhalothrin 5% SE 30+15
T18 isocycloseram 9%+abamectin 1.8% SC 30+9
T19 isocycloseram 7.5%+tolfenpyrad 15% SC 30+90
T20 isocycloseram 7.5%+bifenthrin 7.5% SC 30+45
T21 isocycloseram 9.2% w/w (10% w/v) DC 45
T22 chlorantraniliprole 18.5% w/w (20% w/v) SC 30
T23 cyantraniliprole 10.26% w/w (10% w/v ) SC 45
T24 lambda cyhalothrin 5% EC 15
T25 abamectin 1.9% EC 9
T26 tolfenpyrad 15% EC 90
T27 bifenthrin 10% EC 45
T28 Untreated Check (UTC) -

SE suspo emulsion, SC suspension concentrate, ZC zeon concentrate, OD oil dispersion, EC emulsifiable concentrate, T1 to T8-present compositions, T9 to T20-known formulations.

Table 2a: Thrips control in chilli crop.

Treatment Number Thrips control (%)
at 7 DAA at 14 DAA
control observed control expected Colby's ratio Synergism (Y/N) control observed control expected Colby's ratio Synergism (Y/N)
T1 96.2 88.3 1.09 Y 88.4 78.9 1.12 Y
T2 97.4 90.7 1.07 Y 92.0 83.7 1.10 Y
T3 98.2 91.6 1.07 Y 93.2 85.4 1.09 Y
T4 96.4 89.2 1.08 Y 91.4 80.8 1.13 Y
T5 100.0 93.8 1.07 Y 97.8 89.2 1.10 Y
T6 100.0 95.1 1.05 Y 98.4 91.6 1.07 Y
T7 100.0 95.6 1.05 Y 99.0 92.5 1.07 Y
T8 100.0 94.3 1.06 Y 98.8 90.2 1.10 Y
T9 61.2 60.8 1.01 Y 41.0 43.9 0.93 N
T10 69.2 68.9 1.00 Y 54.8 56.7 0.97 N
T11 71.8 71.7 1.00 Y 59.2 61.1 0.97 N
T12 64.0 63.6 1.01 Y 48.4 49.0 0.99 N
T13 80.4 79.4 1.01 Y 68.2 71.2 0.96 N
T14 84.2 83.6 1.01 Y 75.0 77.7 0.96 N
T15 86.4 85.1 1.02 Y 78.2 80.0 0.98 N
T16 81.2 80.9 1.00 Y 71.2 73.8 0.96 N
T17 77.0 85.3 0.90 Y 64.8 66.6 0.97 N
T18 88.2 88.3 1.00 Y 80.0 82.9 0.97 N
T19 89.4 89.4 1.00 Y 78.6 81.7 0.96 N
T20 90.0 86.4 1.04 Y 80.4 83.5 0.96 N
T21 70.2 62.4
T22 20.6 11.2
T23 58.2 54.4
T24 50.6 36.8
T25 60.8 51.2
T26 64.4 56.2
T27 54.2 42.6
T28 0.0 0.0
DAA-days after application, Y-yes, N-no.

All the inventive compositions (T1 to T8) provide synergistic control as well as residual control up to 14 days as compared to all known formulations (T9 to T20) and market products (T21 to T27). All the inventive composition (T1 to T8) depicts Colby’s ratio >1 which means stronger synergism.

Table 2b: Fruit borer larval control and chilli fruit yield.
Treatment Number Fruit borer larval control (%) at 14 DAA Number of healthy fruits per plant Increase (%) in fruits over UTC

T1 100.0 51.2 206.6
T2 100.0 52.0 211.4
T3 100.0 52.2 212.6
T4 100.0 51.7 209.6
T5 100.0 53.2 218.6
T6 100.0 54.1 224.0
T7 100.0 54.3 225.1
T8 100.0 53.6 221.0
T9 85.6 38.8 132.3
T10 82.2 40.1 140.1
T11 87.8 40.7 143.7
T12 86.2 39.8 138.3
T13 82.4 42.9 156.9
T14 80.6 43.8 162.3
T15 86.2 44.1 164.1
T16 84.6 43.2 158.7
T17 82.4 44.5 166.5
T18 79.2 45.1 170.1
T19 85.6 45.7 173.7
T20 83.4 44.9 168.9
T21 64.4 35.3 111.4
T22 65.4 31.6 89.2
T23 63.2 33.7 101.8
T24 47.8 30.2 80.8
T25 33.4 32.4 94.0
T26 55.4 33.1 98.2
T27 52.2 30.7 83.8
T28 0.0 16.7 0.0

All the inventive compositions (T1 to T8) provide synergistic control of fruit borer larvae as well as produces highest number of marketable fruits per plant (<206% increase over UTC (T28).
Conclusion: Among the various compositions as shown in Table 1, treatment number T1-T8 are considered to be present compositions which showed excellent synergism and effectiveness against chilli thrips and fruit borer larva on chilli crop. The thrips control observed at 7 DAA (days after application) of T1-T8 were >96% whereas the Colby’s ratio was found to be >1 which means strong synergism. Whereas at 14 DAA the thrips control observed was more than 88%. Particularly, T7 (99%) followed by T8 (98.8%) and T6 (98.4%) showed highest thrips control at 14 DAA, achieving >1 Colby’s ratio depicting effective synergism when compared to other known and market products.

Furthermore, the fruit borer larval control of T1-T8 showed 100% effectiveness at 14 DAA providing with more than 54 healthy fruits per plant from which T7 proved the maximum 54.3 followed by T6 (54.1) and T8 (53.6) of healthy fruits per plant. In addition to that, T1-T8 showed drastic increment >206% in fruits over UTC (untreated check), especially T7 exhibited 225.1% followed by T6 (224%) and T8 (221%) increase in fruits over UTC as compared to other known and market products.

Example 2: Insect-pests control in brinjal crop.
Crop : Brinjal
Location : Sonipat, Haryana
Number of Treatments: 28
Plot size : 40 sq.m.
Crop age : 75 days after transplanting.
Method of application: foliar spray with battery operated backpack sprayer.
Water volume : 500 liter per hectare

Observation Methods:
Damage by Shoot & Fruit borer (Leucinoides orbonalis): The larvae of shoot & fruit borer cause damage to shoots and fruits in brinjal crop. It’s an internal feeder, i.e. bore inside shoot and fruits and causes damage. The efficacy can be assessed by counting the number of healthy and infested shoots, healthy and infested fruits per plant. Record the observations from randomly selected 10 plants per plot.

Fruit counts: Count the number of healthy marketable fruits from 5 plants per plot and calculate increase in healthy fruits over UTC.
Red spider mite (Tetranychus urticae): Count the number of motile stages of mite per unit area using 10X pocket microscope. Record the observations from 5 spots on randomly selected leaves (young growing leaves) per plant. Observe 10 plants per plot. Calculate mite control (%) as per formula given for thrips control.

Table 3: Treatment details
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 6%+chlorantraniliprole 10%+fenpyroximate 5% SC 24+40+20
T2 isocycloseram 6%+chlorantraniliprole 10%+hexythiazox 5% SE 24+40+20
T3 isocycloseram 6%+chlorantraniliprole 10%+etoxazole 6% SC 24+40+24
T4 isocycloseram 4.8%+chlorantraniliprole 8%+cyenopyrafen 12% SC 24+40+60
T5 isocycloseram 6%+cyantraniliprole 12%+fenpyroximate 5% SC 24+48+20
T6 isocycloseram 6%+cyantraniliprole 12%+hexythiazox 5% SE 24+48+20
T7 isocycloseram 6%+cyantraniliprole 12%+etoxazole 6% SC 24+48+24
T8 isocycloseram 4.8%+cyantraniliprole 9.6%+cyenopyrafen 12% SC 24+48+60
T9 chlorantraniliprole 10%+fenpyroximate 5% SC 40+20
T10 chlorantraniliprole 10%+hexythiazox 5% SE 40+20
T11 chlorantraniliprole 10%+etoxazole 6% SC 40+24
T12 chlorantraniliprole 8%+cyenopyrafen 12% SC 40+60
T13 cyantraniliprole 12%+fenpyroximate 5% SC 48+20
T14 cyantraniliprole 12%+hexythiazox 5% SE 48+20
T15 cyantraniliprole 12%+etoxazole 6% SC 48+24
T16 cyantraniliprole 9.6%+cyenopyrafen 12% SC 48+60
T17 isocycloseram 6%+fenpyroximate 5% SC 24+20
T18 isocycloseram 6%+hexythiazox 5% SE 24+20
T19 isocycloseram 6%+etoxazole 6% SC 24+24
T20 isocycloseram 4.8%+cyenopyrafen 12% SC 24+60
T21 isocycloseram 9.2% w/w (10% w/v) DC 24
T22 chlorantraniliprole 18.5% w/w (20% w/v) SC 40
T23 cyantraniliprole 10.26% w/w (10% w/v ) SC 48
T24 fenpyroximate 5% EC 20
T25 hexythiazox 5% SC 20
T26 etoxazole 10% SC 24
T27 cyenopyrafen 30% SC 60
T28 Untreated Check (UTC) -
T1 to T8-present compositions, T9 to T20-known compositions, T21 to T27-market products.

Table 4a: Red spider mite control in brinjal.
Treatment Number Red spider mite control (%) at 7 DAA
Observed Expected/Calculated Colby's ratio Synergism (Y/N)
T1 97.4 87.8 1.11 Y
T2 98.2 88.4 1.11 Y
T3 97.8 88.1 1.11 Y
T4 97.2 87.3 1.11 Y
T5 98.2 88.3 1.11 Y
T6 99.2 88.9 1.12 Y
T7 98.4 88.6 1.11 Y
T8 97.6 87.9 1.11 Y
T9 60.2 60.9 0.99 N
T10 62.6 62.9 1.00 N
T11 61.6 62.0 0.99 N
T12 58.4 59.4 0.98 N
T13 61.8 62.5 0.99 N
T14 63.6 64.4 0.99 N
T15 62.4 63.6 0.98 N
T16 60.8 61.1 0.99 N
T17 85.4 86.6 0.99 N
T18 86.6 87.3 0.99 N
T19 86.2 87.0 0.99 N
T20 85.8 86.1 1.00 N
T21 68.8
T22 8.6
T23 12.4
T24 57.2
T25 59.4
T26 58.4
T27 55.6
T28 0.0
All present compositions (T1 to T8) provide synergistic control of red spider mite.

Table 4b: Efficacy against shoot and fruit borer damage and yield in brinjal corp.

Treatment Number Shoot damage (%) Fruit damage (%) Number of healthy fruits per five plants Increase (%) in fruits over UTC
T1 0.0 0.0 78.4 146.5
T2 0.0 0.0 77.3 143.1
T3 0.0 0.0 78.1 145.6
T4 0.0 0.0 76.9 141.8
T5 0.0 0.0 74.6 134.6
T6 0.0 0.0 73.9 132.4
T7 0.0 0.0 74.2 133.3
T8 0.0 0.0 72.7 128.6
T9 0.92 0.76 63.6 100.0
T10 0.96 0.82 62.5 96.5
T11 0.93 0.78 63.0 98.1
T12 0.96 0.83 61.8 94.3
T13 1.14 1.04 60.3 89.6
T14 1.12 1.02 59.7 87.7
T15 1.17 1.08 60.2 89.3
T16 1.15 1.07 59.1 85.8
T17 0.82 0.78 68.2 114.5
T18 0.80 0.73 66.7 109.7
T19 0.77 0.68 65.9 107.2
T20 0.82 0.76 67.3 111.6
T21 1.87 1.71 53.7 68.9
T22 2.37 2.14 50.2 57.9
T23 3.64 3.28 48.7 53.1
T24 7.92 6.88 40.4 27.0
T25 8.24 7.24 38.8 22.0
T26 7.68 6.95 39.6 24.5
T27 8.25 7.87 36.4 14.5
T28 16.82 15.48 31.8 0.0

All the inventive compositions (T1 to T8) provided excellent control of shoot and fruit borer and also produced highest number of marketable fruits per plant.

Conclusion: Among the various compositions as shown in Table 3, T1-T8 are the present compositions which showed excellent synergism and effectiveness against red spider mite, shoot and fruit borer in brinjal crop. The control of red spider mite at 7 DAA (days after application) was observed more than 97% among T1-T8 compositions. Moreover, T6 proved the maximum control which is 99.2% followed by T7 (98.4%) and T5 (98.2%) against red spider mite as well as depicting >1 Colby’s ratio proving effective synergism when compared with the known and market products.

Furthermore, T1-T8 showed excellent control against shoot and fruit borer which turned out to be 0% shoot and fruit damage as compared to other known and market products. In addition to that, T1-T8 depicted more than 72 healthy fruits per five plants from which T1 proved 78.4 of healthy fruits per five plants followed by T3 (78.1) and T2 (77.3). Moreover, T1-T8 showed maximum number of increment (>154%) in fruits over UTC (untreated check). Especially, T1 showed 146.5% followed by T3 (145.6%) and T2 (143.1%) increase in fruits over UTC when compared to other known and market products.

Example 3: Pod borer larval control and yield in red gram.
Crop : Red gram
Location : Amarawati, Maharashtra
Treatments : 21
Crop age : 110 days after sowing.
Spray water volume : 500 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Pod borer (Helicoverpa armigera) larval control (%): Count the number of live larvae per plant. Record observations from 10 plants per plot on 14th days after application.

Pod count: count the number of healthy pods of red gram per plant. Record the observations from 10 plants per plot.
Table 5: Treatment details
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 12.5%+flubendiamide 7.5%+emamectin benzoate 2.5% SC 50+30+10
T2 isocycloseram 5%+flubendiamide 3%+methoxyfenozide 20% SC 50+30+200
T3 isocycloseram 5%+flubendiamide 3%+spinosad 5% SC 50+30+50
T4 isocycloseram 5%+flubendiamide 3%+indoxacarb 5% SC 50+30+50
T5 isocycloseram 12.5%+cyclaniliprole 7.5%+emamectin benzoate 2.5% SC 50+30+10
T6 isocycloseram 5%+cyclaniliprole 3%+methoxyfenozide 20% SC 50+30+200
T7 isocycloseram 5%+cyclaniliprole 3%+spinosad 5% SC 50+30+50
T8 isocycloseram 5%+cyclaniliprole 3%+indoxacarb 5% SC 50+30+50
T9 isocycloseram 12.5%+tetraniliprole 11.25%+emamectin benzoate 2% SC 50+45+8
T10 isocycloseram 5%+tetraniliprole 4.5%+methoxyfenozide 17.5% SC 50+45+175
T11 isocycloseram 10%+tetraniliprole 9%+spinosad 9% SC 50+45+45
T12 isocycloseram 10%+tetraniliprole 9%+indoxacarb 9% SC 50+45+45
T13 isocycloseram 9.2% w/w (10% w/v) DC 50
T14 flubendiamide 20% WG 30
T15 cyclaniliprole 9.3% w/w (10% w/v) DC 30
T16 tetraniliprole 18.18% w/w (20% w/v) SC 45
T17 emamectin benzoate 1.9% EC 8
T18 methoxyfenozide 21.8% w/w (24% w/v) SC 175
T19 spinosad 45% SC 45
T20 indoxacarb 15% SC 45
T21 Untreated Check (UTC) -

T1 to T12-present compositions, T13 to T20-market products.

Table 6: Pod borer larval control and pod yield in red gram.
Treatment Number Pod borer larval control (%) at 14 DAA Number of healthy pods per plants Increase (%) in healthy pods over UTC
Observed Expected/
Calculated Colby's ratio Synergism (Y/N)
T1 100.0 91.3 1.10 Y 313.7 141.7
T2 100.0 92.3 1.08 Y 314.5 142.3
T3 100.0 93.2 1.07 Y 312.8 141.0
T4 100.0 93.9 1.06 Y 310.2 139.0
T5 100.0 91.8 1.09 Y 313.0 141.1
T6 100.0 92.8 1.08 Y 311.9 140.3
T7 100.0 93.6 1.07 Y 312.6 140.8
T8 100.0 94.3 1.06 Y 310.9 139.5
T9 100.0 77.0 1.30 Y 311.8 140.2
T10 100.0 79.6 1.26 Y 315.3 142.9
T11 100.0 82.0 1.22 Y 313.3 141.4
T12 100.0 83.9 1.19 Y 314.2 142.1
T13 62.2 257.8 98.6
T14 56.8 242.4 86.7
T15 59.4 257.8 98.6
T16 60.4 258.3 99.0
T17 46.8 230.5 77.6
T18 52.8 240.9 85.6
T19 58.4 252.8 94.8
T20 62.8 259.0 99.5
T21 0.0 129.8 0.0

All the inventive compositions (T1 to T12) provided synergistic and residual control of pod borer larvae and also yielded higher number of healthy pods per plant as compared to all known compositions, farm tank mixes and market products.

Conclusion: Among the various compositions as shown in Table 6 treatment number T1-T12 are considered to be present compositions which showed excellent synergism and effectiveness against pod borer larva control in red gram. Moreover, the control of pod borer at 14 DAA (days after application) showed 100% as compared to other known, farm tank mix and market products. In addition to that, T1-T12 received more than 310 numbers of healthy pods per plants. Particularly, T10 received maximum 115.3 healthy pods per plants followed by T2 (314.5) and T1 (313.7). Furthermore, T1-T12 showed more than 139% of increment in healthy pods over UTC (untreated check). Especially, T10 exhibited 142.9% followed by T2 (142.3%) and T1 (141.7%) increase in healthy pods over UTC when compared to market products (T13-T20).

Example 4: Whitefly and fruit borer larval control and yield in tomato.
Crop : Tomato
Location : Tarapur, Anand, Gujarat
Treatments : 19 including Untreated Check (UTC).
Crop age : 80 days after transplanting.
Spray water volume : 480 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Whitefly (Bemesia tabaci) control (%): Count the number of live whitefly (nymphs and adults) per trifoliate leaves, record the observations from 3 leaves per plant and 10 plants per plot.

Fruit borer (Helicoverpa armigera) larval control (%): Count the number of live larvae per plant. Record the observations from 10 plants per plot. Calculate the fruit borer larval control (%).

Healthy Fruit count: Count the number of healthy marketable fruits per plant. Record the observations from 10 plants per plot and calculate increase (%) in healthy marketable fruits over UTC (untreated check).

Table 7: Fruit borer larvae and whitefly control in tomato crop.
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 8%+cyantraniliprole 10%+pyrifluquinazon 20% WG 40+50+100
T2 isocycloseram 4%+cyantraniliprole 4%+diafenthiuron 25% SC 40+50+250
T3 isocycloseram 16%+cyantraniliprole 20%+flonicamid 24% WG 40+50+60
T4 isocycloseram 6.4%+cyantraniliprole 8%+pyriproxyfen 10% SE 40+50+62.5
T5 isocycloseram 4%+cyantraniliprole 5%+spiromesifen 9% OD 40+50+90
T6 isocycloseram 8%+cyclaniliprole 6%+pyrifluquinazon 20% WG 40+30+100
T7 isocycloseram 4%+cyclaniliprole 3%+diafenthiuron 25% SC 40+30+250
T8 isocycloseram 16%+cyclaniliprole 12%+flonicamid 24% WG 40+30+60
T9 isocycloseram 6.4%+cyclaniliprole 4.8%+pyriproxyfen 10% SE 40+30+62.5
T10 isocycloseram 4%+cyclaniliprole 3%+spiromesifen 9% OD 40+30+90
T11 isocycloseram 9.2% w/w (10% w/v) DC 40
T12 cyantraniliprole 10.26% w/w (10% w/v ) SC 50
T13 cyclaniliprole 9.3% w/w (10% w/v) DC 30
T14 Pyrifluquinazon 20% WG 10
T15 Diafenthiuron 50% WP 250
T16 Flonicamid 50% WG 60
T17 Pyriproxyfen 10% EC 62.5
T18 Spiromesifen 22.9% w/w (24% w/v) SC 90
T19 Untreated Check (UTC) -
DC dispersible concentrate, WG wettable granule, T1-T10 are innovative compositions, T11-T18 are market products.
Table 8: Fruit borer larvae and whitefly control in tomato.
Treatment Number whitefly control (%) at 7 DAA fruit borer larval control (%) at 14 DAA number of healthy fruits per plant Increase (%) in healthy fruits over T19 (UTC)
Observed Expected/Calculated Colby's ratio Synergism (Y/N)
T1 99.0 93.1 1.06 Y 100.0 42.7 125.9
T2 98.8 92.6 1.07 Y 100.0 41.5 119.6
T3 90.8 88.0 1.03 Y 100.0 43.8 131.7
T4 97.4 92.4 1.05 Y 100.0 40.8 115.9
T5 98.4 92.6 1.06 Y 100.0 42.4 124.3
T6 96.4 90.7 1.06 Y 100.0 41.3 118.5
T7 95.8 90.0 1.06 Y 100.0 42.6 125.4
T8 94.2 83.8 1.12 Y 100.0 43.1 128.0
T9 93.6 89.8 1.04 Y 100.0 45.2 139.2
T10 94.8 90.0 1.05 Y 100.0 42.3 123.8
T11 52.4 72.4 34.8 84.1
T12 58.8 66.4 32.5 72.0
T13 44.4 64.2 33.9 79.4
T14 64.8 16.8 26.8 41.8
T15 62.4 20.2 25.9 37.0
T16 38.6 14.8 24.3 28.6
T17 61.4 12.4 22.7 20.1
T18 62.2 13.6 23.2 22.8
T19 0.0 0 18.9 0.0

All the inventive compositions (T1 to T10) provided synergistic control of whitefly and fruit borer and also produced higher number of healthy fruits per plant in tomato.
Conclusion: Among the various compositions as shown in Table 8, treatment number T1-T10 are considered to be present compositions which showed excellent synergism and effectiveness against whitefly and fruit borer larva in tomato. The whitefly control was observed more than 90% for T1-T10. Particularly, T1 gave the maximum control 99% followed by T2 (98.8%) and T5 (98.4%) as well as the Colby’s ratio was >1 showing effective synergism as compared with market products. Furthermore, T1-T10 exhibited 100% control on the fruit borer larva. In addition to that, T1-T10 achieved more than 40 number of healthy fruits per plants whereas T9 exhibited 45.2 followed by T3 (43.8) and T8 (43.1) number of healthy fruits per plants. Furthermore, T1-T10 showed more than 115% of increment in healthy fruits over UTC (untreated check). Especially, T9 (139.2%) followed by T3 (131.7%) and T8 (128%) increase in healthy fruits over UTC when compared with market products.

Example 5: Fruit borer larval control in okra.
Crop : Okra
Location : Sonipat, Haryana
Treatments : 19
Crop age : 70 days after sowing.
Spray water volume : 450 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Fruit borer (mixed infestation of Helicoverpa armigera and Spodoptera exigua) larval control (%): as per example 4.
Table 9: Treatment details
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 15%+chlorantraniliprole 12%+broflanilide 6% SC 30+24+12
T2 isocycloseram 7.5%+cyantraniliprole 10%+broflanilide 3% SC 30+40+12
T3 isocycloseram 15%+tetraniliprole 15%+broflanilide 6% SC 30+30+12
T4 isocycloseram 15%+cyclaniliprole 15%+broflanilide 6% SC 30+30+12
T5 isocycloseram 15%+flubendiamide 15%+broflanilide 6% SC 30+30+12
T6 isocycloseram 7.5%+chlorantraniliprole 6%+fluxametamide 7.5% SC 30+24+30
T7 isocycloseram 6%+cyantraniliprole 8%+fluxametamide 6% OD 30+40+30
T8 isocycloseram 6%+tetraniliprole 6%+fluxametamide 6% SC 30+30+30
T9 isocycloseram 6%+cyclaniliprole 6%+fluxametamide 6% DC 30+30+30
T10 isocycloseram 6%+flubendiamide 6%+fluxametamide 6% SC 30+30+30
T11 isocycloseram 9.2% w/w (10% w/v) DC 30
T12 broflanilide 30% SC 12
T13 fluxametamide 10% EC 30
T14 chlorantraniliprole 18.5% w/w (20% w/v) SC 24
T15 cyantraniliprole 10.26% w/w (10% w/v ) SC 40
T16 tetraniliprole 18.18% w/w (20% w/v) SC 30
T17 cyclaniliprole 9.3% w/w (10% w/v) DC 30
T18 flubendiamide 20% WG 30
T19 Untreated Check (UTC) -

T1 to T4-present compositions, T5 to T13-known compositions, T14 to T19-market products.

Table 9: Fruit borer larval control in okra crop.
Treatment Number At 14 DAA, fruit borer larval control (%)
Observed Expected/Calculated Colby's ratio Synergism (Y/N)
T1 100.0 94.4 1.06 Y
T2 100.0 93.8 1.07 Y
T3 100.0 94.6 1.06 Y
T4 100.0 94.7 1.06 Y
T5 100.0 94.9 1.05 Y
T6 100.0 93.3 1.07 Y
T7 100.0 92.6 1.08 Y
T8 100.0 93.6 1.07 Y
T9 100.0 93.7 1.07 Y
T10 100.0 93.9 1.07 Y
T11 56.8
T12 68.4
T13 62.2
T14 58.8
T15 54.6
T16 60.6
T17 61.4
T18 62.4
T19 0.0

All the present compositions (T1-T10) provide synergistic control of fruit borer larvae infesting okra crops.

Conclusion: Among the various compositions as shown in Table 9 treatment number T1-T10 are considered to be present compositions which showed excellent synergism and effectiveness against fruit borer larva in okra. Moreover, T1-T10 showed excellent fruit borer control of 100% and achieved the Colby’s ratio >1 depicting effective synergism when compared to market products.

Example 6: Pod borer larval control and yield in chickpea.
Crop : Chickpea
Location : Devas, Madhya Pradesh
Treatments : 20
Crop age : 88 days after sowing.
Spray water volume : 400 liters per hectare.
Method of Application: Foliar spray with battery operated knapsack sprayer fitted with hollow cone nozzle.
Observation Methods:
Pod borer (Helicoverpa armigera) larval control: as given in example 4.

Table 10: Treatment details.
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 5%+chlorantraniliprole 3%+methoxyfenozide 20% SC 30+18+120
T2 isocycloseram 10%+chlorantraniliprole 6%+spinosad 10% SC 30+18+30
T3 isocycloseram 10%+chlorantraniliprole 6%+indoxacarb 10% SC 30+18+30
T4 isocycloseram 12.5%+chlorantraniliprole 7.5%+emamectin benzoate 2.5% SC 30+18+6
T5 isocycloseram 5%+methoxyfenozide 20% SC 30+120
T6 isocycloseram 10%+spinosad 10% SC 30+30
T7 isocycloseram 10%+indoxacarb 10% SC 30+30
T8 isocycloseram 12.5%+emamectin benzoate 2.5% SC 30+6
T9 chlorantraniliprole 3%+methoxyfenozide 20% SC 18+120
T10 chlorantraniliprole 6%+spinosad 10% SC 18+30
T11 chlorantraniliprole 6%+indoxacarb 10% SC 18+30
T12 chlorantraniliprole 7.5%+emamectin benzoate 2.5% SC 18+6
T13 isocycloseram 12.5%+chlorantraniliprole 7.5% SC 30+18
T14 isocycloseram 9.2% w/w (10% w/v) DC 30
T15 chlorantraniliprole 18.5% w/w (20% w/v) SC 18
T16 methoxyfenozide 21.8% w/w (24% w/v) SC 120
T17 spinosad 45% SC 30
T18 indoxacarb 15% SC 30
T19 emamectin benzoate 5% SG 6
T20 Untreated Check (UTC) -

T1-T4: present compositions, T5-T13: known formulations, T14-T19:market products.
Table 11: Pod borer larval control in chickpea.
Treatment Number At 14 DAA, larval control (%)
Observed Expected/Calculated Colby's ratio Synergism (Y/N)
T1 99.4 83.0 1.20 Y
T2 98.2 82.6 1.19 Y
T3 99.8 83.1 1.20 Y
T4 97.8 82.0 1.19 Y
T5 66.8 69.4 0.96 N
T6 65.2 68.5 0.95 N
T7 65.6 69.5 0.94 N
T8 64.4 67.4 0.95 N
T9 65.2 68.1 0.96 N
T10 64.6 67.2 0.96 N
T11 64.8 68.2 0.95 N
T12 63.0 66.1 0.95 N
T13 66.4 70.5 0.94 N
T14 46.8
T15 44.6
T16 42.4
T17 40.8
T18 42.6
T19 38.8
T20 0.0

All the present compositions (T1-T4) provide synergistic control of pod borer larvae infesting gram/chick pea crop.

Conclusion: Among the various compositions as shown in Table 11 treatment number T1-T4 are considered to be present compositions which showed excellent synergism and effectiveness against pod borer larva in gram. Moreover, T1-T4 showed excellent pod borer control of 100% and achieved the Colby’s ratio >1 depicting effective synergism when compared to known compositions (T5-T13) and market products (T14-T19).

Example 7: Control of stem borer in rice.
Crop : Rice
Location : Rajim, Chhattisgarh
Treatments : 24
Method of Application: Manual broadcasting at 20 days after transplanting the paddy crop (T1-T22), by dissolving into water and then mixed with sand (T23).

Observation Methods:
Stem borer control:
The infestation by stem borer was observed as dead heart (DH) symptoms during vegetative seedling and tillering stage, as a white earheads (WE) during ripening stage of the crop. Calculate stem borer incidence by counting number of dead heart (infested tiller) per hill (infested+healthy tillers) and by counting number of white earheads and productive tillers per hill at ripening stage.
The percent DH and WE incidence calculated by using formulae described below:

Productive tiller count: Count the number of productive tillers per hill. Record observations from 10 hills per plot at the time of harvesting.
Table 12: Treatment details
Treatment Number Treatment compositions gram actives per hectare
T1 isocycloseram 1%+chlorantraniliprole 0.64%+cartap hydrochloride 6.4% GR 50+32+320
T2 isocycloseram 1%+chlorantraniliprole 0.64%+thiocyclam hydrogen oxalate 6.4% GR 50+32+320
T3 isocycloseram 1%+chlorantraniliprole 0.64%+clothianidin 2% GR 50+32+100
T4 isocycloseram 1%+chlorantraniliprole 0.64%+fipronil 1.2% GR 50+32+60
T5 isocycloseram 1.25% + chlorantraniliprole 0.8% + emamectin benzoate 0.35% GR 50+32+14
T6 isocycloseram 1%+cartap hydrochloride 6.4% GR 50+320
T7 isocycloseram 1%+thiocyclam hydrogen oxalate 6.4% GR 50+320
T8 isocycloseram 1%+clothianidin 2% GR 50+100
T9 isocycloseram 1%+fipronil 1.2% GR 50+60
T10 isocycloseram 1.25%+emamectin benzoate 0.35% GR 50+14
T11 chlorantraniliprole 0.64%+cartap hydrochloride 6.4% GR 32+320
T12 chlorantraniliprole 0.64%+thiocyclam hydrogen oxalate 6.4% GR 32+320
T13 chlorantraniliprole 0.64%+clothianidin 2% GR 32+100
T14 chlorantraniliprole 0.64%+fipronil 1.2% GR 32+60
T15 chlorantraniliprole 0.8%+emamectin benzoate 0.35% GR 32+14
T16 isocycloseram 1.25%+chlorantraniliprole 0.8% GR 50+32
T17 isocycloseram 18.1% w/w (20% w/v) SC 50
T18 chlorantraniliprole 0.4% GR 32
T19 cartap hydrochloride 4% GR 320
T20 thiocyclam hydrogen oxalate 4% GR 320
T21 clothianidin 0.5% GR 100
T22 fipronil 0.5% GR 60
T23 emamectin benzoate 5% SG 14
T24 Untreated Check (UTC) -
T1-T5: present compositions, T6-T16: known compositions, T17-T23: market products.
Table 13: Control of stem borer and productive tillers in rice crop.
Treatment Number Stem borer Incidence (%) Productive tillers (per 1 sq.m.) at harvest Increase (%) in productive tillers over UTC
Dead Heart White ear
T1 0.00 0.00 305.7 63.0
T2 0.00 0.00 308.5 64.4
T3 0.00 0.00 301.3 60.6
T4 0.00 0.00 304.2 62.2
T5 0.00 0.00 302.9 61.5
T6 1.92 1.98 283.5 51.1
T7 1.88 1.92 287.5 53.3
T8 2.16 2.43 271.1 44.5
T9 2.06 2.15 275.4 46.8
T10 2.23 2.28 267.8 42.8
T11 1.72 1.94 288.1 53.6
T12 1.68 1.74 288.7 53.9
T13 2.11 2.26 271.4 44.7
T14 1.97 2.10 280.6 49.6
T15 2.04 2.27 277.3 47.8
T16 2.34 2.48 261.6 39.4
T17 3.17 4.15 245.4 30.8
T18 2.85 3.10 256.7 36.8
T19 2.96 3.16 253.2 35.0
T20 2.88 3.08 256.2 36.6
T21 4.58 6.16 232.2 23.8
T22 3.87 4.86 240.8 28.4
T23 4.08 5.88 235.6 25.6
T24 10.64 16.38 187.6 0.0

All the inventive compositions (T1 to T5) provided complete protection against rice stem borer (in terms of dead heart and white ear), also produces higher number of productive tillers per hill, which are directly contributing to the grain yield.

Conclusion: Among the various compositions as shown in Table 13 treatment number T1-T5 are considered to be present compositions which showed excellent synergism and effectiveness against stem borer (dead 10 heart and white ear) in rice plant. Further, T1-T5 indicated 0% stem borer incident (dead heart and white ear) as compared to other known composition market products. In addition to that, the numbers of productive tillers per sq.m. T1-T5 were between 301-308. Particularly, T2 depicted 308.5 followed by T1 (305.7) and T4 (304.2) numbers of productive tillers per sq.m. when compared to other known compositions and market products. Further increase % in productive tillers over T24 was between 60 to 65.

,CLAIMS:CLAIMS:
We claim;

[CLAIM 1]. A synergistic insecticidal composition comprising:
a. Isocycloseram present in an amount of 1 to 20%w/w;
b. an insecticide is selected from chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, tetrachlorantraniliprole, tyclopyrazoflor, cyhalodiamide, flubendiamide, fluchlordiniliprole, tiorantraniliprole present in an amount of 0.5% to 30% w/w; and
c. an insecticide is selected from carbaryl, carbofuran, carbosulfan, fenobucarb, methomyl, oxamyl, pirimicarb, thiodicarb, acephate, cadusafos, chlorpyrifos, chlorpyrifos-methyl, demeton-S-methyl, dimethoate, ethion, fenamiphos, fenitrothion, fenthion, fosthiazate, methamidophos, monocrotophos, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosphamidon, profenofos, quinalphos, triazophos, ethiprole, fipronil, flufiprole, nicofluprole, pyrafluprole, pyriprole, broflanilide, cyproflanilide, fluxametamide, afoxolaner, esafoxolaner, fluralaner, lotilaner, sarolaner, bifenthrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, fenpropathrin, fenvalerate, tau-fluvalinate, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (pyrethrum), acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, flupyrimin, cycloxaprid, paichongding, guadipyr, cycloxylidin, sulfoxaflor, flupyradifurone, triflumezopyrim, dichloromezotiaz, fenmezoditiaz; bensultap, monosultap, cartap hydrochloride, thiocyclam, thiocyclam hydrogen oxalate, thiocyclam hydrochloride, thiosultap sodium, spinosad, spinetoram, abamectin, emamectin benzoate, ivermectin, lepimectin, milbemectin; hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen, chloropicrin, dazomet, metam, pymetrozine, pyrifluquinazon, afidopyropen, flonicamid, clofentezine, hexythiazox, diflovidazin or etoxazole, bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, buprofezin, cyromazine, Bacillus thuringiensis and insecticidal proteins they product; chlorfenapyr, DNOC, or sulfluramid, methoxyfenozide, tebufenozide, halofenozide, fufenozide or chromafenozide, amitraz, diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, or tetradifon, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad, flufenerim, rotenone, fluacrypyrim, pyriminostrobin, cyenopyrafen, cyflumetofen, pyflubumide, hydramethylnon, acequinocyl, fluacrypyrim, bifenazate, flometoquin, phosphides and cyanides, indoxacarb, metaflumizone, spirodiclofen, spiromesifen, spirotetramat, spidoxamat, spiropidion, spirobudifen, granuloviruses and nucleopolyhedrosis viruses, acynonapyr, azadirachtin, benzoximate, bromopropylate, benzpyrimoxan, chinomethionat, dicofol, pyridalyl, oxazosulfyl, dimpropyridaz, indazapyroxamet, fluhexafon, cyetpyrafen, flupentiofenox, acyonapyr, trifluenfuronate, cyclobutrifluram, fluazaindolizine, tioxazafen, sulfiflumin, sulfiflumin, ledprona present in an amount of 0.5% to 30% w/w.

[CLAIM 2]. The synergistic insecticidal composition as claimed in claim 1, wherein the formulation for the said composition is selected from Suspension concentrate (SC), Emulsion Concentrate (EC), Wettable Granule (WG)/ Water Dispersible Granule (WDG), Granule (GR), Oil dispersion (OD), Suspo-Emulsion (SE), Capsule suspension (CS), a mixed formulation of CS and SC (ZC).

[CLAIM 3]. The synergistic insecticidal composition as claimed in claim 2, wherein, the Suspension concentrate (SC) formulation comprises:
i. Isocycloseram present in an amount of 1 to 20%w/w;
ii. an insecticide is selected from Chlorantraniliprole, Cyantraniliprole, Tetraniliprole, Cyclaniliprole, Flubendiamide present in an amount of 0.5% to 30% w/w; and
iii. an insecticide is selected from Tolfenpyrad, Bifenthrin, Abamectin, Fipronil, diafenthiuron, spiromesifen, Fenpyroximate, Etoxazole, cyenopyrafen, Methoxyfenozide, Spinosad, Indoxacarb, Emamectin benzoate, Flupyrimin, Triflumezopyrim, emamectin benzoate, Broflanilide, Fluxametamide present in an amount of 0.5% to 30% w/w;
iv. super wetting-spreading-penetrating agent in an amount of 2 to 6 % by weight;
v. dispersing agent in an amount of 1 to 6 % by weight;
vi. suspending agent in an amount of 0.1 to 4.0 % by weight;
vii. antifoaming agent in an amount of 0.1 to 1.5 % by weight;
viii. preservative in an amount of 0.1 to 0.5 % by weight;
ix. anti-freezing agent in an amount of 2 to 6 % by weight;
x. thickner in an amount of 0.1 to 1.0 % by weight;
xi. diluent water in an amount of 50 to 70 % by weight.

[CLAIM 4]. The synergistic insecticidal composition as claimed in claim 3, wherein wetting-spreading-penetrating agent is selected from trisiloxane ethoxylate, heptamethyl trisiloxane, modified form includes polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane, polyalkyleneoxide modified trisiloxane, polyalkyleneoxide modified polydimethylsiloxane, may be liquid or powder form.

[CLAIM 5]. The synergistic insecticidal composition as claimed in claim 3, wherein dispersing agent is selected from Naphthalenesulfonic acid, sodium salt condensated with formaldehyde, alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium ligno sulfonate, sodium polycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propylene oxide-ethylene oxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycol ether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycol ether-phosphate, oleyl-polyglycol ether with ethylene oxide, tallow fatty amine polyethylene oxide, nonylphenol polyglycol ether with 9-10 moles ethylene oxide.

[CLAIM 6]. The synergistic insecticidal composition as claimed in claim 4, wherein suspending agent is selected from aluminum magnesium silicate, bentonite clay, silica, attapulgite clay.

[CLAIM 7]. The synergistic insecticidal composition as claimed in claim 3, wherein antifoaming agent is selected from silicone antifoam emulsion, dimethyl siloxane, polydimethyl siloxane, vegetable oil based antifoam, tallow based fatty acids.

[CLAIM 8]. The synergistic insecticidal composition as claimed in claim 3, wherein anti-freezing agent is selected from ethylene glycol, propane diols, glycerin or the urea, glycol (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride.

[CLAIM 9]. The synergistic insecticidal composition as claimed in claim 3, wherein preservative is selected from 1, 2-benzisothiazolin-3(2H)-one, sodium salt, sodium benzoate, 2-bromo-2-nitropropane-1, 3-diol, formaldehyde, sodium o-phenyl phenate, 5-chloro-2-methyl-4-isothiazolin-3-one & 2-methyl-4-isothiazolin-3-one.

[CLAIM 10]. The synergistic insecticidal composition as claimed in claim 2, wherein, the Wettable Granule formulation comprises
i. Isocycloseram present in an amount of 1 to 20%w/w;
ii. an insecticide is selected from Chlorantraniliprole, Cyantraniliprole, Tetraniliprole, Cyclaniliprole, Flubendiamide present in an amount of 0.5% to 30% w/w; and
iii. an insecticide is selected from Acetamiprid, Pymetrozine, Methoxyfenozide, flonicamid, emamectin benzoate, pyrifluquinazon, Fipronil present in an amount of 0.5% to 30% w/w;
iv. wetting agent in an amount of 2 to 6 % % by weight;
v. dispersing agent in an amount of 2 to 8 % by weight;
vi. antifoaming agent in an amount of 0.1 to 2.0 % by weight;
vii. carrier in an amount of 20 to 40 % by weight.

[CLAIM 11]. The synergistic insecticidal composition as claimed in claim 10, wherein dispersing agent is selected from sodium polycarboxylate (sodium polyacrylate), naphthalene sulfonic acid, sodium salt condensates with formaldehyde, polyalcoxylated alkyl phenol, naphthalene sulfonic acid formaldehyde condensate, methyl naphthalene-formaldehyde-condensate sodium salt, naphthalene condensates, lignosulfonates, calcium lignosulfonate, lignin sulfonate sodium salt, alkyl naphthalene sulfonate sodium salt.

[CLAIM 12]. The synergistic insecticidal composition as claimed in claim 10, wherein wetting agent is selected from sodium N-methyl-N-oleoyl taurate, alkylated naphthalene sulfonate, sodium salt, mixture of isomers of dibutyl naphthalene sulphonic acid sodium salt, sodium di-isopropyl naphthalene sulphonate, sodium Lauryl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulphosuccinates and non-ionic such as tridecyl alcohol ethoxylate, alkyl or alkaryl sulfonates such as alkylbenzene sulfonates, alpha olefin sulfonate and alkyl naphthalene sulfonates, ethoxylated or non-ethoxylated alkyl or alkaryl carboxylates, alkyl or alkaryl phosphate esters, alkyl polysaccharide, di or mono alkyl sulfosuccinate derivatives, alpha olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulphosuccinates, butyl, dibutyl, isopropyl and di-isopropyl naphthalene sulfonate salts, C12 alkyl benzene sulfonate or C10-C16 alkyl benzene sulfonate, organosilicons surfactants includes trisiloxane ethoxylate, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethyl siloxane copolymer, trisiloxane heptamethyl, Polyalkyleneoxide modified heptamethyl trisiloxane, polyether modified polysiloxane.

[CLAIM 13]. The synergistic insecticidal composition as claimed in claim 10, wherein antifoaming agent is polydimethylsiloxane.

[CLAIM 14]. The synergistic insecticidal composition as claimed in claim 10, wherein carrier is selected from china clay, silica, lactose anhydrous, ammonium sulfate, sodium sulfate anhydrous, corn starch, urea, EDTA, urea formaldehyde resin, diatomaceous earth, kaolin, bentonite, kieselguhr, fuller's earth, attapulgite clay, bole, loess, talc, chalk, dolomite, limestone, lime, calcium carbonate, powdered magnesia, magnesium oxide, magnesium sulphate, sodium chloride, gypsum, calcium sulphate, pyrophyllite, silicates and silica gels.

[CLAIM 15]. The synergistic insecticidal composition as claimed in claim 2, wherein the Suspo-Emulsion (SE) formulation comprises:
i. Isocycloseram present in an amount of 1 to 20%w/w;
ii. an insecticide is selected from Chlorantraniliprole, Cyantraniliprole, Tetraniliprole, Cyclaniliprole present in an amount of 0.5% to 30% w/w; and
iii. an insecticide is selected from lambda cyhalothrin, pyriproxyfen, Hexythiazox present in an amount of 0.5% to 30% w/w;
iv. solvent in an amount of 10 to 20% by weight;
v. emulsifier in an amount of 1.0 to 4% by weight;
vi. dispersing agent in an amount of 2 to 6% by weight;
vii. suspending agent in an amount of 0.1 to 1.0% by weight;
viii. preservative in an amount of 0.01 to 1.0% by weight;
ix. anti-freezing in an amount of 4.0 to 6.0% by weight;
x. thickener in an amount of 0.10 to 0.5% by weight;
xi. diluent water in an amount of 40 to 60% by weight.

[CLAIM 16]. The synergistic insecticidal composition as claimed in claim 15, wherein emulsifier is selected from salts of dodecylbenzene sulphonate, e.g. Ca-salts or amine salts, and sulphonates of other C11-C16 alkylbenzenes, alkylether sulphates, alkylphenoletherphosphates and ester phosphates; non-ionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, e.g. ethoxylated castor oil, fatty acid esters, e.g. of sorbitol, and their ethoxylated derivatives, ethoxylated amines, and condensates of glycerol; and catanionic emulsifiers such as a cationic amine, optionally in combination with an alkylsulphonate or ether sulphonate or ether phosphate, alkoxylated alcohols; alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; ethoxylated tristyrylphenol (tristyrlphenol with 16 moles EO), tristyrylphenol-polyglycolether-phosphate, fatty acid esters of sorbitol and ethoxylated derivatives thereof; ethoxylated amines and condensates of glycerol; sulfonated alkylbenzenes in the range C11-C16 and salts thereof; alkylether sulphates; alkyletherphosphates; alkylphenoletherphosphates; or combinations thereof; salts of phosphate esters of ethoxylated tristyrylphenol; salts of sulphated ethers of ethoxylated tristyrylphenol; or a catanionic system, wherein a cationic amine is present in combination with an alkylsulphonate, an alkylethersulphonate, an ether sulphate, or an ether phosphate such as an alkyletherphosphate, nonylphenol polyethoxy ethanols, castor oil polyglycol ethers, polyadducts of ethylene oxide and polypropylene, tributyl phenoxy polyethoxy ethanol, octyl phenoxy polyethoxy ethanol.

[CLAIM 17]. The synergistic insecticidal composition as claimed in claim 15, wherein dispersing agent is selected from polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylic polymers, acrylic graft copolymer, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymers and mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methyl- methacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxy-butyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof. The examples of dispersing agents are alkylated naphthalene sulfonate, sodium salt, sodium salt of naphthalene sulfonate condensate, sodium salt of alkyl naphthalene sulfonate, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.

[CLAIM 18]. The synergistic insecticidal composition as claimed in claim 15, wherein antifoaming agent is selected from polyesters, polyamides, aluminum magnesium silicate, bentonite clay, silica, silicone dioxide, attapulgite clay.

[CLAIM 19]. The synergistic insecticidal composition as claimed in claim 2, wherein, Oil dispersion (OD) formulation comprises:
i. Isocycloseram present in an amount of 1 to 20%w/w;
ii. an insecticide is selected from Cyclaniliprole, Chlorantraniliprole, Cyantraniliprole present in an amount of 0.5% to 30% w/w; and
iii. an insecticide is selected from Spiromesifen, Fluxametamide, Emamectin benzoate present in an amount of 0.5% to 30% w/w;
iv. solvent in an amount of 40 to 70 % w/w;
v. dispersing agent in an amount of 1 to 8 % w/w;
vi. emulsifying agent in an amount of 2 to 12 % w/w;
vii. stabilizer or rheology modifier in an amount of 0.5 to 3.0 % w/w;

[CLAIM 20]. The synergistic insecticidal composition as claimed in claim 19, wherein dispersing agent is selected from alkyl sulfonates, alkyl benzene sulfonates, alkyl aryl sulfonates, alkylphenolalkoxylates, tristyrylphenol ethoxylates, natural or synthetic fatty ethoxylate alcohols, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohols alkoxylates, alkoxylated alcohols (such as n-butyl alcohol poly glycol ether), block copolymers (such as ethylene oxide-propylene oxide block copolymers and ethylene oxide-butylene oxide block copolymers), fatty acid-polyalkylene glycol condensates, polyamine-fatty acid condensates, polyester condensates, salts of polyolefin condensates, sodium ligno sulfonate, sodium ploycarboxylate, EO/PO based copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene acrylic acid copolymer, propyleneoxide-ethyleneoxide-copolymer, polyethylene glycol 2,4,6-tristyrylphenyl ether, tristyrylphenol-polyglycolether-phosphate, tristyrylphenole with 16 moles EO, tristyrylphenol-polyglycolether-phosphate, oleyl-polyglycolether with ethylene oxide, tallow fattyamine polyethylene oxide, nonylphenol polyglycolether with 9-10 moles ethylene oxide.

[CLAIM 21]. The synergistic insecticidal composition as claimed in claim 19, wherein Emulsifying agent is selected from castor oil ethoxylates, alcohol ethoxylates, fatty acid ethoxylates, sorbitan ester ethoxylates, sulphosuccinate, calcium salts of dodecylbenzene sulphonate, alkylammonium salts of alkylbenzene sulphonate, alkylsulphosuccinate salts, ethylene oxide-propylene oxide block copolymers, ethoxylated alkylamines, ethoxylated alkyl phenols, Polyoxyethylene sorbitol hexaoleate, polyoxyethylene sorbitan monolaurate.

[CLAIM 22]. The synergistic insecticidal composition as claimed in claim 19, wherein stabilizer cum rheology modifier is selected from hectorite clay, aluminium magnesium silicate, bentonite clay, silica, attapulgite clay.

[CLAIM 23]. The synergistic insecticidal composition as claimed in claim 19, wherein solvent is selected from vegetable oil (plant, seed or tree) or its alkylated or ethoxylated or esterified; alkylated vegetable oil may be methylated vegetable oil or ethylated vegetable oil; the vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cotton seed oil, soybean oil, groundnut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, coconut oil; the alkyl ester of vegetable oils includes methyl ester, ethyl ester, propyl ester or butyl ester of vegetable oils; methylated seed oil, polyalkyleneoxide modified polydimethylsiloxane alkyl phenol ethoxylate, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl esters, rapeseed oil butyl esters, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cotton seed oil methyl ester, cotton seed oil ethyl ester, cotton seed oil butyl ester, cotton seed oil propyl ester, tall oil fatty acids esters-tallow methyl ester, tallow ethyl ester, tallow propyl ester, bio-diesel, mineral oil (aromatic solvents, isoparaffin, base solvent), fatty acid amides (e.g. C1 -C3 amines, alkylamines or alkanolamines with C6–C18 carboxylic acids), fatty acids, alkyl esters of fatty acids, methyl and ethyl oleate, methyl and ethyl soyate, alkyl benzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, dialkylene carbonates, ketones and alcohols; used as solo or mixture thereof.

[CLAIM 24]. The synergistic insecticidal composition as claimed in claim 2, wherein the Granule (GR) formulation comprises:
i. Isocycloseram present in an amount of 1 to 20%w/w;
ii. an insecticide is selected from Chlorantraniliprole, Cyclaniliprole, Flubendiamide present in an amount of 0.5% to 30% w/w; and
iii. an insecticide is selected from Cartap hydrochloride, thiocyclam hydrogen oxalate, Clothianidin, fipronil, emamectin benzoate present in an amount of 0.5% to 30% w/w;
iv. phosphoric acid (buffering agent) present in an amount of 0.1 to 1.0%w/w;
v. phosphate ester of alcohol present in an amount of 1.0 to 2.0%w/w;
vi. alcohol alkoxylate present in an amount of 1.0 to 2.0%w/w;
vii. china clay present in an amount of 1.0 to 4.0%w/w;
viii. Rhodamine present in an amount of 0.1 to 1.0%w/w;
ix. River sand (Silica) present in an amount of 60 to 90%w/w.